LOCUS       NM_011804               2169 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus cellular repressor of E1A-stimulated genes 1 (Creg1),
            transcript variant 1, mRNA.
ACCESSION   NM_011804 XM_358337
VERSION     NM_011804.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Song,H., Tian,X., He,L., Liu,D., Li,J., Mei,Z., Zhou,T., Liu,C.,
            He,J., Jia,X., Yang,Z., Yan,C. and Han,Y.
  TITLE     CREG1 deficiency impaired myoblast differentiation and skeletal
            muscle regeneration
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (2), 587-602 (2024)
   PUBMED   38272853
  REMARK    GeneRIF: CREG1 deficiency impaired myoblast differentiation and
            skeletal muscle regeneration.
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Zeng,S., Du,L., Lu,G. and Xing,Y.
  TITLE     CREG Protects Retinal Ganglion Cells loss and Retinal Function
            Impairment Against ischemia-reperfusion Injury in mice via Akt
            Signaling Pathway
  JOURNAL   Mol Neurobiol 60 (10), 6018-6028 (2023)
   PUBMED   37402034
  REMARK    GeneRIF: CREG Protects Retinal Ganglion Cells loss and Retinal
            Function Impairment Against ischemia-reperfusion Injury in mice via
            Akt Signaling Pathway.
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Liu,D., Xing,R., Zhang,Q., Tian,X., Qi,Y., Song,H., Liu,Y., Yu,H.,
            Zhang,X., Jing,Q., Yan,C. and Han,Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Song,H., Li,J., Peng,C., Liu,D., Mei,Z., Yang,Z., Tian,X.,
            Zhang,X., Jing,Q., Yan,C. and Han,Y.
  TITLE     The role of CREG1 in megakaryocyte maturation and
            thrombocytopoiesis
  JOURNAL   Int J Biol Sci 19 (11), 3614-3627 (2023)
   PUBMED   37496998
  REMARK    GeneRIF: The role of CREG1 in megakaryocyte maturation and
            thrombocytopoiesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Goto,A., Endo,Y. and Yamashita,H.
  TITLE     CREG1 stimulates AMPK phosphorylation and glucose uptake in
            skeletal muscle cells
  JOURNAL   Biochem Biophys Res Commun 641, 162-167 (2023)
   PUBMED   36528955
  REMARK    GeneRIF: CREG1 stimulates AMPK phosphorylation and glucose uptake
            in skeletal muscle cells.
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Schahs,P., Weidinger,P., Probst,O.C., Svoboda,B., Stadlmann,J.,
            Beug,H., Waerner,T. and Mach,L.
  TITLE     Cellular repressor of E1A-stimulated genes is a bona fide lysosomal
            protein which undergoes proteolytic maturation during its
            biosynthesis
  JOURNAL   Exp Cell Res 314 (16), 3036-3047 (2008)
   PUBMED   18621046
  REMARK    GeneRIF: Results show that CREG is a lysosomal protein that
            undergoes proteolytic maturation during biosynthesis, carries the
            mannose 6-phosphate recognition marker and depends on the
            interaction with M-6-P receptors for efficient delivery to
            lysosomes.
REFERENCE   7  (bases 1 to 2169)
  AUTHORS   Peters,L.L., Zhang,W., Lambert,A.J., Brugnara,C., Churchill,G.A.
            and Platt,O.S.
  TITLE     Quantitative trait loci for baseline white blood cell count,
            platelet count, and mean platelet volume
  JOURNAL   Mamm Genome 16 (10), 749-763 (2005)
   PUBMED   16261417
REFERENCE   8  (bases 1 to 2169)
  AUTHORS   Kunita,R., Otomo,A. and Ikeda,J.E.
  TITLE     Identification and characterization of novel members of the CREG
            family, putative secreted glycoproteins expressed specifically in
            brain
  JOURNAL   Genomics 80 (5), 456-460 (2002)
   PUBMED   12408961
REFERENCE   9  (bases 1 to 2169)
  AUTHORS   Veal,E., Groisman,R., Eisenstein,M. and Gill,G.
  TITLE     The secreted glycoprotein CREG enhances differentiation of NTERA-2
            human embryonal carcinoma cells
  JOURNAL   Oncogene 19 (17), 2120-2128 (2000)
   PUBMED   10815803
REFERENCE   10 (bases 1 to 2169)
  AUTHORS   Veal,E., Eisenstein,M., Tseng,Z.H. and Gill,G.
  TITLE     A cellular repressor of E1A-stimulated genes that inhibits
            activation by E2F
  JOURNAL   Mol Cell Biol 18 (9), 5032-5041 (1998)
   PUBMED   9710587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124587.5 and AW495378.1.
