LOCUS       NM_001025432            7507 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus CREB binding protein (Crebbp), mRNA.
ACCESSION   NM_001025432 XM_148699 XM_622591
VERSION     NM_001025432.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7507)
  AUTHORS   Li,J., Chin,C.R., Ying,H.Y., Meydan,C., Teater,M.R., Xia,M.,
            Farinha,P., Takata,K., Chu,C.S., Jiang,Y., Eagles,J., Passerini,V.,
            Tang,Z., Rivas,M.A., Weigert,O., Pugh,T.J., Chadburn,A., Steidl,C.,
            Scott,D.W., Roeder,R.G., Mason,C.E., Zappasodi,R., Beguelin,W. and
            Melnick,A.M.
  TITLE     Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis
            and shape the lymphoma immune microenvironment
  JOURNAL   Nat Commun 15 (1), 2879 (2024)
   PUBMED   38570506
  REMARK    GeneRIF: Loss of CREBBP and KMT2D cooperate to accelerate
            lymphomagenesis and shape the lymphoma immune microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7507)
  AUTHORS   Zhang,L., Zhu,K., Xu,J., Chen,X., Sheng,C., Zhang,D., Yang,Y.,
            Sun,L., Zhao,H., Wang,X., Tao,B., Zhou,L. and Liu,J.
  TITLE     Acetyltransferases CBP/p300 Control Transcriptional Switch of
            beta-Catenin and Stat1 Promoting Osteoblast Differentiation
  JOURNAL   J Bone Miner Res 38 (12), 1885-1899 (2023)
   PUBMED   37850815
  REMARK    GeneRIF: Acetyltransferases CBP/p300 Control Transcriptional Switch
            of beta-Catenin and Stat1 Promoting Osteoblast Differentiation.
REFERENCE   3  (bases 1 to 7507)
  AUTHORS   Tseng,C., Han,Y., Lv,Z., Song,Q., Wang,K., Shen,H. and Chen,Z.
  TITLE     Glucose-stimulated PGC-1alpha couples with CBP and Runx2 to mediate
            intervertebral disc degeneration through transactivation of
            ADAMTS4/5 in diet-induced obesity mice
  JOURNAL   Bone 167, 116617 (2023)
   PUBMED   36403758
  REMARK    GeneRIF: Glucose-stimulated PGC-1alpha couples with CBP and Runx2
            to mediate intervertebral disc degeneration through transactivation
            of ADAMTS4/5 in diet-induced obesity mice.
REFERENCE   4  (bases 1 to 7507)
  AUTHORS   Wang,M., Chen,Z. and Zhang,Y.
  TITLE     CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics
            and zygotic genome activation in mouse preimplantation embryos
  JOURNAL   EMBO J 41 (22), e112012 (2022)
   PUBMED   36215692
  REMARK    GeneRIF: CBP/p300 and HDAC activities regulate H3K27 acetylation
            dynamics and zygotic genome activation in mouse preimplantation
            embryos.
REFERENCE   5  (bases 1 to 7507)
  AUTHORS   de Thonel,A., Ahlskog,J.K., Daupin,K., Dubreuil,V., Berthelet,J.,
            Chaput,C., Pires,G., Leonetti,C., Abane,R., Barris,L.C., Leray,I.,
            Aalto,A.L., Naceri,S., Cordonnier,M., Benasolo,C., Sanial,M.,
            Duchateau,A., Vihervaara,A., Puustinen,M.C., Miozzo,F.,
            Fergelot,P., Lebigot,E., Verloes,A., Gressens,P., Lacombe,D.,
            Gobbo,J., Garrido,C., Westerheide,S.D., David,L., Petitjean,M.,
            Taboureau,O., Rodrigues-Lima,F., Passemard,S., Saberan-Djoneidi,D.,
            Nguyen,L., Lancaster,M., Sistonen,L. and Mezger,V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. doi:
            10.1038/s41467-023-41869-4.. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7507)
  AUTHORS   Parker,D., Ferreri,K., Nakajima,T., LaMorte,V.J., Evans,R.,
            Koerber,S.C., Hoeger,C. and Montminy,M.R.
