LOCUS       NM_001310635            4186 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus cysteine-rich secretory protein LCCL domain containing
            2 (Crispld2), transcript variant 1, mRNA.
ACCESSION   NM_001310635 XM_006531507
VERSION     NM_001310635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Seow,B.K.L., McDougall,A.R.A., Short,K.L., Wallace,M.J.,
            Hooper,S.B. and Cole,T.J.
  TITLE     Identification of Betamethasone-Regulated Target Genes and Cell
            Pathways in Fetal Rat Lung Mesenchymal Fibroblasts
  JOURNAL   Endocrinology 160 (8), 1868-1884 (2019)
   PUBMED   31107524
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Wang,Z.Q., Xing,W.M., Fan,H.H., Wang,K.S., Zhang,H.K., Wang,Q.W.,
            Qi,J., Yang,H.M., Yang,J., Ren,Y.N., Cui,S.J., Zhang,X., Liu,F.,
            Lin,D.H., Wang,W.H., Hoffmann,M.K. and Han,Z.G.
  TITLE     The novel lipopolysaccharide-binding protein CRISPLD2 is a critical
            serum protein to regulate endotoxin function
  JOURNAL   J Immunol 183 (10), 6646-6656 (2009)
   PUBMED   19864597
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Quinlan,J., Kaplan,F., Sweezey,N. and Goodyer,P.
  TITLE     LGL1, a novel branching morphogen in developing kidney, is induced
            by retinoic acid
  JOURNAL   Am J Physiol Renal Physiol 293 (4), F987-F993 (2007)
   PUBMED   17670908
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Chiquet,B.T., Lidral,A.C., Stal,S., Mulliken,J.B., Moreno,L.M.,
            Arcos-Burgos,M., Valencia-Ramirez,C., Blanton,S.H. and Hecht,J.T.
  TITLE     CRISPLD2: a novel NSCLP candidate gene
  JOURNAL   Hum Mol Genet 16 (18), 2241-2248 (2007)
   PUBMED   17616516
  REMARK    GeneRIF: CRISPLD2 is expressed in the mandible, palate and
            nasopharynx regions during craniofacial development at E13.5-E17.5,
            respectively. Altogether, these data suggest that genetic variation
            in CRISPLD2 has a role in the etiology of NSCLP.
            Erratum:[Hum Mol Genet. 2008 Apr 1;17(7):1061. Arco-Burgos,
            Mauricio [corrected to Arcos-Burgos, Mauricio]]
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Yu,J., Farjo,R., MacNee,S.P., Baehr,W., Stambolian,D.E. and
            Swaroop,A.
  TITLE     Annotation and analysis of 10,000 expressed sequence tags from
            developing mouse eye and adult retina
  JOURNAL   Genome Biol 4 (10), R65 (2003)
   PUBMED   14519200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120144.11, BY201813.1, AK033858.1, AV380818.2, CK626589.1,
            AK132171.1 and AV243162.1.
