LOCUS       NM_001327821            7886 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus cAMP responsive element binding protein 5 (Creb5),
            transcript variant 1, mRNA.
ACCESSION   NM_001327821
VERSION     NM_001327821.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7886)
  AUTHORS   Li,Z., Dai,F., Zhu,R., Zhang,Y., Chen,J., Chen,L., Liu,H. and
            Cheng,Y.
  TITLE     Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal
            Interactions by Inhibiting Autophagy in Recurrent Spontaneous
            Abortion
  JOURNAL   Reprod Sci 31 (7), 1983-2000 (2024)
   PUBMED   38424407
  REMARK    GeneRIF: Dysregulation of CREB5 Impairs Decidualization and
            Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent
            Spontaneous Abortion.
REFERENCE   2  (bases 1 to 7886)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   3  (bases 1 to 7886)
  AUTHORS   Feng,J., Han,X., Yuan,Y., Cho,C.K., Janeckova,E., Guo,T.,
            Pareek,S., Rahman,M.S., Zheng,B., Bi,J., Jing,J., Zhang,M., Xu,J.,
            Ho,T.V. and Chai,Y.
  TITLE     TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to
            control pharyngeal muscle development
  JOURNAL   Elife 11, e80405 (2022)
   PUBMED   36542062
  REMARK    GeneRIF: TGF-beta signaling and Creb5 cooperatively regulate Fgf18
            to control pharyngeal muscle development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7886)
  AUTHORS   Zhang,C.H., Gao,Y., Hung,H.H., Zhuo,Z., Grodzinsky,A.J. and
            Lassar,A.B.
  TITLE     Creb5 coordinates synovial joint formation with the genesis of
            articular cartilage
  JOURNAL   Nat Commun 13 (1), 7295 (2022)
   PUBMED   36435829
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7886)
  AUTHORS   Liu,X., Netto,K.G., Sokulsky,L.A., Zhou,L., Xu,H., Liu,C., Wang,M.,
            Wang,H., Li,H., Zhang,G., Foster,P.S., Li,F. and Yang,M.
  TITLE     Single-cell RNA transcriptomic analysis identifies Creb5 and
            CD11b-DCs as regulator of asthma exacerbations
  JOURNAL   Mucosal Immunol 15 (6), 1363-1374 (2022)
   PUBMED   36038770
  REMARK    GeneRIF: Single-cell RNA transcriptomic analysis identifies Creb5
            and CD11b-DCs as regulator of asthma exacerbations.
REFERENCE   6  (bases 1 to 7886)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (bases 1 to 7886)
  AUTHORS   Paschaki,M., Schneider,C., Rhinn,M., Thibault-Carpentier,C.,
            Dembele,D., Niederreither,K. and Dolle,P.
  TITLE     Transcriptomic analysis of murine embryos lacking endogenous
            retinoic acid signaling
  JOURNAL   PLoS One 8 (4), e62274 (2013)
   PUBMED   23638021
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7886)
  AUTHORS   Maekawa,T., Jin,W. and Ishii,S.
  TITLE     The role of ATF-2 family transcription factors in adipocyte
            differentiation: antiobesity effects of p38 inhibitors
  JOURNAL   Mol Cell Biol 30 (3), 613-625 (2010)
   PUBMED   19948881
REFERENCE   9  (bases 1 to 7886)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   10 (bases 1 to 7886)
  AUTHORS   Lehoczky,J.A., Williams,M.E. and Innis,J.W.
