LOCUS       NM_133930               2264 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cysteine-rich with EGF-like domains 1 (Creld1),
            transcript variant 1, mRNA.
ACCESSION   NM_133930
VERSION     NM_133930.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Beckert,V., Rassmann,S., Kayvanjoo,A.H., Klausen,C., Bonaguro,L.,
            Botermann,D.S., Krause,M., Moreth,K., Spielmann,N., da
            Silva-Buttkus,P., Fuchs,H., Gailus-Durner,V., de Angelis,M.H.,
            Handler,K., Ulas,T., Aschenbrenner,A.C., Mass,E. and Wachten,D.
  TITLE     Creld1 regulates myocardial development and function
  JOURNAL   J Mol Cell Cardiol 156, 45-56 (2021)
   PUBMED   33773996
  REMARK    GeneRIF: Creld1 regulates myocardial development and function.
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Bonaguro,L., Kohne,M., Schmidleithner,L., Schulte-Schrepping,J.,
            Warnat-Herresthal,S., Horne,A., Kern,P., Gunther,P., Ter Horst,R.,
            Jaeger,M., Rahmouni,S., Georges,M., Falk,C.S., Li,Y., Mass,E.,
            Beyer,M., Joosten,L.A.B., Netea,M.G., Ulas,T., Schultze,J.L. and
            Aschenbrenner,A.C.
  TITLE     CRELD1 modulates homeostasis of the immune system in mice and
            humans
  JOURNAL   Nat Immunol 21 (12), 1517-1527 (2020)
   PUBMED   33169013
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Li,H., Edie,S., Klinedinst,D., Jeong,J.S., Blackshaw,S.,
            Maslen,C.L. and Reeves,R.H.
  TITLE     Penetrance of Congenital Heart Disease in a Mouse Model of Down
            Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier
  JOURNAL   Genetics 203 (2), 763-770 (2016)
   PUBMED   27029737
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Mass,E., Wachten,D., Aschenbrenner,A.C., Voelzmann,A. and Hoch,M.
  TITLE     Murine Creld1 controls cardiac development through activation of
            calcineurin/NFATc1 signaling
  JOURNAL   Dev Cell 28 (6), 711-726 (2014)
   PUBMED   24697899
  REMARK    GeneRIF: Murine Creld1 controls cardiac development through
            activation of calcineurin/NFATc1 signaling.
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Robinson,S.W., Morris,C.D., Goldmuntz,E., Reller,M.D., Jones,M.A.,
            Steiner,R.D. and Maslen,C.L.
  TITLE     Missense mutations in CRELD1 are associated with cardiac
            atrioventricular septal defects
  JOURNAL   Am J Hum Genet 72 (4), 1047-1052 (2003)
   PUBMED   12632326
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   Rupp,P.A., Fouad,G.T., Egelston,C.A., Reifsteck,C.A., Olson,S.B.,
            Knosp,W.M., Glanville,R.W., Thornburg,K.L., Robinson,S.W. and
            Maslen,C.L.
  TITLE     Identification, genomic organization and mRNA expression of CRELD1,
            the founding member of a unique family of matricellular proteins
  JOURNAL   Gene 293 (1-2), 47-57 (2002)
   PUBMED   12137942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153910.6, AK155777.1, AK077726.1 and BQ573596.1.
            
            On Feb 8, 2017 this sequence version replaced NM_133930.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010804.1, AK077726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC153910.6         158497-158700
            205-1449            AK155777.1         2-1246
            1450-2247           AK077726.1         1382-2179
            2248-2251           AC153910.6         168480-168483
            2252-2264           BQ573596.1         740-752
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.77 cM"
     gene            1..2264
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /note="cysteine-rich with EGF-like domains 1"
                     /db_xref="GeneID:171508"
                     /db_xref="MGI:MGI:2152539"
     exon            1..721
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..1810
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /EC_number="5.3.4.1"
                     /note="cysteine-rich with EGF-like domain protein 1;
                     protein disulfide isomerase Creld1"
                     /codon_start=1
                     /product="protein disulfide isomerase Creld1 precursor"
                     /protein_id="NP_598691.1"
                     /db_xref="CCDS:CCDS20423.1"