            
            On Jul 16, 2015 this sequence version replaced XM_006531507.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033858.1, SRR11927934.1722977.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC120144.11        38867-38900         c
            35-71               BY201813.1         3-39
            72-2968             AK033858.1         1-2897
            2969-3186           AV380818.2         463-680
            3187-3539           CK626589.1         257-609
            3540-4179           AK132171.1         3450-4089
            4180-4186           AV243162.1         289-295
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.76 cM"
     gene            1..4186
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /note="cysteine-rich secretory protein LCCL domain
                     containing 2"
                     /db_xref="GeneID:78892"
                     /db_xref="MGI:MGI:1926142"
     exon            1..163
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..481
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..600
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..733
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..849
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..950
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1088
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1149
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1216
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1347
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1391
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1464
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1540
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1674
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..4186
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4159..4164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /note="hexamer: AATAAA"
     polyA_site      4185
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /note="major polyA site"
ORIGIN      
        1 cgctgcctgt ggacttgggg ggcgtggctc aggatgctct aagaagctac taggggccgc
       61 gctcaagtcc tggacccact cagagcgccc agcatccgca aggttccaga tctgcaactt
      121 gcttgcccag cgctccccag gttgaggcca gagttccgca cagaaccttc cggtgcccag
      181 ccctacttca ggagcccagg ctgcccccac ccctcttagt tgtggctgaa ggcgtgaagc
      241 catgagctgt cttctgaaca atatggtcct gatggggctg gctctgctgg tctgtggagt
      301 acaggccttt ttccttccca acaccacgag cctggagaag ctgctgagca aataccagca
      361 tgcagagcca cactcacgcg tgcgcagggc catccccatg tcagaccgcc aagagatcct
      421 catgctacac aacaagctgc gaggccaggt gtatccccct gcctccaaca tggaacacat
      481 gacttgggat gaggagctag agagatctgc agcagcgtgg gcacatagat gcctgtggga
      541 gcacgggccc gccggccttc tgaggtccat cgggcagaac ctggctgtgc actggggcag
      601 gtaccgctct cctgggttcc atgtgcagtc atggtacgac gaggtgaagg attacaccta
      661 cccatacccc cacgagtgca ctccacggtg ccgggagcgg tgctcaggcc ccatgtgcac
      721 ccactacaca cagatggtct gggccaccac caacaagatc ggctgtgccg tgcacacctg
      781 tcggaacatg aacgtctggg gagacacttg ggagaatgcc gtgtatctcg tctgcaatta
      841 ttctcccaag ggaaactgga ttggcgaggc cccctacaag catggccgtc cctgctctga
      901 gtgtccatcc agctacggag gaggctgcct gaacaatctt tgccaccgag cagaaaagcc
      961 tcacaagcat aaaccagagg tggatatgat gaacgaggtg gaatcgcccc ctgctccaga
     1021 ggaaacccat gtctgggttc agcccagggt gatcaagacc aagaagaccc cagtcatcaa
     1081 cttcatgacc caagtggtcc actgtgacac caagatgaag gactcatgca aaggatccac
     1141 gtgtaacagg taccagtgcc cagcaggctg tctgagcaac aaggcgaagg tctttggctc
     1201 tctgttttat gaaagttctt ccagcatatg ccgagctgct atccactacg gtgtcatcga
     1261 tgatcgaggt ggcctggtgg atgtcaccag gaatgggatg gtacccttct ttgtcaagtc
