LOCUS       NM_007761               1474 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus calcitonin gene-related peptide-receptor component
            protein (Crcp), mRNA.
ACCESSION   NM_007761
VERSION     NM_007761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Nelson-Maney,N.P., Balint,L., Beeson,A.L., Serafin,D.S.,
            Kistner,B.M., Douglas,E.S., Siddiqui,A.H., Tauro,A.M. and
            Caron,K.M.
  TITLE     Meningeal lymphatic CGRP signaling governs pain via cerebrospinal
            fluid efflux and neuroinflammation in migraine models
  JOURNAL   J Clin Invest 134 (15), e175616 (2024)
   PUBMED   38743922
  REMARK    GeneRIF: Meningeal lymphatic CGRP signaling governs pain via
            cerebrospinal fluid efflux and neuroinflammation in migraine
            models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Sardi,C., Zambusi,L., Finardi,A., Ruffini,F., Tolun,A.A.,
            Dickerson,I.M., Righi,M., Zacchetti,D., Grohovaz,F., Provini,L.,
            Furlan,R. and Morara,S.
  TITLE     Involvement of calcitonin gene-related peptide and receptor
            component protein in experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 271 (1-2), 18-29 (2014)
   PUBMED   24746422
  REMARK    GeneRIF: CGRP can inhibit microglia activation in vivo in EAE. CGRP
            and its receptor may represent novel protective factors in EAE.
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Egea,S.C. and Dickerson,I.M.
  TITLE     Direct interactions between calcitonin-like receptor (CLR) and
            CGRP-receptor component protein (RCP) regulate CGRP receptor
            signaling
  JOURNAL   Endocrinology 153 (4), 1850-1860 (2012)
   PUBMED   22315449
  REMARK    GeneRIF: CGRP-receptor component protein has been found to interact
            only with calcitonin-like receptor and represents a novel
            neuroendocrine regulatory step in calcitonin gene-related peptide
            signaling.
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Miyauchi,K., Tadotsu,N., Hayashi,T., Ono,Y., Tokoyoda,K.,
            Tsujikawa,K. and Yamamoto,H.
  TITLE     Molecular cloning and characterization of mouse calcitonin
            gene-related peptide receptor
  JOURNAL   Neuropeptides 36 (1), 22-33 (2002)
   PUBMED   12147211
  REMARK    GeneRIF: The mouse cDNA for calcitonin receptor-like receptor
            (CRLR) was cloned. The signal transduction mechanism through the
            CGRP receptor was studied. mCRLR is a 462-amino acid
            G-protein-coupled heptahelical receptor.
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Rosenblatt,M.I., Dahl,G.P. and Dickerson,I.M.
  TITLE     Characterization and localization of the rabbit ocular calcitonin
            gene-related peptide (CGRP)-receptor component protein (RCP)
  JOURNAL   Invest Ophthalmol Vis Sci 41 (5), 1159-1167 (2000)
   PUBMED   10752955
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Balkan,W., Oates,E.L., Howard,G.A. and Roos,B.A.
  TITLE     Testes exhibit elevated expression of calcitonin gene-related
            peptide receptor component protein
  JOURNAL   Endocrinology 140 (3), 1459-1469 (1999)
   PUBMED   10067875
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Ashby,B.
  TITLE     Co-expression of prostaglandin receptors with opposite effects: a
            model for homeostatic control of autocrine and paracrine signaling
  JOURNAL   Biochem Pharmacol 55 (3), 239-246 (1998)
   PUBMED   9484788
  REMARK    Review article
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Naghashpour,M., Rosenblatt,M.I., Dickerson,I.M. and Dahl,G.P.
  TITLE     Inhibitory effect of calcitonin gene-related peptide on myometrial
            contractility is diminished at parturition
  JOURNAL   Endocrinology 138 (10), 4207-4214 (1997)
   PUBMED   9322931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161345.4 and
            AC122339.3.
