LOCUS       NM_001288618            2700 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus corticotropin releasing hormone receptor 2 (Crhr2),
            transcript variant 1, mRNA.
ACCESSION   NM_001288618 XM_006505480
VERSION     NM_001288618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Schappe,M.S., Brinn,P.A., Joshi,N.R., Greenberg,R.S., Min,S.,
            Alabi,A.A., Zhang,C. and Liberles,S.D.
  TITLE     A vagal reflex evoked by airway closure
  JOURNAL   Nature 627 (8005), 830-838 (2024)
   PUBMED   38448588
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Hafenbreidel,M., Pandey,S., Briggs,S.B., Arza,M., Bonthu,S.,
            Fisher,C., Tiller,A., Hall,A.B., Reed,S., Mayorga,N., Lin,L.,
            Khan,S., Cameron,M.D., Rumbaugh,G. and Miller,C.A.
  TITLE     Basolateral amygdala corticotropin releasing factor receptor 2
            interacts with nonmuscle myosin II to destabilize memory in males
  JOURNAL   Neurobiol Learn Mem 206, 107865 (2023)
   PUBMED   37995804
  REMARK    GeneRIF: Basolateral amygdala corticotropin releasing factor
            receptor 2 interacts with nonmuscle myosin II to destabilize memory
            in males.
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Alcantara-Alonso,V., Dallmann,R., Lehnert,H., de Gortari,P. and
            Grammatopoulos,D.K.
  TITLE     CRH-R2 signalling modulates feeding and circadian gene expression
            in hypothalamic mHypoA-2/30 neurons
  JOURNAL   Front Endocrinol (Lausanne) 14, 1266081 (2023)
   PUBMED   37900150
  REMARK    GeneRIF: CRH-R2 signalling modulates feeding and circadian gene
            expression in hypothalamic mHypoA-2/30 neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Wu,S.J., Sevier,E., Dwivedi,D., Saldi,G.A., Hairston,A., Yu,S.,
            Abbott,L., Choi,D.H., Sherer,M., Qiu,Y., Shinde,A., Lenahan,M.,
            Rizzo,D., Xu,Q., Barrera,I., Kumar,V., Marrero,G., Pronneke,A.,
            Huang,S., Kullander,K., Stafford,D.A., Macosko,E., Chen,F., Rudy,B.
            and Fishell,G.
  TITLE     Cortical somatostatin interneuron subtypes form cell-type-specific
            circuits
  JOURNAL   Neuron 111 (17), 2675-2692 (2023)
   PUBMED   37390821
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Flaherty,S.E. 3rd, Bezy,O., Zheng,W., Yan,D., Li,X.,
            Jagarlapudi,S., Albuquerque,B., Esquejo,R.M., Peloquin,M.,
            Semache,M., Mancini,A., Kang,L., Drujan,D., Breitkopf,S.B.,
            Griffin,J.D., Jean Beltran,P.M., Xue,L., Stansfield,J., Pashos,E.,
            Shakey,Q., Pehmoller,C., Monetti,M., Birnbaum,M.J., Fortin,J.P. and
            Wu,Z.
  TITLE     Chronic UCN2 treatment desensitizes CRHR2 and improves insulin
            sensitivity
  JOURNAL   Nat Commun 14 (1), 3953 (2023)
   PUBMED   37402735
  REMARK    GeneRIF: Chronic UCN2 treatment desensitizes CRHR2 and improves
            insulin sensitivity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Coste,S.C., Kesterson,R.A., Heldwein,K.A., Stevens,S.L.,
            Heard,A.D., Hollis,J.H., Murray,S.E., Hill,J.K., Pantely,G.A.,
            Hohimer,A.R., Hatton,D.C., Phillips,T.J., Finn,D.A., Low,M.J.,
            Rittenberg,M.B., Stenzel,P. and Stenzel-Poore,M.P.
  TITLE     Abnormal adaptations to stress and impaired cardiovascular function
            in mice lacking corticotropin-releasing hormone receptor-2
  JOURNAL   Nat Genet 24 (4), 403-409 (2000)
   PUBMED   10742107
REFERENCE   7  (bases 1 to 2700)
  AUTHORS   Lesh,J.S., Burrows,H.L., Seasholtz,A.F. and Camper,S.A.
