LOCUS       NM_178661               3318 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cAMP responsive element binding protein 3-like 2
            (Creb3l2), mRNA.
ACCESSION   NM_178661
VERSION     NM_178661.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3318)
  AUTHORS   Sue,N., Thai,L.M., Saito,A., Boyer,C.K., Fordham,A.M., Yan,C.,
            Davenport,A., Tao,J., Bensellam,M., Cantley,J., Shi,Y.C.,
            Stephens,S.B., Imaizumi,K. and Biden,T.J.
  TITLE     Independent activation of CREB3L2 by glucose fills a regulatory gap
            in mouse beta-cells by co-ordinating insulin biosynthesis with
            secretory granule formation
  JOURNAL   Mol Metab 79, 101845 (2024)
   PUBMED   38013154
  REMARK    GeneRIF: Independent activation of CREB3L2 by glucose fills a
            regulatory gap in mouse beta-cells by co-ordinating insulin
            biosynthesis with secretory granule formation.
REFERENCE   2  (bases 1 to 3318)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3318)
  AUTHORS   Ariyasu,D., Kubo,E., Higa,D., Shibata,S., Takaoka,Y., Sugimoto,M.,
            Imaizumi,K., Hasegawa,T. and Araki,K.
  TITLE     Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly
            Inherited GH Deficiency in Humanized GH1 Mouse Models
  JOURNAL   Endocrinology 160 (11), 2673-2691 (2019)
   PUBMED   31436800
REFERENCE   4  (bases 1 to 3318)
  AUTHORS   Khetchoumian,K., Balsalobre,A., Mayran,A., Christian,H.,
            Chenard,V., St-Pierre,J. and Drouin,J.
  TITLE     Pituitary cell translation and secretory capacities are enhanced
            cell autonomously by the transcription factor Creb3l2
  JOURNAL   Nat Commun 10 (1), 3960 (2019)
   PUBMED   31481663
  REMARK    GeneRIF: Creb3l2 expression and its downstream regulatory network
            are dependent on Tpit. Creb3l2 acts by direct targeting of
            translation effector genes in parallel with signaling pathways that
            otherwise regulate protein synthesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3318)
  AUTHORS   Nakayama,S., Yumimoto,K., Kawamura,A. and Nakayama,K.I.
  TITLE     Degradation of the endoplasmic reticulum-anchored transcription
            factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent
            on the kinase GSK-3
  JOURNAL   J Biol Chem 293 (15), 5705-5714 (2018)
   PUBMED   29472293
REFERENCE   6  (bases 1 to 3318)
  AUTHORS   Sheng,Z., Li,L., Zhu,L.J., Smith,T.W., Demers,A., Ross,A.H.,
            Moser,R.P. and Green,M.R.
  TITLE     A genome-wide RNA interference screen reveals an essential
            CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with
            therapeutic implications
  JOURNAL   Nat Med 16 (6), 671-677 (2010)
   PUBMED   20495567
  REMARK    GeneRIF: induction by RAS-mitogen-activated protein kinase or
            phosphoinositide-3-kinase signaling cascade, which directly
            activates ATF5 expression and glioma survival
REFERENCE   7  (bases 1 to 3318)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 3318)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 3318)
  AUTHORS   Saito,A., Hino,S., Murakami,T., Kanemoto,S., Kondo,S., Saitoh,M.,
            Nishimura,R., Yoneda,T., Furuichi,T., Ikegawa,S., Ikawa,M.,
            Okabe,M. and Imaizumi,K.
  TITLE     Regulation of endoplasmic reticulum stress response by a
            BBF2H7-mediated Sec23a pathway is essential for chondrogenesis
  JOURNAL   Nat Cell Biol 11 (10), 1197-1204 (2009)
   PUBMED   19767744
REFERENCE   10 (bases 1 to 3318)
  AUTHORS   Kondo,S., Saito,A., Hino,S., Murakami,T., Ogata,M., Kanemoto,S.,
            Nara,S., Yamashita,A., Yoshinaga,K., Hara,H. and Imaizumi,K.
  TITLE     BBF2H7, a novel transmembrane bZIP transcription factor, is a new
            type of endoplasmic reticulum stress transducer
  JOURNAL   Mol Cell Biol 27 (5), 1716-1729 (2007)
   PUBMED   17178827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202578.1, BC138471.1 and AK036712.1.