  TITLE     Conserved expression domains for genes upstream and within the HoxA
            and HoxD clusters suggests a long-range enhancer existed before
            cluster duplication
  JOURNAL   Evol Dev 6 (6), 423-430 (2004)
   PUBMED   15509224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068064.4, AC069141.4, AC068661.5, AK052451.1, AC079130.4 and
            BE943969.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.316684.1,
                                           SRR11927937.4690929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC068064.4         94706-94776
            72-143              AC069141.4         33928-33999
            144-237             AC069141.4         40080-40173
            238-359             AC069141.4         52926-53047
            360-532             AC069141.4         111687-111859
            533-659             AC068661.5         79541-79667
            660-770             AC068661.5         85501-85611
            771-3340            AK052451.1         305-2874
            3341-7379           AC079130.4         28659-32697
            7380-7886           BE943969.1         1-507               c
FEATURES             Location/Qualifiers
     source          1..7886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.9 cM"
     gene            1..7886
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /note="cAMP responsive element binding protein 5"
                     /db_xref="GeneID:231991"
                     /db_xref="MGI:MGI:2443973"
     exon            1..71
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            72..143
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1595
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic AMP-responsive element-binding protein 5"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 5
                     isoform 1"
                     /protein_id="NP_001314750.1"
                     /db_xref="CCDS:CCDS85049.1"
                     /db_xref="GeneID:231991"
                     /db_xref="MGI:MGI:2443973"
                     /translation="MNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKT
                     DNMLSDQTPTPTRFLKNCEEVGLFSELDCSFEHEFRKAQEEENSKRNISMHNTVGGTM
                     TGPGAHQLGSTRMPNHDSSVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHL
                     HNRQRQPMPASMPGTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQV
                     QPMHSEAKMRLKAALTHHPAAMSNGNMSTIGHMMEMMGSRQDQTPHHHLHSHPHQHQT
                     LPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLPTGNQA
                     QVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVW
                     VMSLEKKAEELTQTNMQLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPE
                     SSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLNPIL"
     exon            144..237
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            238..359
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..532
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            533..659
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..770
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1094
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1322
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1431
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..7872
