LOCUS       NM_029870               7455 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CREB3 regulatory factor (Crebrf), mRNA.
ACCESSION   NM_029870
VERSION     NM_029870.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7455)
  AUTHORS   Metcalfe,L.K., Shepherd,P.R., Smith,G.C. and Turner,N.
  TITLE     Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice
  JOURNAL   Cells 11 (3), 497 (2022)
   PUBMED   35159305
  REMARK    GeneRIF: Limited Metabolic Effect of the CREBRF(R457Q) Obesity
            Variant in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7455)
  AUTHORS   Kanshana,J.S., Mattila,P.E., Ewing,M.C., Wood,A.N., Schoiswohl,G.,
            Meyer,A.C., Kowalski,A., Rosenthal,S.L., Gingras,S., Kaufman,B.A.,
            Lu,R., Weeks,D.E., McGarvey,S.T., Minster,R.L., Hawley,N.L. and
            Kershaw,E.E.
  TITLE     A murine model of the human CREBRFR457Q obesity-risk variant does
            not influence energy or glucose homeostasis in response to
            nutritional stress
  JOURNAL   PLoS One 16 (9), e0251895 (2021)
   PUBMED   34520472
  REMARK    GeneRIF: A murine model of the human CREBRFR457Q obesity-risk
            variant does not influence energy or glucose homeostasis in
            response to nutritional stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7455)
  AUTHORS   Oh-Hashi,K., Hasegawa,T., Naruse,Y. and Hirata,Y.
  TITLE     Molecular characterization of mouse CREB3 regulatory factor in
            Neuro2a cells
  JOURNAL   Mol Biol Rep 48 (7), 5411-5420 (2021)
   PUBMED   34275032
  REMARK    GeneRIF: Molecular characterization of mouse CREB3 regulatory
            factor in Neuro2a cells.
REFERENCE   4  (bases 1 to 7455)
  AUTHORS   Frahm,K.A., Williams,A.A., Wood,A.N., Ewing,M.C., Mattila,P.E.,
            Chuan,B.W., Guo,L., Shah,F.A., O'Donnell,C.P., Lu,R. and
            DeFranco,D.B.
  TITLE     Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating
            Glucocorticoids in Male and Female Mice
  JOURNAL   Endocrinology 161 (11) (2020)
   PUBMED   32901804
  REMARK    GeneRIF: Loss of CREBRF Reduces Anxiety-like Behaviors and
            Circulating Glucocorticoids in Male and Female Mice.
REFERENCE   5  (bases 1 to 7455)
  AUTHORS   Yang,Y., Jin,Y., Martyn,A.C., Lin,P., Song,Y., Chen,F., Hu,L.,
            Cui,C., Li,X., Li,Q., Lu,R. and Wang,A.
  TITLE     Expression pattern implicates a potential role for luman
            recruitment factor in the process of implantation in uteri and
            development of preimplantation embryos in mice
  JOURNAL   J Reprod Dev 59 (3), 245-251 (2013)
   PUBMED   23400243
  REMARK    GeneRIF: LRF has a role in the process of implantation in uteri and
            development of preimplantation embryos in mice
REFERENCE   6  (bases 1 to 7455)
  AUTHORS   Martyn,A.C., Choleris,E., Gillis,D.J., Armstrong,J.N., Amor,T.R.,
            McCluggage,A.R., Turner,P.V., Liang,G., Cai,K. and Lu,R.
  TITLE     Luman/CREB3 recruitment factor regulates glucocorticoid receptor
            activity and is essential for prolactin-mediated maternal instinct
  JOURNAL   Mol Cell Biol 32 (24), 5140-5150 (2012)
   PUBMED   23071095
  REMARK    GeneRIF: postulate that LRF plays a critical role in the
            attenuation of the HPA axis through repression of glucocorticoid
            stress signaling during parturition and the postpartum period
REFERENCE   7  (bases 1 to 7455)
  AUTHORS   Audas,T.E., Li,Y., Liang,G. and Lu,R.
