LOCUS       NM_198408               1697 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus corticotropin releasing hormone binding protein
            (Crhbp), mRNA.
ACCESSION   NM_198408 XM_354766
VERSION     NM_198408.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Locci,A., Yan,Y., Rodriguez,G. and Dong,H.
  TITLE     Sex differences in CRF1, CRF, and CRFBP expression in C57BL/6J
            mouse brain across the lifespan and in response to acute stress
  JOURNAL   J Neurochem 158 (4), 943-959 (2021)
   PUBMED   32813270
  REMARK    GeneRIF: Sex differences in CRF1, CRF, and CRFBP expression in
            C57BL/6J mouse brain across the lifespan and in response to acute
            stress.
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Xie,Y., Kaufmann,D., Moulton,M.J., Panahi,S., Gaynes,J.A.,
            Watters,H.N., Zhou,D., Xue,H.H., Fung,C.M., Levine,E.M., Letsou,A.,
            Brennan,K.C. and Dorsky,R.I.
  TITLE     Lef1-dependent hypothalamic neurogenesis inhibits anxiety
  JOURNAL   PLoS Biol 15 (8), e2002257 (2017)
   PUBMED   28837622
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Ketchesin,K.D., Stinnett,G.S. and Seasholtz,A.F.
  TITLE     Binge Drinking Decreases Corticotropin-Releasing Factor-Binding
            Protein Expression in the Medial Prefrontal Cortex of Mice
  JOURNAL   Alcohol Clin Exp Res 40 (8), 1641-1650 (2016)
   PUBMED   27374820
  REMARK    GeneRIF: Repeated cycles of binge drinking alter CRF-BP mRNA
            expression in the medial prefrontal cortex.
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Knoll,A.T., Halladay,L.R., Holmes,A.J. and Levitt,P.
  TITLE     Quantitative Trait Loci and a Novel Genetic Candidate for Fear
            Learning
  JOURNAL   J Neurosci 36 (23), 6258-6268 (2016)
   PUBMED   27277803
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Albrechet-Souza,L., Hwa,L.S., Han,X., Zhang,E.Y., DeBold,J.F. and
            Miczek,K.A.
  TITLE     Corticotropin Releasing Factor Binding Protein and CRF2 Receptors
            in the Ventral Tegmental Area: Modulation of Ethanol Binge Drinking
            in C57BL/6J Mice
  JOURNAL   Alcohol Clin Exp Res 39 (9), 1609-1618 (2015)
   PUBMED   26247973
  REMARK    GeneRIF: Ventral tegmental area CRH-BP is involved in the initial
            stages of escalated ethanol drinking.
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Valverde,R.A., Seasholtz,A.F., Cortright,D.N. and Denver,R.J.
  TITLE     Biochemical characterization and expression analysis of the Xenopus
            laevis corticotropin-releasing hormone binding protein
  JOURNAL   Mol Cell Endocrinol 173 (1-2), 29-40 (2001)
   PUBMED   11223175
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Karolyi,I.J., Burrows,H.L., Ramesh,T.M., Nakajima,M., Lesh,J.S.,
            Seong,E., Camper,S.A. and Seasholtz,A.F.
  TITLE     Altered anxiety and weight gain in corticotropin-releasing
            hormone-binding protein-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11595-11600 (1999)
   PUBMED   10500222
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Cabib,S., Oliverio,A., Ventura,R., Lucchese,F. and
            Puglisi-Allegra,S.
  TITLE     Brain dopamine receptor plasticity: testing a diathesis-stress
            hypothesis in an animal model
  JOURNAL   Psychopharmacology (Berl) 132 (2), 153-160 (1997)
   PUBMED   9266612
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Cortright,D.N., Nicoletti,A. and Seasholtz,A.F.
  TITLE     Molecular and biochemical characterization of the mouse brain
            corticotropin-releasing hormone-binding protein
  JOURNAL   Mol Cell Endocrinol 111 (2), 147-157 (1995)
   PUBMED   7556876
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Behan,D.P., Potter,E., Lewis,K.A., Jenkins,N.A., Copeland,N.,
            Lowry,P.J. and Vale,W.W.
  TITLE     Cloning and structure of the human corticotrophin releasing
            factor-binding protein gene (CRHBP)
  JOURNAL   Genomics 16 (1), 63-68 (1993)
   PUBMED   8198617
  REMARK    Erratum:[Genomics 1994 Jan 1;19(1):198]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135067.1 and AI854101.1.
