LOCUS       NM_013497               1559 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus cAMP responsive element binding protein 3 (Creb3),
            mRNA.
ACCESSION   NM_013497
VERSION     NM_013497.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Locke,B., Campbell,E. and Lu,R.
  TITLE     CREB3 mediates the transcriptional regulation of PGC-1alpha, a
            master regulator of energy homeostasis and mitochondrial biogenesis
  JOURNAL   FEBS Lett 598 (14), 1730-1739 (2024)
   PUBMED   38697949
  REMARK    GeneRIF: CREB3 mediates the transcriptional regulation of
            PGC-1alpha, a master regulator of energy homeostasis and
            mitochondrial biogenesis.
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Smith,B.S., Hewitt,T., Bakovic,M. and Lu,R.
  TITLE     ER stress-associated transcription factor CREB3 is essential for
            normal Ca2+, ATP, and ROS homeostasis
  JOURNAL   Mitochondrion 69, 10-17 (2023)
   PUBMED   36627030
  REMARK    GeneRIF: ER stress-associated transcription factor CREB3 is
            essential for normal Ca[2+], ATP, and ROS homeostasis.
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Smith,B.S., Diaguarachchige De Silva,K.H., Hashemi,A., Duncan,R.E.,
            Grapentine,S., Bakovic,M. and Lu,R.
  TITLE     Transcription factor CREB3 is a potent regulator of high-fat
            diet-induced obesity and energy metabolism
  JOURNAL   Int J Obes (Lond) 46 (8), 1446-1455 (2022)
   PUBMED   35637262
  REMARK    GeneRIF: Transcription factor CREB3 is a potent regulator of
            high-fat diet-induced obesity and energy metabolism.
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Xu,J., Xu,L., Sui,P., Chen,J., Moya,E.A., Hume,P., Janssen,W.J.,
            Duran,J.M., Thistlethwaite,P., Carlin,A., Gulleman,P.,
            Banaschewski,B., Goldy,M.K., Yuan,J.X., Malhotra,A., Pryhuber,G.,
            Crotty-Alexander,L., Deutsch,G., Young,L.R. and Sun,X.
  TITLE     Excess neuropeptides in lung signal through endothelial cells to
            impair gas exchange
  JOURNAL   Dev Cell 57 (7), 839-853 (2022)
   PUBMED   35303432
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Shen,W.B., Plachez,C., Mongi,A.S. and Richards,L.J.
  TITLE     Identification of candidate genes at the corticoseptal boundary
            during development
  JOURNAL   Gene Expr Patterns 6 (5), 471-481 (2006)
   PUBMED   16458080
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Luciano,R.L. and Wilson,A.C.
  TITLE     N-terminal transcriptional activation domain of LZIP comprises two
            LxxLL motifs and the host cell factor-1 binding motif
  JOURNAL   Proc Natl Acad Sci U S A 97 (20), 10757-10762 (2000)
   PUBMED   10984507
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Chen,C., Kim,M.G., Soo Lyu,M., Kozak,C.A., Schwartz,R.H. and
            Flomerfelt,F.A.
  TITLE     Characterization of the mouse gene, human promoter and human cDNA
            of TSCOT reveals strong interspecies homology
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 159-169 (2000)
   PUBMED   10978518
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Burbelo,P.D. and Kozak,C.A.
  TITLE     Mapping of the murine LZIP gene (Creb3) to chromosome 4
  JOURNAL   Genomics 54 (2), 357-358 (1998)
   PUBMED   9828144
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Burbelo,P.D., Gabriel,G.C., Kibbey,M.C., Yamada,Y., Kleinman,H.K.
            and Weeks,B.S.
  TITLE     LZIP-1 and LZIP-2: two novel members of the bZIP family
  JOURNAL   Gene 139 (2), 241-245 (1994)
   PUBMED   8112612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132785.1 and BQ746877.1.