  TITLE     Phosphorylation of CREB at Ser-133 induces complex formation with
            CREB-binding protein via a direct mechanism
  JOURNAL   Mol Cell Biol 16 (2), 694-703 (1996)
   PUBMED   8552098
REFERENCE   7  (bases 1 to 7507)
  AUTHORS   Chen,X.N. and Korenberg,J.R.
  TITLE     Localization of human CREBBP (CREB binding protein) to 16p13.3 by
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 71 (1), 56-57 (1995)
   PUBMED   7606928
REFERENCE   8  (bases 1 to 7507)
  AUTHORS   Kwok,R.P., Lundblad,J.R., Chrivia,J.C., Richards,J.P.,
            Bachinger,H.P., Brennan,R.G., Roberts,S.G., Green,M.R. and
            Goodman,R.H.
  TITLE     Nuclear protein CBP is a coactivator for the transcription factor
            CREB
  JOURNAL   Nature 370 (6486), 223-226 (1994)
   PUBMED   7913207
REFERENCE   9  (bases 1 to 7507)
  AUTHORS   Chrivia,J.C., Kwok,R.P., Lamb,N., Hagiwara,M., Montminy,M.R. and
            Goodman,R.H.
  TITLE     Phosphorylated CREB binds specifically to the nuclear protein CBP
  JOURNAL   Nature 365 (6449), 855-859 (1993)
   PUBMED   8413673
REFERENCE   10 (bases 1 to 7507)
  AUTHORS   Kozak,L.P., Britton,J.H., Kozak,U.C. and Wells,J.M.
  TITLE     The mitochondrial uncoupling protein gene. Correlation of exon
            structure to transmembrane domains
  JOURNAL   J Biol Chem 263 (25), 12274-12277 (1988)
   PUBMED   3410843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010297.1, BC072594.1, BU705617.1 and CAAA01026247.1.
            
            On or before Jul 20, 2005 this sequence version replaced
            XM_148699.5, XM_622591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1087              BC010297.1         4-1090
            1088-4869           BC072594.1         1074-4855
            4870-5482           BU705617.1         63-675
            5483-7507           CAAA01026247.1     35486-37510
FEATURES             Location/Qualifiers
     source          1..7507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.4 cM"
     gene            1..7507
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /note="CREB binding protein"
                     /db_xref="GeneID:12914"
                     /db_xref="MGI:MGI:1098280"
     exon            1..266
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..7507
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /EC_number="2.3.1.48"
                     /note="protein-lysine acetyltransferase CREBBP; protein
                     lactyltransferas CREBBP"
                     /codon_start=1
                     /product="histone lysine acetyltransferase CREBBP"
                     /protein_id="NP_001020603.1"
                     /db_xref="CCDS:CCDS27915.1"
                     /db_xref="GeneID:12914"
                     /db_xref="MGI:MGI:1098280"
                     /translation="MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDEL
                     IPNGELSLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQA
                     QGQPNSTNMASLGAMGKSPLNQGDSSTPNLPKQAASTSGPTPPASQALNPQAQKQVGL
                     VTSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRG
                     RGAGMPYPAPAMQGATSSVLAETLTQVSPQMAGHAGLNTAQAGGMTKMGMTGTTSPFG
                     QPFSQTGGQQMGATGVNPQLASKQSMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIV
                     PTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLN
                     HMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPAS
                     GIQNTIGSVGAGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQP
                     AQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSN
                     SGNIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRR
                     MENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQP
                     ALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGP
                     RAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQF
                     PSSSGAMSVNSVGMGQPAAQAGVSQGQVPGAALPNPLNMLAPQASQLPCPPVTQSPLH
                     PTPPPASTAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQ
                     STPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGTPLSQAAASIDNR
                     VPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRSEMMEEDLQGS
                     SQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQPRKKIFKP
                     EELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTG
                     QYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRK
                     YEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTT
                     ISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPR
                     KENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKS
                     RFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLD
                     SIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKI
                     PKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEE
                     SIKELEQEEEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPS
                     MPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAF
                     LTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCED
                     YDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHAC
                     QCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVP
                     FCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPST
                     PQTPQPPAQPQPSPVNMSPAGFPNVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVE
                     AARQIEREAQQQQHLYRANINNGMPPGRAGMGTPGSQMTPVGLNVPRPNQVSGPVMSS
                     MPPGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRT
                     LKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQP
                     GMHQQPSLQNLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNPGHNPNMTNMNPQY
                     REMVRRQLLQHQQQQQQQQQQQQQQQNSASLAGGMAGHSQFQQPQGPGGYAPAMQQQR
                     MQQHLPIQGSSMGQMAAPMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGS
                     PGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSP
                     RIQPQPSPHHVSPQTGSPHPGLAVTMASSMDQGHLGNPEQSAMLPQLNTPNRSALSSE
                     LSLVGDTTGDTLEKFVEGL"
     exon            267..976
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1153
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1394
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1508
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1751
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1854
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2001
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2119
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2291
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2336
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2461
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2650
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..3064
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3244