            
            On Dec 30, 2009 this sequence version replaced NM_178661.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036712.1, AK041669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BY202578.1         2-155
            155-2376            BC138471.1         1-2222
            2377-3318           AK036712.1         2369-3310
FEATURES             Location/Qualifiers
     source          1..3318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 16.18 cM"
     gene            1..3318
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /note="cAMP responsive element binding protein 3-like 2"
                     /db_xref="GeneID:208647"
                     /db_xref="MGI:MGI:2442695"
     exon            1..450
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1914
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /note="cAMP-responsive element-binding protein 3-like
                     protein 2"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 2"
                     /protein_id="NP_848776.2"
                     /db_xref="CCDS:CCDS20006.1"
                     /db_xref="GeneID:208647"
                     /db_xref="MGI:MGI:2442695"
                     /translation="MEVLESGEQSVLQWDRKLSELSEPGETEALMYHTHFSELLDEFS
                     QNVLGQLLSDPFLSEKSESMEVEPSPTSPAPLIQAEHSYSLSEEPRTQSPFTHAATSD
                     SFNDEEVESEKWYLSTEFPSATIKTEPITEEQPPGLVPSVTLTITAISTPFEKEESPL
                     DMNAGGDSSCQTLIPKIKLEPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSL
                     SPNPRLHPFSLSQAHSPARAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLVA
                     EGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENL
                     ELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFG
                     SFFQGYGPYPSATKMALPSQHPLSEPYTASVVRSRNLLIYEEHAPLEESSSPASAGEL
                     GGWDRGSSLLRASSGLEALPEVDLPHFLISNETSLEKSVLLELQQHLVSSKLEGNETL
                     KVVELERRVNATF"
     exon            451..667
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            668..843
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            844..931
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1116
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1263
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1322
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1391
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1491
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1618
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1838
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..3318
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /note="hexamer: AGTAAA"
     polyA_site      3217
                     /gene="Creb3l2"
                     /gene_synonym="BBF2H7; C530025K05Rik; SCIRR69"
                     /note="major polyA site"
ORIGIN      
        1 gggagtctca aagtttgtct ggagccctag tggggagtgg gcttgttgcg cgaggacttt
       61 cttgggatga gcgctgcctt tttgccttcc ttttggatgc acagcccgat ttaacccctg
      121 caccttccgc ccgatcccag caggcttgtc ctccccgggg agtcacagat ttccgaggac
      181 aagggtcgcg tagccttcgg cagggctctc ccgagttcct gctccagtgc ataagttcca
      241 cgcgcgcaca cgccaagtac acggggagaa gcgtctcacc ggcccgcggc ggctctgcgc
      301 ggtcccctcc tgcctcagca tcctcggccc tgcgcggcgc ccaccgccat ggaggtgctg
      361 gagagcgggg agcagagcgt cctgcagtgg gaccgcaagc tgagcgagct gtcagagccc
      421 ggagagactg aggccctcat gtaccacacg cacttctcgg agctcctaga cgagttttcc
      481 cagaacgtcc tgggtcagct cctgagtgac cctttcctct cagagaagag cgagtcaatg
