LOCUS       NM_001382818            1928 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus cAMP responsive element binding protein 3-like 3
            (Creb3l3), transcript variant 1, mRNA.
ACCESSION   NM_001382818 XM_030244976
VERSION     NM_001382818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1928)
  AUTHORS   Deng,X., Liu,B., Jiang,Q., Li,G., Li,J. and Xu,K.
  TITLE     CREBH promotes autophagy to ameliorate NASH by regulating Coro1a
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166914 (2024)
   PUBMED   37837948
REFERENCE   2  (bases 1 to 1928)
  AUTHORS   Vecchi,C., Montosi,G., Garuti,C., Canali,S., Sabelli,M.,
            Bergamini,E., Ricci,A., Buzzetti,E., Corradini,E. and
            Pietrangelo,A.
  TITLE     CREB-H is a stress-regulator of hepcidin gene expression during
            early postnatal development
  JOURNAL   J Mol Med (Berl) 101 (9), 1113-1124 (2023)
   PUBMED   37493829
  REMARK    GeneRIF: CREB-H is a stress-regulator of hepcidin gene expression
            during early postnatal development.
REFERENCE   3  (bases 1 to 1928)
  AUTHORS   Ohta,K., Ito,M., Chida,T., Nakashima,K., Sakai,S., Kanegae,Y.,
            Kawasaki,H., Aoshima,T., Takabayashi,S., Takahashi,H., Kawata,K.,
            Shoji,I., Sawasaki,T., Suda,T. and Suzuki,T.
  TITLE     Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation
  JOURNAL   PLoS Pathog 19 (8), e1011591 (2023)
   PUBMED   37585449
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1928)
  AUTHORS   Junli,Z., Shuhan,W., Yajuan,Z., Xiaoling,D., Jiahuan,L. and
            Keshu,X.
  TITLE     The Role and Mechanism of CREBH Regulating SIRT3 in Metabolic
            Associated Fatty Liver Disease
  JOURNAL   Life Sci 306, 120838 (2022)
   PUBMED   35902030
  REMARK    GeneRIF: The Role and Mechanism of CREBH Regulating SIRT3 in
            Metabolic Associated Fatty Liver Disease.
REFERENCE   5  (bases 1 to 1928)
  AUTHORS   Zhang,J., Zhao,Y., Wang,S., Li,G. and Xu,K.
  TITLE     CREBH alleviates mitochondrial oxidative stress through SIRT3
            mediating deacetylation of MnSOD and suppression of Nlrp3
            inflammasome in NASH
  JOURNAL   Free Radic Biol Med 190, 28-41 (2022)
   PUBMED   35926687
  REMARK    GeneRIF: CREBH alleviates mitochondrial oxidative stress through
            SIRT3 mediating deacetylation of MnSOD and suppression of Nlrp3
            inflammasome in NASH.
REFERENCE   6  (bases 1 to 1928)
  AUTHORS   Luebke-Wheeler,J., Zhang,K., Battle,M., Si-Tayeb,K., Garrison,W.,
            Chhinder,S., Li,J., Kaufman,R.J. and Duncan,S.A.
  TITLE     Hepatocyte nuclear factor 4alpha is implicated in endoplasmic
            reticulum stress-induced acute phase response by regulating
            expression of cyclic adenosine monophosphate responsive element
            binding protein H
  JOURNAL   Hepatology 48 (4), 1242-1250 (2008)
   PUBMED   18704925
  REMARK    GeneRIF: HNF4alpha has a role in controlling the acute phase
            response of the liver induced by ER stress by regulating expression
            of CrebH.
REFERENCE   7  (bases 1 to 1928)
  AUTHORS   Li,X., Madison,B.B., Zacharias,W., Kolterud,A., States,D. and
            Gumucio,D.L.
