LOCUS       NM_133828               8389 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus cAMP responsive element binding protein 1 (Creb1),
            transcript variant A, mRNA.
ACCESSION   NM_133828
VERSION     NM_133828.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8389)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8389)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   3  (bases 1 to 8389)
  AUTHORS   He,C., Zeng,Z., Yang,Y., Ye,S., Wu,Q., Liu,X., Liu,C., Zeng,W. and
            Liu,S.
  TITLE     Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes
            chondrogenesis in osteoarthritis
  JOURNAL   Autoimmunity 57 (1), 2361749 (2024)
   PUBMED   39007896
  REMARK    GeneRIF: Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes
            chondrogenesis in osteoarthritis.
            Erratum:[Autoimmunity. 2024 Dec;57(1):2435720. doi:
            10.1080/08916934.2024.2435720.. PMID: 39621026]
REFERENCE   4  (bases 1 to 8389)
  AUTHORS   Morgan,H.J.N., Delfino,H.B.P., Schavinski,A.Z., Malone,S.A.,
            Charoy,C., Reis,N.G., Assis,A.P., Lautherbach,N., Silveira,W.A.,
            Heck,L.C., Guton,D., Domingos,A.I., Kettelhut,I.C., Montminy,M. and
            Navegantes,L.C.C.
  TITLE     Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate
            gluconeogenesis during cold
  JOURNAL   Metabolism 157, 155940 (2024)
   PUBMED   38878857
  REMARK    GeneRIF: Hepatic noradrenergic innervation acts via CREB/CRTC2 to
            activate gluconeogenesis during cold.
REFERENCE   5  (bases 1 to 8389)
  AUTHORS   Yan,Y.S., Mo,J.Y., Huang,Y.T., Zhu,H., Wu,H.Y., Lin,Z.L., Liu,R.,
            Liu,X.Q., Lv,P.P., Feng,C., Sheng,J.Z., Jin,M. and Huang,H.F.
  TITLE     Intrauterine hyperglycaemia during late gestation caused
            mitochondrial dysfunction in skeletal muscle of male offspring
            through CREB/PGC1A signaling
  JOURNAL   Nutr Diabetes 14 (1), 56 (2024)
   PUBMED   39043630
  REMARK    GeneRIF: Intrauterine hyperglycaemia during late gestation caused
            mitochondrial dysfunction in skeletal muscle of male offspring
            through CREB/PGC1A signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8389)
  AUTHORS   Barton,C.H., Ajioka,J.W., Roach,T.I. and Blackwell,J.M.
  TITLE     Mapping Creb-1 to chromosome 1 in the mouse
  JOURNAL   Genomics 14 (3), 790-792 (1992)
   PUBMED   1358811
REFERENCE   7  (bases 1 to 8389)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   8  (bases 1 to 8389)
  AUTHORS   Ruppert,S., Cole,T.J., Boshart,M., Schmid,E. and Schutz,G.
  TITLE     Multiple mRNA isoforms of the transcription activator protein CREB:
            generation by alternative splicing and specific expression in
            primary spermatocytes
  JOURNAL   EMBO J 11 (4), 1503-1512 (1992)
   PUBMED   1532935
REFERENCE   9  (bases 1 to 8389)
  AUTHORS   Struthers,R.S., Vale,W.W., Arias,C., Sawchenko,P.E. and
            Montminy,M.R.
  TITLE     Somatotroph hypoplasia and dwarfism in transgenic mice expressing a
            non-phosphorylatable CREB mutant
  JOURNAL   Nature 350 (6319), 622-624 (1991)
   PUBMED   1826763
REFERENCE   10 (bases 1 to 8389)
  AUTHORS   Capetanaki,Y., Kuisk,I., Rothblum,K. and Starnes,S.
  TITLE     Mouse vimentin: structural relationship to fos, jun, CREB and tpr
  JOURNAL   Oncogene 5 (5), 645-655 (1990)
   PUBMED   2140597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY315899.1, BY782293.1, AK044992.1, AC124361.4 and CD776417.1.
            
            On Nov 18, 2005 this sequence version replaced NM_133828.1.
