LOCUS       NM_024223               1454 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cysteine rich protein 2 (Crip2), transcript variant 1,
            mRNA.
ACCESSION   NM_024223
VERSION     NM_024223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1454)
  AUTHORS   Langst,N., Adler,J., Kuret,A., Peter,A., Ruth,P., Boldt,K. and
            Lukowski,R.
  TITLE     Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in
            the ApoE-/- Mouse Model
  JOURNAL   Cells 11 (8), 1364 (2022)
   PUBMED   35456043
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1454)
  AUTHORS   Langst,N., Adler,J., Schweigert,O., Kleusberg,F., Cruz Santos,M.,
            Knauer,A., Sausbier,M., Zeller,T., Ruth,P. and Lukowski,R.
  TITLE     Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure
            Involves Cysteine-Rich LIM-Only Protein 4 (CRP4)
  JOURNAL   Int J Mol Sci 22 (18), 9925 (2021)
   PUBMED   34576086
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1454)
  AUTHORS   Bowen,M.E., McClendon,J., Long,H.K., Sorayya,A., Van Nostrand,J.L.,
            Wysocka,J. and Attardi,L.D.
  TITLE     The Spatiotemporal Pattern and Intensity of p53 Activation Dictates
            Phenotypic Diversity in p53-Driven Developmental Syndromes
  JOURNAL   Dev Cell 50 (2), 212-228 (2019)
   PUBMED   31178404
REFERENCE   5  (bases 1 to 1454)
  AUTHORS   Zhou,L., Wang,Y., Zhou,M., Zhang,Y., Wang,P., Li,X., Yang,J.,
            Wang,H. and Ding,Z.
  TITLE     HOXA9 inhibits HIF-1alpha-mediated glycolysis through interacting
            with CRIP2 to repress cutaneous squamous cell carcinoma development
  JOURNAL   Nat Commun 9 (1), 1480 (2018)
   PUBMED   29662084
  REMARK    GeneRIF: HOXA9 inhibits HIF1A-mediated glycolysis through
            interacting with CRIP2 to repress cutaneous squamous cell carcinoma
            development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1454)
  AUTHORS   Schneider,B., Hanke,P., Jagla,W., Wattler,S., Nehls,M., Grosse,J.,
            Schroder,A. and Laufs,J.
  TITLE     Synergistic interaction of two independent genetic loci causes
            extreme elevation of serum IgA in mice
  JOURNAL   Genes Immun 5 (5), 375-380 (2004)
   PUBMED   15175647
REFERENCE   7  (bases 1 to 1454)
  AUTHORS   van Ham,M., Croes,H., Schepens,J., Fransen,J., Wieringa,B. and
            Hendriks,W.
  TITLE     Cloning and characterization of mCRIP2, a mouse LIM-only protein
            that interacts with PDZ domain IV of PTP-BL
  JOURNAL   Genes Cells 8 (7), 631-644 (2003)
   PUBMED   12839623
  REMARK    GeneRIF: observed characteristics of the LIM domain-containing
            adaptor protein CRIP2 are consistent with a potential role of
            PTP-BL in the dynamics of the cortical actin cytoskeleton
REFERENCE   8  (bases 1 to 1454)
  AUTHORS   Zhou,J., Ashouian,N., Delepine,M., Matsuda,F., Chevillard,C.,
            Riblet,R., Schildkraut,C.L. and Birshtein,B.K.
  TITLE     The origin of a developmentally regulated Igh replicon is located
            near the border of regulatory domains for Igh replication and
            expression
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13693-13698 (2002)
   PUBMED   12370427
REFERENCE   9  (bases 1 to 1454)
  AUTHORS   Yu,T.S., Moctezuma-Anaya,M., Kubo,A., Keller,G. and Robertson,S.
  TITLE     The heart LIM protein gene (Hlp), expressed in the developing and
            adult heart, defines a new tissue-specific LIM-only protein family
  JOURNAL   Mech Dev 116 (1-2), 187-192 (2002)
   PUBMED   12128222
  REMARK    GeneRIF: role for the two LIM-domain gene Hlp in the very earliest
            stages of heart differentiation and development
REFERENCE   10 (bases 1 to 1454)
  AUTHORS   Karim,M.A., Ohta,K., Egashira,M., Jinno,Y., Niikawa,N., Matsuda,I.
            and Indo,Y.
  TITLE     Human ESP1/CRP2, a member of the LIM domain protein family:
            characterization of the cDNA and assignment of the gene locus to
            chromosome 14q32.3
  JOURNAL   Genomics 31 (2), 167-176 (1996)
   PUBMED   8824798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX217539.1, AK002484.1 and AI851454.1.