                     /db_xref="GeneID:171508"
                     /db_xref="MGI:MGI:2152539"
                     /translation="MAPLPPRGLVPSLLWCLSLFLSLPGPVWLQPSPPPHPSPRAEPH
                     PCHTCRALVDNFNKGLERTIRDNFGGGNTAWEEEKLSKYKDSETRLVEVLEGVCSRSD
                     FECHRLLELSEELVENWWFHRQQEAPDLFQWLCSDSLKLCCPSGTFGPSCLPCPGGTE
                     RPCGGYGQCEGEGTRGGSGHCDCQAGYGGEACGQCGLGYFEAERNSSHLVCSACFGPC
                     ARCTGPEESHCLQCKKGWALHHLKCVDIDECGTEQATCGADQFCVNTEGSYECRDCAK
                     ACLGCMGAGPGRCKKCSRGYQQVGSKCLDVDECETVVCPGENEKCENTEGGYRCVCAE
                     GYRQEDGICVKEQVPESAGFFAEMTEDEMVVLQQMFFGVIICALATLAAKGDLVFTAI
                     FIGAVAAMTGYWLSERSDRVLEGFIKGR"
     exon            722..804
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            805..915
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1007
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1184
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1280
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1364
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1460
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1595
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..2252
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /note="hexamer: AATAAA"
     polyA_site      2247
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /note="major polyA site"
ORIGIN      
        1 ctttgaggcg actcggccca cagcgcccgg ggcggaggcg gggacttttt tttttttttt
       61 ttccctcctc ctctaaggtc tagcagggtt tggatcctcc cagtcctgtt tcaggctgtg
      121 cctccatctc ccaaagaggc tctgaacttg accccttctc ttcatatccg gatccgggct
      181 cctcctccag gaccgcccat ccgcctttct ctcggaatat tttgggatcc aaccctctct
      241 ctaattttgg cccctaataa ctcactgaga ccctaaaaca atgggctgac gcttattctt
      301 ttgcccgcga tcccggccac ctccccctac ggtaacggag aaataatttc tctgctggaa
      361 tcgtagatta ggctctttca ccccttccag cgcctctgct tccactaccc cagtttatcc
      421 tcgttttgta attacgtagg tctggggctc tgagccccaa ggcgcctcgc tttcctccct
      481 tacagcctgg cttctccagt gaaccctccc cctgccctct atctgcacgt ccccagcctg
      541 ggaaaagatg gctccactgc ccccaagggg cctggtccca tctctgctct ggtgcttgag
      601 cctgtttctg agcctcccag gacctgtctg gctccaaccc tctcctcctc cccatccttc
      661 tccccgagct gagccccatc cgtgtcatac ctgccgggca ctggtggaca acttcaacaa
      721 gggcctggag agaaccatcc gggacaactt cgggggtgga aacacggcct gggaggaaga
      781 gaagttgtcc aaatacaaag acagtgagac ccgcctggtg gaggtgctgg agggcgtgtg
      841 cagcaggtca gacttcgagt gccaccgcct gctcgagctg agcgaggagc tggtggaaaa
      901 ctggtggttt cacaggcagc aggaagcccc cgacctcttc cagtggctct gttccgattc
      961 cctgaagctc tgctgcccct ctggcacctt tgggccctcc tgcctgccat gtcctggggg
     1021 cacagagagg ccctgcggtg gctacgggca gtgtgaaggg gaagggactc gagggggcag
     1081 cgggcactgt gactgccaag ccggctatgg gggcgaggcc tgtggccagt gtggccttgg
     1141 ctactttgag gcggagcgca acagcagcca tctggtatgt tcggcgtgtt ttggtccttg
     1201 tgcccgctgc acgggacctg aggaatccca ttgtctgcag tgcaagaaag gctgggccct
     1261 gcatcacctc aagtgtgtag acatcgatga gtgtggtaca gagcaagcca cctgtggagc
     1321 tgaccagttc tgtgtgaaca cagaaggatc ctacgagtgc cgagactgtg caaaggcctg
     1381 cctgggctgt atgggagcag ggccagggcg ctgcaaaaag tgcagccgtg gctaccagca
     1441 ggtgggctcc aagtgcctag atgtggatga gtgtgagact gtggtgtgtc caggagagaa
     1501 tgagaagtgt gaaaacacgg agggaggcta ccgctgtgtc tgtgctgagg gctacagaca
     1561 ggaggacggc atctgcgtga aggagcaggt cccggagtcg gcgggcttct ttgcggagat
     1621 gacggaggat gaaatggtgg ttctgcagca gatgttcttt ggtgtaatca tctgtgcgct
     1681 ggccacgctt gctgccaagg gtgacttggt gttcactgcc atcttcattg gagctgtggc
     1741 agccatgact gggtactggt tgtcagagcg gagtgaccgt gtgctggagg gcttcatcaa
     1801 gggtagataa tccctgccgc cactcacagg atttcctccc acccaggctg ctcctagagg
     1861 ttatttctct ctccctatgg atacctggga cagcatagtt tctctttgag actggggtaa
     1921 acaccctttt acctgcctta ctgagcagcc caggacccca gtggccccag ggggttgaaa
     1981 aagaggtcct gaagcagatg ccacgagatc ctagcctagg acactggcag gcctcaccgt
     2041 gtatgaatcc caagacagtt tctccccagg gaggttgcag gtgggctttg gcccctgacc
     2101 cggatgagag gtgtcccctc aggggtgggc ccccataggc cccttgccag gtgcatgctg
     2161 ccagctccag ctgtgtattc accgcccacg ccctagccat cgacttattt attcatctca
     2221 ggaaataaag gacggtcttg aaaatgggaa aaaaaaaaaa aaaa
//
