LOCUS       NP_001297564             495 aa            linear   ROD 11-FEB-2025
DEFINITION  cysteine-rich secretory protein LCCL domain-containing 2 isoform 1
            precursor [Mus musculus].
ACCESSION   NP_001297564 XP_006531570
VERSION     NP_001297564.1
DBSOURCE    REFSEQ: accession NM_001310635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Seow,B.K.L., McDougall,A.R.A., Short,K.L., Wallace,M.J.,
            Hooper,S.B. and Cole,T.J.
  TITLE     Identification of Betamethasone-Regulated Target Genes and Cell
            Pathways in Fetal Rat Lung Mesenchymal Fibroblasts
  JOURNAL   Endocrinology 160 (8), 1868-1884 (2019)
   PUBMED   31107524
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Wang,Z.Q., Xing,W.M., Fan,H.H., Wang,K.S., Zhang,H.K., Wang,Q.W.,
            Qi,J., Yang,H.M., Yang,J., Ren,Y.N., Cui,S.J., Zhang,X., Liu,F.,
            Lin,D.H., Wang,W.H., Hoffmann,M.K. and Han,Z.G.
  TITLE     The novel lipopolysaccharide-binding protein CRISPLD2 is a critical
            serum protein to regulate endotoxin function
  JOURNAL   J Immunol 183 (10), 6646-6656 (2009)
   PUBMED   19864597
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Quinlan,J., Kaplan,F., Sweezey,N. and Goodyer,P.
  TITLE     LGL1, a novel branching morphogen in developing kidney, is induced
            by retinoic acid
  JOURNAL   Am J Physiol Renal Physiol 293 (4), F987-F993 (2007)
   PUBMED   17670908
REFERENCE   9  (residues 1 to 495)
  AUTHORS   Chiquet,B.T., Lidral,A.C., Stal,S., Mulliken,J.B., Moreno,L.M.,
            Arcos-Burgos,M., Valencia-Ramirez,C., Blanton,S.H. and Hecht,J.T.
  TITLE     CRISPLD2: a novel NSCLP candidate gene
  JOURNAL   Hum Mol Genet 16 (18), 2241-2248 (2007)
   PUBMED   17616516
  REMARK    GeneRIF: CRISPLD2 is expressed in the mandible, palate and
            nasopharynx regions during craniofacial development at E13.5-E17.5,
            respectively. Altogether, these data suggest that genetic variation
            in CRISPLD2 has a role in the etiology of NSCLP.
            Erratum:[Hum Mol Genet. 2008 Apr 1;17(7):1061. Arco-Burgos,
            Mauricio [corrected to Arcos-Burgos, Mauricio]]
REFERENCE   10 (residues 1 to 495)
  AUTHORS   Yu,J., Farjo,R., MacNee,S.P., Baehr,W., Stambolian,D.E. and
            Swaroop,A.
  TITLE     Annotation and analysis of 10,000 expressed sequence tags from
            developing mouse eye and adult retina
  JOURNAL   Genome Biol 4 (10), R65 (2003)
   PUBMED   14519200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120144.11, BY201813.1, AK033858.1, AV380818.2, CK626589.1,
            AK132171.1 and AV243162.1.
            
            On Jul 16, 2015 this sequence version replaced XP_006531570.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033858.1, SRR11927934.1722977.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.76 cM"
     Protein         1..495
                     /product="cysteine-rich secretory protein LCCL
                     domain-containing 2 isoform 1 precursor"
                     /calculated_mol_wt=53157
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2294
     mat_peptide     23..495
                     /product="Cysteine-rich secretory protein LCCL
                     domain-containing 2. /id=PRO_0000363885"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZQ2.1)"
                     /calculated_mol_wt=53157
     Site            27
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ2.1)"
     Region          56..201
                     /region_name="CAP"
                     /note="CAP (cysteine-rich secretory proteins, antigen 5,
                     and pathogenesis-related 1 proteins) domain family;
                     cl00133"
                     /db_xref="CDD:412178"
     Region          284..368
                     /region_name="LCCL"
                     /note="LCCL domain; smart00603"
                     /db_xref="CDD:128866"
     Region          387..486
                     /region_name="LCCL"
                     /note="LCCL domain; pfam03815"
                     /db_xref="CDD:427521"
     CDS             1..495
                     /gene="Crispld2"
                     /gene_synonym="1810049K24Rik; coffeecrisp; Lcrisp2; Lgl1"
                     /coded_by="NM_001310635.1:242..1729"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS80939.1"
                     /db_xref="GeneID:78892"
                     /db_xref="MGI:MGI:1926142"
ORIGIN      
        1 mscllnnmvl mglallvcgv qafflpntts lekllskyqh aephsrvrra ipmsdrqeil
       61 mlhnklrgqv yppasnmehm twdeelersa aawahrclwe hgpagllrsi gqnlavhwgr
      121 yrspgfhvqs wydevkdyty pyphectprc rercsgpmct hytqmvwatt nkigcavhtc
      181 rnmnvwgdtw enavylvcny spkgnwigea pykhgrpcse cpssygggcl nnlchraekp
      241 hkhkpevdmm nevesppape ethvwvqprv iktkktpvin fmtqvvhcdt kmkdsckgst
      301 cnryqcpagc lsnkakvfgs lfyessssic raaihygvid drgglvdvtr ngmvpffvks
      361 qkngmeslsk ykpsssftvs kvtetavdch atvaqlcpfe kpathcpriq cparcgeeps
      421 ywapvygtni yadtssicka avhagvivde vggyadvmpv dkkksyvgsl rngvqsesln
      481 tpqngnafri favrq
//
