LOCUS       NM_001374833            2912 bp    mRNA    linear   ROD 12-OCT-2024
DEFINITION  Mus musculus cAMP responsive element modulator (Crem), transcript
            variant 19, mRNA.
ACCESSION   NM_001374833 XM_006525558
VERSION     NM_001374833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2912)
  AUTHORS   Chen,J., Qin,H., Hao,J., Wang,Q., Chen,S., Yang,G., Li,M., Zhu,X.,
            Wang,D., Chen,H., Cui,C. and Chen,M.
  TITLE     Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9
            in mice presents a new model of atrial cardiomyopathy with
            spontaneous atrial fibrillation
  JOURNAL   Transl Res 267, 54-66 (2024)
   PUBMED   38199433
  REMARK    GeneRIF: Cardiac-specific overexpression of CREM-IbDeltaC-X via
            CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy
            with spontaneous atrial fibrillation.
REFERENCE   2  (bases 1 to 2912)
  AUTHORS   Yuan,X.X. and Wang,Y.
  TITLE     [Expression of the CREM gene in the semen and testis of miR-199b-5p
            knockout male mice]
  JOURNAL   Zhonghua Nan Ke Xue 30 (2), 111-117 (2024)
   PUBMED   39177342
  REMARK    GeneRIF: [Expression of the CREM gene in the semen and testis of
            miR-199b-5p knockout male mice].
REFERENCE   3  (bases 1 to 2912)
  AUTHORS   Li,P., Jiang,M., Li,K., Li,H., Zhou,Y., Xiao,X., Xu,Y.,
            Krishfield,S., Lipsky,P.E., Tsokos,G.C. and Zhang,X.
  TITLE     Glutathione peroxidase 4-regulated neutrophil ferroptosis induces
            systemic autoimmunity
  JOURNAL   Nat Immunol 22 (9), 1107-1117 (2021)
   PUBMED   34385713
REFERENCE   4  (bases 1 to 2912)
  AUTHORS   Liu,F., Huang,Y.F. and Kream,B.E.
  TITLE     Identification of novel cAMP responsive element modulator (CREM)
            isoforms expressed by osteoblasts
  JOURNAL   Calcif Tissue Int 77 (2), 91-95 (2005)
   PUBMED   16059773
REFERENCE   5  (bases 1 to 2912)
  AUTHORS   Daniel,P.B., Rohrbach,L. and Habener,J.F.
  TITLE     Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element
            modulator theta isoforms expressed by two newly identified
            cAMP-responsive promoters active in the testis
  JOURNAL   Endocrinology 141 (11), 3923-3930 (2000)
   PUBMED   11089521
REFERENCE   6  (bases 1 to 2912)
  AUTHORS   Molina,C.A., Foulkes,N.S., Lalli,E. and Sassone-Corsi,P.
  TITLE     Inducibility and negative autoregulation of CREM: an alternative
            promoter directs the expression of ICER, an early response
            repressor
  JOURNAL   Cell 75 (5), 875-886 (1993)
   PUBMED   8252624
REFERENCE   7  (bases 1 to 2912)
  AUTHORS   Masquilier,D., Foulkes,N.S., Mattei,M.G. and Sassone-Corsi,P.
  TITLE     Human CREM gene: evolutionary conservation, chromosomal
            localization, and inducibility of the transcript
  JOURNAL   Cell Growth Differ 4 (11), 931-937 (1993)
   PUBMED   7916662
REFERENCE   8  (bases 1 to 2912)
  AUTHORS   Brindle,P., Linke,S. and Montminy,M.
  TITLE     Protein-kinase-A-dependent activator in transcription factor CREB
            reveals new role for CREM repressors
  JOURNAL   Nature 364 (6440), 821-824 (1993)
   PUBMED   8102791
REFERENCE   9  (bases 1 to 2912)
  AUTHORS   Foulkes,N.S., Mellstrom,B., Benusiglio,E. and Sassone-Corsi,P.
  TITLE     Developmental switch of CREM function during spermatogenesis: from
            antagonist to activator
  JOURNAL   Nature 355 (6355), 80-84 (1992)
   PUBMED   1370576
REFERENCE   10 (bases 1 to 2912)
  AUTHORS   Foulkes,N.S., Borrelli,E. and Sassone-Corsi,P.
