LOCUS       NM_029720               1364 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cysteine-rich with EGF-like domains 2 (Creld2), mRNA.
ACCESSION   NM_029720
VERSION     NM_029720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Wu,X., Zheng,L., Reboll,M.R., Hyde,L.F., Mass,E., Niessen,H.W.,
            Kosanke,M., Pich,A., Giannitsis,E., Tillmanns,J., Bauersachs,J.,
            Heineke,J., Wang,Y., Korf-Klingebiel,M., Polten,F. and Wollert,K.C.
  TITLE     Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic
            reticulum stress-inducible angiogenic growth factor promoting
            ischemic heart repair
  JOURNAL   Nat Cardiovasc Res 3 (2), 186-202 (2024)
   PUBMED   39196188
  REMARK    GeneRIF: Cysteine-rich with EGF-like domains 2 (CRELD2) is an
            endoplasmic reticulum stress-inducible angiogenic growth factor
            promoting ischemic heart repair.
REFERENCE   4  (bases 1 to 1364)
  AUTHORS   Pakarinen,E., Lindholm,P., Saarma,M. and Lindahl,M.
  TITLE     CDNF and MANF regulate ER stress in a tissue-specific manner
  JOURNAL   Cell Mol Life Sci 79 (2), 124 (2022)
   PUBMED   35129674
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1364)
  AUTHORS   Kern,P., Balzer,N.R., Blank,N., Cygon,C., Wunderling,K., Bender,F.,
            Frolov,A., Sowa,J.P., Bonaguro,L., Ulas,T., Homrich,M.,
            Kiermaier,E., Thiele,C., Schultze,J.L., Canbay,A., Bauer,R. and
            Mass,E.
  TITLE     Creld2 function during unfolded protein response is essential for
            liver metabolism homeostasis
  JOURNAL   FASEB J 35 (10), e21939 (2021)
   PUBMED   34549824
  REMARK    GeneRIF: Creld2 function during unfolded protein response is
            essential for liver metabolism homeostasis.
REFERENCE   6  (bases 1 to 1364)
  AUTHORS   Zhang,J., Weng,Y., Liu,X., Wang,J., Zhang,W., Kim,S.H., Zhang,H.,
            Li,R., Kong,Y., Chen,X., Shui,W., Wang,N., Zhao,C., Wu,N., He,Y.,
            Nan,G., Chen,X., Wen,S., Zhang,H., Deng,F., Wan,L., Luu,H.H.,
            Haydon,R.C., Shi,L.L., He,T.C. and Shi,Q.
  TITLE     Endoplasmic reticulum (ER) stress inducible factor cysteine-rich
            with EGF-like domains 2 (Creld2) is an important mediator of
            BMP9-regulated osteogenic differentiation of mesenchymal stem cells
  JOURNAL   PLoS One 8 (9), e73086 (2013)
   PUBMED   24019898
  REMARK    GeneRIF: results strongly suggest that Creld2 may be directly
            regulated by BMP9 and ER stress response may play an important role
            in regulating osteogenic differentiation
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1364)
  AUTHORS   Oh-hashi,K., Kunieda,R., Hirata,Y. and Kiuchi,K.
  TITLE     Biosynthesis and secretion of mouse cysteine-rich with EGF-like
            domains 2
  JOURNAL   FEBS Lett 585 (15), 2481-2487 (2011)
   PUBMED   21729698
REFERENCE   8  (bases 1 to 1364)
  AUTHORS   Oh-Hashi,K., Koga,H., Ikeda,S., Shimada,K., Hirata,Y. and Kiuchi,K.
  TITLE     Role of an ER stress response element in regulating the
            bidirectional promoter of the mouse CRELD2 - ALG12 gene pair
  JOURNAL   BMC Genomics 11, 664 (2010)
   PUBMED   21106106
  REMARK    GeneRIF: These results show that the mouse CRELD2 and ALG12 genes
            are arranged as a unique bidirectional gene pair.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1364)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 1364)
  AUTHORS   Oh-hashi,K., Koga,H., Ikeda,S., Shimada,K., Hirata,Y. and Kiuchi,K.
  TITLE     CRELD2 is a novel endoplasmic reticulum stress-inducible gene
  JOURNAL   Biochem Biophys Res Commun 387 (3), 504-510 (2009)
   PUBMED   19615339
  REMARK    GeneRIF: CRELD2 could be a novel mediator in regulating the onset
            and progression of various ER stress-associated diseases.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK017880.1.
