LOCUS       NM_177638               1206 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus crumbs family member 3 (Crb3), transcript variant 1,
            mRNA.
ACCESSION   NM_177638
VERSION     NM_177638.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1206)
  AUTHORS   Wang,B., Liang,Z., Tan,T., Zhang,M., Jiang,Y., Shang,Y., Gao,X.,
            Song,S., Wang,R., Chen,H., Liu,J., Li,J., Ren,Y. and Liu,P.
  TITLE     CRB3 navigates Rab11 trafficking vesicles to promote gammaTuRC
            assembly during ciliogenesis
  JOURNAL   Elife 12, 86689 (2023)
   PUBMED   37737843
  REMARK    GeneRIF: CRB3 navigates Rab11 trafficking vesicles to promote
            gammaTuRC assembly during ciliogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1206)
  AUTHORS   Barlow,H.R., Ahuja,N., Bierschenk,T., Htike,Y., Fassetta,L.,
            Azizoglu,D.B., Flores,J., Gao,N., De la,O. S, Sneddon,J.B.,
            Marciano,D.K. and Cleaver,O.
  TITLE     Rab11 is essential to pancreas morphogenesis, lumen formation and
            endocrine mass
  JOURNAL   Dev Biol 499, 59-74 (2023)
   PUBMED   37172642
REFERENCE   3  (bases 1 to 1206)
  AUTHORS   Brault,J.B., Bardin,S., Lampic,M., Carpentieri,J.A., Coquand,L.,
            Penisson,M., Lachuer,H., Victoria,G.S., Baloul,S., El Marjou,F.,
            Boncompain,G., Miserey-Lenkei,S., Belvindrah,R., Fraisier,V.,
            Francis,F., Perez,F., Goud,B. and Baffet,A.D.
  TITLE     RAB6 and dynein drive post-Golgi apical transport to prevent
            neuronal progenitor delamination
  JOURNAL   EMBO Rep 23 (10), e54605 (2022)
   PUBMED   35979738
REFERENCE   4  (bases 1 to 1206)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1206)
  AUTHORS   Tilston-Lunel,A., Mazzilli,S., Kingston,N.M., Szymaniak,A.D.,
            Hicks-Berthet,J., Kern,J.G., Abo,K., Reid,M.E., Perdomo,C.,
            Wilson,A.A., Spira,A., Beane,J. and Varelas,X.
  TITLE     Aberrant epithelial polarity cues drive the development of
            precancerous airway lesions
  JOURNAL   Proc Natl Acad Sci U S A 118 (18) (2021)
   PUBMED   33903236
REFERENCE   6  (bases 1 to 1206)
  AUTHORS   Fan,S., Hurd,T.W., Liu,C.J., Straight,S.W., Weimbs,T., Hurd,E.A.,
            Domino,S.E. and Margolis,B.
  TITLE     Polarity proteins control ciliogenesis via kinesin motor
            interactions
  JOURNAL   Curr Biol 14 (16), 1451-1461 (2004)
   PUBMED   15324661
REFERENCE   7  (bases 1 to 1206)
  AUTHORS   Saotome,I., Curto,M. and McClatchey,A.I.
  TITLE     Ezrin is essential for epithelial organization and villus
            morphogenesis in the developing intestine
  JOURNAL   Dev Cell 6 (6), 855-864 (2004)
   PUBMED   15177033
REFERENCE   8  (bases 1 to 1206)
  AUTHORS   Lemmers,C., Michel,D., Lane-Guermonprez,L., Delgrossi,M.H.,
            Medina,E., Arsanto,J.P. and Le Bivic,A.
  TITLE     CRB3 binds directly to Par6 and regulates the morphogenesis of the
            tight junctions in mammalian epithelial cells
  JOURNAL   Mol Biol Cell 15 (3), 1324-1333 (2004)
   PUBMED   14718572
REFERENCE   9  (bases 1 to 1206)
  AUTHORS   Roh,M.H., Fan,S., Liu,C.J. and Margolis,B.
  TITLE     The Crumbs3-Pals1 complex participates in the establishment of
            polarity in mammalian epithelial cells
  JOURNAL   J Cell Sci 116 (Pt 14), 2895-2906 (2003)
   PUBMED   12771187
REFERENCE   10 (bases 1 to 1206)
  AUTHORS   Rubio-Aliaga,I., Frey,I., Boll,M., Groneberg,D.A., Eichinger,H.M.,
            Balling,R. and Daniel,H.