            
            On Aug 15, 2009 this sequence version replaced NM_024223.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002093.1, AF469648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               CX217539.1         1-315
            316-1214            AK002484.1         1-899
            1215-1454           AI851454.1         1-240               c
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     gene            1..1454
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /note="cysteine rich protein 2"
                     /db_xref="GeneID:68337"
                     /db_xref="MGI:MGI:1915587"
     exon            1..379
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..963
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     only protein HLP; CRP-2; heart LIM protein"
                     /codon_start=1
                     /product="cysteine-rich protein 2 isoform 1"
                     /protein_id="NP_077185.1"
                     /db_xref="CCDS:CCDS26204.1"
                     /db_xref="GeneID:68337"
                     /db_xref="MGI:MGI:1915587"
                     /translation="MASKCPKCDKTVYFAEKVSSLGKDWHKFCLKCERCNKTLTPGGH
                     AEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEKPQTEAPQVTGPIEVPVVRTEERK
                     TSGPPKGPSKASSVTTFTGEPNMCPRCNKRVYFAEKVTSLGKDWHRPCLRCERCSKTL
                     TPGGHAEHDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDKDPEGTVQP"
     exon            380..532
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     exon            533..673
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     exon            674..742
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     exon            743..837
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     exon            838..895
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1439
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /note="hexamer: AATAAA"
     polyA_site      1439
                     /gene="Crip2"
                     /gene_synonym="0610010I23Rik; Crp; CRP2; CRP4; ESP1; Hlp"
                     /note="major polyA site"
ORIGIN      
        1 ccttctacca cgagcaggcc cggacctcga gacctaaagc tggggatccc aagtccgttc
       61 tacagctaga gatcactatg tggccatgga atcctcgggc gatccctgtg gacgccacct
      121 cactccgggg tagggggcgc taggccgggc ccttccgacc ctggcaggtg cgccccgcct
      181 gcagcgcgcc cagctgctgg cgtctagggg gcgggctcca gaggccccgc ccaggtctcg
      241 gagccaatcg acgtccgggg gcgggcgggg caggcgcggg cggcggcaca gagacgagcg
      301 cgggtggagg gcgcggaccg accgagcgca ccgaccatgg cctccaagtg tcccaagtgt
      361 gacaagaccg tatacttcgc tgagaaggtg agctccctgg gcaaggactg gcacaagttc
      421 tgtctcaagt gtgagcgctg caacaagaca ctgacccccg gcggccatgc tgagcatgat
      481 gggaagccct tctgccacaa gccctgctat gccacgctgt ttggacccaa aggcgtgaac
      541 atcgggggcg ctggctccta catctacgag aagcctcaga ccgaggcccc tcaggtcact
      601 ggccccatcg aggtccctgt ggtgagaact gaggagcgaa agaccagcgg cccccccaag
      661 ggtcccagca aagcctctag tgtcaccaca ttcactgggg agcccaacat gtgtcctcga
      721 tgcaacaaga gagtgtactt cgctgagaag gtgacctctc tgggcaagga ctggcaccgg
      781 ccctgcctgc gctgtgagcg ctgctccaag accctgaccc caggcgggca tgctgagcac
      841 gatggccagc cctactgcca caagccttgc tatggaatac tctttggacc caaaggagtg
      901 aatactggtg ctgtgggcag ctatatctac gacaaggacc cggaaggcac agttcagccc
      961 tagatctgca gatgctgtcc tcggggtccc cctgtttgac ccggaggcaa agtggcctgt
     1021 tgcctagtcc tgcctcagcg tgtctcgcct gcaaatccgg gacctaagtg gtggaggaga
     1081 aagcctggat agtcccagag cttcagcccc ctttgtcacc ttggcgtgtc ccgtgctgcc
     1141 caccgtttac ttcctgtctg tgtgcctccg tagccccatg ggtcctgtgt tcctgtgtcc
     1201 ctgatagctc tccaaggtga ctgtcctatg atatatccct ttgcccacac ctgcccacca
     1261 gtattattta tgctctgctt gccggtgatg gccgtgagct cacagcattc ccagggtgat
     1321 ggctggcgcc cttgcgagga gccctctgct ggttccacac tactccctac ctaccctcac
     1381 atggttcatg gctatggaga cttttgctgt caataaatag tttggtttga ggattgcaaa
     1441 aaaaaaaaaa aaaa
//
