LOCUS       NM_175357               4067 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus cereblon (Crbn), transcript variant 2, mRNA.
ACCESSION   NM_175357
VERSION     NM_175357.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4067)
  AUTHORS   Costas-Insua,C., Hermoso-Lopez,A., Moreno,E., Montero-Fernandez,C.,
            Alvaro-Blazquez,A., Maroto,I.B., Sanchez-Ruiz,A., Diez-Alarcia,R.,
            Blazquez,C., Morales,P., Canela,E.I., Casado,V., Uriguen,L.,
            Perea,G., Bellocchio,L., Rodriguez-Crespo,I. and Guzman,M.
  TITLE     The CB1 receptor interacts with cereblon and drives cereblon
            deficiency-associated memory shortfalls
  JOURNAL   EMBO Mol Med 16 (4), 755-783 (2024)
   PUBMED   38514794
  REMARK    GeneRIF: The CB1 receptor interacts with cereblon and drives
            cereblon deficiency-associated memory shortfalls.
REFERENCE   2  (bases 1 to 4067)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4067)
  AUTHORS   Welsh,S.J., Barwick,B.G., Meermeier,E.W., Riggs,D.L., Shi,C.X.,
            Zhu,Y.X., Sharik,M.E., Du,M.T., Abrego Rocha,L.D., Garbitt,V.M.,
            Stein,C.K., Petit,J.L., Meurice,N., Tafoya Alvarado,Y., Fonseca,R.,
            Todd,K.T., Brown,S., Hammond,Z.J., Cuc,N.H., Wittenberg,C.,
            Herzog,C., Roschke,A.V., Demchenko,Y.N., Chen,W.D., Li,P., Liao,W.,
            Leonard,W.J., Lonial,S., Bahlis,N.J., Neri,P., Boise,L.H., Chesi,M.
            and Bergsagel,P.L.
  TITLE     Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting
            Drug Combinations in Multiple Myeloma
  JOURNAL   Blood Cancer Discov 5 (1), 34-55 (2024)
   PUBMED   37767768
REFERENCE   4  (bases 1 to 4067)
  AUTHORS   Akber,U., Bong,S., Park,Z.Y. and Park,C.S.
  TITLE     Effects of cereblon on stress-activated redox proteins and core
            behavior
  JOURNAL   Brain Res 1793, 148054 (2022)
   PUBMED   35973609
REFERENCE   5  (bases 1 to 4067)
  AUTHORS   Sellar,R.S., Sperling,A.S., Slabicki,M., Gasser,J.A.,
            McConkey,M.E., Donovan,K.A., Mageed,N., Adams,D.N., Zou,C.,
            Miller,P.G., Dutta,R.K., Boettcher,S., Lin,A.E., Sandoval,B.,
            Quevedo Barrios,V.A., Kovalcik,V., Koeppel,J., Henderson,E.K.,
            Fink,E.C., Yang,L., Chan,A., Pokharel,S.P., Bergstrom,E.J.,
            Burt,R., Udeshi,N.D., Carr,S.A., Fischer,E.S., Chen,C.W. and
            Ebert,B.L.
  TITLE     Degradation of GSPT1 causes TP53-independent cell death in leukemia
            while sparing normal hematopoietic stem cells
  JOURNAL   J Clin Invest 132 (16) (2022)
   PUBMED   35763353
REFERENCE   6  (bases 1 to 4067)
  AUTHORS   Rajadhyaksha,A.M., Ra,S., Kishinevsky,S., Lee,A.S., Romanienko,P.,
            DuBoff,M., Yang,C., Zupan,B., Byrne,M., Daruwalla,Z.R., Mark,W.,
            Kosofsky,B.E., Toth,M. and Higgins,J.J.
  TITLE     Behavioral characterization of cereblon forebrain-specific
            conditional null mice: a model for human non-syndromic intellectual
            disability
  JOURNAL   Behav Brain Res 226 (2), 428-434 (2012)
   PUBMED   21995942
  REMARK    GeneRIF: findings suggest that crbn-/- mice exhibit selective
            HPC-dependent deficits in associative learning.
