LOCUS       NM_145151               5263 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CREB/ATF bZIP transcription factor (Crebzf),
            transcript variant 1, mRNA.
ACCESSION   NM_145151
VERSION     NM_145151.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5263)
  AUTHORS   Liu,Y., Su,W., Liu,Z., Hu,Z., Shen,J., Zheng,Z., Ding,D., Huang,W.,
            Li,W., Cai,G., Wei,S., Li,N., Fang,X., Li,H., Qin,J., Zhang,H.,
            Xiao,Y., Bi,Y., Cui,A., Zhang,C. and Li,Y.
  TITLE     Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate
            Insulin Resistance and Type 2 Diabetes
  JOURNAL   Adv Sci (Weinh) 11 (13), e2306685 (2024)
   PUBMED   38286660
  REMARK    GeneRIF: Macrophage CREBZF Orchestrates Inflammatory Response to
            Potentiate Insulin Resistance and Type 2 Diabetes.
REFERENCE   2  (bases 1 to 5263)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5263)
  AUTHORS   Ma,F., Liu,Y., Hu,Z., Xue,Y., Liu,Z., Cai,G., Su,W., Zheng,Z.,
            Fang,X., Yan,X., Ding,D., Sun,X., Jiang,Y., Wei,S., Li,W., Zhao,J.,
            Zhang,H., Li,H., Xiao,D., Zhang,C., Ying,H., Qin,J., Gao,X.,
            Dai,X., Fu,W., Xu,Y., Li,Y. and Cui,A.
  TITLE     Intrahepatic osteopontin signaling by CREBZF defines a checkpoint
            for steatosis-to-NASH progression
  JOURNAL   Hepatology 78 (5), 1492-1505 (2023)
   PUBMED   36680394
  REMARK    GeneRIF: Intrahepatic osteopontin signaling by CREBZF defines a
            checkpoint for steatosis-to-NASH progression.
REFERENCE   4  (bases 1 to 5263)
  AUTHORS   Jhun,J., Moon,J., Kwon,J.Y., Cho,K.H., Lee,S.Y., Na,H.S., Cho,M.L.
            and Min,J.K.
  TITLE     Small heterodimer partner interacting leucine zipper protein
            (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway
            and the regulation of B cell activation
  JOURNAL   Cell Commun Signal 21 (1), 98 (2023)
   PUBMED   37143079
  REMARK    GeneRIF: Small heterodimer partner interacting leucine zipper
            protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling
            pathway and the regulation of B cell activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5263)
  AUTHORS   Liu,Y.X., Su,W.T. and Li,Y.
  TITLE     [Biological functions of CREB/ATF bZIP transcription factor in
            metabolism and cell growth]
  JOURNAL   Sheng Li Xue Bao 73 (5), 761-771 (2021)
   PUBMED   34708233
  REMARK    GeneRIF: [Biological functions of CREB/ATF bZIP transcription
            factor in metabolism and cell growth].
REFERENCE   6  (bases 1 to 5263)
  AUTHORS   Lin,P., Chen,F., Wang,N., Wang,X., Li,X., Zhou,J., Jin,Y. and
            Wang,A.
  TITLE     CREBZF expression and hormonal regulation in the mouse uterus
  JOURNAL   Reprod Biol Endocrinol 11, 110 (2013)
   PUBMED   24325733
  REMARK    GeneRIF: CREBZF is involved in implantation and is up-regulated by
            oestrogen.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5263)
  AUTHORS   Yun,E.J. and Vu,T.H.
  TITLE     mSmile is necessary for bronchial smooth muscle and alveolar
            myofibroblast development
  JOURNAL   Anat Rec (Hoboken) 295 (1), 167-176 (2012)
   PUBMED   21956870
  REMARK    GeneRIF: Smile is a novel gene specifying both bronchial smooth
            muscle and lung alveolar myofibroblast lineages, contributing to
            our understanding of the biological control of the development of
            these cells.
REFERENCE   8  (bases 1 to 5263)
  AUTHORS   Misra,J., Chanda,D., Kim,D.K., Li,T., Koo,S.H., Back,S.H.,
            Chiang,J.Y.L. and Choi,H.S.