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3434
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3553
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3793
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3882
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..3963
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4020
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4098
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4166
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4317
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4464
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4578
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4579..4744
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4912
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4913..5074
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..5356
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5357..7507
                     /gene="Crebbp"
                     /gene_synonym="CBP; CBP/p300; KAT3A; p300/CBP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgttgctg aggctgagat ttggccgccg cctcccccac ccggcctgcg ccctccgcgg
       61 cccggcccgc gctcctgcgc tcgctcctcg ctggctcgcc tgctcgcagc cgccggcccg
      121 acccccgtcc gggccgcgtc gcgccgcccg cgctcagggc tgtttccgcg agcaggtgaa
      181 gatggccgag aacttgctgg acggaccgcc caaccccaaa cgagccaaac tcagctcgcc
      241 cggcttctcc gcgaatgaca acacagattt tggatcattg tttgacttgg aaaatgacct
      301 tcctgatgag ctgatcccca atggagaatt aagcctttta aacagtggga accttgttcc
      361 agatgctgcg tccaaacata aacaactgtc agagcttctt agaggaggca gcggctctag
      421 catcaaccca gggataggca atgtgagtgc cagcagccct gtgcaacagg gccttggtgg
      481 ccaggctcag gggcagccga acagtacaaa catggccagc ttaggtgcca tgggcaagag
      541 ccctctgaac caaggagact catcaacacc caacctgccc aaacaggcag ccagcacctc
      601 tgggcccact ccccctgcct cccaagcact gaatccacaa gcacaaaagc aagtagggct
      661 ggtgaccagt agtcctgcca catcacagac tggacctggg atctgcatga atgctaactt
      721 caaccagacc cacccaggcc ttctcaatag taactctggc catagcttaa tgaatcaggc
      781 tcaacaaggg caagctcaag tcatgaatgg atctcttggg gctgctggaa gaggaagggg
      841 agctggaatg ccctaccctg ctccagccat gcagggggcc acaagcagtg tgctggcgga
      901 gaccttgaca caggtttccc cacaaatggc tggccatgct ggactaaata cagcacaggc
      961 aggaggcatg accaagatgg gaatgactgg taccacaagt ccatttggac aaccctttag
     1021 tcaaactgga gggcagcaga tgggagccac tggagtgaac ccccagttag ccagcaaaca
     1081 gagcatggtc aatagtttac ctgcttttcc tacagatatc aagaatactt cagtcaccac
     1141 tgtgccaaat atgtcccagt tgcaaacatc agtgggaatt gtacccacac aagcaattgc
     1201 aacaggcccc acagcagacc ctgaaaaacg caaactgata cagcagcagc tggttctact
     1261 gcttcatgcc cacaaatgtc agagacgaga gcaagcaaat ggagaggttc gagcctgttc
     1321 tctcccacac tgtcgaacca tgaaaaacgt tttgaatcac atgacacatt gtcaggctgg
     1381 gaaagcctgc caagttgccc attgtgcatc ttcacgacaa atcatctctc attggaagaa
     1441 ctgcacacga catgactgtc ctgtttgcct ccctttgaaa aatgccagtg acaagcgaaa
     1501 ccaacaaacc atcctgggat ctccagctag tggaattcaa aacacaattg gttctgttgg
     1561 tgcagggcaa cagaatgcca cttccttaag taacccaaat cccatagacc ccagttccat
     1621 gcagcgggcc tatgctgctc taggactccc ctacatgaac cagcctcaga cgcagctgca
     1681 gcctcaggtt cctggccagc aaccagcaca gcctccagcc caccagcaga tgaggactct
     1741 caatgcccta ggaaacaacc ccatgagtat cccagcagga ggaataacaa cagatcaaca
     1801 gccaccaaac ttgatttcag aatcagctct tccaacttcc ttgggggcta ccaatccact
     1861 gatgaatgat ggttcaaact ctggtaacat tggaagcctc agcacgatac ctacagcagc
