LOCUS       NM_011562               1948 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus cripto, EGF-CFC family member (Cripto), mRNA.
ACCESSION   NM_011562 XM_489615
VERSION     NM_011562.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Guardiola,O., Iavarone,F., Nicoletti,C., Ventre,M., Rodriguez,C.,
            Pisapia,L., Andolfi,G., Saccone,V., Patriarca,E.J., Puri,P.L. and
            Minchiotti,G.
  TITLE     CRIPTO-based micro-heterogeneity of mouse muscle satellite cells
            enables adaptive response to regenerative microenvironment
  JOURNAL   Dev Cell 58 (24), 2896-2913 (2023)
   PUBMED   38056454
  REMARK    GeneRIF: CRIPTO-based micro-heterogeneity of mouse muscle satellite
            cells enables adaptive response to regenerative microenvironment.
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Angrisano,T., Varrone,F., Ragozzino,E., Fico,A., Minchiotti,G. and
            Brancaccio,M.
  TITLE     Cripto Is Targeted by miR-1a-3p in a Mouse Model of Heart
            Development
  JOURNAL   Int J Mol Sci 24 (15), 12251 (2023)
   PUBMED   37569627
  REMARK    GeneRIF: Cripto Is Targeted by miR-1a-3p in a Mouse Model of Heart
            Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Krup,A.L., Winchester,S.A.B., Ranade,S.S., Agrawal,A., Devine,W.P.,
            Sinha,T., Choudhary,K., Dominguez,M.H., Thomas,R., Black,B.L.,
            Srivastava,D. and Bruneau,B.G.
  TITLE     A Mesp1-dependent developmental breakpoint in transcriptional and
            epigenomic specification of early cardiac precursors
  JOURNAL   Development 150 (9) (2023)
   PUBMED   36994838
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Acampora,D., Mazan,S., Lallemand,Y., Avantaggiato,V., Maury,M.,
            Simeone,A. and Brulet,P.
  TITLE     Forebrain and midbrain regions are deleted in Otx2-/- mutants due
            to a defective anterior neuroectoderm specification during
            gastrulation
  JOURNAL   Development 121 (10), 3279-3290 (1995)
   PUBMED   7588062
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Johnson,S.E., Rothstein,J.L. and Knowles,B.B.
  TITLE     Expression of epidermal growth factor family gene members in early
            mouse development
  JOURNAL   Dev Dyn 201 (3), 216-226 (1994)
   PUBMED   7881126
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Brandt,R., Normanno,N., Gullick,W.J., Lin,J.H., Harkins,R.,
            Schneider,D., Jones,B.W., Ciardiello,F., Persico,M.G., Armenante,F.
            et al.
  TITLE     Identification and biological characterization of an epidermal
            growth factor-related protein: cripto-1
  JOURNAL   J Biol Chem 269 (25), 17320-17328 (1994)
   PUBMED   8006041
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Dono,R., Scalera,L., Pacifico,F., Acampora,D., Persico,M.G. and
            Simeone,A.
  TITLE     The murine cripto gene: expression during mesoderm induction and
            early heart morphogenesis
  JOURNAL   Development 118 (4), 1157-1168 (1993)
   PUBMED   7916676
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Ciccodicola,A., Dono,R., Obici,S., Simeone,A., Zollo,M. and
            Persico,M.G.
  TITLE     Molecular characterization of a gene of the 'EGF family' expressed
            in undifferentiated human NTERA2 teratocarcinoma cells
  JOURNAL   EMBO J 8 (7), 1987-1991 (1989)
   PUBMED   2792079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074826.1, AK133730.1 and BC052646.1.