REFERENCE   7  (bases 1 to 4067)
  AUTHORS   Aizawa,M., Abe,Y., Ito,T., Handa,H. and Nawa,H.
  TITLE     mRNA distribution of the thalidomide binding protein cereblon in
            adult mouse brain
  JOURNAL   Neurosci Res 69 (4), 343-347 (2011)
   PUBMED   21241746
REFERENCE   8  (bases 1 to 4067)
  AUTHORS   Lee,K.M., Jo,S., Kim,H., Lee,J. and Park,C.S.
  TITLE     Functional modulation of AMP-activated protein kinase by cereblon
  JOURNAL   Biochim Biophys Acta 1813 (3), 448-455 (2011)
   PUBMED   21232561
  REMARK    GeneRIF: CRBN directly interacts with the alpha1 subunit of
            AMP-activated protein kinase (AMPK alpha1) and inhibits the
            activation of AMPK activation.
REFERENCE   9  (bases 1 to 4067)
  AUTHORS   Lee,K.J., Lee,K.M., Jo,S., Kang,K.W. and Park,C.S.
  TITLE     Induction of cereblon by NF-E2-related factor 2 in neuroblastoma
            cells exposed to hypoxia-reoxygenation
  JOURNAL   Biochem Biophys Res Commun 399 (4), 711-715 (2010)
   PUBMED   20691658
  REMARK    GeneRIF: These results imply that Nrf2 stimulates CRBN gene
            transcription under hypoxia-reoxygenation conditions in neuronal
            cells.
REFERENCE   10 (bases 1 to 4067)
  AUTHORS   Higgins,J.J., Tal,A.L., Sun,X., Hauck,S.C., Hao,J., Kosofosky,B.E.
            and Rajadhyaksha,A.M.
  TITLE     Temporal and spatial mouse brain expression of cereblon, an ionic
            channel regulator involved in human intelligence
  JOURNAL   J Neurogenet 24 (1), 18-26 (2010)
   PUBMED   20131966
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ073661.1, BQ749260.1 and
            BC046967.1.
            
            On Jan 17, 2013 this sequence version replaced NM_175357.2.
            
            Summary: This gene encodes a protein with a Lon protease domain, a
            'regulators of G protein-signaling' (RGS)-like domain and a leucine
            zipper. It has been proposed to regulate the assembly and surface
            expression of large-conductance calcium-activated potassium
            channels in brain and to bind thalidomide. In humans mutation in
            this gene causes autosomal recessive nonsyndromic cognitive
            disability. In mouse deficiency of this gene serves as a model to
            study the molecular mechanisms governing learning and memory as
            they relate to intellectual disability. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site in the coding region compared to variant 1. It
            encodes isoform 2 which is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046967.1, SRR13861890.95453.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CJ073661.1         1-67
            68-85               BQ749260.1         13-30
            86-4067             BC046967.1         1-3982
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.24 cM"
     gene            1..4067
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="cereblon"
                     /db_xref="GeneID:58799"
                     /db_xref="MGI:MGI:1913277"
     exon            1..97
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1368
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="isoform 2 is encoded by transcript variant 2; novel
                     lethal; protein cereblon; protein PiL"
                     /codon_start=1
                     /product="protein cereblon isoform 2"
                     /protein_id="NP_780566.1"
                     /db_xref="CCDS:CCDS39583.1"
                     /db_xref="GeneID:58799"
