LOCUS       NM_001163566            6372 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus crumbs family member 2 (Crb2), transcript variant 1,
            mRNA.
ACCESSION   NM_001163566 XM_140952
VERSION     NM_001163566.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6372)
  AUTHORS   Cho,S.H., Kim,J.H. and Kim,S.
  TITLE     Perturbed cell cycle phase-dependent positioning and nuclear
            migration of retinal progenitors along the apico-basal axis
            underlie global retinal disorganization in the LCA8-like mouse
            model
  JOURNAL   Dev Biol 517, 39-54 (2025)
   PUBMED   39284539
REFERENCE   2  (bases 1 to 6372)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6372)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   4  (bases 1 to 6372)
  AUTHORS   Hada,I., Shimizu,A., Takematsu,H., Nishibori,Y., Kimura,T.,
            Fukutomi,T., Kudo,A., Ito-Nitta,N., Kiuchi,Z., Patrakka,J.,
            Mikami,N., Leclerc,S., Akimoto,Y., Hirayama,Y., Mori,S., Takano,T.
            and Yan,K.
  TITLE     A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by
            Immunization with the Podocyte Protein Crb2
  JOURNAL   J Am Soc Nephrol 33 (11), 2008-2025 (2022)
   PUBMED   35985815
  REMARK    GeneRIF: A Novel Mouse Model of Idiopathic Nephrotic Syndrome
            Induced by Immunization with the Podocyte Protein Crb2.
REFERENCE   5  (bases 1 to 6372)
  AUTHORS   Tanoue,A., Katayama,K., Ito,Y., Joh,K., Toda,M., Yasuma,T.,
            D'Alessandro-Gabazza,C.N., Kawachi,H., Yan,K., Ito,M.,
            Gabazza,E.C., Tryggvason,K. and Dohi,K.
  TITLE     Podocyte-specific Crb2 knockout mice develop focal segmental
            glomerulosclerosis
  JOURNAL   Sci Rep 11 (1), 20556 (2021)
   PUBMED   34654837
  REMARK    GeneRIF: Podocyte-specific Crb2 knockout mice develop focal
            segmental glomerulosclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6372)
  AUTHORS   Gosens,I., Sessa,A., den Hollander,A.I., Letteboer,S.J.,
            Belloni,V., Arends,M.L., Le Bivic,A., Cremers,F.P., Broccoli,V. and
            Roepman,R.
  TITLE     FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5
            polarity complex
  JOURNAL   Exp Cell Res 313 (19), 3959-3970 (2007)
   PUBMED   17920587
REFERENCE   7  (bases 1 to 6372)
  AUTHORS   Lee,J.D., Silva-Gagliardi,N.F., Tepass,U., McGlade,C.J. and
            Anderson,K.V.
  TITLE     The FERM protein Epb4.1l5 is required for organization of the
            neural plate and for the epithelial-mesenchymal transition at the
            primitive streak of the mouse embryo
  JOURNAL   Development 134 (11), 2007-2016 (2007)
   PUBMED   17507402
REFERENCE   8  (bases 1 to 6372)
  AUTHORS   van Rossum,A.G., Aartsen,W.M., Meuleman,J., Klooster,J.,
            Malysheva,A., Versteeg,I., Arsanto,J.P., Le Bivic,A. and
            Wijnholds,J.
  TITLE     Pals1/Mpp5 is required for correct localization of Crb1 at the
            subapical region in polarized Muller glia cells
  JOURNAL   Hum Mol Genet 15 (18), 2659-2672 (2006)
   PUBMED   16885194
REFERENCE   9  (bases 1 to 6372)
  AUTHORS   Augustin,M., Sedlmeier,R., Peters,T., Huffstadt,U., Kochmann,E.,
            Simon,D., Schoniger,M., Garke-Mayerthaler,S., Laufs,J., Mayhaus,M.,
            Franke,S., Klose,M., Graupner,A., Kurzmann,M., Zinser,C., Wolf,A.,
            Voelkel,M., Kellner,M., Kilian,M., Seelig,S., Koppius,A.,
            Teubner,A., Korthaus,D., Nehls,M. and Wattler,S.
  TITLE     Efficient and fast targeted production of murine models based on
            ENU mutagenesis
  JOURNAL   Mamm Genome 16 (6), 405-413 (2005)
   PUBMED   16075367
REFERENCE   10 (bases 1 to 6372)
  AUTHORS   van den Hurk,J.A., Rashbass,P., Roepman,R., Davis,J.,
            Voesenek,K.E., Arends,M.L., Zonneveld,M.N., van Roekel,M.H.,
            Cameron,K., Rohrschneider,K., Heckenlively,J.R., Koenekoop,R.K.,
            Hoyng,C.B., Cremers,F.P. and den Hollander,A.I.
  TITLE     Characterization of the Crumbs homolog 2 (CRB2) gene and analysis
            of its role in retinitis pigmentosa and Leber congenital amaurosis
  JOURNAL   Mol Vis 11, 263-273 (2005)
   PUBMED   15851977
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805959.11.