            
            Transcript Variant: This variant (A) encodes isoform A.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044992.1, AK044993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY315899.1         11-54
            45-186              BY782293.1         2-143
            187-2598            AK044992.1         2-2413
            2599-7888           AC124361.4         4270-9559           c
            7889-8389           CD776417.1         8-508               c
FEATURES             Location/Qualifiers
     source          1..8389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.74 cM"
     gene            1..8389
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="cAMP responsive element binding protein 1"
                     /db_xref="GeneID:12912"
                     /db_xref="MGI:MGI:88494"
     exon            1..217
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..339
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1209
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="isoform A is encoded by transcript variant A;
                     cyclic AMP-responsive element-binding protein 1"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 1
                     isoform A"
                     /protein_id="NP_598589.2"
                     /db_xref="CCDS:CCDS15005.1"
                     /db_xref="GeneID:12912"
                     /db_xref="MGI:MGI:88494"
                     /translation="MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAA
                     HATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVD
                     SVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPI
                     YQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQ
                     ILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRL
                     MKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD"
     exon            340..486
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..587
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..730
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..913
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1064
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..8379
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6663..6668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6691
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
     regulatory      6779..6784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="hexamer: CATAAA"
     polyA_site      6801
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="major polyA site"
     regulatory      7119..7124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="hexamer: AATAAA"
     polyA_site      7149
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
     regulatory      8357..8362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
                     /note="hexamer: AATAAA"
     polyA_site      8379
                     /gene="Creb1"
                     /gene_synonym="2310001E10Rik; 3526402H21Rik; Creb; Creb-1"
ORIGIN      
        1 tcggcactgg gcggcgctgg ctggctccct ggctgcggct cctcagtcgg cggcggctgc
       61 tgctgcctgt ggcccgggcg gctgggagaa gcggagtgtt ggtgagtgac gcggcggagg
      121 tgtagtttga cgcggtgtgt tacgtggggg agagaataaa actccagcga gatccgggcc
      181 gcgaacgaaa gcagtgacgg aggagcttgt accaccggta actaaatgac catggaatct
      241 ggagcagaca accagcagag tggagatgct gctgtaacag aagctgaaaa tcaacaaatg
