LOCUS       NM_009639               1436 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cysteine-rich secretory protein 3 (Crisp3), mRNA.
ACCESSION   NM_009639 XM_001002056
VERSION     NM_009639.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Curci,L., Brukman,N.G., Weigel Munoz,M., Rojo,D., Carvajal,G.,
            Sulzyk,V., Gonzalez,S.N., Rubinstein,M., Da Ros,V.G. and
            Cuasnicu,P.S.
  TITLE     Functional redundancy and compensation: Deletion of multiple murine
            Crisp genes reveals their essential role for male fertility
  JOURNAL   FASEB J 34 (12), 15718-15733 (2020)
   PUBMED   33037689
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Evans,J., D'Sylva,R., Volpert,M., Jamsai,D., Merriner,D.J., Nie,G.,
            Salamonsen,L.A. and O'Bryan,M.K.
  TITLE     Endometrial CRISP3 is regulated throughout the mouse estrous and
            human menstrual cycle and facilitates adhesion and proliferation of
            endometrial epithelial cells
  JOURNAL   Biol Reprod 92 (4), 99 (2015)
   PUBMED   25715794
  REMARK    GeneRIF: These data suggest roles for epithelial and
            neutrophil-derived CRISP3 in endometrial repair and regeneration
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Islam,M.N., Itoh,S., Yanagita,T., Sumiyoshi,K., Hayano,S.,
            Kuremoto,K., Kurosaka,H., Honjo,T., Kawanabe,N., Kamioka,H.,
            Sakai,T., Ishimaru,N., Taniuchi,I. and Yamashiro,T.
  TITLE     Runx/Cbfb signaling regulates postnatal development of granular
            convoluted tubule in the mouse submandibular gland
  JOURNAL   Dev Dyn 244 (3), 488-496 (2015)
   PUBMED   25410786
REFERENCE   5  (bases 1 to 1436)
  AUTHORS   Dike,S., Balija,V.S., Nascimento,L.U., Xuan,Z., Ou,J., Zutavern,T.,
            Palmer,L.E., Hannon,G., Zhang,M.Q. and McCombie,W.R.
  TITLE     The mouse genome: experimental examination of gene predictions and
            transcriptional start sites
  JOURNAL   Genome Res 14 (12), 2424-2429 (2004)
   PUBMED   15574821
REFERENCE   6  (bases 1 to 1436)
  AUTHORS   Haendler,B., Habenicht,U.F., Schwidetzky,U., Schuttke,I. and
            Schleuning,W.D.
  TITLE     Differential androgen regulation of the murine genes for
            cysteine-rich secretory proteins (CRISP)
  JOURNAL   Eur J Biochem 250 (2), 440-446 (1997)
   PUBMED   9428696
REFERENCE   7  (bases 1 to 1436)
  AUTHORS   Schwidetzky,U., Haendler,B. and Schleuning,W.D.
  TITLE     Isolation and characterization of the androgen-dependent mouse
            cysteine-rich secretory protein-3 (CRISP-3) gene
  JOURNAL   Biochem J 309 (Pt 3) (Pt 3), 831-836 (1995)
   PUBMED   7639699
REFERENCE   8  (bases 1 to 1436)
  AUTHORS   Kasahara,M., Hayashi,M., Yoshida,M.C., Nadeau,J.H., Fujimoto,S. and
            Ishibashi,T.
  TITLE     Mapping of acidic epididymal glycoprotein (Aeg) genes to mouse
            chromosome 17
  JOURNAL   Mamm Genome 6 (1), 52-54 (1995)
   PUBMED   7719028
REFERENCE   9  (bases 1 to 1436)
  AUTHORS   Haendler,B., Kratzschmar,J., Theuring,F. and Schleuning,W.D.
  TITLE     Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG)
            and the novel related CRISP-3 are expressed under androgen control
            in the mouse salivary gland
  JOURNAL   Endocrinology 133 (1), 192-198 (1993)
   PUBMED   8319566
REFERENCE   10 (bases 1 to 1436)
  AUTHORS   Mizuki,N. and Kasahara,M.
  TITLE     Mouse submandibular glands express an androgen-regulated transcript
            encoding an acidic epididymal glycoprotein-like molecule
  JOURNAL   Mol Cell Endocrinol 89 (1-2), 25-32 (1992)
   PUBMED   1301383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV307357.1 and L05560.1.