            
            On Feb 13, 2019 this sequence version replaced NM_013497.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.645694.1,
                                           SRR7652917.694829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1493              AK132785.1         35-1527
            1494-1559           BQ746877.1         602-667
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..1559
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /note="cAMP responsive element binding protein 3"
                     /db_xref="GeneID:12913"
                     /db_xref="MGI:MGI:99946"
     exon            1..302
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1295
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /note="CREB-3; transcription factor LZIP"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 3"
                     /protein_id="NP_038525.2"
                     /db_xref="CCDS:CCDS18102.1"
                     /db_xref="GeneID:12913"
                     /db_xref="MGI:MGI:99946"
                     /translation="MDPGGQDLLALDPGDQDLLGFLLEESGDLWAATEPDVKAPLDLE
                     LSPSENSVQELSDWEVEDLLSSLLSPSVSRDVLGSSSSSILHDHNYSLPQEHVSIDLD
                     TESFEKEGFHVTPLPGEERAAEQEMSRLILTEEEKKLLEKEGLTLPSTLPLTKVEEQV
                     LKRVRRKIRNKRAAQESRKKKKVYVVGLESRVLKYTAQNRELQNKVQRLEEQNLSLLD
                     QLRKLQAMVIEIANKTSSGSTCVLVLVFSFCLLLVPAMYSSDARGSVPAEYVVLHRKL
                     RALPSEDDHQPKPSALSSELPMDSTHQSLDSSEHMFLVSSNFSCVLYHAPQAEQPLHW
                     PLWDLSSEMLFSDSNLLLQANLSESEGWQPNHSPSLVIFQGRYSG"
     exon            303..459
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..530
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..620
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..727
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..796
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..881
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..966
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1559
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1345..1350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1365
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /note="major polyA site"
     regulatory      1475..1480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /note="hexamer: AATAGA"
     polyA_site      1494
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
     regulatory      1540..1545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1559
                     /gene="Creb3"
                     /gene_synonym="Luman; LZIP; LZIP-1; LZIP-2"
ORIGIN      
        1 agaagctgag agacgggtgc ggtttagagt gacagctagg cccttgtccc ggagtgacgg
       61 aggttaagtc gagccgactg gacagactga ggggtcgtgc ctgaggttcg gaggttggat
      121 ctgcgcggag ggatttctat ccatagatat cccaaatgga tcctggtggt caggatctgc
      181 tagctttgga tcccggtgat caggacctgc tgggcttcct gctagaggaa agcggagatt
      241 tgtgggctgc gactgagccg gacgtgaagg ctccgctgga cttagagctg tcaccttccg
      301 agaactccgt gcaagaactg agcgactggg aggtagagga tttactgagc tctctgctca
      361 gtccctcagt atcgcgggat gttctcggct cttccagctc ttccattctc catgatcaca
      421 actactccct tccacaggag cacgtctcca tagatctaga tactgagagc ttcgaaaagg
      481 aggggttcca cgtgactcca ctgccagggg aggaaagagc agcggaacag gagatgtcta
      541 ggctgatact gaccgaggaa gagaagaagc tcttggagaa ggaggggctc actctgccct
      601 caacccttcc tctcactaag gtggaggaac aagttctgaa acgagtgcgg aggaagattc
      661 gtaacaagag agcagctcaa gaaagccgca agaagaagaa ggtgtatgtc gtggggctgg
      721 agagcagggt cttgaaatac acagctcaga atcgggagct gcagaacaag gtgcagcgtt
      781 tggaggaaca gaatctgtcc cttctagatc aactgaggaa gcttcaagcc atggtgattg
      841 agatagccaa caaaaccagc agcggcagca cttgtgttct ggtcctcgtg ttctccttct
      901 gtcttctcct ggtacccgct atgtactcct ctgatgcaag gggaagtgtg cccgcggagt
      961 atgttgtgtt gcaccgcaag cttcgtgccc tccccagcga ggacgatcat cagccgaagc
     1021 catctgctct atcgtcagag ctacccatgg acagcacaca ccagtcactg gacagctcag
     1081 aacatatgtt cttggtctcc agcaactttt cctgtgtact gtaccacgcg cctcaggcag
     1141 agcagcccct gcactggcca ctctgggatc tttcttcaga gatgctcttc tccgactcca
     1201 accttctcct gcaggcaaac ctttcagaaa gcgagggatg gcaacctaac cacagccctt
     1261 ctttggtcat ctttcagggc aggtattcag gttaggtgtg aggatgtggg gtgtcctcag
     1321 cctgaggact cctgtctgta ttcaaataaa aaggagcagg ggaaagctgg cctttgctca
     1381 cgtgctctgt taggatgccc aggaactcag acacaccaca ctaactagtt ttctgagtat
     1441 tttatttata cccatatgta tctgttgccc cgtgaataga tttggagaca tttactggcc
     1501 ttgaatactt catccatgga aggactgggt agggtaagaa ataaataagt ggttcctca
//