      541 gaggtggagc catctccaac atcaccagcg cctctcatcc aggctgaaca cagctactct
      601 ctgagcgagg agccccggac tcagtcacca tttacccatg cggctaccag cgacagcttc
      661 aatgacgagg aggtggagag tgaaaaatgg tacctgtcta cagagtttcc ttcagctacc
      721 atcaagacag agccaatcac agaggagcag cccccgggac ttgtcccttc tgtcactctg
      781 accatcacag ccatttccac tccttttgaa aaagaagagt cccctctgga tatgaatgct
      841 gggggggact cctcatgcca gacgcttatt cctaagatta agctggagcc gcacgaagtg
      901 gatcagttct taaacttctc cccgaaagaa gcctccgtgg atcaactgca cttaccacca
      961 acaccaccca gtagtcacag cagtgactct gagggcagct tgagccccaa cccacgcctg
     1021 catcccttca gcctgtctca ggcccacagc cctgccagag ccatgccccg gggcccctct
     1081 gccttgtcca catctcctct cctcacagct ccacataagc tgcagggatc gggccccctg
     1141 gtcctgacag aagaggagaa gaggaccctg gttgccgagg gctatcccat tcccaccaag
     1201 ctgcctctga caaaatctga ggagaaggcc ctgaagaaaa tccggagaaa gatcaagaat
     1261 aagatttctg cccaagaaag caggagaaag aagaaagaat acatggacag cctggagaaa
     1321 aaagtggagt cttgttcaac tgagaacttg gagcttcgga agaaggtgga ggtgctggag
     1381 aacaccaata ggactctcct tcagcaactt cagaagcttc agactttggt gatggggaag
     1441 gtctctcgaa cctgcaagtt agctggcaca cagactggca cctgcctcat ggtcgttgtg
     1501 ctttgctttg ctgttgcatt tggaagcttc tttcaaggct atgggcctta tccttctgcc
     1561 accaagatgg ctctgcccag ccagcatcct ctgtcagagc catacacagc ctccgtggtg
     1621 agatccagga acctgctaat ctatgaggaa cacgctcccc tggaagagtc gtcgagccca
     1681 gcctcagccg gggagctggg gggctgggac agaggctcct ctctgctcag ggcatcgtcg
     1741 gggcttgagg ccctgccaga ggtggatctt ccccatttcc ttatctccaa tgagacgagc
     1801 ttggagaagt cagtactgtt ggagcttcag cagcacctgg tcagcagcaa actggaaggg
     1861 aacgaaacac tcaaggttgt agagctggag aggagagtga acgccacctt ctgaggagag
     1921 ctccaccctc ctcttctcct aactccatct gatcgtcctt tcagtttccc cttcaccact
     1981 ggatctcgag gaggagatgg cctagtgtta cggctcgaga caggaggcca gcccaggggg
     2041 ttctgcttat gtgtccccgt ggctctccac aaaagggagc tagcacctct ccatcccttt
     2101 ctcttactgc cattggaaat tattttaggg ctgagatagg ggtggaacga gcaggcttgt
     2161 ttccaccaat agtgccaaga agacactgcc tgattcttcc ccgggaggag tgactcctct
     2221 gaagaagaca tgactcatgt tcagttgaga ccccagactc tagccacaca catgccacag
     2281 acatgccagg gagtggcaaa gcactgactc ctgagctccc ttcctcacta ggactccagt
     2341 gtgaccctgc actgagagga ccaaagcgtc attgcagtct tctctccacc ctgtaccccg
     2401 gagtcctgat tggatgtctg cagaggcaga tggggctccc accatatttt caggccgcaa
     2461 gtgcaattcc tgaaggcatc aggctcttct ctcccaggct ctcctgccca ctgtgttgtt
     2521 tgtaggacac ccccacaccc actcatacac agcctgcatc tccacaggac aatagctctg
     2581 tctccctggc ctcccctccc catttgtaaa tagtatttat tagcttgctc aagctcccag
     2641 ctggccatag tgaaaagatt tcccctttca accagcaaag tcttctgttg gcctttggaa
     2701 caggagagtc cccggaatct aggaccctag tctttgtact tgatgccttg tttcccccct
     2761 tttcttcttt aaaattgggg acctataaca tcatcgctgt tgcggaatcc acttaggcat
     2821 gtgtcccctg atggatgaat acatgggaat ggtggatact gtcttctgac tcaggctcta
     2881 ggctccatgg cttcctctct ctggtcctgc cacacagaag gaaagccctg tccaggataa
     2941 tgagcgttgc tgacaccctt gctagcttgt cctgcctacc tgcttacccc actccctcac
     3001 cttcctcctt cccttctgcc ctccatccac ctgccttaac taattggggc tggagttggt
     3061 catttttgta cacccacagt ggtacctttt acagtcaggt ttggatactt tgcagctcat
     3121 ccaaagagac ataactaaac cctaaactct ttttttgttg ttgttgttgt tgtttttttt
     3181 ttttatgatt aaaaagtaaa aattgtagtt taaaaaatcc tttcctcttt catacaaata
     3241 agaaatggaa attgctcgtt tattgtataa gatagaagat tcgtttaaag tgtttcccca
     3301 cccccacccc cagcttgt
//