                     /db_xref="MGI:MGI:1913277"
                     /translation="MAGEGDQQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEA
                     RKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVLMILIPGQTLPL
                     QLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKV
                     KAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQVFPSKPISW
                     EDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSL
                     PENPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEI
                     TTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIA
                     QCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL"
     exon            98..213
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            214..416
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            417..566
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            567..726
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            727..789
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            790..874
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            875..990
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1055
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1187
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..4054
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="hexamer: AATAAA"
     polyA_site      2097
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="major polyA site"
     regulatory      3414..3419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
     regulatory      4026..4031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="hexamer: AATAAA"
     polyA_site      4054
                     /gene="Crbn"
                     /gene_synonym="2610203G15Rik; 2900045O07Rik; piL"
                     /note="major polyA site"
ORIGIN      
        1 tttcccaggc tcctttgcgg gtaaacagac atggccggcg agggagatca gcaggacgct
       61 gcgcacaaca tgggaaacca cctgccgctt ctgcctgcag acagtgaaga tgaagatgat
      121 gaaattgaaa tggaagttga agaccaagat agtaaagaag ccagaaaacc gaatatcata
      181 aactttgaca ccagtctgcc aacctcacat acatacctgg gagctgatat ggaggagttc
      241 cacgggagaa ctttgcatga cgacgacagc tgccaggtga tcccagtcct tcctgaggtg
      301 ctgatgatcc tgattcctgg gcagacactc ccactgcagc tctctcaccc acaggaagtc
      361 agcatggtgc ggaacttaat ccagaaagac aggacctttg cagtccttgc atacagtaat
      421 gtgcaagaaa gggaagcaca gtttgggaca acagcagaga tctatgccta tcgagaagag
      481 caggagtttg gaattgaagt agtgaaagtg aaagcaattg gaaggcagcg gttcaaggtc
      541 ctcgaacttc gaacacagtc agatggaatc cagcaagcta aagtgcagat tttgccagag
      601 tgtgtgttgc cgtcaaccat gtctgcagtg cagttagaat cactcaataa gtgccaggta
      661 tttccttcaa aacccatctc ctgggaagac cagtattcat gtaaatggtg gcagaaatac
      721 cagaagagaa agtttcactg tgcaaatcta acatcatggc ctcgctggct gtattcatta
      781 tatgatgctg aaacattaat ggatagaatt aagaaacagc tacgtgaatg ggatgaaaat
      841 ctcaaagatg attctcttcc tgaaaatcca atagactttt cttacagagt agctgcttgt
      901 cttcctattg atgatgtatt gagaattcag ctccttaaaa tcggcagtgc tattcaacgg
      961 cttcgctgtg aattggacat catgaacaaa tgtacttccc tttgctgtaa acaatgtcaa
     1021 gaaacagaaa taacgacaaa gaatgaaata tttagtttat ccttatgtgg tccaatggca
     1081 gcatatgtga atcctcatgg atatgtacat gagacactga ctgtgtataa agcgtccaac
     1141 ctgaatctga taggccggcc ttctacagtg cacagctggt ttcccgggta tgcatggacc
     1201 attgcccagt gcaagatctg tgcaagccat attggatgga aatttacagc cacaaaaaaa