            
            On Dec 11, 2007 this sequence version replaced NM_198408.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061247.1, AK135067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1634              AK135067.1         2-1635
            1635-1697           AI854101.1         1-63                c
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.5 cM"
     gene            1..1697
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /note="corticotropin releasing hormone binding protein"
                     /db_xref="GeneID:12919"
                     /db_xref="MGI:MGI:88497"
     exon            1..232
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1120
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /note="corticotropin-releasing factor-binding protein;
                     CRF-BP; CRF-binding protein"
                     /codon_start=1
                     /product="corticotropin-releasing factor-binding protein
                     precursor"
                     /protein_id="NP_940800.1"
                     /db_xref="CCDS:CCDS26698.1"
                     /db_xref="GeneID:12919"
                     /db_xref="MGI:MGI:88497"
                     /translation="MSPNFKLQCHFILILLTALRGESRYLEVQEAAVYDPLLLFSANL
                     KRDLAEEQPYRRALRCLDMLSLPGQFTFTADRPQLHCAAFFIGEPEEFITIHYDLVSI
                     DCQGGDFLKVFDGWILKGEKFPSSQDHPLPTMKRYTDFCESGLTRRSIRSSQNVAMVF
                     FRVHEPGNGFTITIKTDPNLFPCNVISQTPSGRFTLVVPYQHQNCSFSIIYPVAIKIS
                     DLTLGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDPSKMMPLADLCYPFLGPAQMKIS
                     CDNAVVRMVSSGKHINRVTFEYRQLEPFELETSTGNSIPEYCLSSL"
     exon            233..326
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            327..484
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            485..695
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            696..844
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            845..962
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1681
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /note="hexamer: AATAAA"
     polyA_site      1681
                     /gene="Crhbp"
                     /gene_synonym="CRH-BP"
                     /note="major polyA site"
ORIGIN      
        1 aaggggcaga gagcctcccc tctactgctc tataaaagag acccagcaaa gggaccctcg
       61 ctgctttgag ctctcagtgt gggcgaaggt gtgggaagaa acgcctaaga tctccgcagc
      121 agagcactcc agctgcagac acaaggccag catgtcaccg aacttcaaac tccaatgtca
      181 cttcattctg atcctcctga cagctctaag gggagagagc cgctacctag aggtgcaaga
      241 agccgcggtc tacgaccctc tcctgctctt cagtgccaat ctgaagcggg acctggcaga
      301 ggagcagccg taccgacggg ctctgcggtg cctggacatg ctgagcctcc ctggccagtt
      361 caccttcacc gcagaccggc cgcagctgca ctgcgccgcc ttcttcatcg gcgaacccga
      421 ggaattcatc accatccact atgacctggt ctccatcgac tgccaaggcg gggatttcct
      481 gaaggtattt gatggttgga tcctaaaggg agagaaattc ccaagttctc aggatcaccc
      541 tctgcccact atgaagaggt acacagattt ctgtgagagt ggtcttacca gaaggagcat
      601 caggtcttcc cagaatgtgg ccatggtctt cttccgggtc cacgaaccag gaaatggatt
      661 cacgataacc ataaagacag atcccaacct cttcccttgc aatgtcatct ctcagactcc
      721 gagtggaagg tttactttag tggttccata ccagcaccaa aactgcagct tctccatcat
      781 ctatccagtg gcaatcaaaa tctctgatct taccctcgga cacttgcatg gccttcagtt
      841 aaagaaacct gcggctggct gcggtgggac tggtgacttt gtggagctgc tgggaggaac
      901 tggattggac ccctccaaga tgatgccctt agcagacctg tgttacccct ttctcggccc
      961 tgcccagatg aaaattagct gcgacaatgc tgtggtacgc atggtctcca gtgggaaaca
     1021 cattaaccgt gtgacatttg agtatcgtca gctggagcca ttcgagctag aaacctcgac
     1081 cggaaacagc atcccagaat actgtttgtc tagtctgtga atggccggct tcagtgattg
     1141 acatgctgtt agcccagtga gttctccaca gttactgtat gtgatcttca tgggcagcaa
     1201 atggaaagtc ttccaatcag tactccaggc cttgaacacg tgcacacatg agttccaatt
     1261 ttgcttcctt ttgttataat gtttcaacaa acagaaggta gacaacaggt tgttggtgga
     1321 catgcttggt gcttttggta tgctgcaaac acaaagtggt ggaacaaggg tcactggacc
     1381 cttggggaaa gtgggaaaag agctatgtgc aagggcagat gctccaaaga cagagaaatg
     1441 gtggcactca cagtttcatg acagaataaa aataaataaa taaaaaaaga agaagtcaaa
     1501 gtcttgagta taccaaagga attgcatctg ttatttttac ttcatacttc cattcacaaa
     1561 ttgtagctat ccattattaa ttgctagtac ttgtttttta aacaacactt tgtagcatgg
     1621 gaacaaccct ccccctttcc attcataagt ccaaatgtaa ataaacgtat gcagaatgtt
     1681 aaaaaaaaaa aaaaaaa
//