            
            On Mar 24, 2007 this sequence version replaced NM_011562.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052646.1, AK133730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                CJ074826.1         1-64
            65-722              AK133730.1         3-660
            723-1448            BC052646.1         665-1390
            1449-1925           AK133730.1         1387-1863
            1926-1948           BC052646.1         1868-1890
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.79 cM"
     gene            1..1948
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /note="cripto, EGF-CFC family member"
                     /db_xref="GeneID:21667"
                     /db_xref="MGI:MGI:98658"
     exon            1..335
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..388
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..490
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..605
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..715
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..1927
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /note="hexamer: AATAAT"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /note="hexamer: AGTAAA"
     polyA_site      1924
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
     polyA_site      1927
                     /gene="Cripto"
                     /gene_synonym="CR1; Tdgf1"
                     /note="major polyA site"
ORIGIN      
        1 acctgagggt cctactcaac accttaagtt tcttttaagg gaggtatatt cctccgaagt
       61 cctcaatcac aaaccgttta taggaagaag aggccccatc ccctgccggt ctacacggag
      121 atcttggctg ctaacttccc acagactctc caggacgggg gcctctctca tttggcatat
      181 ctttcttttt aatctactgt tttcattttg tgaaattagc ctttgggtgt ttcgagaatg
      241 gctttatgaa ctaaagccat ctgctaatat tgtgtttctt gtcttttcct ccaacgtttt
      301 tacgagccgt cgaagatggg gtacttctca tccagtgtgg ttttgcttgt ggccatttcc
      361 agtgcgtttg aatttggacc cgttgctggg agagaccttg ccatcagaga taacagcatt
      421 tgggaccaga aagaacctgc cgtacgcgat cggtctttcc agtttgtgcc ttccgtgggg
      481 atacagaaca gtaagtcgct taataaaact tgctgtctga atggagggac ttgcatcctg
      541 gggtccttct gtgcctgccc tccttccttc tatggacgca actgtgaaca tgatgttcgc
      601 aaagagcact gtgggtctat cctccatggc acctggctgc ccaagaagtg ttccctgtgc
      661 agatgctggc acggccagct ccactgtctt cctcagacct ttctacctgg ctgtgatggt
      721 cacgtgatgg accaggacct caaagcatcc gggactccgt gtcaaacgcc gtctgtgacg
      781 accactttta tgctagctgg cgcctgcctt tttctagata tgaaagtata ggtgtcatgt
      841 gaattccatg ccagtgccat agcaaagatg tcattcatct tgatgctcac agtgaatccc
      901 taatgttacc cctcaaaaca ctaactaggc cttacctctg cacagcccct cctctttctg
      961 gaaaactatg gcgtgtgtgc caagcactgt aacagcgagt tacattccta gcctaaaagc
     1021 tactctaaga atgtgctgtc tgccatagcc tgagtttctt gatagaagta actctcttac
     1081 ttttcttcct aagactttta aacagttctg aaggttatta ttaaatccca atgtgcaact
     1141 ggaagtaaat tcagagtagc tgaaaacagc taaattatct ttaagcaggg aggtggtggt
     1201 gtctacctta aatcaggcaa aggcaggtat atttcttgag ttccaggaca gacaggccta
     1261 cacagaaacc ctgtctcggg gagaaaaaag agagagagag aagaaaaact attatcttaa
     1321 aagaaaatta atggaccagg cattgtggca gatggcttta atcccagccc tcaggaggta
     1381 gggataggag gatctcaaga gttcaaggcc agcctggtct atgtagcgaa cccctgtctc
     1441 aaaaaggaaa aagcatccta cgagggagtt gaggaagtaa tgagggtctg tgcagaggga
     1501 gcagcagatg gggaagtgac taagactggg gaaacagagt ggattgtttg attgatgttt
     1561 acggaggtac tgggaattta aaagctaagt tcttcagcca agcacagtgg tgcacactat
     1621 taatgtcagc tctcaggagg ctacaacagg actactaaaa gctcatgtcc aacctgggct
     1681 atgtacagag taccaggcca acaaagactg aatggcaaga ccctcacaga aaacccaaac
     1741 acccgagtct cttttctgca aaagtacgaa ggctttctcc aagctatata caattattca
     1801 actgttgtgg aggaaagaaa gtgtttatta ttgtagtagt aaaccagatt ataaaaacca
     1861 cgtattgtca agtcagtttt tataataatt gttcatgaat atgcacagta aaaatgggaa
     1921 ctctgaaaaa aaaaaaaaaa aaaaaaaa
//
