LOCUS       NM_205769               1338 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus corticotropin releasing hormone (Crh), mRNA.
ACCESSION   NM_205769 XM_357335
VERSION     NM_205769.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Maltese,F., Pacinelli,G., Monai,A., Bernardi,F., Capaz,A.M.,
            Niello,M., Walle,R., de Leon,N., Manago,F., Leroy,F. and Papaleo,F.
  TITLE     Self-experience of a negative event alters responses to others in
            similar states through prefrontal cortex CRF mechanisms
  JOURNAL   Nat Neurosci 28 (1), 122-136 (2025)
   PUBMED   39627538
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   Holt,M.K., Valderrama,N., Polanco,M.J., Hayter,I., Badenoch,E.G.,
            Trapp,S. and Rinaman,L.
  TITLE     Modulation of stress-related behaviour by preproglucagon neurons
            and hypothalamic projections to the nucleus of the solitary tract
  JOURNAL   Mol Metab 91, 102076 (2025)
   PUBMED   39603502
REFERENCE   3  (bases 1 to 1338)
  AUTHORS   Doyle,M.A., Salimando,G.J., Altemus,M.E., Badt,J.K.,
            Bedenbaugh,M.N., Vardy,A.S., Adank,D.N., Park,A.S. and Winder,D.G.
  TITLE     BNST GluN2D-containing NMDARs contribute to ethanol intake but not
            negative affective behaviors in female mice
  JOURNAL   Alcohol Clin Exp Res (Hoboken) 48 (10), 1876-1891 (2024)
   PUBMED   39179522
REFERENCE   4  (bases 1 to 1338)
  AUTHORS   Olson,K.L., Ingebretson,A.E., Vogiatzoglou,E., Mermelstein,P.G. and
            Lemos,J.C.
  TITLE     Cholinergic interneurons in the nucleus accumbens are a site of
            cellular convergence for corticotropin-releasing factor and
            estrogen regulation in male and female mice
  JOURNAL   Eur J Neurosci 60 (5), 4937-4953 (2024)
   PUBMED   39080914
  REMARK    GeneRIF: Cholinergic interneurons in the nucleus accumbens are a
            site of cellular convergence for corticotropin-releasing factor and
            estrogen regulation in male and female mice.
REFERENCE   5  (bases 1 to 1338)
  AUTHORS   Demaestri,C., Pisciotta,M., Altunkeser,N., Berry,G., Hyland,H.,
            Breton,J., Darling,A., Williams,B. and Bath,K.G.
  TITLE     Central amygdala CRF+ neurons promote heightened threat reactivity
            following early life adversity in mice
  JOURNAL   Nat Commun 15 (1), 5522 (2024)
   PUBMED   38951506
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1338)
  AUTHORS   Im,E.
  TITLE     Corticotropin-releasing Hormone and Its Biological Diversity toward
            Angiogenesis
  JOURNAL   Intest Res 12 (2), 96-102 (2014)
   PUBMED   25349575
  REMARK    Review article
REFERENCE   7  (bases 1 to 1338)
  AUTHORS   Keegan,C.E., Karolyi,I.J., Knapp,L.T., Bourbonais,F.J., Camper,S.A.
            and Seasholtz,A.F.
  TITLE     Expression of corticotropin-releasing hormone transgenes in neurons
            of adult and developing mice
  JOURNAL   Mol Cell Neurosci 5 (6), 505-514 (1994)
   PUBMED   7704423
REFERENCE   8  (bases 1 to 1338)
  AUTHORS   Koob,G.F. and Bloom,F.E.
  TITLE     Corticotropin-releasing factor and behavior
  JOURNAL   Fed Proc 44 (1 Pt 2), 259-263 (1985)
   PUBMED   3871412
REFERENCE   9  (bases 1 to 1338)
  AUTHORS   Brown,M.R. and Fisher,L.A.
  TITLE     Corticotropin-releasing factor: effects on the autonomic nervous
            system and visceral systems
  JOURNAL   Fed Proc 44 (1 Pt 2), 243-248 (1985)
   PUBMED   2981744
REFERENCE   10 (bases 1 to 1338)
  AUTHORS   Vale,W., Spiess,J., Rivier,C. and Rivier,J.
  TITLE     Characterization of a 41-residue ovine hypothalamic peptide that
            stimulates secretion of corticotropin and beta-endorphin
  JOURNAL   Science 213 (4514), 1394-1397 (1981)
   PUBMED   6267699
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ050024.1, BC116921.1 and
            BE993430.1.
            
            On Aug 12, 2015 this sequence version replaced NM_205769.2.