      301 acagttcaag cccagccaca gattgccaca ttagcccagg tatccatgcc agcagctcat
      361 gcaacatcat ctgctcccac tgtaacctta gtgcagctgc ccaatgggca gacagtccag
      421 gtccatggcg ttatccaggc ggcccagcca tcagttatcc agtctccaca agtccaaaca
      481 gttcagattt caactattgc agaaagtgaa gattcacagg agtctgtgga tagtgtaact
      541 gattcccaaa aacgaaggga aatcctttca aggaggcctt cctacaggaa aattttgaat
      601 gacttatctt ctgatgcacc aggggtgcca aggattgaag aagaaaagtc agaagaggag
      661 acttcagccc ctgccatcac cactgtaaca gtgccaaccc ccatttacca aactagcagt
      721 gggcagtaca ttgccattac ccagggagga gcaatacagc tggctaacaa tggtacggat
      781 ggggtacagg gcctgcagac attaaccatg accaatgcag ctgccactca gccgggtact
      841 accattctac agtatgcaca gaccactgat ggacagcaga ttctagtgcc cagcaaccaa
      901 gttgttgttc aagctgcctc aggcgatgta caaacatacc agatccgcac agcacccacg
      961 agcaccattg cccctggagt tgttatggcg tcctccccag cacttcctac acagcctgct
     1021 gaagaagcag cacggaagag agaggtccgt ctaatgaaga acagggaggc agcaagagaa
     1081 tgtcgtagaa agaagaaaga atatgtgaaa tgtttagaga acagagtggc agtgcttgaa
     1141 aaccaaaaca aaacattgat tgaggagcta aaagcactta aggaccttta ctgccacaaa
     1201 tcagattaat ttgggattta agttctctcc tgttacggtg gagaatggac tggcttggcc
     1261 acaaccagaa agacaagtaa acatttattt tctaaacatt tctttttttc tatgcgcaaa
     1321 actgcctgaa agcaactaca gaatttcatt catttctgct tttgcattaa actgtgaatg
     1381 ttccaaaaac tacttccact tctgccctca agaaatgtgc agcgccagga atcatgaaga
     1441 gacttctgcc ctccgtctcc accaccctca agaagtaatc atttgcttat ttgtaaattg
     1501 ttgggggaaa tgaggaaaat gaaatcttgg ctttcttatt tttgttttag gtttgttttg
     1561 tttgttttct tattaatgac ttcaaggttt gttgagctcc atgattgcct tagggacagt
     1621 tacccagcct gctgagctga cgtaatgtgt gggccacaca ggaaagtaag gaaggtgcaa
     1681 tgaagaagtg ttgactgcca aattaatgtt tttacacttt cattgtgaat tatgtcgaac
     1741 tattaaaaac atcctttaaa taaggatatt agtgtggtgt tgggagtaaa ctttatatgt
     1801 atgttccttt cttcagcact gacaagttgt ccttggtgct gagaagcacg gtattggcta
     1861 cagttcctct gtagggcagt tgttgcttct tcattcagtt ctgtgtgttc agcagtttga
     1921 atacattaac agaagtaacc aactgaatgg aaagcatggt tttgaatttt gagttaagtt
     1981 aaaatcatac tataaagctt attctggtga gtactaagtc ttaatgagta ggtgctggcc
     2041 aggaagctaa ctccttgagt tatacaataa ggtgtttaat aaataaagac ttttgtcctt
     2101 gctttccgaa tcctcatact gtcactcatt tacctagtcc actgctgcat ttacactgtg
     2161 cagccaacag gagcgttttc aagatgtcca gccaaagtga tggaaagtac taaatagaca
     2221 accttttcta tagtcatatt tttatcagag aatctcttgg gatttttttt tttaaatcaa
     2281 agaagttaca aggatgtgat tctaaaacat tgtgttaaat gcacacaaga aaagtaattt
     2341 ccttcagaca ttggagtgtg tgctatggta caatatttgg caaacacttt tttttttctc
     2401 ctaaaaaagg tggtactgct ttaactatcc aaaagctgtt ctgtttctga agatgtttct
     2461 acttacatcc ttacctatag tctacattta tgtgtaacat tgtttctgat aagacttagt
     2521 aataactcat ttttttttta ttaaacctaa taaaatctaa gagttacctc tttaaaagac
     2581 aaatatgagg acagtggagg ctggcatgtt aggttacttc acgtttgagg aagaactcag
     2641 actcagaaga gtgtcttata tttgctttgg gatattaaga aagttaatat taatatcagt
     2701 atacgtatga gcgggaactg tttggcccat ttctaagcta agactaggtt gctatctgta
     2761 aatgttctac gttgtttata acaaaccatt gtcttttttc aaggatgaac agtttgtgaa
     2821 ggacatgatt ctaggagttg agtgatgtaa taatccttct gtctggacag ttcaccagat
     2881 tctccagaag gctttcaaac ggctaaagtt tgatctttgt cctgctgagc ttgctgggaa
     2941 ggagatagca taaaagctgt ctgtgctagc aagtagatgt atcatttgct aaacgtggtg