  TITLE     Curcumin differentially regulates endoplasmic reticulum stress
            through transcriptional corepressor SMILE (small heterodimer
            partner-interacting leucine zipper protein)-mediated inhibition of
            CREBH (cAMP responsive element-binding protein H)
  JOURNAL   J Biol Chem 286 (49), 41972-41984 (2011)
   PUBMED   21994947
  REMARK    GeneRIF: the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway
            differentially regulates ER stress-mediated gene transcription
REFERENCE   9  (bases 1 to 5263)
  AUTHORS   Xie,Y.B., Park,J.H., Kim,D.K., Hwang,J.H., Oh,S., Park,S.B.,
            Shong,M., Lee,I.K. and Choi,H.S.
  TITLE     Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear
            receptor estrogen receptor-related receptor gamma transactivation
  JOURNAL   J Biol Chem 284 (42), 28762-28774 (2009)
   PUBMED   19690166
REFERENCE   10 (bases 1 to 5263)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100322.8 and AK004085.1.
            
            On Nov 21, 2012 this sequence version replaced NM_145151.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF408398.1, SRR7974084.26215.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2079              AC100322.8         104324-106402
            2080-3323           AK004085.1         1-1244
            3324-5263           AC100322.8         107647-109586
FEATURES             Location/Qualifiers
     source          1..5263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.59 cM"
     gene            1..5263
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /note="CREB/ATF bZIP transcription factor"
                     /db_xref="GeneID:233490"
                     /db_xref="MGI:MGI:2675296"
     exon            1..5263
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1311
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /note="HCF-binding transcription factor Zhangfei; host
                     cell factor-binding transcription factor Zhangfei;
                     tyrosine kinase-associated leucine zipper protein LAZip;
                     tyrosine kinase-associated leucine zipper protein LAZipII"
                     /codon_start=1
                     /product="CREB/ATF bZIP transcription factor"
                     /protein_id="NP_660133.2"
                     /db_xref="CCDS:CCDS40020.1"
                     /db_xref="GeneID:233490"
                     /db_xref="MGI:MGI:2675296"
                     /translation="MRHSLTKLLAASGRDFPSRRDSREPPATRAPPREPSGAAAGAET
                     PRPGSPDREQPHGDGDGGEPEARSGSRGSVAVRAPAPSPLKMEEEEEDAIAMVPKEEP
                     EDMDFLSGLELADLLDPRQPDWHLEPGLSSPGPLSSSGGGSESGGLLRGDDDDDTAAA
                     EMQRFSDLLQRLLNGIGGCSSGGDRGGGEKRRRKSPGAGGGGANDGNQAATKSPRKAA
                     AAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLA
                     NETGLARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQPPEPREEDDAAGGVCLH
                     VDKDKVSVEFCSACARKASSSLKM"
     regulatory      4922..4927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /note="hexamer: AATAAA"
     regulatory      4935..4940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /note="hexamer: ACTAAA"
     polyA_site      4941
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /note="major polyA site"
     polyA_site      4957
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
     regulatory      5197..5202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