            
            Summary: This gene encodes a member of the corticotropin-releasing
            factor family and preproprotein that is proteolytically processed
            to generate a mature protein product. This protein product is a
            neuropeptide hormone that binds to the corticotropin releasing
            hormone receptors (CRHR1 and CRHR2) to stimulate the release of
            adrenocorticotropic hormone from the pituitary gland in response to
            stress. The encoded protein may also regulate angiogenesis and
            inflammation. Homozygous knockout mice for this gene exhibit
            reduced corticosterone levels while the offspring of these mice die
            perinatally. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO714297.1, CJ050024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               CJ050024.1         2-504
            504-1149            BC116921.1         286-931
            1150-1338           BE993430.1         1-189               c
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 5.75 cM"
     gene            1..1338
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /note="corticotropin releasing hormone"
                     /db_xref="GeneID:12918"
                     /db_xref="MGI:MGI:88496"
     exon            1..230
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /inference="alignment:Splign:2.1.0"
     exon            231..1320
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..808
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /note="corticoliberin; corticotropin releasing factor"
                     /codon_start=1
                     /product="corticoliberin preproprotein"
                     /protein_id="NP_991338.1"
                     /db_xref="CCDS:CCDS17258.1"
                     /db_xref="GeneID:12918"
                     /db_xref="MGI:MGI:88496"
                     /translation="MRLRLLVSAGMLLVALSSCLPCRALLSRGSVPRAPRAPQPLNFL
                     QPEQPQQPQPVLIRMGEEYFLRLGNLNRSPAARLSPNSTPLTAGRGSRPSHDQAAANF
                     FRVLLQQLQMPQRSLDSRAEPAERGAEDALGGHQGALERERRSEEPPISLDLTFHLLR
                     EVLEMARAEQLAQQAHSNRKLMEIIGK"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /note="hexamer: AATAAA"
     polyA_site      1267
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /note="major polyA site"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /note="major polyA site"
ORIGIN      
        1 aggcaaatgc tgcgtgcttt ctgaagaggg tcgacattat aaaatctcac tccaggctct
       61 ggtgtggaga aactcagagc ccaagtacgt tgagagactg aagagaaagg gaaaaggcaa
      121 aagaaaaaaa gaagagaaag gagaagagga agaaaacctg caggaggcat cctgagagaa
      181 gtccctctgc agaggcagca gtgcgggctc acctaccaag ggaggagaag agagcgcccc
      241 taacatgcgg ctgcggctgc tggtgtccgc gggcatgctg ctggtggctc tgtcgtcctg
      301 cctgccttgc agggccctgc tcagcagggg atccgtcccc cgagcgccgc gggccccgca
      361 gcccttgaat ttcttgcagc cggagcagcc ccagcaacct cagccggttc tgatccgcat
      421 gggtgaagaa tacttcctcc gcctggggaa tctcaacaga agtcccgctg ctcggctgtc
      481 ccccaactcc acgcccctca ccgcgggtcg cggcagccgc ccctcgcacg accaggctgc
      541 ggctaacttt ttccgcgtgt tgctgcagca gctgcagatg cctcagcgct cgctcgacag
      601 ccgcgcggag ccggccgaac gcggcgccga ggatgccctc ggtggccacc agggggcgct
      661 ggagagggag aggcggtcgg aggagccgcc catctctctg gatctcacct tccaccttct
      721 gcgggaagtc ttggaaatgg cccgggcaga gcagttagct cagcaagctc acagcaacag
      781 gaaactgatg gagattatcg ggaaatgaaa tgttgcgctt ggccaaaacg attctgcatt
      841 tagcacacaa gtaaaaataa aaatttaaaa cacagtattc tgtaccatat cgcagctccg
      901 atatcatttg tttattttta tatagcttga agcatagaag atgtacaggg agagagccta
      961 tatacccctt aattagcatg cacaaagtgt atttctgtgt cgtaacaaaa cagcgttatt
     1021 tgtattgccc atgcttaatt tctatgtgca aataagcgtc tttatagcga tatcttaaag
     1081 aaaatgtggc cccaaggagg aaacctttga aaaagcagat gggagtcatc cagttgtttt
     1141 tatttggagc tgcagtggaa gagaattcat tcttgagggg tggctaggac gaaatgtgta
     1201 agctctttga atcaactttt tcttgtaaat gtttcagtaa taaaacatct ttctgattct
     1261 tggtcaattt ggttgtgtaa gagaacgtta aatatatttt taataaaatc tgcaaaggtt
     1321 aaaaaaaaaa aaaaaaaa
//