     1921 gcctccttcc agcactggtg ttcgaaaagg ctggcatgaa catgtgactc aggacctacg
     1981 gagtcatcta gtccataaac tcgttcaagc catcttccca actccagacc ctgcagctct
     2041 gaaagatcgc cgcatggaga acctggttgc ctatgctaag aaagtggagg gagacatgta
     2101 tgagtctgct aatagcaggg atgaatacta tcatttatta gcagagaaaa tctataaaat
     2161 acaaaaagaa ctagaagaaa agcggaggtc acgtttacat aagcaaggca tcctgggtaa
     2221 ccagccagct ttaccagctt ctggggctca gccccctgtg attccaccag cccagtctgt
     2281 aagacctcca aatgggcccc tgcctttgcc agtgaatcgc atgcaggttt ctcaagggat
     2341 gaattcattt aacccaatgt ccctgggaaa cgtccagttg ccacaggcac ccatgggacc
     2401 tcgtgcagcc tcccctatga accactctgt gcagatgaac agcatggcct cagttccggg
     2461 tatggccatt tctccttcac ggatgcctca gcctccaaat atgatgggca ctcatgccaa
     2521 caacattatg gcccaggcac ctactcagaa ccagtttctg ccacagaacc agtttccatc
     2581 atccagtggg gcaatgagtg tgaacagtgt gggcatgggg caaccagcag cccaggcagg
     2641 tgtttcacag ggtcaggtac ctggagctgc tctccctaac cctctgaaca tgctggcacc
     2701 ccaggccagc cagctgcctt gcccaccagt gacacagtca ccattgcacc cgactccacc
     2761 tcctgcttcc acagctgctg gcatgccctc tctccaacat ccaacggcac caggaatgac
     2821 ccctcctcag ccagcagctc ccactcagcc atctactcct gtgtcatctg ggcagactcc
     2881 taccccaact cctggctcag tgcccagcgc tgcccaaaca cagagtaccc ctacagtcca
     2941 ggcagcagca caggctcagg tgactccaca gcctcagacc ccagtgcagc caccatctgt
     3001 ggctactcct cagtcatcac agcagcaacc aacgcctgtg catactcagc ctcctggcac
     3061 accgctttct caggcagcag ccagcattga taatagagtc cctactccct cctctgtgac
     3121 cagtgctgaa accagttccc agcagccagg acccgatgtg cccatgctgg aaatgaagac
     3181 agaggtgcag acagatgatg ctgagcctga acctactgaa tccaaggggg aacctcggtc
     3241 tgagatgatg gaagaggatt tacaaggttc ttcccaagta aaagaagaga cagatacgac
     3301 agagcagaag tcagagccaa tggaagtaga agaaaagaaa cctgaagtaa aagtggaagc
     3361 taaagaggaa gaagagaaca gttcgaacga cacagcctca caatcaacat ctccttccca
     3421 gccacgcaaa aaaatcttta aacccgagga gctacgccag gcacttatgc caactctaga
     3481 agcactctat cgacaggacc cagagtcttt gccttttcgt cagcctgtag atcctcagct
     3541 cctaggaatc ccagattatt ttgatatagt gaagaatcct atggaccttt ctaccatcaa
     3601 acgaaagctg gacacagggc aatatcaaga accctggcag tatgtggatg atgtctggct
     3661 tatgttcaac aatgcgtggc tatataatcg taaaacgtcc cgtgtatata aattttgcag
     3721 taaacttgca gaggtctttg aacaagaaat tgaccctgtc atgcagtctc ttggatattg
     3781 ctgtggacga aagtatgagt tctccccaca gactttgtgc tgttacggaa agcagctgtg
     3841 tacaattcct cgtgatgcag cctactacag ctatcagaat aggtatcatt tctgtgagaa
     3901 gtgtttcaca gagatccagg gcgagaatgt gaccctgggt gacgaccctt cccaacctca
     3961 gacgacaatt tccaaggatc aatttgaaaa gaagaaaaat gataccttag atcctgaacc
     4021 ttttgttgac tgcaaagagt gtggccggaa gatgcatcag atttgtgttc tacactatga
     4081 catcatttgg ccttcaggtt ttgtgtgtga caactgtttg aagaaaactg gcagacctcg
     4141 gaaagaaaac aaattcagtg ctaagaggct gcagaccaca cgattgggaa accacttaga
     4201 agacagagtg aataagtttt tgcggcgcca gaatcaccct gaagctgggg aggtttttgt
     4261 cagagtggtg gccagctcag acaagactgt ggaggtcaag ccgggaatga agtcaaggtt
     4321 tgtggattct ggagagatgt cggaatcttt cccatatcgt accaaagcac tctttgcttt
     4381 tgaggagatc gatggagtcg atgtgtgctt ttttgggatg catgtgcaag aatacggctc
     4441 tgattgcccc ccaccaaata caaggcgtgt atacatatct tatctggaca gtattcattt
     4501 cttccggccc cgctgcctcc ggacagctgt ttaccatgag atcctcatcg gatatctcga
     4561 gtatgtgaag aaattggggt atgtgacagg acatatttgg gcctgtcccc caagtgaagg
     4621 agatgactat atctttcatt gccacccccc tgaccagaaa atccccaaac caaaacgact
     4681 acaggagtgg tacaagaaga tgctggacaa ggcgtttgca gagaggatca ttaacgacta