                     /note="hexamer: AGTAAA"
     polyA_site      5215
                     /gene="Crebzf"
                     /gene_synonym="1110034C16Rik; 6330417B10Rik; LAZip;
                     LAZipII; SMILE; Zf"
ORIGIN      
        1 agagagtaac ttccggccag gccgctgtct gggtggcgcg gccgagtcct cccccgggcc
       61 tcgccgcttc gcgcttccac tgccttcccc ccgcctcgtg cggggggttg ggcggccgcc
      121 ggaggccact cggaccttgc cccgcgcctg cggtcggccc ggcgccgtgg ctctgcgcgc
      181 tgggggcccg gggtcggagt ggctgcggcc tacccgggcc cgccgctcag ccccatgagg
      241 cacagcctga ccaagctgct ggcagcctcg ggccgcgact tcccgagccg ccgcgacagc
      301 cgggagccgc ccgccacgcg cgcgccgccc cgggagccga gcggggcagc cgcgggggcg
      361 gagaccccga ggcccggatc gcctgaccgc gagcaacctc acggggacgg ggacgggggc
      421 gagccggagg cccggagcgg gagccgcggc agcgtggccg tgcgcgcgcc cgcgccctcg
      481 cccctgaaga tggaggagga ggaggaggac gcgatcgcca tggtccccaa ggaagagccg
      541 gaggacatgg actttctctc cgggctggag ctggccgatc tgctggaccc tcggcaaccg
      601 gactggcacc tggagcccgg gctcagctcg cccgggcccc tgtcctcgtc cggcggaggc
      661 tcggagagcg gcggcctgtt gaggggggac gacgacgacg acaccgcggc cgccgagatg
      721 cagcgcttct ccgacttgct gcagaggctg ttgaacggca tcggaggctg cagcagcggc
      781 ggtgaccgcg gcggcgggga gaagaggcgg agaaagtccc cgggagcagg aggcggtggc
      841 gccaacgacg gcaaccaggc ggcgaccaag agtccccgga aggcggcggc ggccgctgcc
      901 cgtcttaatc ggctcaagaa gaaggagtac gtgatggggc tggagagtcg ggtccgggga
      961 ctggcagccg agaaccagga gctgcgggcc gagaatcggg agctgggcaa gcgcgtgcaa
     1021 gcactgcagg aggagagtcg ctacctacgg gccgtcctgg ccaacgagac cggactagct
     1081 cgcctgctga gccgactgag cggcgtggga ctgcggctga ccacctccct cttcagagac
     1141 tcgcccgccg gcgaccacga ctacgccctg ccggtgggga agcagccgcc ggagccgcgg
     1201 gaagaggacg acgcggcggg aggagtgtgt ctccatgtgg acaaggataa ggtgtcggtg
     1261 gagttctgct cggcgtgcgc tcggaaggcg tcgtcgtctc ttaaaatgta gggtcaagta
     1321 atctgctctt tatccgcgtt tacccctttc tcctccctta caccatgtca aacaccttag
     1381 tgggacatcg tcaccggacg catttcagag gcggaaaaaa aagtaatatt aaatctttta
     1441 agtgtttagc taaaagcatg aatgtgacac tgtaaccaac tcctaatgat aacctgtgac
     1501 tattaaatct ctctgacagt ttctttttta ggtgatttcc ttcctgccag gctccgttgt
     1561 aggggttaca gagcagtcgt tcccgcctca caacctggta aggatccatc tcttcccgta
     1621 acgctcatgc tcggctgctt aggctacttt aatgggcaga catctcaatg tgtgtgtgtg
     1681 tgtgatatct ttttctgttt gtttttcttt ttgaaaggtg gtgggagggg aatcttaatt
     1741 tgggccttgt ccaccctgga aacagacttg tgctggtcat taatgtactt aagttgcttc
     1801 tggttgaaat agctgttaaa tgtgtcccct tgttcagagt tgcgtgtacc tagctcttct
     1861 gtccccagtg tggacatggc cttggatgac atcggttcca actgtacaca gaaacctgct
     1921 aatagagata cagtttggag acagtcaaac aggtgaagtt gaatggaagt tccgagttgt
     1981 acaaggtgca aattggaatt ccaattgtag agcaactttt cagaggttga caataagtat
     2041 tgaggcatgc gcaaatgtgg tatttttctg gagatgacaa gtctcctaaa atacttaatg
     2101 aatgccttat agttttcagt agaaaatgca gaaatacagt ctatttaaag accctaatag
     2161 ttcaccactt gagaagttgg aaattaacat acccatcaga tttctgtgtt ttaattagaa
     2221 gacgataaat gaaatgtttc tttgaggacc agcacagtaa ttactaatca atgagtatga
     2281 agaaattgtt gaaagtattt atttttgttg tattaaaatt taggctaaat ttctgtatga
     2341 ttagatattg aaggttgtga aatgtgaatg aaaacatgta aagtgaggct tcacaaagaa
     2401 tcttttctcc atatttctaa aacttttgtc ctatttaaaa atacttgttt aaattaatga
     2461 aatgatcgat actgtttttc caaagacgga aaagtctttc cttaaaatac tgtttttttg