  TITLE     Deconvoluting the intestine: molecular evidence for a major role of
            the mesenchyme in the modulation of signaling cross talk
  JOURNAL   Physiol Genomics 29 (3), 290-301 (2007)
   PUBMED   17299133
REFERENCE   8  (bases 1 to 1928)
  AUTHORS   Zhang,K., Shen,X., Wu,J., Sakaki,K., Saunders,T., Rutkowski,D.T.,
            Back,S.H. and Kaufman,R.J.
  TITLE     Endoplasmic reticulum stress activates cleavage of CREBH to induce
            a systemic inflammatory response
  JOURNAL   Cell 124 (3), 587-599 (2006)
   PUBMED   16469704
  REMARK    GeneRIF: molecular mechanism for activation of an ER-localized
            transcription factor, CREBH
REFERENCE   9  (bases 1 to 1928)
  AUTHORS   Chin,K.T., Zhou,H.J., Wong,C.M., Lee,J.M., Chan,C.P., Qiang,B.Q.,
            Yuan,J.G., Ng,I.O. and Jin,D.Y.
  TITLE     The liver-enriched transcription factor CREB-H is a growth
            suppressor protein underexpressed in hepatocellular carcinoma
  JOURNAL   Nucleic Acids Res 33 (6), 1859-1873 (2005)
   PUBMED   15800215
  REMARK    GeneRIF: CREB-H is a liver-enriched bZIP transcription factor that
            may be involved in hepatic physiology and hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1928)
  AUTHORS   Puttagunta,R., Gordon,L.A., Meyer,G.E., Kapfhamer,D.,
            Lamerdin,J.E., Kantheti,P., Portman,K.M., Chung,W.K., Jenne,D.E.,
            Olsen,A.S. and Burmeister,M.
  TITLE     Comparative maps of human 19p13.3 and mouse chromosome 10 allow
            identification of sequences at evolutionary breakpoints
  JOURNAL   Genome Res 10 (9), 1369-1380 (2000)
   PUBMED   10984455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152500.7.
            
            On May 22, 2020 this sequence version replaced XM_030244976.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028820.1, AF392874.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC152500.7         5655-5743
            90-221              AC152500.7         6317-6448
            222-519             AC152500.7         6811-7108
            520-626             AC152500.7         8063-8169
            627-764             AC152500.7         8802-8939
            765-871             AC152500.7         9630-9736
            872-940             AC152500.7         11661-11729
            941-1025            AC152500.7         12132-12216
            1026-1122           AC152500.7         12500-12596
            1123-1928           AC152500.7         13112-13917
FEATURES             Location/Qualifiers
     source          1..1928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1928
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /note="cAMP responsive element binding protein 3-like 3"
                     /db_xref="GeneID:208677"
                     /db_xref="MGI:MGI:2384786"
     exon            1..89
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1502
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /note="transcription factor CREB-H; cAMP-responsive
                     element-binding protein 3-like protein 3"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 3"
                     /protein_id="NP_001369747.1"
                     /db_xref="GeneID:208677"
                     /db_xref="MGI:MGI:2384786"
                     /translation="MDGDIAAGKMASPVCAMAPLDSMEVLDLLFDRQDGILRNVELAE
                     GWILAREEQKVLLNSDSDEFLNCILGPGDSDPSSPLWSPADSDSGISEDLPSDPQDTP
                     PRSGTEPANTVARCHTREQGKGPCPSYLPSTPCPEPPRTQVQESSVAIDLDMWSTDTL
                     YPEEPAGSPSRFNLTVKELLLSGGSGDLQQHSLAASQLLGPGSGHCQELVLTEDEKKL
