LOCUS       NM_007762               2551 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus corticotropin releasing hormone receptor 1 (Crhr1),
            transcript variant 1, mRNA.
ACCESSION   NM_007762
VERSION     NM_007762.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   de Leon Reyes,N.S., Sierra Diaz,P., Nogueira,R., Ruiz-Pino,A.,
            Nomura,Y., de Solis,C.A., Schulkin,J., Asok,A. and Leroy,F.
  TITLE     Corticotropin-releasing hormone signaling from prefrontal cortex to
            lateral septum suppresses interaction with familiar mice
  JOURNAL   Cell 186 (19), 4152-4171 (2023)
   PUBMED   37669667
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Wang,T., Ma,Y.N., Zhang,C.C., Liu,X., Sun,Y.X., Wang,H.L., Wang,H.,
            Zhong,Y.H., Su,Y.A., Li,J.T. and Si,T.M.
  TITLE     The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life
            Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult
            Mouse
  JOURNAL   Neurosci Bull 39 (1), 41-56 (2023)
   PUBMED   35750984
  REMARK    GeneRIF: The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life
            Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult
            Mouse.
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   De Guzman,R.M., Rosinger,Z.J., Rybka,K.A., Jacobskind,J.S.,
            Thrasher,C.A., Caballero,A.L., Sturm,K.L., Sharif,M.S., Abbas,M.S.,
            Parra,K.E., Zuloaga,K.L., Justice,N.J. and Zuloaga,D.G.
  TITLE     Changes in Corticotropin-Releasing Factor Receptor Type 1,
            Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and
            Anxiety-Like Behaviors across the Postpartum Period in Mice
  JOURNAL   Neuroendocrinology 113 (8), 795-810 (2023)
   PUBMED   36917957
  REMARK    GeneRIF: Changes in Corticotropin-Releasing Factor Receptor Type 1,
            Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and
            Anxiety-Like Behaviors across the Postpartum Period in Mice.
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Pauli,J.L., Chen,J.Y., Basiri,M.L., Park,S., Carter,M.E., Sanz,E.,
            McKnight,G.S., Stuber,G.D. and Palmiter,R.D.
  TITLE     Molecular and anatomical characterization of parabrachial neurons
            and their axonal projections
  JOURNAL   Elife 11, e81868 (2022)
   PUBMED   36317965
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Spicer,A.P., Roller,M.L., Camper,S.A., McPherson,J.D.,
            Wasmuth,J.J., Hakim,S., Wang,C., Turley,E.A. and McDonald,J.A.
  TITLE     The human and mouse receptors for hyaluronan-mediated motility,
            RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse
            chromosome 11
  JOURNAL   Genomics 30 (1), 115-117 (1995)
   PUBMED   8595891
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Xiong,Y., Xie,L.Y. and Abou-Samra,A.B.
  TITLE     Signaling properties of mouse and human corticotropin-releasing
            factor (CRF) receptors: decreased coupling efficiency of human type
            II CRF receptor
  JOURNAL   Endocrinology 136 (5), 1828-1834 (1995)
   PUBMED   7720627
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Stenzel,P., Kesterson,R., Yeung,W., Cone,R.D., Rittenberg,M.B. and
            Stenzel-Poore,M.P.
  TITLE     Identification of a novel murine receptor for
            corticotropin-releasing hormone expressed in the heart
  JOURNAL   Mol Endocrinol 9 (5), 637-645 (1995)
   PUBMED   7565810
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Burrows,H.L., Seasholtz,A.F. and Camper,S.A.
  TITLE     Localization of the corticotropin-releasing hormone receptor gene
            on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (1), 55-56 (1995)
   PUBMED   7719029
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Vita,N., Laurent,P., Lefort,S., Chalon,P., Lelias,J.M., Kaghad,M.,
            Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     Primary structure and functional expression of mouse pituitary and
            human brain corticotrophin releasing factor receptors
  JOURNAL   FEBS Lett 335 (1), 1-5 (1993)
   PUBMED   8243652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ155572.1, AK144430.1,
            CJ143058.1, AK158806.1 and BQ174858.1.
            
            On Sep 11, 2015 this sequence version replaced NM_007762.4.