  TITLE     A novel protein, Luman/CREB3 recruitment factor, inhibits Luman
            activation of the unfolded protein response
  JOURNAL   Mol Cell Biol 28 (12), 3952-3966 (2008)
   PUBMED   18391022
REFERENCE   8  (bases 1 to 7455)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 7455)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7455)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030092.1 and CT025550.11.
            
            On Oct 20, 2009 this sequence version replaced NM_029870.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030092.1, AK132423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AK030092.1         1-146
            147-2771            AK030092.1         148-2772
            2772-7455           CT025550.11        149552-154235
FEATURES             Location/Qualifiers
     source          1..7455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.5 cM"
     gene            1..7455
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /note="CREB3 regulatory factor"
                     /db_xref="GeneID:77128"
                     /db_xref="MGI:MGI:1924378"
     exon            1..125
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            126..320
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            321..446
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            447..1536
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1731
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1921
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1995
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2118
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..7455
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5947..5952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /note="hexamer: AATAAA"
     polyA_site      5974
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /note="major polyA site"
     regulatory      7434..7439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
                     /note="hexamer: AATAAA"
     polyA_site      7445
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
     polyA_site      7455
                     /gene="Crebrf"
                     /gene_synonym="A930001N09Rik; LRF"
ORIGIN      
        1 gagtcacgcg atttccggga acccgtcagg aaggacataa acaaaacaaa ccgaggcagc
       61 atggagacgg cccgcggccg cgtaagcgcg gccggatcca gtgcctgaac cgccttcagc
      121 ctcagaaccg caaatttatt ttttttaaaa agtggtgacc caagcagttg aactgaaggt
      181 attctgggaa aatctgctgt ttattgtgaa aatcatcttt gatcttggaa ttaaaagtaa
      241 agctggaaag gaatttacaa acaagaaaaa gaagaagttt ggaattggac tcacaggatc
      301 tgggcttgga aatgcctcag cccagcgtaa gcggaatgga cccgcctttt ggggatgcct
      361 ttcgaagcca caccttttca gaacagactc tgatgagcac agatctctta gccaacagtt
      421 ctgatccaga tttcatgtat gagctggata gagagatgaa ttatcaacag aatcctagag
      481 acaacttcct ttctttggaa gactgcaaag acattgaaaa tctggagact ttcacagatg