            
            On Mar 28, 2018 this sequence version replaced NM_009639.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L05560.1, BC022573.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CV307357.1         1-30
            31-1436             L05560.1           1-1406
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.45 cM"
     gene            1..1436
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /note="cysteine-rich secretory protein 3"
                     /db_xref="GeneID:11572"
                     /db_xref="MGI:MGI:102552"
     exon            1..53
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     exon            54..127
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..781
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /note="SCP 2; sperm-coating glycoprotein 2; acidic
                     epididymal glycoprotein 2"
                     /codon_start=1
                     /product="cysteine-rich secretory protein 3 precursor"
                     /protein_id="NP_033769.1"
                     /db_xref="CCDS:CCDS28783.1"
                     /db_xref="GeneID:11572"
                     /db_xref="MGI:MGI:102552"
                     /translation="MALMLVLFFLAAVLPPSLLQDNSQENSLEKLSTSKKSVQEEIVS
                     KHNQLRRKVSPSGSDLLNMEWNYDAQVNAQQRADKCTFSHSPIELRTTNLKCGENLFM
                     SSYLVPWSSVIQGWYNESKGLIFGVGPKQNVSVVGHHTQVVWKSNLQVACGVAECPEN
                     PLRYFYVCRYCPVLNYSGHYPSRPYLAYTARAPCASCPDRCEDGLCTKSCQYKDMSFW
                     CKRLEYVCKHPGLKKRCLATCQC"
     exon            128..244
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     exon            245..332
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     exon            333..478
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     exon            574..674
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1417
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1392..1397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /note="hexamer: AATAAA"
     polyA_site      1417
                     /gene="Crisp3"
                     /gene_synonym="Aeg2; CRISP-3; CRS3; SGP28"
                     /note="major polyA site"
ORIGIN      
        1 gtcacctttc ttcttcctgc aggacaacac ctcattctac tctgaagcca gcaccatggc
       61 attaatgctt gtgctgttct tcctggctgc tgtactgccc ccatcccttc ttcaagataa
      121 ctctcaggag aacagtcttg agaaactttc aaccagtaaa aaatcagtcc aagaagagat
      181 tgtaagcaag cacaaccaat tgagacgaaa ggtttctcca tctggcagtg acttactaaa
      241 tatggaatgg aactatgatg ctcaagtgaa tgctcagcaa cgggcagaca agtgtacatt
      301 cagtcacagt cctatagaac tcaggacaac taatttaaaa tgtggtgaga atttgttcat
      361 gtcatcttac cttgtaccat ggtcttctgt aatccaagga tggtataatg aatccaaagg
      421 tcttatattt ggtgtgggcc caaagcaaaa tgttagtgtg gttggacatc atactcaggt
      481 tgtttggaaa tcaaatttac aagttgcatg tggagttgct gaatgccctg aaaatccact
      541 gagatacttt tatgtttgtc gctattgtcc tgtattgaat tacagtggcc attatccaag
      601 caggccatac ctagcttaca cagcaagagc accatgtgcc agttgtcctg atcgctgtga
      661 agatggactg tgcaccaaga gttgtcaata taaggatatg tctttttggt gtaaacgtct
      721 ggaatacgtc tgtaaacatc caggtcttaa aaaacgttgc ctagctacat gccaatgtta
      781 aggcaaaatt cactaaattt cctgtccagg ctgccaggac caagtagaga aaggtcatac
      841 tctctagtca ggcttatcac atcccaccaa gaatatatag atttaataca ttggaacaat
      901 tccagatggt aaagattctg tttcttcttc tatttctttc tattttgcag atatcattta
      961 ccccaaatat tttaaagtaa caaaattgat aataaccttt ggaccttgac atttgaaatc
     1021 tgtgacacat tcatgaagtc aaatctagcc aatgactata cattgtctgt atgactaaag
     1081 tcactaaaac tcatatgact aatgttccaa gagcacaatg aagtaaggga atagaaaaca
     1141 tatagttcct gtgtaatggt cagtcatctt ttgtagctct acctagttaa gtctctctga
     1201 agaaaattca cattgtcttt ttttttttct cactattcat tattcttcac attcaacata
     1261 atcagtggtt taaattctaa aataccattt acattttagt tgtttttttt tctaagaatg
     1321 atataaaatg taccttaatg agaagaattt gcttgttcag gggacaatga cctttgttgc
     1381 tttagaaaaa aaataaatct taatcttggc ttattaaaaa aaaaaaaaaa aaaaaa
//