            
            On Sep 20, 2017 this sequence version replaced NM_011804.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027426.1, AK144101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               AC124587.5         31117-31497         c
            382-501             AC124587.5         25323-25442         c
            502-686             AC124587.5         24439-24623         c
            687-2147            AC124587.5         19951-21411         c
            2148-2169           AW495378.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.11 cM"
     gene            1..2169
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="cellular repressor of E1A-stimulated genes 1"
                     /db_xref="GeneID:433375"
                     /db_xref="MGI:MGI:1344382"
     exon            1..381
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     exon            382..501
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     exon            502..686
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     exon            687..2152
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      877..882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="hexamer: AAGAAA"
     polyA_site      903
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="major polyA site"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="hexamer: ATTAAA"
     polyA_site      2147
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcaggg actccgcagt cagcgtcatg gctgcccgtg ctcctgagct cgcgcgttcc
       61 ctgcttgctg cccttctggc gcccgcgctg gtggcactac tggtgtcgcc ggcctcgggt
      121 cgcggaggcc gggaccacgg ggactgggac gtggacaggc gattgcctcc gctgccaccc
      181 cgcgaagacg ggccgcgcgt ggcccgcttc gtgactcacg tctcagactg gggctcgctg
      241 gccactatct ccacaataaa ggaggtgcgc ggctggccct tcgcggacat catctcaatc
      301 agtgacggtc ctccgggaga aggcacgggc gagccctaca tgtacctgag tccactgcag
      361 caagccgtga gcgacctgca ggaaaatcca gaggctacgc tgactatgtc tttagcacag
      421 actgtctact gtaggaatca tggatttgat ccccagagtc ccctgtgtgt tcatataatg
      481 atgtcgggaa ctgtgaccaa ggtgaacaag acagaagagg actatgcaag ggattcgctg
      541 tttgttcgac accctgagat gaagcactgg ccttccagcc ataactggtt ctttgctaaa
      601 ttaaaaataa gccgtatctg ggtcttggac tactttggtg gacctaaagt agtgacacct
      661 gaagaatatt ttaacgtcac gctgcagtga agcaggatat ggtggactga gtcacaccag
      721 agaagtgtct tcggaggctc atgcacactt gaagggttgg ccctgcttgg gacgtctcca
      781 gctgtcagct tactctgcca cctcttgttt taatcttgtt tgcttgtgtt aacagagagt
      841 tgtccgtcag aagatgtggt tgctggattt ttaaaaaaga aaaaaaaatg tattttgaag
      901 ccattttcag agaaaaatgc cattcattat aaccaaggaa gttttctttc agccattccc
      961 ggtggctttt cctcagtggt gcccacagaa gggcaacata gaccagctgt agatcgccca
     1021 ttggctctgg aggaagagag gtgcaggtgc tttgtgcccg acggccactg tgcctgaggg
     1081 gtgctgtcct cacacagctg cctcaggagt ctgtcagagg ggcctagagt cgggaggcct
     1141 gggcagggcg tgggtcccgg atacagagtg cttgaatgaa tccttcagtc gaggacagca
     1201 atggccacac acggagcttc ccactcacgt ccacccgtac agctgatcca tcacaaggca
     1261 aaactgggtc ctctataaaa ctccataaac atcatacatc ctaaagtcat agttacccag
     1321 gacaaaataa gacaaaaaga ttttcctgta ttcattttcc acccaagtag actgtatatt
     1381 tatttctcat ccttcaaaac acacacacac acaggagctg gggtgcagct ttcttggtag
     1441 agcgattgtc tagtatgaga ccatagctct cttccccagc attgaaacaa aaacaaccag
     1501 caataacatt tttatttgca tgagaaagga accgcaggaa ttttacatat gttgggttcc
     1561 tttttttgac ccaacaccaa ccataacccc agcccttctc gggcactctg tatctccagg
     1621 ctcctggcac tgcagcccgg agtcctccat gggagataac cacggtacca cggcatagaa
     1681 acaaactaca acaacaacac aacatgcttc tggcctagag ggttggctca gcacttaaga
     1741 agattgctct agcagggacc caagttcagg acctggcgct ggagtcagac aggcacactg
     1801 gccatcactc cagttccagg aaatcatata cctctagtct ccaaggtcac ctgcactcaa
     1861 gtgcacgtac ccacgcagac acacaccgac acataattgt aaaccatgca tcttttcttc
     1921 agaagaggta ctacttagtt ttactacgtg tattcatgct cttggatgac gtaagagtcc
     1981 ttttaattga gtgtgcgtat cagacttctt aaacagcaaa agagttgaac atgagccatc
     2041 atgttggaga aagagataga aatccagcaa gtgacttctc agtaaaaacc cactaagcag
     2101 caagaatcca gtttttttca aatcaataat taaaagcata attctaacaa agaaaaaaaa
     2161 aaaaaaaaa
//
