LOCUS       NM_177687               2536 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus cAMP responsive element binding protein-like 2
            (Crebl2), mRNA.
ACCESSION   NM_177687
VERSION     NM_177687.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2536)
  AUTHORS   Hong,T., Xiong,X., Chen,Y., Wang,Q., Fu,X., Meng,Q., Lu,Y. and
            Li,X.
  TITLE     Parathyroid hormone receptor-1 signaling aggravates hepatic
            fibrosis through upregulating cAMP response element-binding
            protein-like 2
  JOURNAL   Hepatology 78 (6), 1763-1776 (2023)
   PUBMED   36939197
  REMARK    GeneRIF: Parathyroid hormone receptor-1 signaling aggravates
            hepatic fibrosis through upregulating cAMP response element-binding
            protein-like 2.
REFERENCE   2  (bases 1 to 2536)
  AUTHORS   Ma,X., Zhang,H., Yuan,L., Jing,H., Thacker,P. and Li,D.
  TITLE     CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1
            adipocytes
  JOURNAL   Biochem J 439 (1), 27-38 (2011)
   PUBMED   21728997
  REMARK    GeneRIF: Results of the present study indicate that CREBL2 plays a
            critical role in adipogenesis and lipogenesis via interaction with
            CREB.
REFERENCE   3  (bases 1 to 2536)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK045467.1.
            
            On Apr 6, 2007 this sequence version replaced NM_177687.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045467.1, SRR1660811.101539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2536              AK045467.1         2-2537
FEATURES             Location/Qualifiers
     source          1..2536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.77 cM"
     gene            1..2536
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /note="cAMP responsive element binding protein-like 2"
                     /db_xref="GeneID:232430"
                     /db_xref="MGI:MGI:1889385"
     exon            1..246
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..603
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /codon_start=1
                     /product="cAMP-responsive element-binding protein-like 2"
                     /protein_id="NP_808355.1"
                     /db_xref="CCDS:CCDS20640.1"
                     /db_xref="GeneID:232430"
                     /db_xref="MGI:MGI:1889385"
                     /translation="MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARK
                     KLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIRALLTGEEQSKPQQ
                     SSSRHPKAGKTDADTNSLVGN"
     exon            247..444
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /inference="alignment:Splign:2.1.0"
     exon            445..589
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /inference="alignment:Splign:2.1.0"
     exon            590..626
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /inference="alignment:Splign:2.1.0"
     exon            627..2536
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1234..1239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /note="hexamer: AATACA"
     polyA_site      1257
                     /gene="Crebl2"
                     /gene_synonym="B230205M03"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcggtg gccgagcggg gaggtgcctg gggcagcctc cagggtccgc tctgccattc
       61 ctgaactggt ccgggtcccc gtgaccgtgg cttcagggaa gcgaactgtt aggcgaagga
      121 ggaggcagtc agagccatat ccccttcttc cccggggcgg gggccgggcc tggcccgctg
      181 aggagaggga gggccgggag ggcgtcgggc cgggccggcc tgtctgcgga gatggatgac
      241 agcaaggtgg ttggaggcaa agtgaagaag cctggtaagc gaggacggaa gccagccaaa
      301 atcgacttga aagcgaaact tgagcgaagc cggcagagtg cgagagaatg ccgggccagg
      361 aaaaagctga ggtaccagta cttggaggag ttggtatcca gtcgggaaag agctatatgt
      421 gcactccgag aggaactgga aatgtacaag cagtggtgca tggcaatgga ccaagggaaa
      481 atcccttctg aaataagggc cctactcact ggcgaggagc agagcaagcc tcagcagagc
      541 tcaagcaggc atcccaaagc tgggaagaca gacgctgaca ccaactcgtt ggtggggaat
      601 tgaacctgtg gcttcagata cgatgaggtg aagatcatat aaaaggcagt ccgtgatcaa
      661 agccaatggt gtgatgtcta tggaggacga atggggcagg actttgcttc ttggctccat
      721 tttctgctta ctgctcagta agcgtctctg tgaacccaaa gtttctaccg taatgtgtga
      781 tgatgcgtcg ggaaggtcct tgcgcagcac ttagacttgc cggcgacctt cagacctgct
      841 ctgtgtcgct caccacatcg gttaacagtc gtgatgccga gcctgtggga gcggaggaag
      901 tggatggaag cgcacgtttg caccttagcc ctgtggcttt catggttaat ttctacttgt
      961 cctatgtaat tgatggattt gtgtgtgtgt gtttagttgt cacttctttt cttgttttta
     1021 atcaccctac aaaaagaaac caaataggct gtttgtctcc cgtggttctc agcctttatg
     1081 gacccaatat tactcctttc tagttacttg agtaatgttt gcttgtctgt gagccattcc
     1141 agcataagct gtgagtatta acagatatac acacttctat ttttataacc catagtgata
     1201 tgcctgtttt aaagaatgtc cataacaaag cccaatacaa ggcccctgac agcctcattt
     1261 tgctcttcct ctgactgtat ttatgaaagc tggctagggc caaatccatg cttggagaat
     1321 aattagccac agtttatttt taagtgaaaa gttctcttag tagcatccgt taccttaacc
     1381 tgcagtatgt gtgacgtggt ttctgctgta tgtctccatg tacacacatt ggcacacaca
     1441 tttgcttgtg cactcagctg aggcatgggg tttttctaaa gcgtacagaa tgaacgtagc
     1501 tgctgagact gggtatctgc tgtgtagagc acaggccatc ctgctgctga cgctatggct
     1561 gctgctgttg gcagaatact cagttcttcc ctgacatgag tgtccttatg aatgtgttct
     1621 gagccagaga gaaagaagcc tactgtgtgc ttgtacctgc tttagcctgt gcccccactg
     1681 tgctggggca tcctgagctg caccctgtac tgcagcctgg ggcctggtgg gtatttggag
     1741 tcgcatgtgg ctctgtatgg ttcccagcac agccgaattt gcacgtggag tgtggttagg
     1801 ggcaaagctc atagtaggag aggttcagag acaaggaatt tctactttac tcgcttctct
     1861 cactagttca gtcatatgta ttctctgttg ctgctaatta caattgttcc tccctctgat
     1921 gaagcaggaa tttgacttcc agaaaaagaa gtatttgcca cagactggca gttgaaggga
     1981 ggtatcatag ttacaggcat gtccaacctt ttgatgttgt gacttgaagc ctgagaattg
     2041 aatgttttaa gtgagtttac agtttagtgc tgggccacat tcctagttat tctgaggtat
     2101 acgcagcctg caagctgcgg ttcagacgtg cctggaaggt tgtctgtgag gtgggacgag
     2161 agatggactg tgtagcttgt gatctcttga caggcatgtc tcctgaccag ttgccttctg
     2221 ttagctgaag atcccttgag cgcaggcgtg gaactcagat ctccatgcta ggtgtgtgtg
     2281 cccgccgaca gagcacctgc ccagcttgct gggattcgct gtgttttaga aaaatgggca
     2341 ttaagggtat ttaatgtctt cttaggacca taagtggaga caaggactgt tgatgttcag
     2401 gcccttcgaa tgtaagtgtt ttcaatgtag tgttctgact gggatggcgt gttctgccag
     2461 tggggcgact cagtcgtaga ctcttacttt gcagaacttt gtgttgcttt gtttgttact
     2521 ttttgaattc tccagg
//