                     LAKEGVTLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLENRMSACTA
                     QNQELQRKVLHLEKQNLSLLEQLKHLQALVVQSTSKPAHAGTCIAVLLLSFALIILPS
                     ISPFNSNKVDSPGDFVPVRVFSRTLHNHAASRVAPDVTPGSEVPGPWPDVGTPHKGPS
                     SGGLSADWGNFLEIPMLDNLTEELDNSTLVLANSTEDLGRATLLDWVASEPLLSPGRV
                     GLEIPGEMWLSWVPRWLRVRLVQDALGVL"
     exon            90..221
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            222..519
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            520..626
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            627..764
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            765..871
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            872..940
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1025
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1122
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1928
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="Creb3l3"
                     /gene_synonym="CREB-H; D10Bur1e"
                     /note="major polyA site"
ORIGIN      
        1 ggcaaaggct gtagcaggcg gtgacaggga cccgaaaaga ggctgccaca ggcacgggac
       61 tcatggatgg ggacatagcg gctggaaaga tggcgtcccc tgtctgtgct atggcgccct
      121 tggacagcat ggaggtcctt gacctcctgt ttgatcggca ggacggcatc ctgagaaacg
      181 tggagctggc cgagggctgg atcctcgcca gagaggagca gaaagttcta ctaaattctg
      241 attctgatga attcctaaat tgcatcctgg gacctggaga ctctgacccc agctctccat
      301 tatggtcccc cgctgacagt gacagtggca tctctgagga tctaccttca gacccccagg
      361 acacccctcc tcgtagtggc actgaaccag ccaacacggt agccaggtgt cacaccaggg
      421 agcaaggcaa ggggccctgc ccctcctatc tgcccagcac cccatgccct gagcctccaa
      481 ggacacaagt ccaggagtcc tcagtggcca ttgacctgga catgtggagc acagataccc
      541 tgtacccgga ggagccggct ggctcgccct cccgcttcaa cctcactgtg aaggaactgc
      601 tgctgtccgg tggcagcggg gacttgcaac agcattcctt ggctgcctcc cagctgctgg
      661 gacctgggag tgggcactgc caggagctgg tgctgacaga ggatgagaag aagctgctgg
      721 ctaaagaggg ggtgaccctc cccacccagc tgcctctcac caagtatgag gaacgagttt
      781 tgaaaaaaat ccgcagaaag atccggaaca aacagtcagc tcaagaaagc aggaagaaga
      841 aaaaagaata cattgatggt ctggagaacc ggatgtcagc gtgtactgcc cagaaccagg
      901 agctgcagag gaaggttttg catttagaaa agcaaaattt gtctcttctg gagcagctga
      961 aacacctgca ggcacttgtg gtccagtcaa ccagcaagcc agcccatgca ggcacctgca
     1021 tagcggtcct tctgctgtcc ttcgccctga tcatcctccc ctccatcagc cctttcaact
     1081 ccaacaaagt tgacagccct ggagacttcg tgccagtgcg agtgttttcc agaaccctcc
     1141 acaaccacgc tgcatcccgc gtggctcccg atgtcacccc aggatctgag gtcccaggac
     1201 cttggcccga cgttggtacc ccccacaaag gcccttcctc cggtggtctc agtgcagact
     1261 ggggaaattt tctggaaatt ccaatgttgg acaacctgac agaagagcta gacaactcca
     1321 ccctggtgct ggccaactcc acagaggacc tgggacgggc caccctgctg gactgggtgg
     1381 cttcagaacc actgctcagt ccaggccggg ttgggctgga gataccaggg gagatgtggc
     1441 tgtcctgggt accaaggtgg cttagggtcc gtctggtgca agatgcattg ggggtgctgt
     1501 gacagactca gacagccctg gggacgactg cctcctggag aagctgaccc ccaagtcagg
     1561 gggaaatggg gtttccaggc acagagacat gaaggccctg gggtagaaca ggaaccagag
     1621 ccctttaccc atacatgcag acagactgac actaacacct gaaccctaac ctccaaccat
     1681 ggagctccta ctctcccctg accaccagga agatgcagag tctctgggac ctgggcttcc
     1741 caaatcaagg tttagcccac aaacttccat cttcctcttt tggagagagg tcttcctctt
     1801 gtagaccagg ctggcctcag atttacagag ctctacctgc ttctgtgtct caagtgctag
     1861 gattaaaggt gtgagcacca cctccttttc taagactttg tgaccttcaa taaagtattt
     1921 tgacaaaa
//
