LOCUS       NM_007763                460 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cysteine-rich protein 1 (Crip1), mRNA.
ACCESSION   NM_007763
VERSION     NM_007763.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 460)
  AUTHORS   Latonen,L., Jarvinen,P.M., Suomela,S., Moore,H.M.,
            Saarialho-Kere,U. and Laiho,M.
  TITLE     Ultraviolet B radiation regulates cysteine-rich protein 1 in human
            keratinocytes
  JOURNAL   Photodermatol Photoimmunol Photomed 26 (2), 70-77 (2010)
   PUBMED   20415737
REFERENCE   4  (bases 1 to 460)
  AUTHORS   Chen,B., Young,J. and Leng,F.
  TITLE     DNA bending by the mammalian high-mobility group protein AT hook 2
  JOURNAL   Biochemistry 49 (8), 1590-1595 (2010)
   PUBMED   20108983
REFERENCE   5  (bases 1 to 460)
  AUTHORS   Hao,J., Serohijos,A.W., Newton,G., Tassone,G., Wang,Z., Sgroi,D.C.,
            Dokholyan,N.V. and Basilion,J.P.
  TITLE     Identification and rational redesign of peptide ligands to CRIP1, a
            novel biomarker for cancers
  JOURNAL   PLoS Comput Biol 4 (8), e1000138 (2008)
   PUBMED   18670594
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 460)
  AUTHORS   Miner,L.L. and Marley,R.J.
  TITLE     Chromosomal mapping of loci influencing sensitivity to
            cocaine-induced seizures in BXD recombinant inbred strains of mice
  JOURNAL   Psychopharmacology (Berl) 117 (1), 62-66 (1995)
   PUBMED   7724703
REFERENCE   7  (bases 1 to 460)
  AUTHORS   de Meeus,A., Alonso,S., Demaille,J. and Bouvagnet,P.
  TITLE     A detailed linkage map of subtelomeric murine chromosome 12 region
            including the situs inversus mutation locus IV
  JOURNAL   Mamm Genome 3 (11), 637-643 (1992)
   PUBMED   1360279
REFERENCE   8  (bases 1 to 460)
  AUTHORS   Cho,M., Villani,V. and D'Eustachio,P.
  TITLE     A linkage map of distal mouse chromosome 12
  JOURNAL   Mamm Genome 1 (1), 30-36 (1991)
   PUBMED   1794043
REFERENCE   9  (bases 1 to 460)
  AUTHORS   Birkenmeier,C.S., McFarland-Starr,E.C. and Barker,J.E.
  TITLE     Chromosomal location of three spectrin genes: relationship to the
            inherited hemolytic anemias of mouse and man
  JOURNAL   Proc Natl Acad Sci U S A 85 (21), 8121-8125 (1988)
   PUBMED   3186715
REFERENCE   10 (bases 1 to 460)
  AUTHORS   Birkenmeier,E.H. and Gordon,J.I.
  TITLE     Developmental regulation of a gene that encodes a cysteine-rich
            intestinal protein and maps near the murine immunoglobulin heavy
            chain locus
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2516-2520 (1986)
   PUBMED   3085096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DT908028.1, AK008269.1 and BX511593.1.
            
            [WARNING] On Mar 4, 2025 this sequence was replaced by NM_007763.4.
            
            On Jan 20, 2007 this sequence version replaced NM_007763.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN833602.1, AA855762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DT908028.1         1-39
            40-443              AK008269.1         2-405
            444-460             BX511593.1         390-406
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.59 cM"
     gene            1..460
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /note="cysteine-rich protein 1"
                     /db_xref="GeneID:12925"
                     /db_xref="MGI:MGI:88501"
     exon            1..142
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..336
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /note="cysteine-rich intestinal protein; CRP-1;
                     cysteine-rich protein 1 (intestinal)"
                     /codon_start=1
                     /product="cysteine-rich protein 1"
                     /protein_id="NP_031789.1"
                     /db_xref="CCDS:CCDS26205.1"
                     /db_xref="GeneID:12925"
                     /db_xref="MGI:MGI:88501"
                     /translation="MPKCPKCDKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHA
                     EHEGKPYCNHPCYSAMFGPKGFGRGGAESHTFK"
     exon            143..237
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..295
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..342
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..447
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      428..433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /note="hexamer: AATAAA"
     polyA_site      447
                     /gene="Crip1"
                     /gene_synonym="CRHP; Crip; CRP1"
                     /note="major polyA site"
ORIGIN      
        1 cggggtccct gaaaagcgcg gaccaggcgg gcgccaccca gtccagagcc tgcaacctac
       61 ttccttctag ctgcagccac ttgtgcagga ccaggtaccg ccatgccgaa gtgccccaag
      121 tgcgacaagg aggtgtattt cgctgagcga gtgacttcac taggcaagga ctggcatcgt
      181 ccctgcctga agtgtgagaa atgtggaaag acactgacct ctgggggtca tgctgagcat
      241 gaaggcaagc cctactgcaa tcatccctgc tactccgcca tgtttgggcc caaaggcttt
      301 gggcgaggtg gagctgagag ccacactttc aagtagaccg aggttgtgga aactctccct
      361 gcccgcccag gcacatgcca ggccttaccc ccggacagca gggctctcgg gaaccctcag
      421 tgcctttaat aaacctgatc tttggaaaaa aaaaaaaaaa
//