      541 tcctggacaa tgaggatgct ttaacttcaa actgggaaca gtgggataca tactgtgaag
      601 acttaactaa gtacacgaag ctcaccagct gtgacatttg ggggacaaaa gaggtggatt
      661 acctgggtct tgatgacttt tctagccctt accaagatga agaggtcatc agtaaaactc
      721 caacactggc ccagctcaat agtgaggact ctcagtctgt ttccgattcc ctttattatc
      781 ctgactcact cttcagtgtc aaacaaaatc ccttgccccc ctcctctttt cctagtaaaa
      841 agatcacaaa tagagcagct gcccctgtgt gttcttcaaa gacacttcag gctgaggtcc
      901 catcatcaga ctgtgtccaa aaagcaagca aacctacttc aagcacacag atcatggtga
      961 agaccaacat gtatcataat gaaaaggtga attttcatgt tgaatgtaaa gactatgtaa
     1021 aaaaagcaaa agtcaagatc aaccctgtgc aacagggccg gcccttgctg agccaggtcc
     1081 acatagatgc agcaaaggag aacacctgct actgtggagc tgtggcaaag agacaggaga
     1141 gaaggggggt ggagccgcat cagggtcggg gcactcctgc tttgcctttc aaagaaaccc
     1201 aggagctatt acttagtcct ctgacgcagg atagtcctgg gttggttgcc acagcagaga
     1261 gtggcagcct ttctgccagc acttctgttt cagattcatc ccagaaaaaa gaagagcaca
     1321 attattctct ttttgtctct gacaacatga gagaacagcc aaccaaatac agtcctgaag
     1381 atgatgagga tgatgaagat gagtttgatg atgaggacca tgatgaaggg tttggcagcg
     1441 agcatgagct ttctgaaaat gaagaggagg aagaagagga agaggattat gaggatgaca
     1501 gagatgatga tatcagcgac acgttctctg aaccaggtta tgaaaatgac tctgtagagg
     1561 acttgaagga gatgacgtcc atatcttctc ggaagagagg gaaaagaagg tacttctggg
     1621 agtatagtga gcagcttaca ccatcacagc aagagaggat tctgaggcct tctgagtgga
     1681 atcgagatac cttgccaagt aatatgtacc agaaaaatgg cttacatcat gggaaatacg
     1741 cagtgaagaa atcacggaga actgatgtgg aagaccttac tccaaaccct aaaaaactac
     1801 ttcagattgg taatgagctg cgcaagctga ataaggtgat cagtgacctg actccagtta
     1861 gtgagcttcc cttaacagca aggccaaggt caaggaaaga aaaaaataag ctggcatcca
     1921 gagcttgtag gctaaagaag aaagcccagt atgaagctaa taaagtgaag ttgtggggcc
     1981 tcaacactga atatgacaat ttattgtttg taatcaactc catcaagcaa gacattgtaa
     2041 accgagttca gaatccaaga gaagagagag aacccagcat ggggcagaag cttgaaatcc
     2101 tcattaaaga tacactgggt ctcccagtcg ctgggcaaac ctcagaattt gttaaccaag
     2161 tgttagggaa gactgctgaa ggcaacccca ctggaggcct tgtaggacta aggataccag
     2221 catcaaaagt gtaatcagcc tcattggacc actggtcaga aatgtctgtt tttgtcatgt
     2281 tatccattgt aaattttcat tctgttttgc atgtcaatta gcattatgta aacatttata
     2341 attaggttac attgttttaa aaacaatagc ataagtgaag catgatccaa aatacttgat
     2401 tattgcattt tcagagcata aaccagtgac cctgctgctg gcatgagaaa gaagctcaca
     2461 cattaagtaa atatgaggta cagattgtaa acatttgttg aagcagagtg ttttgggtga
     2521 gtgaatatat tagtataatg ctgagtgtta aggtgggttt atgctctgaa ccacacaaaa
     2581 ataccgagga agcatttttt ttcaaagtcc atttagattg tttttagaat gactgctttt
     2641 tgttctaatt ttttacagcc attaatctca catgtacatg gcgcacccag cactcacgtg
     2701 tgtaccatgt ttagatgttt ttcagaactc aatatgatat ataaaaatac atatatatat
     2761 atatatatat atacatacat atatatatat agaattgtct gtgcaagtaa gaaaaagcat
