LOCUS       NM_170597               5799 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cellular repressor of E1A-stimulated genes 2 (Creg2),
            mRNA.
ACCESSION   NM_170597 XM_979689
VERSION     NM_170597.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5799)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5799)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   3  (bases 1 to 5799)
  AUTHORS   Yang,G., Han,Y., Tian,X., Tao,J., Sun,M., Kang,J. and Yan,C.
  TITLE     Pattern of expression of the CREG gene and CREG protein in the
            mouse embryo
  JOURNAL   Mol Biol Rep 38 (3), 2133-2140 (2011)
   PUBMED   20857207
REFERENCE   4  (bases 1 to 5799)
  AUTHORS   Kunita,R., Otomo,A. and Ikeda,J.E.
  TITLE     Identification and characterization of novel members of the CREG
            family, putative secreted glycoproteins expressed specifically in
            brain
  JOURNAL   Genomics 80 (5), 456-460 (2002)
   PUBMED   12408961
  REMARK    GeneRIF: CREG2 are putative secreted glycoproteins and may be novel
            neuronal extracellular molecules.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044192.1 and AC119809.10.
            
            On or before May 4, 2006 this sequence version replaced
            XM_979689.1, NM_170597.3.
            
            Sequence Note: This sequence has been modified as follows: removed
            30 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134713.1, AK134861.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1460              AK044192.1         1-1460
            1461-5799           AC119809.10        102163-106501       c
FEATURES             Location/Qualifiers
     source          1..5799
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.37 cM"
     gene            1..5799
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /note="cellular repressor of E1A-stimulated genes 2"
                     /db_xref="GeneID:263764"
                     /db_xref="MGI:MGI:1928333"
     exon            1..677
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1109
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /note="protein CREG2"
                     /codon_start=1
                     /product="protein CREG2 precursor"
                     /protein_id="NP_733485.1"
                     /db_xref="CCDS:CCDS14908.1"
                     /db_xref="GeneID:263764"
                     /db_xref="MGI:MGI:1928333"
                     /translation="MSLSGRERPAWPGSRLSWLLCCSALLSPAAGYVIVSSVSWAVTN
                     EVDEELDSASTEEALPALLEDSSSIWQQSFPASAHKEDTHLRPRGSARARPAPAARGM
                     FSYRRESGSSEASPGPRVHAGTARSLAHASSWGCLATVSTHEKIQGLPFGSCLAISDG
                     PVHNSTGIPFFYMTAKDPAVADLVKNPTASLVLPESEGEFCRKNIVDPEDPRCARLTL
                     TGRMVTVPPGEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMWVEHIWLQKWYGGVSDIP
                     REEYFKAAPRKA"
     exon            678..847
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            848..961
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            962..5799
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1430..1435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /note="hexamer: AACAAA"
     polyA_site      1443
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /note="major polyA site"
     polyA_site      1446
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      3117
                     /gene="Creg2"
                     /gene_synonym="A830098L22Rik"
ORIGIN      
        1 tggactctgc gcccagcagc ggcggtggac gcaggggact ctggtcgtgc agcagacttc