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7852..7857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7872
                     /gene="Creb5"
                     /gene_synonym="9430076C15Rik; CRE-BPa; Crebpa;
                     D430026C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttgtaatctt tgctcagtcc aacgtggtcc cttcacccgg gctcggctct tgccttctcc
       61 acacttgttt gatttatgag gaatccaaga tgaacttgga gcaggagagg ccgtttgtct
      121 gcagtgcccc aggctgctcc cagcgtttcc caacagagga ccatctgatg attcataggc
      181 acaagcacga gatgactttg aagttccctt caataaagac agacaatatg ctgtcagatc
      241 agactccgac gcccacaaga ttcctgaaga actgtgaaga ggtgggtctc ttcagcgagc
      301 tggactgctc ctttgagcac gagttcagga aggctcaaga ggaagagaac agcaagcgga
      361 atatctccat gcataataca gttggtggga ccatgacggg acccggagct caccagctag
      421 gcagcactcg gatgcccaac catgacagca gcgttgtgat tcagcaagcc atgccttctc
      481 cccagtccag ctcggtcatc actcaggctc cttccaccaa ccgccagatt gggcctgtcc
      541 caggctctct atcatctcta ctccatctcc acaacagaca gaggcagccc atgccggcct
      601 ccatgcctgg aaccctgccc aaccccacca tgccaggatc ttctgccgtc ttgatgccta
      661 tggagagaca gatgtcagtg aactccagca tcatgggcat gcaaggtcca aacctcagca
      721 acccctgtgc ttctccccaa gtccagccaa tgcattcaga agccaaaatg agactgaagg
      781 ctgcgctgac tcaccatcct gccgccatgt cgaacgggaa catgagcacc atcggacaca
      841 tgatggagat gatgggctcc cggcaagacc agacaccgca ccaccacctg cactcacacc
      901 cgcatcagca ccagacactg ccgccccacc acccctaccc acaccagcac cagcaccccg
      961 cacaccatcc ccacccacag cctcaccacc agcagaacca cccgcaccac cactcccatt
     1021 cccaccttca cgcacacccg gcgcaccacc agacctcgcc acacccaccc ctgcccaccg
     1081 gcaaccaagc acaggtttca ccagctacac aacagatgca gccaacccag acaatacaac
     1141 cgccccagcc cacaggggga cgccggcgaa gagtggtgga tgaggaccca gatgagaggc
     1201 ggaggaaatt tctggaaagg aaccgggccg ccgccacccg ctgcagacag aagaggaagg
     1261 tctgggtgat gtcactggaa aagaaagctg aagagctcac ccagacaaac atgcagcttc
     1321 agaatgaagt gtccatgttg aaaaacgagg tggcccagct gaagcagttg ttgttaacac
     1381 ataaagactg tccgataaca gccatgcaga aagaatccca agggtattta agtccagaga
     1441 gcagccctcc tgcgagccct gtgccagcat gctctcagca gcaagttatc caacacaaca
     1501 ccatcactac atcctcatcg gtcagcgagg tcgtggggag ctccaccctc agtcagctta
     1561 caactcacag aacagacctg aatcctattc tttaaaaggc atcggtcaaa cctggccttt
     1621 gagaagagct gtagcatgcc gtacatcctt tctcaaaggg gcattttttt tagaattatc
     1681 tcagacctgg aagacgcctc agcccttcaa agactggctt tcatttttat agttattatg
     1741 gaaatgttgt cttttatact tagttatata agaaaaaagg gagatatgca atgaatatct
     1801 atcagcttgg ggagcacgtt ggtgcttctc tgcaattttc tggtaccagt ttcttgttta
     1861 taaacggaac ctttcctgta tatagccatg gtttcattct taccagccca accctttgcc
     1921 tggaacaatg aatcttgttc aactacagct tttagccaaa atgaggtatg cttagatgtc
     1981 aagcgagatg gatccacaca gtaactgggt gggaaagctc atgatgtcat aactcatgtt
     2041 gagtttgtgc tgtgatgtca ccagaatctc agataaacac atgggccttc ctgaatattt
     2101 ttttctcttg ctagaaaaaa ataaattatg gtccatccat atcccatgaa agccaccaag
     2161 catctcaggc cccctccttc ctctcttttc tacttgcgca gatgtccaat atccatctca
     2221 ttttcctttc cccggatccc ttgtttactc tttgttttga ctttttttct gtttcctttt
     2281 ctccccttta gctttgcatg taaaaaagaa aataatgttt aaagaagaga aaaagcaaat
     2341 ctggaaactg tggacctagc cacagtttaa cccacagctg gagttcattc aatttttgcc
     2401 tttcacaaaa tagcaaccag gagatgttta atgtgcctga tttaatgttt ttaataacca
     2461 gagcaaataa aaggtggttt ggttataggt gaagcactgt tgaatgccag ctgtggggac