     1261 gacatgtcac ctcaaaaatt ttggggctta actcgctctg ctctgttacc cacaattcca
     1321 gagactgaag atgaaataag tccagacaaa gtaatacttt gtttataagt gcacctgtag
     1381 gagtgacttc ctgacagata tttcctcaag tcagatctgc ccagtcatca ctgcctctga
     1441 tatatgtgta tagtgggtta cagcatttgc ctaccaagtt caagagcata tttagggaat
     1501 gagaaagcag tataaaacat aaggctgggt tccaaaatac ttgcttttta gtagcttggt
     1561 gccatggatt atcctgttga gtctatgtca tgacaggata ggaaaacaca gttgaaataa
     1621 tgggaatggc catggaacag gataggggca ccactgctct aaatgatgaa gctctaaatg
     1681 atgaatgctc cagaaactgg gttggtaagc acaagataga ggcaaggcag tgtaatttta
     1741 aaaggacttt gctcctttca attttcctta gcttgtctga gatactgacc tgtacatttt
     1801 gaacatatta aagagtaact aagtattctg agcagaaata gcagcatttg gtgtagttgc
     1861 acttttgatt tgatgagcct gtgatgtgct agatcccttt aactaatgta tatgtccatt
     1921 ttgcatttta tttgcaaata taagtgaaca gtatatattt ctaggattat accatttagg
     1981 aaacaggttt acataaacat aaatatccaa atctattcta tttggctgaa ttatgtcaaa
     2041 gtaatcaagt agaatactga aaagtgtaag tacgtaataa aatgcaactc aagaataggc
     2101 tgctccttaa tgtcattttt tcaaaagttc tacttgtgtt tcattcaagc tgctgtgatg
     2161 gagtggggaa ttatgccttt actgctgcag tataatctga tgatccatgg actgtttacc
     2221 attactttca gataggactg tttaaaggaa tcttacacaa tatagcagct ttgatgtcac
     2281 tccatctgtg cagatgacaa cagcagaaac tccatagttt aaaatccagg tatttactga
     2341 cctgggtgaa gtagattttg acacgccctt ttatagcaca tcaccttatt tgacttcaag
     2401 aaaattcaaa atccaaaagc tgctgtttac ttgtacagta cacagatatc tatgagcagc
     2461 tatgcagtaa gtaactatgt aagctatcag aaagctaagc catatccatc taacttgtaa
     2521 aataaacaat gtgttcacta tctgtggcac ctgatataaa ggcaagagtc tcagcacaag
     2581 ccctcctgtt attcctgcaa ctttctgaaa tcagaacaat cctgttataa atagatgcta
     2641 ctatggactc attcaggaaa ccactaagaa aacatagttt ctcttcaaca gttactacat
     2701 tttaagatca acagcactgc tccacaagca ttgggaaatt caggaggtag acttgagctt
     2761 agtttttcta cctacactca tgctggtttt ggggtctcag taacacagga ggggagaaca
     2821 ccagccttac caagacttcc cctgtttcat acagggctca tctttaggtc ttctttatgt
     2881 aacttagtag ttcatctttt tccatccggt aaccactttt cttccactgt tcacgcaact
     2941 gctgtagcag ggccccaatt tccttccctg aagaaatacc cactttcctg atgtcatgtc
     3001 cactcacagg gaacggcggg acagaccact gctgcatctc tttgagaaga ccatgctctc
     3061 cttggtactt cagcagctca caaacacggg cagttgcatc tggttcccta gactaaatga
     3121 cacagtttta tcacatacta aacactcaca atttcattct actatttaaa tacttacatc
     3181 aaatctacag tgtgaaaaag ttacttttct ctagttagtg agaactattt tctgctcaga
     3241 cctaatacat acttacgtct atcacaaagt cttggtatgg tttcaatggt tctgaactat
     3301 ctgttgcttt aatcaagtct ttcctgtttt taactataaa taaacccagg tttttctcct
     3361 cttttgaaat tttcaatctc aagtccaatt ttgtgacatc atcttgtact ttgaataaag
     3421 aagccaaaag agtcattggt tttggtgaaa agccttcaac atttttactg actttgttaa
     3481 attcttctaa atttgcatta gcaggtaaac ctgtaaacaa aagagaaaag tcattttttt
     3541 cttaactaca aaaccctcac tcacctctta aactatgcag atttttaaga atgtgtagtg
     3601 ttctttctcc actgcttatt atcagcccat tcgtcactcc cttaactcct agaagaaatc
     3661 tatcatgttc ctgtttcctg tagcagcatg tcttgtgaag ctcaggagct gtgatcatat
     3721 caggtaccag catatgcctt ctcagtcatg atcctgtctg cacacattcc ctactcagca
     3781 attgtatgtt cttgtaaaac agtcaaagtt actgtctaaa atatactggc tatagttatt
     3841 aatttccttt ctatatatta agtgttttgt gaaagagctt attatacatt aacttattgc
     3901 ttcatcctcc tctctatgaa gtagctttta ttttgaaccc tttgtgatta taaaccaacc
     3961 caacctgcaa aaccagtaag cttcatcaaa ttcaggtgtt ctctctgaac tattctttac
     4021 caataaataa actatttcca tctttaatcc caaaaaaaaa aaaaaaa
//