       61 gcttcttacg ggagtgtaag gcaataggga accccggccc ccggactgat tggagaccct
      121 caacccggga atcctatcac gaggagaagg gttccgacgc acgctccgcc gcaggggggc
      181 gcccctggct ggccgctgct tggtcagtgg tccccgccac agggcgcgtc gcctccaaga
      241 agatgtcgct gtccggcagg gagcgtcctg cttggccagg gagtcgcctg tcctggttgc
      301 tatgctgcag cgccctgttg tccccagccg ccggctacgt gatcgtgagc tccgtgtcct
      361 gggctgtcac caacgaggta gatgaggagc tggacagtgc atccactgag gaggcgctgc
      421 ccgcgctgct ggaggactcg agtagcatct ggcagcagag ctttccggcc tcggcgcaca
      481 aggaggacac gcacctgcga cctcggggct ccgcccgcgc caggcccgca ccggccgcgc
      541 gtggcatgtt ctcctaccgg cgggagagcg gctcatctga ggcatcccct ggccccaggg
      601 tgcatgccgg caccgcccgc tccctagccc acgctagctc ctggggctgt ctggccactg
      661 tgtccaccca cgaaaagatc caaggactgc cctttgggag ctgcctggcc atcagtgatg
      721 gccccgtcca caacagcaca gggatccctt tcttctacat gacagccaag gaccctgcgg
      781 tggctgacct ggtgaagaat cccacagcct cgctggtgct gccggagtct gagggggagt
      841 tttgcagaaa aaacatcgtc gacccagaag acccccgatg tgcccggtta acgctcaccg
      901 gccggatggt cacggtgcca ccaggggagg tggagttcgc caagcaagcc atgttttcaa
      961 ggcacccagg gatgaggaag tggccccgac agtatgaatg gttcttcatg aagatgtggg
     1021 tagaacacat ctggcttcag aaatggtatg gaggtgtatc tgacatcccg agggaggaat
     1081 acttcaaggc agctccaagg aaggcctgat agtaacacaa aagtcttggg gtttgcatca
     1141 aaatgaagac ctttgaagta aagaagccag acagtctctg actgccgtct ctttgtttga
     1201 agggtgccca gctgccctgt caccctacag cagaatgaga aaagatgaac agggagcctt
     1261 gggctagagt tgagattcat cggagtggtc ctttgccgac ccatcatcta cacaggcact
     1321 catagagacg tttctgttta tgccgtacgc cgtactcaat ccagacacac ccatttggaa
     1381 atcttggttg tcaaaatgga agtggtagtt gctaatcctg tcctttaaaa acaaacaaac
     1441 aaacaacgcc tgtatgtagc atgttattgc cttctatcat gagaacaccg tgttgcttac
     1501 catccacaag tcgtgctttg gatggaagct cgttgcataa aaagagctgg gcgtgcatca
     1561 cacagcgtgg ctgtggggtt gggggatggg aggctctttg tctgaaggtt gttcactagg
     1621 tcactgagtt gcagatgtgt tttctagaat gtacaggtca cttggggagc ctttctccca
     1681 ctgtggcata gcaaatagag taagcacatg caggtttgtg catggcctgc tctgtgtgag
     1741 cagactacag cagaacatta acgagaatga agtagctttg ccattgagct tccaggattc
     1801 ccactgttaa tatttccggt agaaagtgcc cctctactat tcaggaagtg tggtgttcaa
     1861 ggtaagaagc gcctccttcc acacggtgta gcaaagacag agggaagaat gcaagggaga
     1921 aagcaaaggc agaaggagcc tgagagtcgg ctcactgcct agcctcaggc cagaccctca
     1981 atagaatcac ctcacttaag ccctacccag tcagatgctc ggcctggtgt ctccttcaga
     2041 cccggaggct gaggcttaga aagcaccagt cagcacccca agatcattgt gtgttcaccg
     2101 cacacagtgg gcgagacgct ccccctgtgt ttccaatttt taaaatgtgt tactgaaatg
     2161 cacagagggt catcagacac aggctgtgat tttaaaggac aatgactaac tggcctgctg
     2221 ggggagtgcc cggtgcaggg gtaggtagca tgctctgaac ttgttcaaca aaccatttac
     2281 aagagctcct ggcattcgga ggagactaaa ctgaaactgt gtacgtacct ggggcctgac
     2341 tggaccagag cacacaccgc caaggccaag ttttctaact ttccacaatg acaagacatt
     2401 ctctatgatg gatcaggtat gttgtataac aaaaaaacac atcaccaaca tagaaaatat
     2461 acacattctt aaaataattt tgtttaacaa agtaagacgc gaacagagct tgtgttgtta
     2521 aaacctatct aagtactaat tactagaaac ctagcagagc tgcagaatcc tttttttatt
     2581 tgacataagc cagctcacaa gagttcccag caatcattat ttctaataca taattatagg
     2641 gtggctttgt tagaggtatt tcctatttcc agggtttaaa tttattgcta ctcccaattt
     2701 agaagaaggt ggagggccgg aagaacaagc tgcaggtgtc aggtactcca taggtcaacc
     2761 tcagatatca gtccttgaag catcactgcc tctcatggct tcctcatcat ggcttcccag
     2821 accacctcac tggtaccttt tgctatgtta gcttgttatg agttagctcc ttaaggactc
     2881 ctgaggcgtc aaaggctttg aagagcaggt tccaattaga aaccccaaag agcattatca
