LOCUS       NP_598691                420 aa            linear   ROD 05-JUN-2024
DEFINITION  protein disulfide isomerase Creld1 precursor [Mus musculus].
ACCESSION   NP_598691
VERSION     NP_598691.1
DBSOURCE    REFSEQ: accession NM_133930.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 420)
  AUTHORS   Beckert,V., Rassmann,S., Kayvanjoo,A.H., Klausen,C., Bonaguro,L.,
            Botermann,D.S., Krause,M., Moreth,K., Spielmann,N., da
            Silva-Buttkus,P., Fuchs,H., Gailus-Durner,V., de Angelis,M.H.,
            Handler,K., Ulas,T., Aschenbrenner,A.C., Mass,E. and Wachten,D.
  TITLE     Creld1 regulates myocardial development and function
  JOURNAL   J Mol Cell Cardiol 156, 45-56 (2021)
   PUBMED   33773996
  REMARK    GeneRIF: Creld1 regulates myocardial development and function.
REFERENCE   2  (residues 1 to 420)
  AUTHORS   Bonaguro,L., Kohne,M., Schmidleithner,L., Schulte-Schrepping,J.,
            Warnat-Herresthal,S., Horne,A., Kern,P., Gunther,P., Ter Horst,R.,
            Jaeger,M., Rahmouni,S., Georges,M., Falk,C.S., Li,Y., Mass,E.,
            Beyer,M., Joosten,L.A.B., Netea,M.G., Ulas,T., Schultze,J.L. and
            Aschenbrenner,A.C.
  TITLE     CRELD1 modulates homeostasis of the immune system in mice and
            humans
  JOURNAL   Nat Immunol 21 (12), 1517-1527 (2020)
   PUBMED   33169013
REFERENCE   3  (residues 1 to 420)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   4  (residues 1 to 420)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 420)
  AUTHORS   Li,H., Edie,S., Klinedinst,D., Jeong,J.S., Blackshaw,S.,
            Maslen,C.L. and Reeves,R.H.
  TITLE     Penetrance of Congenital Heart Disease in a Mouse Model of Down
            Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier
  JOURNAL   Genetics 203 (2), 763-770 (2016)
   PUBMED   27029737
REFERENCE   6  (residues 1 to 420)
  AUTHORS   Mass,E., Wachten,D., Aschenbrenner,A.C., Voelzmann,A. and Hoch,M.
  TITLE     Murine Creld1 controls cardiac development through activation of
            calcineurin/NFATc1 signaling
  JOURNAL   Dev Cell 28 (6), 711-726 (2014)
   PUBMED   24697899
  REMARK    GeneRIF: Murine Creld1 controls cardiac development through
            activation of calcineurin/NFATc1 signaling.
REFERENCE   7  (residues 1 to 420)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   8  (residues 1 to 420)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (residues 1 to 420)
  AUTHORS   Robinson,S.W., Morris,C.D., Goldmuntz,E., Reller,M.D., Jones,M.A.,
            Steiner,R.D. and Maslen,C.L.
  TITLE     Missense mutations in CRELD1 are associated with cardiac
            atrioventricular septal defects
  JOURNAL   Am J Hum Genet 72 (4), 1047-1052 (2003)
   PUBMED   12632326
REFERENCE   10 (residues 1 to 420)
  AUTHORS   Rupp,P.A., Fouad,G.T., Egelston,C.A., Reifsteck,C.A., Olson,S.B.,
            Knosp,W.M., Glanville,R.W., Thornburg,K.L., Robinson,S.W. and
            Maslen,C.L.
  TITLE     Identification, genomic organization and mRNA expression of CRELD1,
            the founding member of a unique family of matricellular proteins
  JOURNAL   Gene 293 (1-2), 47-57 (2002)
   PUBMED   12137942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153910.6, AK155777.1, AK077726.1 and BQ573596.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010804.1, AK077726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.77 cM"
     Protein         1..420
                     /product="protein disulfide isomerase Creld1 precursor"
                     /EC_number="5.3.4.1"
                     /note="cysteine-rich with EGF-like domain protein 1;
                     protein disulfide isomerase Creld1"
                     /calculated_mol_wt=42562
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3174
     mat_peptide     30..420
                     /product="Protein disulfide isomerase Creld1.
                     /id=PRO_0000042782"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
                     /calculated_mol_wt=42562
     Region          46..>100
                     /region_name="DUF3456"
                     /note="TLR4 regulator and MIR-interacting MSAP; pfam11938"
                     /db_xref="CDD:463404"
     Region          46..49
                     /region_name="CXXC.
                     /evidence=ECO:0000250|UniProtKB:Q19267"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
     Site            205
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91XD7.1)"
     Region          208..255
                     /region_name="FU 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
     Region          210..245
                     /region_name="FU"
                     /note="Furin-like repeats; smart00261"
                     /db_xref="CDD:214589"
     Region          245..272
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF domain; pfam07645"
                     /db_xref="CDD:429571"
     Region          268..315
                     /region_name="FU 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
     Region          278..281
                     /region_name="CXXC.
                     /evidence=ECO:0000250|UniProtKB:Q9CYA0"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
     Region          305..335
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF domain; pfam07645"
                     /db_xref="CDD:429571"
     Site            order(305,308,323)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            363..383
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
     Site            385..405
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XD7.1)"
     CDS             1..420
                     /gene="Creld1"
                     /gene_synonym="i11E7"
                     /coded_by="NM_133930.2:548..1810"
                     /db_xref="CCDS:CCDS20423.1"
                     /db_xref="GeneID:171508"
                     /db_xref="MGI:MGI:2152539"
ORIGIN      
        1 maplpprglv psllwclslf lslpgpvwlq psppphpspr aephpchtcr alvdnfnkgl
       61 ertirdnfgg gntaweeekl skykdsetrl vevlegvcsr sdfechrlle lseelvenww
      121 fhrqqeapdl fqwlcsdslk lccpsgtfgp sclpcpggte rpcggygqce gegtrggsgh
      181 cdcqagygge acgqcglgyf eaernsshlv csacfgpcar ctgpeeshcl qckkgwalhh
      241 lkcvdidecg teqatcgadq fcvntegsye crdcakaclg cmgagpgrck kcsrgyqqvg
      301 skcldvdece tvvcpgenek centeggyrc vcaegyrqed gicvkeqvpe sagffaemte
      361 demvvlqqmf fgviicalat laakgdlvft aifigavaam tgywlsersd rvlegfikgr
//