            
            Summary: The protein encoded by this gene is a G-protein coupled
            receptor that binds corticotropin-releasing factor (CRH) and
            urocortin (UCN) with high affinity. The encoded protein upregulates
            adenylate cyclase activity and intracellular cAMP levels. This
            protein is essential for the activation of signal transduction
            pathways that regulate diverse physiological processes including
            stress, reproduction, immune response, and obesity. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158806.1, AK144430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                CJ155572.1         8-42
            36-85               AK144430.1         4-53
            86-101              CJ143058.1         21-36
            102-2527            AK158806.1         2-2427
            2528-2551           BQ174858.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.77 cM"
     gene            1..2551
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /note="corticotropin releasing hormone receptor 1"
                     /db_xref="GeneID:12921"
                     /db_xref="MGI:MGI:88498"
     exon            1..324
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1539
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; corticotropin-releasing factor receptor 1; CRF
                     1 receptor"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_031788.1"
                     /db_xref="CCDS:CCDS25526.1"
                     /db_xref="GeneID:12921"
                     /db_xref="MGI:MGI:88498"
                     /translation="MGQRPQLRLVKALLLLGLNPVSTSLQDQQCESLSLASNVSGLQC
                     NASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSEC
                     QEILNEEKKSKVHYHIAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLIS
                     AFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV
                     LTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPM
                     ILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNP
                     GEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVA
                     RAMSIPTSPTRVSFHSIKQSTAV"
     exon            325..412
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            413..532
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            533..618
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            619..725
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            726..846
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1000
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1061
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1134
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1220
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1356
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1398
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..2534
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /note="hexamer: AATAAT"
     polyA_site      2534
                     /gene="Crhr1"
                     /gene_synonym="CRF-R1alpha; CRF1R; CRFR1; Crhr"
                     /note="major polyA site"
ORIGIN      
        1 aggcgagagg caggcggacc gtgggggagg cgaccgggct aggcgggatc caggcaggag
       61 agaggtagct gtgggcccag ctgagtgggg agaaggcgac cagacttgct cgcgcagggc
      121 gagccagagc ctgccggtgg ggcggggcgg gagggtgcga agccgggcgc ctgggagcag
      181 ctcagcgacc cgggagactg gccgcccaac ggagaccgca gccgcccgct cttcgctctg
      241 ggatgtcgga gcgatcctgg catccaggac gctgacagag cgagcccgag gatgggacag
      301 cgcccgcagc tccggctcgt gaaggccctt ctccttctgg ggctgaaccc cgtctccacc
      361 tccctccagg atcagcagtg tgagagcctg tccctggcca gcaatgtctc tggcctgcag
      421 tgcaatgcct ccgtggacct cattggcacc tgctggccca ggagccctgc agggcagttg
      481 gtggttcggc cctgccctgc ctttttctac ggtgtccgct acaacaccac aaacaatggc
      541 taccgggaat gcctggccaa cggcagctgg gcagcccgtg tgaattattc tgagtgccag
      601 gagattctca acgaagagaa gaagagcaaa gtgcactacc acattgccgt catcatcaac
      661 tacctgggcc actgcatctc cctggtggcc ctcctggtgg cctttgtcct cttcctgcgg
      721 ctcaggagca tccggtgcct gaggaacatc atccactgga acctcatctc ggctttcatc
      781 ctgcgcaacg ccacgtggtt tgtggtccag ctcaccgtga gccccgaggt ccaccagagc
      841 aacgtggcct ggtgcaggct ggtgacagcc gcctacaact acttccacgt aaccaacttc
      901 ttctggatgt tcggtgaggg ctgctacctg cacacagcca tcgtactcac gtactccacc
      961 gaccgtctgc gcaagtggat gttcgtctgc atcggctggg gtgtgccttt ccccatcatt
     1021 gtggcttggg ccattgggaa actttactac gacaatgaaa agtgctggtt tggcaaacgt
     1081 cctggagtat atactgacta catctaccag ggccccatga tcctggtcct gctgatcaac
     1141 tttatctttc tcttcaacat tgtccgcatc ctcatgacca aactccgagc atccaccaca
     1201 tctgagacta ttcagtacag gaaggctgtg aaggccactc tggtgctctt gcccctcctg
     1261 ggcatcacct acatgttgtt cttcgtcaac cctggggagg acgaggtctc cagggttgtc
     1321 ttcatctact tcaactcttt cctggagtcc tttcagggct tcttcgtgtc tgtgttctat
     1381 tgttttctga acagtgaggt ccgctctgcc atccggaaga ggtggcggcg atggcaggac
     1441 aagcactcca tcagagcccg agtggcccgc gccatgtcca tccccacctc ccccaccaga
     1501 gtcagcttcc acagcatcaa gcagtccaca gcagtgtgaa cctcaggcca cagagcagcc
     1561 cccaagaccc gaggctgggg aaatgatgca agctcactag cgagcctgtc tgcagaggca
     1621 ggcagccttc ccatccctgc ccctgggatg cagacctgta agcctgccca gccgtggaca
     1681 aagcccatag cactggggtg ggcccttggc atctagctcc ctgctgccca ttctccctgg
     1741 gaagttgaaa tgggcattgg gggctggaaa ccctgcagca gtttgatggg cctgtgagcg
     1801 ctgtcttctc ccagagcagc ttactgaaga tctgtcgtct tcaggagctg ttggggaggc
     1861 caactgttac cctggggcat catggaaaac tcccttctga gactgtaaag tctctgagtg
     1921 ttagcgatgc cttgggatgc taccgaggac caacatggtc cagtcaggag accgggagat
     1981 agcggtagaa atctgggaac gtcatcagat ggcactccac ctccctacaa gtcactcctg
     2041 agccaccagg atttcatcag cactgtggca ctgccactgg aaagccctgc cttgctgctt
     2101 tgctgccctg cacctttaga catttactat tctgcaggcc aagccagctt tctgtcactt
     2161 atccactgac agcaacggtc ccctcgcccc caaatcctcc cacctctggg tatcttctaa
     2221 cctgtgagaa gatgggggtc gggaagggga cttgagttgc caggaaccag agtgggccca
     2281 gtctatgagg aaggagtggc ccctgggtac ccaggccact ggcttcagtg gctggcctct
     2341 tgaacacagt cacaagctgg gggaaggatc tattcaagtg ccctgaccag cgacaggtgg
     2401 ctcctgggac aactaactaa ctaagccctt gctcccaggc ttggaatggc ccagtcctca
     2461 gtgggtagga gagctgagga gccgcagcag gactgaggtg ggggtgatat aaataatatt
     2521 tatcttttca actaaaaaaa aaaaaaaaaa a
//