     3001 aaacaaaaag gaagcagaat cacaaatctg tcaacaaact ggaattactt cacattaagt
     3061 cagaatgtca gattgaacat tttaaatgtc acaagtggaa aatttgccta gcgtgcagaa
     3121 gttgtaatct ctaagtgtct atcttcaaaa gtcgaggttt tctacataat gaggaaacag
     3181 gtggtctcct taacccttta gagaccaagg cagtctcagc catacttcct agttggatgg
     3241 atattaattt acagaggcct gggtctttat gcttggagca tgactgtact agtttgacac
     3301 cagttacttg ataatgtgag aaatatatgg tgttgtgaaa cctgactttg aaatttcagt
     3361 tcatacagaa agaaatcaaa gcctctttaa tgcaagctgg attttttttt taacatgaga
     3421 atgagaaaaa caaaaacaaa aacttgtttt tgagctatgt ggagaatctt tattaagaaa
     3481 atgacataat tttttaaaaa ctcttatatc caaaattgta tgtggccaca ttatcggtaa
     3541 tgttttctct tcatgttggc caaaagggaa tggaactgtc ataggaatct gtacatatgc
     3601 tactgatttg cctagagaat agaagtttgg tactgctcac tttgcatata tatagtggca
     3661 cttttatcta tagggcagat taactctaat aaaaatgaaa tggggatagg tttatttttg
     3721 atatattact cttctgagtt ttcaagcttt gatagtgttt aactgaaaaa tggtttagaa
     3781 agggctagat ccaatatgtt catatttaaa aaattgatat gagatacaat ttaagttctt
     3841 tatcaaaagc aagtaccata ttagcaacca tcatattgtc ctaggtgctg tgcttgttta
     3901 gatggtatag tgtgggtggg gacgtggcat tttgtaatat atgtgtacat atatacatac
     3961 atacagtata tcatctaaat gctctgagag ctggtatgtc aggaatgctg agtattatag
     4021 cgtattgagg tccggtgaga ttccactttg ctgtgctttc tcctgcatct cttctggtgt
     4081 ttcagtgact gttttactcc agcactcaca actgggtttt ctcttttctt ccagtttttt
     4141 attaggtttt tgttttgttt ggcttgatgc ttttgagtat gttaccagtc acttaaaaac
     4201 tcctaaaccc caagctcttt tccccctgct ttgtttctgg cagctataaa attggtaaga
     4261 acattttgaa aaaaggtttt aagagaattg tttcaagaat cattttgggc aaagactttt
     4321 catgtttcat ttgaacaggg atttttgtca agatgtgttt tgatggtagg ccagcaagca
     4381 gtgctactgt ctaaagcaca aaccagtcag gcaggctgtc cagccagaag ccctcttggc
     4441 tgaagccggt ctctgcctct caggactcct ccctactatt ttcgaccatt tagggtgaca
     4501 tggaatcata caaatattgg ggcttagaaa caaacattta tataacccgg aatgctttta
     4561 cgtacttgaa gtgacttcag tcaaaatgtt gcctttcctg tttaggaagc tttggttctc
     4621 tgttgactcg tcagctagta acacaaatcg gtttctctac caatagctgc ttcattttca
     4681 gttccttcca gaggcttttg ttctgccttt gtaacactga aactctggat tggcacagca
     4741 tcccggggcc cagtacacag gctgtatgtt gacttgaggt tgtatttaca gtagttcttt
     4801 gtaaaggttt gctgtaactt gcactttttt ttaaggaccc agtttgggta tcagcaactt
     4861 gggaaattcc ttatcaatga gttctcagct gacccttttg tcttcctcct tcaaatcatg
     4921 actccttaat ggaagcgttt cattgatcac agtatcatag ctagccttaa gcatgttata
     4981 aaagctaaat atctgggaat taggtttgac taatagtgaa ggaaaaataa gtacttataa
     5041 ttttaaattt catcctccaa ctttagttct atgtagagca tgccaaaagt tttttttcag
     5101 aagattacaa accttgttaa agcaattaat ttgttgtcat catgggaaac catgtaatcg
     5161 atgttactaa atcattttaa tttggctttg ttaacttccg agaaatgctg cctaaacgta
     5221 actggtttct gactgcgggg gagtacagta tgctttgtta ggcctgtagg tgactcattc
     5281 tagaataaac gtgttcactg agatgtacaa agcacaacta gagttttggg tggcttgtgt
     5341 gtgtcttgat tactttcaat gttaatgttg actttttaag ttaacagtca ctgttatgta
     5401 ctaggaactg gtttccttga ctttctagaa tcaatggcca agagaggcat ataatccttg
     5461 aggggttgaa ggtatcatga agttgagtca gtatggaaga atttcaaaca aatcaaacag
     5521 ggtgctgaag ttccggctga ctcatctgct catggtatgc ttactgatta gtgaatgtag
     5581 ttttaagcct ttgtgtgtgt cctcaggggc agacagactt taacaaggac cagataacat
     5641 ttgaatggag gaattatatt tcaggtgttt tagcttgaaa tttatttttt aaaaaaaaga