     2821 actctttgtg ccttgtattt tggggaaact ctaaaactgg taatattttg tatgatgaaa
     2881 atcctaatga ggaaaaccaa gatatataga tgagaaaatt atggggttta aatgtctttt
     2941 tgttccaact ctttttcaga tttttttgaa tgtatatagg actatgtcaa aatgtagata
     3001 tatgccacag agtctgtgta ttgtataaaa aaaaaaacaa aaaacaaaaa caaacaaaaa
     3061 aagatggctc tagagaactc ctatttcggt acttgaccgg aagaaaatac ttgcacatta
     3121 ttgcgattgt tttatttttt ctaccaaaga caaatgcaac tggtatggca gactgccagt
     3181 ctaagtaaag ttttgcacag cttacatgat actgtatgaa tgtatgaaac agagaaaaaa
     3241 ttaaaaggtc agggttaggg atcttactca actgtgaact ttatttctgt ttgggtccaa
     3301 ttatctacag aaggagcatc catacatcca aatattattt tgctgtcctc tagtttgctt
     3361 ccatagtaga taagttggtg gccacttagg tgtcttttat ttctgcagtt attgtaggaa
     3421 attttaatat atttcatatt agtaagctat tgataaaata gtttttgact ttgaaaatta
     3481 aagtttattt agcttattgt agtatacttc caccaaacaa ccaaaataca gattattttt
     3541 atcgtattat gtatatatat atgtaaagag ataaaaaagc taaaaatatc taatacttta
     3601 gttgccactt ttccaattga tgttattgtg catgtaatat tttcaaagat caacacaagc
     3661 ttaaaacaaa tttataaatt tttatatttt tgtacaggta ttttcttcaa acttacatgt
     3721 gacttatctt gtgtagtttc tagacttgag aaacatgacc acgcttagtt ttaggtgctc
     3781 ttctttgctt tagtggtcag ttgtagctgt gctcaagctt tgcctcttga tgagagattc
     3841 ctatgcccca caggtccttc catcccgtct ttcttgactg ttttatctca gatcttgtgt
     3901 ttggaactat gaaaactggt ggcttcaaaa gtaaaaacaa acatatctag aagaaaagcc
     3961 tgagatgtca gacatagttg ctgtttctcc accacctttt gatagaacta agatagctgt
     4021 ccttggtctg tctgcacagg agtttctttc ctttttcttt ctcccctttt gtaagctata
     4081 gcacatgaag tttcaattag aaaacacagt tacaatccaa aaatgtgtct gacttgcctc
     4141 tttgacatca tgaatcataa gaaaccaaga cttgtcttga cacgttagct gaaactgtga
     4201 caaggttcct gtgtgtttgg tggaaatgta cctttagttc atccacccta acagataata
     4261 agctcacgtg tcatggttaa cagaattaaa gttttacttt ctatgtggga aaaggcaaac
     4321 cataggttca caaatggaag tgtctgaagt ctcgaaagtg ttccagaacc tggcggtttt
     4381 cagtcaaatg actgtcactt catgatcgcg agtcagttgg cgaagtttat aaaattgccc
     4441 ctttctagct accctgtttt aggaattctg gttttttgat acctttttct tgtctgcaaa
     4501 ccagaatttg atttttggtc ttgcatttca aaacactttg aatctgttta gtagattcca
     4561 tacccgtgca tttcagtgtt ttatatgtac tccttaagtt aaatagttga aagcctttaa
     4621 atagttgagc tttttaatgt tgactcttta ttttgtacct atttatatat gtatgtatat
     4681 cttaggaaag cactttgtta taaaattgca ttttatatga ttcctgccat ttgctgctaa
     4741 acttgggctg gtcagaacgc tgcagcgata cttgatctaa ataaaaacct ggcagtaaaa
     4801 tgtagagtgc aagttaaatc ctcttgctgt ttaagatgac ataggcaagc tgtgcagctt
     4861 tacattttaa ccaggggact ctgtggcatt taaaaccgtc tagaaatggt tgtactttta
     4921 atgccagtaa tgaactgctt cctctattgt ctttaaaata tcctacacct agtgtatcac
     4981 aggcggttct cacaagtgtg taaaaaccca gcagttgtat atgttgtatt ttaaaaaatc
     5041 gtggtttgta tttttgggtg gaaatcgtta gagtgagagc tgtctagagg ttttctgtgt
     5101 tcatacatgg tatacagaga gctcatgaag tccagagcct tcccttaagt gaaggaaggc
