LOCUS       NM_001307934            1476 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cAMP responsive element binding protein 3-like 4
            (Creb3l4), transcript variant 2, mRNA.
ACCESSION   NM_001307934 XM_006502312
VERSION     NM_001307934.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1476)
  AUTHORS   Zhang,X., Hu,C., Ma,Z.G., Hu,M., Yuan,X.P., Yuan,Y.P., Wang,S.S.,
            Kong,C.Y., Teng,T. and Tang,Q.Z.
  TITLE     Tisp40 prevents cardiac ischemia/reperfusion injury through the
            hexosamine biosynthetic pathway in male mice
  JOURNAL   Nat Commun 14 (1), 3383 (2023)
   PUBMED   37291168
  REMARK    GeneRIF: Tisp40 prevents cardiac ischemia/reperfusion injury
            through the hexosamine biosynthetic pathway in male mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1476)
  AUTHORS   Xiao,C., Zhao,H., Zhu,H., Zhang,Y., Su,Q., Zhao,F. and Wang,R.
  TITLE     Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in
            Renal Ischemia-Reperfusion Injury via NF-kappaB Signaling
  JOURNAL   Front Physiol 11, 906 (2020)
   PUBMED   32903383
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1476)
  AUTHORS   Ariyasu,D., Kubo,E., Higa,D., Shibata,S., Takaoka,Y., Sugimoto,M.,
            Imaizumi,K., Hasegawa,T. and Araki,K.
  TITLE     Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly
            Inherited GH Deficiency in Humanized GH1 Mouse Models
  JOURNAL   Endocrinology 160 (11), 2673-2691 (2019)
   PUBMED   31436800
REFERENCE   4  (bases 1 to 1476)
  AUTHORS   Kim,T.H., Jo,S.H., Choi,H., Park,J.M., Kim,M.Y., Nojima,H.,
            Kim,J.W. and Ahn,Y.H.
  TITLE     Identification of Creb3l4 as an essential negative regulator of
            adipogenesis
  JOURNAL   Cell Death Dis 5 (11), e1527 (2014)
   PUBMED   25412305
  REMARK    GeneRIF: Creb3l4 is an essential negative regulator of
            adipogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1476)
  AUTHORS   Gil,S., Yosef,D., Golan,N. and Don,J.
  TITLE     The enigma of ATCE1, an acrosome-associated transcription factor
  JOURNAL   Dev Biol 298 (1), 201-211 (2006)
   PUBMED   16925989
  REMARK    GeneRIF: Expression of full-length ATCE1 in various cell lines
            revealed ER and Golgi localization whereas truncation of the
            C-terminus allowed entrance into the nucleus. A speculation that
            ATCE1 might be paternally delivered to newly formed zygote is
            discussed.
REFERENCE   6  (bases 1 to 1476)
  AUTHORS   El-Alfy,M., Azzi,L., Lessard,J., Lavergne,E., Pelletier,M. and
            Labrie,C.
  TITLE     Stage-specific expression of the Atce1/Tisp40alpha isoform of
            CREB3L4 in mouse spermatids
  JOURNAL   J Androl 27 (5), 686-694 (2006)
   PUBMED   16728718
  REMARK    GeneRIF: we show that Atce1/Tisp40alpha is the major form of
            CREB3L4 in mouse testis. These findings suggest that
            testis-specific isoforms of Creb3l4 could play an important role in
            spermatid differentiation.
REFERENCE   7  (bases 1 to 1476)
  AUTHORS   Nagamori,I., Yomogida,K., Adams,P.D., Sassone-Corsi,P. and
            Nojima,H.
  TITLE     Transcription factors, cAMP-responsive element modulator (CREM) and
            Tisp40, act in concert in postmeiotic transcriptional regulation
  JOURNAL   J Biol Chem 281 (22), 15073-15081 (2006)
   PUBMED   16595651
  REMARK    GeneRIF: Tisp40 and CREM bind to the Tisp40 promoter in vivo
REFERENCE   8  (bases 1 to 1476)
  AUTHORS   Adham,I.M., Eck,T.J., Mierau,K., Muller,N., Sallam,M.A.,
            Paprotta,I., Schubert,S., Hoyer-Fender,S. and Engel,W.
  TITLE     Reduction of spermatogenesis but not fertility in Creb3l4-deficient
            mice
  JOURNAL   Mol Cell Biol 25 (17), 7657-7664 (2005)
   PUBMED   16107712
  REMARK    GeneRIF: Creb3l4 plays a role in male germ cell development
REFERENCE   9  (bases 1 to 1476)
  AUTHORS   Nagamori,I., Yabuta,N., Fujii,T., Tanaka,H., Yomogida,K.,
            Nishimune,Y. and Nojima,H.
  TITLE     Tisp40, a spermatid specific bZip transcription factor, functions
            by binding to the unfolded protein response element via the Rip
            pathway
  JOURNAL   Genes Cells 10 (6), 575-594 (2005)
   PUBMED   15938716
  REMARK    GeneRIF: TISP40 functions by binding to the unfolded protein
            response element via the Rip pathway.
REFERENCE   10 (bases 1 to 1476)
  AUTHORS   Stelzer,G. and Don,J.
  TITLE     Atce1: a novel mouse cyclic adenosine
            3',5'-monophosphate-responsive element-binding protein-like gene
            exclusively expressed in postmeiotic spermatids
  JOURNAL   Endocrinology 143 (5), 1578-1588 (2002)
   PUBMED   11956138
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC119825.11, AB052779.1 and
            BB026279.1.