     4741 taaggacatc ttcaaacaag cgaacgaaga caggctcacg agtgccaagg agttgcccta
     4801 ttttgaagga gatttctggc ctaatgtgtt ggaagaaagc attaaggaac tagaacaaga
     4861 agaagaagaa aggaaaaaag aagagagtac tgcagcgagt gagactcctg agggcagtca
     4921 gggtgacagc aaaaatgcga agaaaaagaa caacaagaag accaacaaaa acaaaagcag
     4981 cattagccgc gccaacaaga agaagcccag catgcccaat gtttccaacg acctgtcgca
     5041 gaagctgtat gccaccatgg agaagcacaa ggaggtattc tttgtgattc atctgcatgc
     5101 tgggcctgtt atcagcactc agccccccat cgtggaccct gatcctctgc ttagctgtga
     5161 cctcatggat gggcgagatg ccttcctcac cctggccaga gacaagcact gggaattctc
     5221 ttccttacgc cgctccaaat ggtccactct gtgcatgctg gtggagctgc acacacaggg
     5281 ccaggaccgc tttgtttata cctgcaatga gtgcaaacac catgtggaaa cacgctggca
     5341 ctgcactgtg tgtgaggact atgacctttg tatcaattgc tacaacacaa agagccacac
     5401 ccataagatg gtgaagtggg ggctaggcct agatgatgag ggcagcagtc agggtgagcc
     5461 acagtccaag agcccccagg aatcccggcg tctcagcatc cagcgctgca tccagtccct
     5521 ggtgcatgcc tgccagtgtc gcaatgccaa ctgctcactg ccgtcttgcc agaagatgaa
     5581 gcgagtcgtg cagcacacca agggctgcaa gcgcaagact aatggaggat gcccagtgtg
     5641 caagcagctc attgctcttt gctgctacca cgccaaacac tgccaagaaa ataaatgccc
     5701 tgtgcccttc tgcctcaaca tcaaacataa gctccgccag cagcagatcc agcatcgcct
     5761 gcagcaggct cagctcatgc gccggcgaat ggcaaccatg aacacccgca atgtgcctca
     5821 gcagagtttg ccttctccta cctcagcacc acccgggact cctacacagc agcccagcac
     5881 accccaaaca ccacagcccc cagcccagcc tcagccttca cctgttaaca tgtcaccagc
     5941 tggcttccct aatgtagccc ggactcagcc cccaacaata gtgtctgctg ggaagcctac
     6001 caaccaggtg ccagctcccc caccccctgc ccagccccca cctgcagcag tagaagcagc
     6061 ccggcaaatt gaacgtgagg cccagcagca gcagcaccta taccgagcaa acatcaacaa
     6121 tggcatgccc ccaggacgtg caggtatggg gaccccagga agccaaatga ctcctgtggg
     6181 cctgaatgtg ccccgtccca accaagtcag tgggcctgtc atgtctagta tgccacctgg
     6241 gcagtggcag caggcaccca tccctcagca gcagccgatg ccaggcatgc ccaggcctgt
     6301 aatgtccatg caggcccagg cagcagtggc tgggccacgg atgcccaatg tgcagccacc
     6361 aaggagcatc tcgccaagtg ccctgcaaga cctgctacgg accctaaagt cacccagctc
     6421 tcctcagcag cagcagcagg tgctgaacat ccttaaatca aacccacagc taatggcagc
     6481 tttcatcaaa cagcgcacag ccaagtatgt ggccaatcag cctggcatgc agccccagcc
     6541 cggacttcaa tcccagcctg gtatgcagcc ccagcctggc atgcaccagc agcctagttt
     6601 gcaaaacctg aacgcaatgc aagctggtgt gccacggcct ggtgtgcctc caccacaacc
     6661 agcaatggga ggcctgaatc cccagggaca agctctgaac atcatgaacc caggacacaa
     6721 ccccaacatg acaaacatga atccacagta ccgagaaatg gtgaggagac agctgctaca
     6781 gcaccagcag cagcagcagc aacagcagca gcagcagcag caacaacaaa atagtgccag
     6841 cttggccggg ggcatggcgg gacacagcca gttccagcag ccacaaggac ctggaggtta
     6901 tgccccagcc atgcagcagc aacgcatgca acagcacctc cccatccagg gcagctccat
     6961 gggccagatg gctgctccaa tgggacaact tggccagatg gggcagcctg ggctaggggc
     7021 agacagcacc cctaatatcc agcaggccct gcagcaacgg attctgcagc agcagcagat
     7081 gaagcaacaa attgggtcac caggccagcc gaaccccatg agcccccagc agcacatgct
     7141 ctcaggacag ccacaggcct cacatctccc tggccagcag atcgccacat cccttagtaa
     7201 ccaggtgcga tctccagccc ctgtgcagtc tccacggccc caatcccaac ctccacattc
     7261 cagcccgtca ccacggatac aaccccagcc ttcaccacac catgtttcac cccagactgg
     7321 ttcccctcac cctggactcg cagtcaccat ggccagctcc atggatcagg gacacctggg
     7381 gaaccctgaa cagagtgcaa tgctccccca gctgaatacc cccaacagga gcgcactgtc
     7441 cagtgaactg tccctggttg gtgataccac gggagacaca ctagaaaagt ttgtggaggg
     7501 tttgtag
//