  TITLE     Targeted disruption of the peptide transporter Pept2 gene in mice
            defines its physiological role in the kidney
  JOURNAL   Mol Cell Biol 23 (9), 3247-3252 (2003)
   PUBMED   12697824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571247.13.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_177638.6.
            
            On Jan 13, 2018 this sequence version replaced NM_177638.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024462.1, BI659084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               CT571247.13        80597-80739
            144-315             CT571247.13        80961-81132
            316-377             CT571247.13        82003-82064
            378-1206            CT571247.13        83456-84284
FEATURES             Location/Qualifiers
     source          1..1206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.65 cM"
     gene            1..1206
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /note="crumbs family member 3"
                     /db_xref="GeneID:224912"
                     /db_xref="MGI:MGI:2670904"
     exon            1..143
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /inference="alignment:Splign:2.1.0"
     exon            144..315
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..584
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein crumbs homolog 3"
                     /codon_start=1
                     /product="protein crumbs homolog 3 isoform 1 precursor"
                     /protein_id="NP_808306.1"
                     /db_xref="CCDS:CCDS28924.1"
                     /db_xref="GeneID:224912"
                     /db_xref="MGI:MGI:2670904"
                     /translation="MATPGLGVLLAFGLPMLPSGWSLTAPDPFTNSTTQPPGDESNGG
                     LSSGAIVAITVVFSILGVLLIAVGLFLLMRKLREKRQTEGTYRPSSEEQVGARAPPPP
                     NLKLPPEERLI"
     exon            316..377
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /inference="alignment:Splign:2.1.0"
     exon            378..1206
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1171..1176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /note="hexamer: AATAAA"
     polyA_site      1206
                     /gene="Crb3"
                     /gene_synonym="5730439B18"
                     /note="major polyA site"
ORIGIN      
        1 gggtgactaa actttccggg tcacgtgagc gggcggggcg ggtgggatct ggagcgaccg
       61 ggtgaaggac ggagactcgg ggttccagct gggaacccgg gattgggaac ctgagcgaag
      121 tccctctcag acgctggagt caggtcctgg gtcgcaggtg ccctcctcga cccaagatgc
      181 ggtaggaatt ggcgccttgg ggaagtcctg tccttggcgt caccaactcg tcgcctaaac
      241 tcatggcgac cccaggcctg ggggtgctct tggcgtttgg tttgccgatg ctgccctccg
      301 gctggagcct aacagcaccg gaccctttca caaatagcac aactcaaccc ccaggtgatg
      361 agtccaacgg gggcctgtct tcaggggcta ttgtagccat cactgtggtc ttttccattc
      421 tgggagtcct ccttatagca gtgggactgt ttctgctcat gcgaaaactt cgggaaaagc
      481 ggcagacaga gggcacctac cggcccagca gtgaggagca ggtgggtgcc cgtgctccac
      541 caccccccaa cctcaagctg cccccggagg agcggctcat ctgaacacag gggtgtcggc
      601 cataggccat catcactacc aacgcctggg actgccttgg cacgccctac cacacagcag
      661 ccacctcgga gacgcgccag cctccagtga ctcaggagga cttgggttgg ggaactctgg
      721 ggcatctagc tggtgggcta tgcagcattg ctacctctgc ttggctctgc atgaaactgg
      781 gggtgctggg gccaggggag gccttactgc ctcaccattt acctcatagg accttgcctc
      841 tgctgtgtct cctactgtga ctgcaggccc aacaaacctc ctgtcctttc tttcagtttt
      901 cccacgcagc agctgaggcc cgggcccccc aggactccaa ggagccagtg cggggctgcc
      961 tgcccatcta gctcctcccc tccttccctg tcatccatct tcccttcctt gctgtgtgac
     1021 cccgtgggaa ggcaacaccc tctttgggca atcagactca cccaatgctt aagaatagaa
     1081 gggaagaaag ttcttcaaag accttgactt tgaaggcaag caggatggga ctgctcactt
     1141 tttatatatt tatatgaaat tgatagggac aataaaggtt ttttgttttt gtggtatgag
     1201 aaaaaa
//