            
            On Apr 17, 2015 this sequence version replaced XM_006502312.2.
            
            Summary: This gene encodes a CREB (cyclic AMP-responsive
            element-binding) protein with a transmembrane domain which
            localizes it to the ER membrane. The encoded protein may play a
            role in adiposity and male germ cell development. Homozygous
            knockout mice for this gene show increased adipogenesis, elevated
            testicular germ cell apoptosis and defects in spermatogenesis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (1, also known as Tisp40beta or CREB3L4beta).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049978.1, AB052779.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC119825.11        138549-138586       c
            39-1404             AB052779.1         1-1366
            1405-1476           BB026279.1         245-316
FEATURES             Location/Qualifiers
     source          1..1476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.21 cM"
     gene            1..1476
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /note="cAMP responsive element binding protein 3-like 4"
                     /db_xref="GeneID:78284"
                     /db_xref="MGI:MGI:1916603"
     exon            1..126
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            127..241
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1243
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /note="isoform 1 is encoded by transcript variant 2;
                     cyclic AMP-responsive element-binding protein 3-like
                     protein 4; attaching to CRE-like 1; transcript induced in
                     spermiogenesis protein 40; cAMP-responsive element-binding
                     protein 3-like protein 4; androgen-induced basic leucine
                     zipper"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 4 isoform 1"
                     /protein_id="NP_001294863.1"
                     /db_xref="CCDS:CCDS17524.1"
                     /db_xref="GeneID:78284"
                     /db_xref="MGI:MGI:1916603"
                     /translation="MELGCPELLEPPEDIFSTGSFLELGFNGPASKVPVTRGLQKSEP
                     DDFLNLFIDPNMIHCSETSPGRDSGVSEDPGSPAQQASSSPALYEVVYDSGTLQGTQR
                     EAGPTFGLISIQIDQWTPALMVPDACTVSGLPSDSHRHILPRVSTRAPAPPAAMPSCQ
                     HHLFLTDEEKQLLAQEGITLPSHLPLTKAEERILKKIRRKIRNKQSAQDSRRRKKEYL
                     DGLESRVAACSEQNQKLQRKVQELERQNIFLMEQVRQLQKLTAQTSSRAAQTSTCVLI
                     LLFSLALIILPSFSPFQGQSEARPEDYQLHGVISRNILTHENVTENLESPVLKSKLEE
                     LPEAPTTNGSTKTHLKMRVKARPPGQIRGMVHTDEM"
     exon            242..476
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            477..598
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            599..694
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            695..801
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            802..870
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            871..955
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1052
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1476
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /note="hexamer: AATAAA"
     polyA_site      1405
                     /gene="Creb3l4"
                     /gene_synonym="1700012K17Rik; 5330432F22Rik; acre1;
                     AIBZIP; CREB4; JAL; TISP40"
                     /note="major polyA site"
ORIGIN      
        1 ctgattgggc aggaccagga tacagatcct ggtggaaaga aaaggtgtag tgtttggggc
       61 ttcagcgggc taggctggtt tggcagagca aagttctccg aacaacaact aaagagaata
      121 aaacagaaac atggagctcg ggtgccctga gttgctggaa cccccagaag atatcttctc
      181 gacgggatcc ttcctggagc tgggattcaa cggtcccgcg tcaaaggtcc cggtgaccag
      241 gggccttcag aagagtgaac ctgacgattt cctgaacctc tttatcgatc ccaatatgat
      301 acactgctca gaaacatctc ctggtaggga cagtggggtc tctgaagatc ctggctcccc
      361 tgcccaacag gcttccagtt cccctgccct ctatgaggtt gtctatgatt cagggaccct
      421 acagggaact cagcgggaag ctgggccaac cttcggactc atctctattc agatagatca
      481 gtggacccct gcacttatgg tccctgatgc atgcacagtc agtggactgc cctccgattc
      541 gcatagacat atcctgccta gggtcagcac cagagcccca gcacctcctg cagccatgcc
      601 gtcctgccaa catcatctgt tcctgacaga tgaagaaaag caactgctgg cacaagaagg
      661 gattactctg ccctctcacc tgcccctcac caaggcagag gagagaatac tcaagaagat
      721 caggaggaaa atccgcaaca agcagtcggc tcaggacagc cggcggcgga agaaagaata
      781 cttagatggg ctggagagca gagtggcggc ctgttcggaa cagaatcaga aactacagag
      841 aaaggtccag gagctggaga ggcagaacat cttcttgatg gaacaggtcc gccagttaca
      901 gaagctcact gctcagacct ccagcagagc tgcccagacc agcacctgtg ttctgattct
      961 tcttttttca ctggctctca tcatcctgcc cagtttcagc ccctttcagg gtcaatcaga
     1021 agctaggccc gaggattatc agcttcatgg agtgatttcc agaaatatct tgactcacga
     1081 gaacgtaaca gaaaacctgg agagtccagt gctaaagtcc aaactggagg agctacctga
     1141 agccccaact acaaatggtt caacaaagac acatctgaag atgcgagtga aggcgagacc
     1201 ccctggacag atcaggggaa tggtgcatac agatgagatg taagccaatc acacaagaca
     1261 ccacacaggc ttccctatca ccttttatca tgtggcaggg cacctcaaat gcttgtcata
     1321 catttgtgat ttcatttctt ctttgtggta aggtcaaagg gaaacaagtt ttaacttgga
     1381 aataaacttc ctagctcaaa ttctatccca agtttttcac tatgtaaact aagctggtct
     1441 caaactcttg acttgcctac aagtatatag taccac
//