  TITLE     Mapping of the mouse corticotropin-releasing hormone receptor 2
            gene (Crhr2) to chromosome 6
  JOURNAL   Mamm Genome 8 (12), 944-945 (1997)
   PUBMED   9383293
REFERENCE   8  (bases 1 to 2700)
  AUTHORS   Stenzel,P., Kesterson,R., Yeung,W., Cone,R.D., Rittenberg,M.B. and
            Stenzel-Poore,M.P.
  TITLE     Identification of a novel murine receptor for
            corticotropin-releasing hormone expressed in the heart
  JOURNAL   Mol Endocrinol 9 (5), 637-645 (1995)
   PUBMED   7565810
REFERENCE   9  (bases 1 to 2700)
  AUTHORS   Perrin,M., Donaldson,C., Chen,R., Blount,A., Berggren,T.,
            Bilezikjian,L., Sawchenko,P. and Vale,W.
  TITLE     Identification of a second corticotropin-releasing factor receptor
            gene and characterization of a cDNA expressed in heart
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2969-2973 (1995)
   PUBMED   7708757
REFERENCE   10 (bases 1 to 2700)
  AUTHORS   Kishimoto,T., Pearse,R.V. 2nd, Lin,C.R. and Rosenfeld,M.G.
  TITLE     A sauvagine/corticotropin-releasing factor receptor expressed in
            heart and skeletal muscle
  JOURNAL   Proc Natl Acad Sci U S A 92 (4), 1108-1112 (1995)
   PUBMED   7755719
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1995 Apr 25;92(9):4074]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085854.1, CJ065172.1 and AK142261.1.
            
            On Jan 5, 2014 this sequence version replaced XM_006505480.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137592.1, U21729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK085854.1         2-52
            52-619              CJ065172.1         2-569
            620-2700            AK142261.1         567-2647
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.33 cM"
     gene            1..2700
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /note="corticotropin releasing hormone receptor 2"
                     /db_xref="GeneID:12922"
                     /db_xref="MGI:MGI:894312"
     exon            1..247
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1471
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; corticotropin-releasing factor 2;
                     corticotropin-releasing factor receptor 2; corticotropin
                     releasing factor receptor type 2 beta; CRF-RB; CRFR-2;
                     CRH-R2; CRF-R-2; CRH-R-2; CRF 2 receptor"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_001275547.1"
                     /db_xref="CCDS:CCDS85053.1"
                     /db_xref="GeneID:12922"
                     /db_xref="MGI:MGI:894312"
                     /translation="MGTPGSLPSAQLLLCLFSLLPVLQVAQPGQAPQDQPLWTLLEQY
                     CHRTTTGNFSGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRE
                     CLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLV
                     LRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTN
                     FFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWF
                     GKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLV
                     LLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRK
                     RWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV"
     exon            248..338
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            339..464
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            465..550
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            551..660
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            661..778
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            779..932
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            933..993
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1066