  TITLE     CREM gene: use of alternative DNA-binding domains generates
            multiple antagonists of cAMP-induced transcription
  JOURNAL   Cell 64 (4), 739-749 (1991)
   PUBMED   1847666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117589.13.
            
            On Oct 16, 2019 this sequence version replaced XM_006525558.4.
            
            Summary: This gene encodes a basic-leucine zipper domain-containing
            protein that localizes to gene promoters, where it binds to the
            cyclic AMP response element (CRE). Different protein isoforms
            encoded by this gene may function as either activators or
            repressors of transcription. Activity of this gene is important in
            multiple developmental processes, including spermatogenesis.
            Mutation of this gene causes male infertility. Alternative splicing
            and promoter usage result in multiple transcript variants for this
            gene. [provided by RefSeq, Oct 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2524068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC117589.13        203406-203656       c
            252-369             AC117589.13        191387-191504       c
            370-516             AC117589.13        165188-165334       c
            517-611             AC117589.13        161348-161442       c
            612-754             AC117589.13        161066-161208       c
            755-943             AC117589.13        153930-154118       c
            944-979             AC117589.13        142720-142755       c
            980-1136            AC117589.13        139448-139604       c
            1137-2912           AC117589.13        132380-134155       c
FEATURES             Location/Qualifiers
     source          1..2912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 2.14 cM"
     gene            1..2912
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="cAMP responsive element modulator"
                     /db_xref="GeneID:12916"
                     /db_xref="MGI:MGI:88495"
     exon            1..251
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            252..369
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1281
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="isoform 18 is encoded by transcript variant 19;
                     inducible cAMP early repressor; cAMP responsive element
                     moderator"
                     /codon_start=1
                     /product="cAMP-responsive element modulator isoform 18"
                     /protein_id="NP_001361762.1"
                     /db_xref="CCDS:CCDS89179.1"
                     /db_xref="GeneID:12916"
                     /db_xref="MGI:MGI:88495"
                     /translation="MTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTLAQVSVAGS
                     GTGRGSPAVTLVQLPSGQTVQVQGVIQTPHPSVIQSPQIQTVQVATIAETDDSADSEV
                     IDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAVPTSIYQ
                     TSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQ
                     FFVPGSQVVVQDEETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQ
                     QLAEEATRKRELRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKD
                     LYCHKAE"
     exon            370..516
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            517..611
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            612..754
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            755..943
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            944..979
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1136
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..2912
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1737..1742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="hexamer: AATATA"
     polyA_site      1755
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="major polyA site"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="hexamer: AATAAA"
     polyA_site      2005
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="major polyA site"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="hexamer: AATAGA"