     2521 actagggaaa gggacttcgt aagctccaac tgtgaaaatt caaataagga tgtgggctct
     2581 aacatcacac cctcgaatta cagctcgctt ctatggcctg tctataatgt aaaaaatcca
     2641 tgcactatat aatagttcag aagggctctg ttcactacac agattacatt gttcaatcat
     2701 cagctgctaa taacctaaga tttattatta ttatttttct taagcctatg gaaccagctc
     2761 tgctgttctg gtgggcaaaa gcaaactcac tcttggagca acagagagaa agcgaggcca
     2821 gcgtttctcg gggactcgca gtctgccaga acagtcagac tccttggctg ctgaccgagt
     2881 cccatggagg tggccaggct ggtgcgctca tctgagtagt tctgatttat attttcagca
     2941 atgtccacgg acttgcccat tacggaaagc agatcaaacc caaaccacag ttgtgcctcc
     3001 ttgaaacaag ccattctact ctgctggtgt tttactatcg tgtttcacaa ataatagggg
     3061 ctaatgtttc tcactagcag tctgggcata tgctggtgtt tcatctctgc ccaaataatt
     3121 cacctcctaa cctatgtgtg tgtgtgtgca catggatgtg tgtgcctgag tgtgtgagtg
     3181 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttta tgaacagtat aggttttaaa
     3241 agaacagtat tttacaaaag ccatcacttt tataagagtt ctgtaaagga aggatgtact
     3301 tcttcgctca ctatagttta aaaaaaattc tattttagag gaaaaaaaaa gaaaatatga
     3361 gggctctgag catgactttt ataactagtt tcagttttat ctaataactt acttttaaaa
     3421 aatcaatatt tatcaataat tttcatgtat gctgtgcttt ttgagagaca tgtttggctg
     3481 ttcagtaaag cataagagta tatggcctaa gaatcaaaaa gaaatgaaaa aataaaataa
     3541 aaagagggaa aagaaaaatg aaaagggaag aaagaagatg gagcaaacag aaatttctat
     3601 tgtattttag gaaaatgcat cattttcaag tattttaaat actgagttaa tattgttatt
     3661 ttttttttaa ttccagcagt aacaaaatgg tttaacctaa ctggcttgct aagaaacgtg
     3721 taagtcttag atttgaaaga atttaacatt catagctctg gattgaaatc aaaggtcatt
     3781 ttctgcaaaa ttccttcctt agatcaggtc agtgctctgc tcccttcaaa atagaagggg
     3841 caagctagag tggcagagct tgtggcttct atctgacact tgctttgggt aaacaggacc
     3901 tttccctcct gcctgcatgt atagcacttg aagaaatgaa ttttttaatc cactagtaat
     3961 ataacatcca gggagtgacc cgccactaaa atgatgattt tcagtttatg tctctcccac
     4021 cactcaactg aagtgcttag ccgttccagg gacagccttt gcagttaaga acttgcctgg
     4081 gttttcttaa ttcagagact cgacagcttg actgatgtgc attatttata gctcaattat
     4141 gtctgttttt tatgctaagt aggcaagcca ccacacacag caaacctttc tcaacatata
     4201 attaggataa actgccttct tgttatgggc aggcccttta ggtgtgtttg tttgcagtat
     4261 ggatagagtc ggtgagggtg ccagctcgct gtcagtcgag aaaaacttct ggggaaatct
     4321 aatttctggt ttatccctag tcaagattcc acagaaaggt ccatccttta ccagatctca
     4381 gagcctgcct gaaacaaccc ttgcactgac tgccatacac cagcgattcg aggagagcat
     4441 ctctctaatt ccttttcatc gtcttctccc atccagttac cagtgtcagc catacagact
     4501 ttcaggagtc agtggtaaca gccttcagag ttcccccgtc caaggaggga aagaaagttc
     4561 aagaaacact gcctctctta ctcctgtgtg gctccattat cacaggatct gcttctgaag
     4621 tccctgccag cctcctgggc acttctccag tacctccctg cctaacatgc tgagggctgg
     4681 aaacttagtg cacatcccca ctcactgaga gaaagacatg gcacatgaat gcttcttaga
     4741 aacacctttc tcaatctacg atgctgggat aggcagactc aaagtcccag ccccggatga
     4801 gtgttcgaat ctcaaagcta gatatggagt tagctatgat ctactgggtg ctggtgaccc
     4861 tcgtcatctc tttacccaca tgtcaatgtg tgcgagttgc catattaaaa cagcctgtgg
     4921 gtgaccgata gtgtgtgtgc tgttgaggtg tgtatcataa agactggggt gacttgctca
     4981 gccagtgctc cgtggaacta atctaatcaa taaaatgcag tggttattcc aagagaggtg
     5041 tcagtgggga aatgttccgg taactgttgc cttctaggaa agcagattat agtggcctag
     5101 agtttgccat tagaatcata aaccagcttc aatttaaaaa aaaagccctt agctgggctt
     5161 atttttaagc atcagtaact gctataaaac tagcctttca gttagaatag gatgtccttc