     2941 gctatttatc aaaattacaa gaaatgaaat ctgaatggtc tggacaccaa gaacaatggg
     3001 cttgaatcag atggtccctc ttcaggcaat ttgtgtttca gcaaatctcc aggaatttat
     3061 agcaagttta aatttgtagt tttagacata gcaacaaggc aagaaaaaga aattaaatgt
     3121 gtacaaattg gaaagaaagg aataaaagtc tccttattta caaggacatg attaactaca
     3181 tagaaaattg cacataatct acttaaaaaa aaaaacagca gaagctggag agatggttca
     3241 gctgttaaga gcactggctg ctcttccaaa ggatccaggt tcaattccca gaacccacac
     3301 ggcagctcac aactgtctgg aactccagtt ccaagggatc caacatacac atgaagactt
     3361 acaaatgatg gggccagcaa gatggttcag ccagtaaagg cgctaaccaa gcagctctga
     3421 tgacctgagt tcaattcctg aaacccacca ataatggtgg gaagagagac atgacttcac
     3481 aaagttttcc tctaacctcc ttctgtatac tacagcataa tgtgtgcccc cccacacaca
     3541 caccattcac acacaattaa aaaacactta cacatgaatt atccttaaca tgagaaaact
     3601 ggaatcagct gggcatgatg ctgcatgtct ttaatcccaa cacgtgggag gtagaggcag
     3661 gcagatctct gtggaatcga ggccagcctg gtctacatgt tcaggacggc cagggttacc
     3721 tagagagacc cccccccccc tctctctctc tcacacacac acacacacac acacacacac
     3781 acacacacac acacacacaa acacacaaac acactcactc ctggaatcaa ctagatgtcc
     3841 ttcaatcctt tgatctggtg tctggcgaga ccaattgtgg tatatctata ccatagaata
     3901 gtactcaaca atataaagga gctaattact gatacaagag gcagcttttg tgaatcttca
     3961 gaagattatg ctaagtgatt aaagcaagcc ataagagtgt tcaaattata taattctatt
     4021 catgtaacat tctgaatgtg acctttaaga atgaagacct ttcagaaagg gggctgtaga
     4081 gtgagacagg agaacctaac tgtaagtaga taatgacgga ttcttacagt gatggaagcc
     4141 ccctaccttg aaccaaatca ttattaaatt ggaaactggg taagatgaat atagggtctc
     4201 ttcatattac ttcttaaaac tgcatctgca tctttaatta tctatagcat ctacaattac
     4261 ctcagaggga actatttaat gggaaaactc aagtagacat tctcgcatct cacttgtaag
     4321 tccctaagga aatgaactgt catatatcaa aatatagcag agatgacaca agatgaactg
     4381 ttcccaaaat atatcaagag aggagacaag atgaactact acatatcaaa atgtagcaga
     4441 gaagagacat tccccttgtt aatcactaat atatatacac acatctgcgg gagccatgga
     4501 ctcttctttt aaaagttttc taaatgtatc caatttaatg ctgaacacaa atgactaagc
     4561 acctggcagg ggctggggta cctttcagca gagcctttgc tgagcatgaa gcaggggtgc
     4621 aaccccagca ccatgaaaat gaaaactggc tagatgtgcc tgggtatgct gtacaaattt
     4681 tctacgagac atttagaaga gatgggtttc ttcaagtttc tggcagatac gtgttgagga
     4741 tatagaagtg atcaagtctg tcaattaggt tttctcgccc caatagtcat cctctaatct
     4801 gggatgggag gtagtctttg ctatgagttt gtcatggctt gccacaaaca caaagctagc
     4861 acgtcagtga gacgctgctg cttctgctgc ccttagtaca tattgactct tggtgactgt
     4921 gttcttttag gattgaaatg tgttcttgta tttcactgtt aataacatgg ctgtcactag
     4981 tgaagtattt attgatggca gacttctcta ggatcaccca ttgatgttca tccgattgtg
     5041 gtagcaagac actcatggga aacttaattg cggtttgtct gtcccgggta ctgcacggag
     5101 agcacaaagt ctgttttcac accaggtatg tctgtttcat caaagactgt ttcattccta
     5161 gtacaacttc cgtgcttgac tatgatatcc taaagatatt gggtagttct acacagtctt
     5221 cttaatgaac tgttataaac aacattatta ggttcctgaa aagaacagag gctactatac
     5281 agtacatctg ctgagaaccc atccaacgga aagaaaagaa tgagcgtttg tacctcttcc
     5341 ctgctgagac tgatcttgct gccgtgccca ggctgatcct gaaaccctag gctcaggcaa
     5401 tcctccagag ctgctgggac tcacgtgctt tgccatcgat catggctgct gtgactttat
     5461 gaggctctga gttatgggaa ctttatctac tgacctagaa atactgttgt aaattccagc
     5521 ccaactgcgg caggagtgca agggaccctg ttcctggctg ccagctgcaa ccacggctgc
     5581 acacacatgc acagaataaa tgggcttagt ggggttttct tttaactaaa acaaagagaa
     5641 gagaagaggg cgtgaaattg agaggtggac ttgggagtag atcccagggg agctgagggg
     5701 gaaattgggg tggaggggta tgataatatt tctttgtaaa catatactaa attgtcaaag
     5761 aataacaata tataaataaa aagaaatgct attgctgcc
//