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1152
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1288
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1330
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..2700
                     /gene="Crhr2"
                     /gene_synonym="CRF-R2; Crfr2; CRFR2alpha; CRFR2beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgctaccc tgggggaggc gggtgaagaa tgccctggtg cccagggctt taccttggtg
       61 ggtaggtcgg gcagggtagg acaggcctaa gagagaggcc ggacagacct cctttggaag
      121 cagccacttc tggtccccat ccctggagcg atcgagcggc aggatctgct gtcccatggg
      181 gaccccaggc tctcttccca gtgcacagct tctcctctgc ctgttttccc tgcttccagt
      241 gctccaggtg gcccaaccag gccaggcacc ccaggaccag cccctgtgga cacttttgga
      301 gcagtactgc cacaggacca caactgggaa tttttcaggt ccctacacct actgcaacac
      361 gaccttggac cagatcggga cctgctggcc acagagcgca cccggagccc tagtagagag
      421 accgtgcccc gagtacttca atggcatcaa gtacaacacg acccggaatg cctacagaga
      481 gtgcctggag aacgggacct gggcctcaag ggtcaactac tcacactgcg aacccatttt
      541 ggatgacaag cagagaaagt atgacctgca ttaccgaatc gccctcattg tcaactacct
      601 gggtcactgt gtttccgtgg tggccctggt ggccgctttc ctgcttttcc tagtgctgcg
      661 gagtatccgc tgcctgagga atgtgatcca ctggaacctc atcaccacct tcattctgag
      721 aaacatcgcg tggttcctgc tgcaactcat cgaccacgaa gtgcacgagg gcaatgaggt
      781 ctggtgccgc tgcatcacca ccatcttcaa ctattttgtg gtcaccaact tcttctggat
      841 gtttgtggag ggctgctacc tgcacacggc cattgtcatg acgtactcca cagagcacct
      901 gcgcaagtgg cttttcctct tcattggatg gtgcattccc tgccctatca tcatcgcctg
      961 ggcagttggc aaactctact atgagaatga gcagtgctgg tttggcaagg aagctggtga
     1021 tttggtggac tacatctacc agggccccgt catgcttgtg ctgttgatca attttgtatt
     1081 tctgtttaac atcgtcagga tcctgatgac gaagttacga gcatccacca cgtccgagac
     1141 aatccaatac aggaaggcag tgaaggccac gctggtcctc ctccccctgt tgggcatcac
     1201 ctacatgctc ttctttgtca atcctggcga ggacgacctg tcccagattg tgttcatcta
     1261 cttcaactct ttcctgcagt ccttccaggg tttctttgtg tccgttttct actgcttctt
     1321 caatggagag gtgcgcgcgg ccctgagaaa gcggtggcac cgctggcagg accaccacgc
     1381 cctccgggtg cctgtggccc gggccatgtc catccctacg tcgcccacca ggatcagctt
     1441 ccacagcatc aagcagacag ctgctgtgtg accctctgtc accgtctgcc cggcagtcca
     1501 ccactgaggc agcttctcca tcctttacag ccttcccctg ggtcctcctt gctaccctga
     1561 cccacagggt acaaggtaca ggagaaggga ggagaacgaa cactcccgcc tggaaggaaa
     1621 ggaaagctat gacatggggg ggctctgaag gaccagggcc cagtgcagcc agccacacat
     1681 ctccaagcac gaaggagcag agggacatca caggaccctc agaagggatg catctcacac
     1741 catcaagcct ctgtgcaccc agcctctttt gtggggtcct cactgcagca ccatttacat
     1801 ctgaagaaac tgaggctcag agcaggcagg gacctggcca agtcacatag ctacttgccc
     1861 cacccacagc acccacagtt ggctctgctc cttgctttcc atctccacac gtgagggcgc
     1921 cctctaaagg tgagggagac aagaatgacc ttatctggct tcatcccaga agctgtcgag
     1981 cagagatgac cagcccttta ccaaggtagc cttcttcttc cccagtctgt ttcccatgtg
     2041 tctccaggag aatgctggct ttcagtcggc catccctcct gggagtcccc aattcagtct
     2101 gggctcagtc tggggaccta gaccacggga agtgagttag atggaaagtc acactctcca
     2161 cagtgccaga cagaagggag aacagaagcg cctggggaag aagggtgagg atcccccaaa
     2221 tcagagtatg cctgggagtg attgaaacaa gggccccagg atctcagtga catcagccag
     2281 gcatctgtgg agttggccac aattcaagca acgagatgtt ggagagatat tgtgagccag
     2341 taataaaggc agaatgtctg caggacatat ccatgcccct cttcttactg gctaggccca
     2401 agcaggcctt cctgtggagt ctttaggttc aaagggcccg aatcattcct gtcaccccca
     2461 aagggtggca tctgcaccac ccccagcgta gaccccacct gtgccaggga ctaatattct
     2521 ggaattggga gggagaggag gcaaggccct tcaggctccg aaagcaagaa gacacagttt
     2581 gatttcaggc ttctcttcca ttcctctgcc cctggagcag aagaggggtg ttggggcaag
     2641 ccaacagact tgaaaaggcc ccttgtctag gtaccccacg aaaataaact ttgaaaacgt
//