     5221 cttttgagca aaaccatcta agaaaatata tatgtatgta tgtacagtgg gattcaagga
     5281 ccaaagcaaa atttgaacag gaatctatta atttagaatg tataagatat ttattaataa
     5341 atgttatttt aaacattcca tttgaacagt attcttctgt aggctctatg tgtcttgaaa
     5401 atgttagtcc ctaatagcct gccctagttt gggtgccatt tttcagggtc ttgggtggct
     5461 cttcctgtca tttgctggaa gcccgcgcgc agatctttgt gcatcttttg aggcttgttt
     5521 actgctctgt gagttcttag ttaatctacc ttctgagaaa gttttttttt ttttaaatgt
     5581 atttcttctt ttcatttttt tttttttcac gtgagctctt tcatttagga agcaaattca
     5641 gctaaagggc atcagtgatg ggaacccgag cggctttgga ttttctttta cccataaaat
     5701 gccttcctcc tggcttctct tcactgcatg cccatctcca agaacaccca gcaccactca
     5761 gctcgctgga gctgcctggc ccctcccaaa cagcgaatga actgtgtgca gcagctttaa
     5821 gcttttaagc tccaccccca cccccacccc cacccccacc cctatcccca ttgtatcaga
     5881 agcaaaaggg aagcaccttc ccaggataaa cccgtgccta cgcgaccgcg gtgatttaga
     5941 acctcttttc tgctttttaa aataatttat attttaaagt tgcactttac ctctttgatt
     6001 ccttctcgtt cctatgccct tttccttgat cttcagcttg cctgggacct ttacaactgt
     6061 ctggtgaaga ctctcggctg caccctttca aatgccttcc agggcatgta cgcccagttt
     6121 atgtgtgcac actcattgct agtcctcaca gccttgtgaa gcgtgctaaa gaatgccaag
     6181 aagagccaat acacgaaatg cttcgtcccc ttgatctctt tcttcctagc attgttttga
     6241 aaaatggttg caccatacaa tggggcaatg aggtcgcagc aaagccacac ttagttttct
     6301 atctcatccc caaaccaaag tatcctgaac aagccaggag acttatcctc tcgtgtgcca
     6361 cgatgcacac ttcactgttt tcctagccat agtcttggta aggctgctga agtcacagtg
     6421 gccctgtcct cccattccca tgtctcaaat atacaatgtt gccttgtagc gagattaaag
     6481 acagcgcctc tgttttatca tttcagtcta aggaaggatc agagaacaca ggagcaataa
     6541 acttacaagt agacatctga taccaaaaca tatagaactt ttgaaatcag cctcgttcgt
     6601 cgtgttgtga caatagaaat gtgtccatgt gctcaaagtc tcttgctatt ccctgtggaa
     6661 tttttcagtg atgtaatgct tgtagccaaa ttgcttaaag agtgtttata tatttttttc
     6721 cttataaatc atctattttt tgacaaagaa aaaacctatt taactgcaaa ctgaagagag
     6781 ggtaaagccg aactgccagc atttgttcaa acattaatac cattaagtgg tcctctgatg
     6841 cctttccaag cctatcatca ggaaggaatc aataatcaac tgctatattt aaaccaagtt
     6901 aaaggatcta gctcatcaga atacaggacc taggaagttc ttcctaagcc attgaaggtt
     6961 ctaccttggg gtctatatct gaaaacttta caggaatttt ttaaaacata aagtcatttt
     7021 gcctcaagtt ggagaatgtg ggacctgaat aagttagctt taaatacatc attagaatct
     7081 tccacacagt caatgtatta gattctcatt tgctccttta cagtgcccac actgccttta
     7141 gagaatcaag attccaagag aaagtagtgg tgccccaggg cagggaatta agagaaagga
     7201 cccctcccaa gcagcttctg gcaagaagac ctgcccaccc cttcccttcc aagagctttg
     7261 ctaatctcat ctgcctcaca gagagaaact gcctttaagg actgtctctg agcgataaat
     7321 aaataaataa ataaataaat aagcaagcct ggaatgcccc ctccccaaaa tcatagctct
     7381 attcaaacac aatgttgtgg gacaattgga gtagaaacat tgtccaaaaa tatagtagaa
     7441 aaaaagttta gcactgtgta aagtaaatgt tgactgaaaa agtccccccc tcccaaaaaa
     7501 aaaggtgccg tcactttaag ttctggactt ggggttgttt gtctttgtaa acagcaaagc
     7561 ctttgtgttt gtgtgtctgt ctgtaaagca accaccttcc aactggaagg agaaataaaa
     7621 cctagggggg ggtacatatg tcatatgtgt aaatattgct gcagcatttt aatgtgttta
     7681 attttctgtt tagctttttg ttgcattgtg aacacattta ttgttaccag tggacaatga
     7741 gttcattaag actgttcaac taggtcagat ttttacttct ctttctagca agaagagaca
     7801 agattttgtg catttgtaca aatgttaata atatcaccgc aattccaata taataaagca
     7861 ctcaaatgca aaaaaaaaaa aaaaaa
//