     5701 aaaattaaaa aaaaaataag agagcaaagt ttgggaagcg agttgacagt atgaaagcag
     5761 cagagctgag gatgagctgg cctgtcccac tgctgcagtg gggtgggtcc cagctgggga
     5821 aatgttacat tgttaccagc aagaaaaagg aagaagggtc aaaaagtagg aaactcctac
     5881 ttttgcaggc atgatttact acttgtccat agtagtatag catttctaag cttctaaggg
     5941 catctcaaaa gataagagta agtccgagat gttgaaaaaa tcagtaggga agaaagatca
     6001 ctgcagatca taatctatgt tggccacatg aaatgattta ttatatttgg gaagttttat
     6061 tttcttatgt tttttaaaat tgaattggta agtgctttat agacgtattt ttacccaggt
     6121 gccacttcaa tgtgtatgta ataaaattat ttatattaaa agtgggaaat tttgtgaaca
     6181 tttttctgtg tgtgtagatt tattaggatg gtgaagaagt gtgctagtta gcagttttct
     6241 gtgtaaagct gtcttgagct gatctgtaca catcggttat aatgccccag tggaacctag
     6301 acatgtcact tgagactttt gaaaaacaaa ataaccaggg aagtcctaga atggtatttg
     6361 gctgtttggt ttttccttga gtactggagt agagaatacc tccccagaac tgtcagcaca
     6421 aaacagggta tcagctttaa ctctgatgtt cctattggag tagagtacta ataactatga
     6481 gaaggggaat acatttctaa taaccttccc tacaatctag aaacgtccct gtttaaattt
     6541 tttacctaaa tctttttgtg ctttatgtgt aaagaataaa agtaccaaga caccatgcat
     6601 tttattaaca ctatgtacat actggctgct ttgtgttcag aatggtagca gttactttgt
     6661 atattaaagt gatccttgtg aatttgtgaa atattgtctt aaagtgcttt tcttactgta
     6721 atctttgtgg tatcaactgt cataatgccc tttttacaca gacatttatg tgcagtcaca
     6781 taaacatgct tttaaaaact ctgtaaagtc tcttttttgg gcctgggaca cccctcccca
     6841 agctagtatt tgtttaccct cattttcttg gacttgatgt tattttgtca aatgagcaaa
     6901 gattacattg aatgatcaca agcttgtaat gcttagcaac agaaaactgt aattcataca
     6961 acacatctaa acactcaatt ttactgaatt ctttttagca cttttttgag taaggctgag
     7021 catgatctaa aactcccaag tgctgttctc ccgtcaagta actaatggag atgtgttccg
     7081 cagtttaaag ttaagacgtg tgcatgccct gaaagaacaa taaaaactcg gatcaccttt
     7141 attctgaaat atgtgactgt ataaaatgca gaaggaaggt gggtacaata gcatggcctt
     7201 gtaatcccag cctcatgaga acaggaggca gaaccaggga ctaggtgggc tatctggtag
     7261 agatcctgta gggaaggtgg gaagggtatg aacaagggaa tcctgaaatg cacgtatcta
     7321 ttattgccaa agaactaata agatccctat aatgttctga agttctggaa cttaggaact
     7381 ttattagtaa gctgtgtaat gttccctggt tgcttgtcag atgtggtttt gaagctcggg
     7441 tcacatggat ttcctgtttc tcctttctgc agagcaacca cacttaaccg aattaccgag
     7501 acttaatatt ttaaaaatga aaggatggaa gctggcatgg tagcacgtac ctttaatccc
     7561 aggttttggg agacagaggc cagcctggtc tacataagtg agttccagga cagccagggc
     7621 tacatagtga gatcccttaa aaaaaaaatc acaacctgaa aggcaggtgt aaaccagagt
     7681 tgtaccaagc agttcagttc tgtgatcata ttacttgtaa gctattgggc ctccggaaag
     7741 ataatagtgc ctatcttcct gtagctgtga cttggcattc atttgaggac ctaggaacta
     7801 gagtaacaga agaaaagtac ttctcaaaat cgaaaatagt cctccaagaa tataacttgg
     7861 tagagttggt atccctttcc tctacaatga attctagact tccatgtgtt tgttagatgg
     7921 gaagcacagg tcccaaacag aacaaatttc tcctccaaat ctgtcccttc aggcattttc
     7981 catgtcatac acacggtgcc actttccatt aagttgactg tcaagcccag gaaagcactg
     8041 ttcgtccgtg ccaccttgcc tgagactgaa ttttcttcag ttttaagcat tcttcagata
     8101 aagacttagc atcaagtgga aggcaggctc atttccagcg atgagtatta tttttgcttt
     8161 ttaactgata agtggttaac agaaccataa agtgacccat ttgcgttcac acacttgggc
     8221 aactaccatt cctgtgcagt tcacagacat ttccatcatc tggataaaac cctacaccta
     8281 ctaaatggtt atctttcccc tttttccttc tgcctctggc aaccagagtc tgccttctgt
     8341 aaattgagaa atttcaaata aatggaatca taatgtgtaa aaaaaaaaa
//