            
            On Nov 17, 2006 this sequence version replaced NM_007761.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF118271.1, AK075587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC161345.4         18646-18747         c
            103-139             AC161345.4         13105-13141         c
            140-238             AC161345.4         10135-10233         c
            239-333             AC161345.4         5753-5847           c
            334-391             AC122339.3         151659-151716       c
            392-1474            AC122339.3         139855-140937       c
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.42 cM"
     gene            1..1474
                     /gene="Crcp"
                     /note="calcitonin gene-related peptide-receptor component
                     protein"
                     /db_xref="GeneID:12909"
                     /db_xref="MGI:MGI:1100818"
     exon            1..102
                     /gene="Crcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..541
                     /gene="Crcp"
                     /note="CGRPRCP; CGRP-RCP; RNA polymerase III subunit C9;
                     CGRP-receptor component protein"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase III subunit RPC9"
                     /protein_id="NP_031787.1"
                     /db_xref="CCDS:CCDS19706.1"
                     /db_xref="GeneID:12909"
                     /db_xref="MGI:MGI:1100818"
                     /translation="MEVKDANAALLSNYEVFQLLTDLKEQRKESGKNKHSAGQQNLNA
                     ITYETLKYISKTPCRNQSPAIVQEFLTAMKSHKLTKAEKLQLLNHRPMTAVEIQLMVE
                     ESEERLTEEQIEALLHTVTSILPAGPEDEQSKSTSNDVAMEEEEPA"
     exon            103..139
                     /gene="Crcp"
                     /inference="alignment:Splign:2.1.0"
     exon            140..238
                     /gene="Crcp"
                     /inference="alignment:Splign:2.1.0"
     exon            239..333
                     /gene="Crcp"
                     /inference="alignment:Splign:2.1.0"
     exon            334..391
                     /gene="Crcp"
                     /inference="alignment:Splign:2.1.0"
     exon            392..1474
                     /gene="Crcp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcggcac acacacggaa ccggtgagca gagcagcgcc ggcgcaacgt gagactcttc
       61 tcacggcggt tgcgtacgct gaggcagagg caacatggaa gtgaaggatg cgaacgcagc
      121 actgctcagc aactatgagg tgttccagtt actaacggat ctcaaagagc agcggaagga
      181 gagtgggaag aacaagcata gcgctgggca gcagaacttg aacgccatca cctatgagac
      241 actaaagtac atatcaaaaa caccatgtag gaaccagagt ccagcgattg tccaagaatt
      301 cctcacagca atgaaaagcc acaagctgac caaagcggag aagctgcagc tgctgaatca
      361 caggccgatg actgcggtgg agatccagct gatggtagaa gagagtgaag aacggctcac
      421 agaggagcag atcgaagccc tcctgcacac tgtcactagc attctgcctg caggtccaga
      481 ggatgaacag agcaaaagca ctagcaatga cgtggctatg gaagaggagg agccagcata
      541 gatgtgcagc tggccaagtt gttcgtgaag ctcaaagctg cagcagccat ttcctggatg
      601 ttcagagaac tctttatttg gcctgacccc ctctctcagt atgcctgatc tcaggatttg
      661 ttgggggaaa aaaatcacaa aaataagatg aaaagaaatc tttgtgcttt ggggtcagag
      721 cagggcaggg gctaagatgg gggagcagga ctgcagctgt ctggggtaga aaggcttgtg
      781 tggcctgtgc cgcacatgca cacagtggga gctcgtcagg cgctttgatg actgttgtag
      841 gcaatgtcag gcactgctgg gtagaatgga gctgggagaa cggactcaga tggtcaccag
      901 ctctcagagc tgcacacagc tgctctaggg gaaatgaccc agagcttagc tcactgtaga
      961 ggaatgtcct tggcggaata ggagataaga gaaaactcca atctgagcct agcctggtgt
     1021 acacacctaa tgtgcatgca tgtcacacac atacaaagaa attagtccaa tttctgtggc
     1081 aaaacccaca actctatagc ctgggtgagt gacaagaaaa agaggcttat cttgactcct
     1141 ggttccggtc caaggtcaaa gggcatctgg atatggccct cttgttgcca gagtacccag
     1201 gtagcatagg ctagcatatt acaaaacacg agaagcgttt gttttcagag tctcttgcag
     1261 cccacattga ccttgaactt attatgcggt cccttctgtc tgtcctcatc agacatctta
     1321 tgattcttct gcctcagcct ccttaatgct tggattcaaa gtgtatgtca ctcacttagg
     1381 aggcggaggc cagcctggtc cacaaagcaa gttccatgcc agccagcgcc acacagaccc
     1441 tgtctcataa aaataaaaat aaaccaacaa aaaa
//