            
            On Apr 6, 2007 this sequence version replaced NM_029720.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017880.1, BC047370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1364              AK017880.1         2-1365
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.31 cM"
     gene            1..1364
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /note="cysteine-rich with EGF-like domains 2"
                     /db_xref="GeneID:76737"
                     /db_xref="MGI:MGI:1923987"
     exon            1..189
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1119
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /EC_number="5.3.4.1"
                     /note="cysteine-rich with EGF-like domain protein 2;
                     protein disulfide isomerase Creld2"
                     /codon_start=1
                     /product="protein disulfide isomerase Creld2 precursor"
                     /protein_id="NP_083996.1"
                     /db_xref="CCDS:CCDS27733.1"
                     /db_xref="GeneID:76737"
                     /db_xref="MGI:MGI:1923987"
                     /translation="MHLLLAAAFGLLLLLPPPGAVASRKPTMCQRCRTLVDKFNQGMA
                     NTARKNFGGGNTAWEEKTLSKYEFSEIRLLEIMEGLCDSSDFECNQLLEQQEEQLEAW
                     WQTLKKEHPNLFEWFCVHTLKACCLPGTYGPDCQECQGGSERPCSGNGYCSGDGSRQG
                     DGSCQCHTGYKGPLCIDCTDGFFSLQRNETHSICSACDESCKTCSGPSNKDCIQCEVG
                     WARVEDACVDVDECAAETSPCSDGQYCENVNGSYTCEDCDSTCVGCTGKGPANCKECI
                     AGYTKESGQCTDIDECSLEEKACKRKNENCYNVPGSFVCVCPEGFEETEDACVQTAEG
                     KVTEENPTQPPSREDL"
     exon            190..272
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            273..383
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..475
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..652
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            653..748
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            749..832
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1069
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1364
                     /gene="Creld2"
                     /gene_synonym="5730592L21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccggtgg gcggaggctc agactccgcc gcagttctcg gtgggtcgcc gggcagccct
       61 cccgccatgc acctgctgct tgcagccgcg ttcgggctgc tgctgctgct gccgccgccc
      121 ggggccgtag cctcccggaa gccgacgatg tgccagagat gccggacgct ggtggacaag
      181 ttcaaccagg ggatggccaa cacggccagg aagaatttcg gtggcggcaa cacggcgtgg
      241 gaagagaaga cgctgtctaa gtacgaattc agtgagatcc ggcttctgga gatcatggag
      301 ggtctgtgtg acagcagtga ctttgagtgc aaccaactct tggagcagca ggaggagcag
      361 ctagaggctt ggtggcagac actgaagaag gagcacccca acctatttga gtggttctgt
      421 gtacacacac tgaaagcgtg ctgtcttcca ggcacctacg ggccagactg tcaagagtgc
      481 cagggtgggt ccgagaggcc ttgcagcgga aacggctatt gcagcggaga cggcagcaga
      541 cagggcgacg ggtcctgcca gtgtcacaca ggctacaagg gaccactgtg tattgactgc
      601 acagacggct tcttcagctt gcagaggaac gagacccaca gcatctgctc agcctgtgat
      661 gagtcttgca agacctgctc tggtccaagc aacaaagact gtatccagtg tgaagtgggc
      721 tgggcacgtg tggaggatgc ctgtgtggat gtggatgagt gtgcagcaga gacatctccg
      781 tgcagcgatg gccagtactg tgagaatgtc aacggctcgt acacatgtga agactgtgat
      841 tctacctgcg tgggctgtac aggaaaaggc ccagccaact gtaaggagtg tattgccggc
      901 tacaccaagg agagtggaca gtgcacagat atagatgaat gctcactaga agaaaaagcc
      961 tgtaagagga aaaacgaaaa ctgctacaat gttccgggga gcttcgtgtg cgtgtgtccg
     1021 gaaggctttg aggagacaga agacgcttgt gtgcagacag cagaaggcaa agtcacagag
     1081 gaaaacccca cacagccacc ctcccgtgag gatttgtgac gggcatccgg attcagaagc
     1141 caaactcacc ctttaagtta ttgagaggat acctatagaa aatgtggccc atggacatga
     1201 accccatttc tccaggaaga cttcagaggg agaagctgcg tactcggaca cagctgatgc
     1261 tcacttggcc ctttcaaaag ctgcatttct tggtggttct tacacagatt tgtatatttt
     1321 gatattgttc tttataataa aaatgatcat tgaaggtcac cagg
//