     polyA_site      2260
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="major polyA site"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="hexamer: AATGAA"
     polyA_site      2396
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
     regulatory      2889..2894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
                     /note="hexamer: TATAAA"
     polyA_site      2912
                     /gene="Crem"
                     /gene_synonym="ICER; ICERI"
ORIGIN      
        1 agtcccctta gagaggcgat cggcgtgggg gaggggaggg tagggctcga ggccgcagtt
       61 cggtccgctg cttgcgcggc tttctgttcg cgtcggcaga gaggccgcga caaccgcatc
      121 agagctgacg tgggcgcgac gtgcggccgc atccgccggg ttgcctgggc ggcggccgtc
      181 gggctctgcg tccccacctc ctcccgtccg taatcagtga cgaggtccgc tacgtaaacc
      241 cttcgcggcg ggcaaatgac catggaaaca gttgaatcac agcaggatcg aagtgtaaca
      301 cgttctgtgg cagagcatag ctctgctcat atgcagactg gtcaaatttc tgttcctact
      361 ctagctcagg tttctgtagc tggatcaggc actggaagag gctccccagc tgtgactcta
      421 gtacagttac cttcaggcca aactgtacag gtccagggag ttattcagac accacatcca
      481 tcggttattc aatcaccaca aatacaaact gttcaggtag caacaattgc agagacagat
      541 gattctgcag actcagaagt aattgattcg cataaacgta gagaaattct ttcacgaaga
      601 ccctcatata gaaaaatact gaatgaactt tcctctgatg tgcctggtat tcccaagatt
      661 gaagaagaaa aatcagagga agaagggaca ccacctaaca ttgctaccat ggcagtacca
      721 actagcatat atcagactag cacggggcaa tacattgcta tagctcaagg tggaacaatc
      781 cagatttcta acccaggatc tgatggtgtt cagggactcc aggcattaac aatgacaaat
      841 tcaggagctc ctccgccagg tgctacaatt gtacagtatg cagcacaatc agccgatggt
      901 acacagcagt tctttgtccc aggcagccag gttgttgttc aagatgagga gactgacctt
      961 gccccaagtc acatggctgc tgccacaggt gacatgccaa cttaccagat ccgagctcct
     1021 actactgctt tgccacaagg tgtggtgatg gctgcctcac caggaagcct gcacagtccc
     1081 cagcaactag cagaagaagc aactcgcaag cgggagctga ggctgatgaa aaacagggaa
     1141 gctgcccggg agtgtcgcag gaagaagaaa gaatatgtca aatgtcttga aaatcgtgtg
     1201 gctgtgcttg aaaatcaaaa caagaccctc attgaggaac tcaaggccct caaagacctt
     1261 tattgccata aagcagagta actgtgtttg atttggacct tgttgactgt gaactctaat
     1321 cggggcaggc gatgcagcat cctcataatg gccatgtgga cttgtagatg ggtctcttaa
     1381 cccttgctta agaatacagt ctgctgtaga gtgtgaattg ggaatactgt tccatgggtt
     1441 ggaatgcagc tcccctcaca ttaccaagct tgctctattg ccaatagcat gcaacatatg
     1501 ttttgtttgc ccttctgctt ctactttttt cagggaagct gctaaagaat gtcgacgtcg
     1561 aaagaaagag tatgtgaagt gtcttgagag tcgagtcgca gtgctggaag ttcagaacaa
     1621 gaagcttata gaggagcttg aaactttgaa agacatttgc tctcccaaaa cagattagta
     1681 gaaatattta actatgaact gattacagca tgtacagttg cttttgaatg caatacaata
     1741 tatagccggc aagaattatg gctttttcct ttgtatcatt catctaactt tctaaaacta
     1801 acattcctaa gatgctttgt tgtatttaat ttgctcttac ctctaaggtc aattttttag
     1861 aagagacaaa ctgtaaaaaa tgtatgtaac aaattcttaa aatgaagtat ttgtaagact
     1921 tgttccagtg caacatattt acagttccca gtctctctgt catgaatagt gtcctatgca
     1981 ataaaaattt tgcaggtttt aagaatcatt ttaggaaagg gtgatcaaag gcagtgcatc
     2041 tctccagtag taagataaaa tcaacccata gagatacctc aggaaagaat gaaaggaagt
     2101 gtatcctgat gacatgacta cgtgagaata gcctacaaat gaatttatgc atttatagat
     2161 ttttataatc gtcactttgt aaagaaagta ttgtattgct gtccttgggt gccacagttg
     2221 aagacagttt taaatagaac catgttggtt gctctttgta ctatttggta tttatttaag
     2281 tatctgagca tttactacag cttcctacta tgtatgtagt atgtgaattt ctacaaaagt
     2341 ttgtgctgct ttgctgttat ttaatgaaag agacaacata ttttcattat ctggaatgag
     2401 ttccacaagt atgaatttat tgctacactg gatcagcagc cttgcaaata ctgggccatt
     2461 tcattagagg acaactgcag ggctctagga gcagagttca gtgtggagca cttgcctggc
     2521 atgctacatg ttcagttgaa agggaagacc tcaagctctg caaatggaat ggggtccagg
     2581 ggaagaggtt agaggttagc ctttgtgctg tactaggctt cttgctgatc gtctggagag
     2641 tttctgctga tgaccctcca ttgtgaattc ttgcaacctc aggaatgtta acgtttaaaa
     2701 aacaacccaa gatgtcattt ttgattttac aacttggatc aattttgttt tgctctttgg
     2761 aatatagctg tgtacatttg tcacgtaggt ttaggctggc cttaaactca cagttctctt
     2821 gcctcagcct tctgagtgct tggattacgg atgtgggcca gaatatccag tttgatcaag
     2881 tattctttta taaaatatta ctttcttttt aa
//