     2521 tccacttgtc ttaagtgtgt gttctgatgc tctgaaatgc aagagacatt aaattctttg
     2581 tgaaacatca ctgtttgata aaggatatac gtatttagca tccttgtttt tctttgtgct
     2641 aaagtggata cagctgttgg ggcagaagag acgggaccag ctgctggcca catttcctgc
     2701 tttattttaa aaggtagtat aagaaataag gaaacagagg taatatcagg gcttctgctg
     2761 tcttttattt ttaaaatgtt cataattaag tattttccag cagtccaaag atgtaagtta
     2821 tcctacacgt aagatgtttt attttgttac ttggttatgg aaatggaatc ttgttcttgc
     2881 acaactgtaa atgttttgtt gctagataat atgattttga gacctaaatt agtctctggt
     2941 ttttcagtct atcacatttt gtaaaaatct ctactgcact tgagcatgaa tgggtagtag
     3001 ccaaactcac aacttggagt gacggacctg cttctacaag ggtaggatac aagccccaca
     3061 atgcagctgc atggatttca gtgcctatga attatatata tatatatata catagatata
     3121 gaaaccaaaa gtagttggaa atttatttga aatgactaat ttgtgctctt tctgaagtat
     3181 gttaaatgta gcttttgaaa cagaagcctt gaattgaaat ttaatacttg aacatttttg
     3241 tatatatttc tttgtatata attttgtgca gaaccaatga caaacatatg gtgtcataat
     3301 aaaatcaggt ttgttgatct ttcagttatg ggctcaaaga atttattcat ctctaacatg
     3361 atattggaaa gtaatggatg aaaataggaa aaatggttgt taatatagac ttaatcgaaa
     3421 ggttctggaa gtagtaagtt tgttttccta aaaactatac catttctgtg gaatattttc
     3481 ttaacctcag tgcttttcct gcatttgaag tgtgggcttg gggaaaatta gtttctgaat
     3541 tgggatgttt tgaaattcca agtacagagt cttaggctgt catttcataa atggcagttt
     3601 ggagaattag gaattctcaa cagtggaaga tcagagtgtc ctgtttttaa agctgctttc
     3661 ttaggttcct tatgtcttat taactgtgtt tttgtttcca tttcattgtt tttttctagt
     3721 tttggtgaca gtgatttttg tcattttttt tgcatcaact catggtcttg tttttacatg
     3781 gtaactgcat gtatgtagga tctatcaggg gctttaaata aattttgctc atatttatgt
     3841 gtaagcacat tttactgtaa atgtttgggt ttaatttaca gcagttgttt atttcagtgt
     3901 gtagtaaaca gtatctagag tgttctgttc actacttgtt aattaaaaaa gttatgatta
     3961 atataaaact gttgtcttac tatttttaga aaacttttgt gaataattag tattttgata
     4021 gagagttctg aaatacaaaa tagattgctt tgaaaatttc aggtttgggt gtatttactg
     4081 tgatgttgag aacaatttag tatttgggga actgtttcag gttttattct tgatttgtac
     4141 ctgtgtaaaa atgatagaaa accttaaaat gtagctttta aatacctgtc ttcctatggt
     4201 agttaatatt catacattaa ttgactaaca catattggca tagtatttct atcatagtag
     4261 cttaagtttt tgtccttttt ttaaccatac ttaaaagtat gtttgttaaa aaatgtagtc
     4321 acacctctga tatatccaac aaagtattca aaatatttta aatatctgta catttcatac
     4381 tcgctaaatt aatctctttc tcttctcttt aaacagctta gcagtatctg caaaaacgaa
     4441 tcttttccta caacctgtta actgactgga ctgatggtaa cagtaattgt gggagccatg
     4501 tcggtcaaaa atttggcatc tgctgaaaga catgaatgcc atttccaagg tcccaaatta
     4561 cttctatact gattacactt tccagaaatg gagatatgaa aagattctct ggaatgcttg
     4621 aaagacttaa tagaaaccca tgagactaag ttaattttgg aacaaaatta cacctctttt
     4681 ttttcattca tggcaattaa cactaaattt atcgtatact ttaaaaaatg gtaaccattg
     4741 gagaagagaa ttctagagtt tcatcaagaa acattaggtt ttacacaatc aaggacactt
     4801 tgtggaatta gacttagtgg gttagaatga cacaagtgag ctagcagtga tcacaaacct
     4861 catgagtttg tattctggga tggaaagagc tgctttggaa gacagacacg ttgctgagta
     4921 gaataaagtc cttaactaaa agattagtgt cttaaaatag atgcattgat tgtgtgtttt
     4981 gaaaaggtga ttctgataac gtgtgggtgc taattcaggg catcatgagc gtgtgagcaa
     5041 tcctggggtt tggtatcttc agtgttctta gtacttggtc tttttgaatg tgttgaggtt
     5101 tctgatgaat gatatagttt ctgttgttct atgttaaaat ttctgtggta ttctgtaagg
     5161 atctttatat tctggatgat aagggctaat tccataagta aacacttaga acccattcat
     5221 ttatcatctg gaatatgcta atgcaccttc cttctggtct aga
//