     1321 tcagaaaaat ggcatggagt ccctgagcaa atacaagccg tctagctcct tcactgtgtc
     1381 aaaagtgaca gagacggccg tggactgcca cgccacggtc gcacagctgt gccccttcga
     1441 gaagccggcc acccactgcc cgagaatcca gtgtcctgcg cgctgtggag aagagccatc
     1501 ctattgggct cctgtgtatg gaaccaacat ctatgctgat acttccagca tttgtaaggc
     1561 cgctgtgcac gcaggtgtca tcgttgacga ggttggtggc tatgcagatg tgatgcccgt
     1621 ggacaaaaag aagagctacg tgggctccct caggaacggg gtgcagtcgg agagcctgaa
     1681 cactcctcag aacggaaacg ccttccggat cttcgccgtc aggcagtgaa tttggcgacc
     1741 tggggagaag ggggtgtcat ctactgggat tcggggtcct gctttttatc tgtactttgt
     1801 cctttggggg tggggggtga cagagagtca ggaatcttcc ttttggtgtc attgaacgtc
     1861 ctgggcctcc atggcctttg gtgagggtga ccgagcacct tccccctcat gagcagcgtg
     1921 ccgtggagtc tcttggctgg acaaccagtg cccaggctgg ccaggtggcg gtccccatct
     1981 ggtggctcac ctcctctcag gagctgctca ctgagacact ccttgccatg ttttctttgg
     2041 tggtggaggg ggaaggcttt cgaaccctga ggatacaggt ttgagatatg tcatgaatgg
     2101 ggctcttgtc tgggtgacaa gagtcgacag ctataaggtt acagtccgtc ctaccgacag
     2161 agaaatgggg tctgtgtttg ctggtcagac agatgggctg cagggagaag ccccgagcaa
     2221 gacctgggct ctgccctggt ggtgtctatc cgtgctcaca ttccccaacc tttttggcag
     2281 tcacgtgctt ataagtccag cagagctggt ctatttaaag ttggtagcac tccagagatt
     2341 tatcttgtct ttgtccttgt ctgtgtggcc ttttctcaca tgacctttgg tctcatggag
     2401 gaccaataca tcaggagcct tccctaccat tccctgaccc tgtggcatct gccccaccct
     2461 cagcagatct aggtgtcctc ctctggggtt tggctttgca agaggctcca ggtctcagat
     2521 gtcttctcac ttcttagaat aagggctgcc tcccagccgc cgtcaagagt gacaattgaa
     2581 cgtcacttcc ccctggtttg ggtgacctag tttttaagct gtgggaggag tagattcctg
     2641 gcacattcct catgggggtt aatggagtgg cctgtggttg taaaaccacc catgacacac
     2701 cagccaccag aaagaggggc ccgggacaca caggaagaac ccctcagtgc ctgccagcat
     2761 ccccaggctc caagagtgtg gtgagccctg gctcccatca cttaggagcc tggtccaaac
     2821 ccactgtaaa atgaagcatg cttctgtaaa cagctttact ctagagaagg tggaatccca
     2881 ccccagtcct gagcatgggg cagattgccg gtgagtgcta gccaaacaca aacagggttg
     2941 cgtgctccag ccaaatattt cttagaccaa aaaaaaaaaa aaaaaaaaag ggaagggggt
     3001 taaaaaataa aacagaacac catcccccca atcaaaaggc tggggaggtg gcttggtggt
     3061 taacagatct tgttgctcta ccggaggacc tgcgctcagt tctcactatt cacaggccgt
     3121 tcaagagatc tctggtctcc acaggcacca cacacattca caggagcaaa gtacaaatgg
     3181 ttctttaaaa aaaaaaaaga aaagaaaaaa accctaaggg agtctgaaca aatctctccc
     3241 cctagttggg ttaaatgttt atttgtttga gacagtttca ctatggtagt ccaggctggc
     3301 cttgacctca ttatgtagcc caggctggcc tcctgagtgc taagatagct tttccccaat
     3361 ccaccccttc tggggagatt ataaaaagca cacagccttg aaccagctct agtcagcctt
     3421 tcactaggct gtttctgcct catgggtgtg ggtgtggtgt ctttgagggc ataaactctt
     3481 ccactccaga tgttggagca gacatctgcg cagtctgtgg aaggggacct ctggttgcta
     3541 ccaaacatct gggaaacttc ccgatacaag gagtgctgcc gtaggaccct tcaccaagcc
     3601 agcagggcaa ggctgacgtg gtaaggaaaa ccatacccct tctgggtttc tagaatgagc
     3661 agccaatccc atcttcaggg aacttgctgt gtgagtctgt actgaggttc tctgagttcc
     3721 ctggctgccc ttccatcagg cacagagcct ggcctagcag cctcgatcga tcaccttcat
     3781 caatagtttg aaactggagg aaacaaaacc acaaatgaca agaccttaca tcagagccct
     3841 tctgaccctg tgtgtccatc catcagctct tccttaaagt gaccacgccc acaccagctg
     3901 cacatccccc caaccccccc agctccggcc tggtcctgcg ttgggtgaga gtttccattt
     3961 gcttccaagc tgtgcccggt ctgttcagag gggtgtgccg attctccatg atctgtaggc
     4021 tttctcagcc cgcagtttac tgtgtgcttt ttttttctat gaaaaatgat atattttaca
     4081 acttcctatg tacaaaagtt tattgtaagt ttttgtgctt cgcatgaaca gggccacact
     4141 ggttgttgct atggtttcaa taaaacggat ttgatttcta acacat
//