     5161 attgtgaatt ctcctcagat caacccaccg ttccaaaggc aaccataaac tgactacagt
     5221 actactacag taaaaaataa caatgaacct tctgcttcct ggcttcagat acactggatt
     5281 ctttagtctg tgcccacatg agagcatgct gccgggctgc tcctacataa gtttcctgtg
     5341 agtcttgcaa tcagtgtggt tgcttgctgt gctgtaccat gtatgtgggt cctcatcctt
     5401 tccatgtcct tcatgagcga gttgggtgtg gcttaacctt gtgccttact tgtacactta
     5461 aatgatgcat cttcattcct tccatcccat tcccaaacct taactctgtt ctttttgtaa
     5521 gagaatcaca actattccag aagcatcatg aaggatttca gatgggcgtc gtttcatagt
     5581 tccctctctt tgtagttgtt ttatacttgt aggagagaac agttttgaat gatctttgag
     5641 taatcgtgtt acgtccttct ctctggcttc tgtgaggctg tcctgcgtct ctgatgcttg
     5701 gcttcgctca caccttagca agtctgcatt tacaggcaga tgtgctcact tcatctgctc
     5761 gaaagtgatt cttttgtttt ccagaagttt ttaggagaag agtacctatt ttgtttgttt
     5821 tttacaacag atgacaagtc tctttaaaag aaactgaagt acagtacttt tgaaatacaa
     5881 tgctattggt atgaagttct cttttatata taatattcat acaattatct gatgtttgcc
     5941 ttcattaata aagctgttag tttattcacc aaaatgtcaa gaatggatgt gcttttcttt
     6001 attccatata tttaaacaat attttagctg ctaagattta gttaacttcc taagaaatga
     6061 attcaagttg ccttcaacaa gaattaacaa aactcatgtc ccctttcttt atatagtctt
     6121 cctaaacttc tgttcaacta ctttctgatt aattatgtga cagaatgtta gcatctctct
     6181 aaatcttgaa acttgaattt tgagaatgca ttgatttcag tgttaatgga aaaggtctca
     6241 gctatgtttc tagtggagtc ttttgtggaa taccatttcc catggaactg cgaccacttg
     6301 cacaactttg cacagaactg cagtcttgtt cttccctgga tcgtgacaaa tgagtcccac
     6361 acagtgccgt catacttgtg gattctaccg tgatttttgt catcttaaat aagggcatta
     6421 tgagaaaatg actccatgtc tttttttttt taatatttca aacacagtgg gatgaaacaa
     6481 catcagaagt agggatggtg gtttcgtttt aaggaataag catgttggag gaatgtgatg
     6541 aaaatgtact actgagagtt ccacacttcc acagcaagtg ggattatgtg ttgaagcata
     6601 gtccccatgc ttagtaaact gactgaaata gaaattacac ctaggaactg cactatgcca
     6661 aattgccatt ttgttttgaa gagacttttg gaggtggcaa taaggtgatg aaatcttata
     6721 gctacttcca aatagtattt tggaattgaa gactagtaaa gagcacccag gtttgtgtct
     6781 cagcgtgcca agtgtgaact gggcttgcct ctttagtcac agtgtaaaca cctagtgtag
     6841 ttattcagtt ccaggtgcca gaagcgggac tgattctgtg tcttgccctt tgtcctttgg
     6901 ggtttttttg tttggttgtt tgttttcaga actaaataac aaaactgtat gtgtactgta
     6961 tttgcttctc cacatgtttt gcgacactgt actcccactg cctgctattg tcttcttgcc
     7021 ctagagtctg tcctgtggtg tagcatttgt ggttaacaat gactccggag ctgctaacac
     7081 ggaagggcaa gaatacaaag catttgctcc tatggtttgg cagcctcttc gaatagttgc
     7141 ccttagggtc ctgtctgtga tacgatcata aatactccgt agttttgttt attccctgcc
     7201 cccagctgga gctgtgactc tttattggat tcagtcttgt cttttgtcta gaaagaattg
     7261 ttatctcgtt cacgcatgag ctgtttaaaa attactcaat gttggttagt agccgtgcag
     7321 ttttcctttt aggagaaggc catgcacagg ttacgttttc tgtcaccctc taactgtcag
     7381 cactgtagtt agacacagag tcatcagtgt atgccgcacc ctttgtaatt tacaataaaa
     7441 aagatgaaaa gaaaa
//