            
            On Nov 8, 2022 this sequence version replaced NM_001163566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.294108.1,
                                           SRR9219382.207580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AL805959.11        79287-79484
            199-522             AL805959.11        86238-86561
            523-718             AL805959.11        89477-89672
            719-858             AL805959.11        89756-89895
            859-1044            AL805959.11        90302-90487
            1045-1158           AL805959.11        90697-90810
            1159-2031           AL805959.11        93166-94038
            2032-2537           AL805959.11        94124-94629
            2538-2703           AL805959.11        95092-95257
            2704-3472           AL805959.11        96137-96905
            3473-3589           AL805959.11        97568-97684
            3590-3716           AL805959.11        98413-98539
            3717-6372           AL805959.11        99486-102141
FEATURES             Location/Qualifiers
     source          1..6372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.19 cM"
     gene            1..6372
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /note="crumbs family member 2"
                     /db_xref="GeneID:241324"
                     /db_xref="MGI:MGI:2679260"
     exon            1..198
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3941
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; crumbs-like protein 2; protein crumbs homolog
                     2; crumbs2"
                     /codon_start=1
                     /product="protein crumbs homolog 2 isoform 1 precursor"
                     /protein_id="NP_001157038.1"
                     /db_xref="CCDS:CCDS50580.1"
                     /db_xref="GeneID:241324"
                     /db_xref="MGI:MGI:2679260"
                     /translation="MALVGPRIWGPRRDIYPLLLLLLLLLLLLLPWVPAGLVPPETPS
                     VCASDPCAPGTKCQATESGGYTCEPSELGGCATQPCHHGALCVPQGPDPNSFRCYCVP
                     GFQGPHCELDIDECASRPCQHGGTCQNLADHYECHCPLGYAGVTCEAEVDECSSAPCL
                     HGGSCLDGVGSYRCVCAPGYAGANCQLDVDECQSQPCAHGGVCHDLVNGFRCDCADTG
                     YEGARCEQEVLECASAPCAHNASCLDGFRSFRCLCWPGFSGERCEVDEDECASGPCQN
                     GGQCLQRSDPTLYGGVQAIFPGAFSFSHAAGFLCSCPLGFAGNDCSMDVDECASGPCL
                     NGGSCQDLPNGFQCYCQDGYTGLTCQEDMDECQSEPCLHGGTCSDTVAGYICQCPEAW
                     GGHDCSVQLTGCQGHTCPLAATCIPTFKSGLHGYFCRCPPGTYGPFCGQNTTFSVVSG
                     SSVWGLVPAAASLGLALRFRTTLLAGTLATLKDTRDSLELVLVGAVLQATLSRHGTAV
                     LILTLPDLALNDGHWHQVEVTLHLGTLELRLWHEGCPGQLCVASGPVATGPTASVASG
                     PPGSYSIYLGGGVFAGCFQDVRVEGHLLLPEELKGTVLLGCERREPCQPLPCAHGGAC
                     VDLWTHFRCDCPRPYRGATCTDEVPAATFGLGGATSSASFLLHQLGPNLTVSFFLRTR
                     EPAGLLLQFANDSVASLTVFLSEGQIRAEGLGHPAVVLPGRWDDGLPHLVMLSFGPDQ
                     LQDLGQRLYVGGRFYPDDTQLWGGPFRGCLQDLQLNSIHLPFFSSPMENSSWPSELEA
                     GQSSNLTQGCVSEDTCNPNPCFNGGTCHVTWNDFYCTCSENFTGPTCAQQRWCPRQPC
                     LPPATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSLSGLTLAFRTRDSEAGLLRAV
                     SAAGAHSNIWLAVRNGSLAGDVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLL
                     WLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDFPLPLAPPRSGT
                     VSGAREHFVAWPGSPAVSLGCRGGPVCSPSPCLHGGACRDLFDAFACSCGPAWEGPRC
                     EIRADPCRSTPCVRGQCHARPDGRFECRCPPGFSGPRCRLPVLPQGCNLNSTCKDGAP
                     CEGGPLGTNCSCQEGLAGLRCQSLDKPCEASPCLNGGTCRVASGIFECTCSAGFSGQF
                     CEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEV
                     AGARLEMDSVLKVPPEERLI"
     exon            199..522
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            523..718
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            719..858
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1044
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1158
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..2031
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2537
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2703
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..3472
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3589
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3716
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..6372
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6353..6358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /note="hexamer: AACAAA"
     polyA_site      6372
                     /gene="Crb2"
                     /gene_synonym="5930402A21"
                     /note="major polyA site"
ORIGIN      
        1 agtgctggtt ggagggacgc aggggcgcgg agcccgccga gcagagggtt cccgcaggca
       61 ggcaggcagg caggcaggca gagccggctg ccatggcgct ggtggggcct aggatttggg
      121 gccctagacg agatatttac cccctgttgc tgctactgct actgctgctg ctgctgctgc
      181 tgccttgggt cccggctggg ctggttcctc cagagactcc aagtgtctgt gcctcagacc
      241 catgtgctcc agggaccaag tgccaggcta cagaaagtgg tggctatacc tgtgagccct
      301 cagagcttgg aggctgtgct actcagccat gccaccacgg ggcactgtgt gtgccccagg
      361 gcccagatcc taacagcttc cgttgctact gtgtgcctgg attccaggga ccccactgtg
      421 aactggacat cgatgagtgt gcgtcccggc cttgccagca tgggggcacc tgccaaaatc
      481 tggcagatca ctacgagtgc cactgtcccc tgggatatgc aggcgtgacc tgtgaggccg
      541 aggtggacga gtgctcgtca gcgccctgcc tgcacggagg ctcgtgcctg gacggtgtgg
      601 gttcctaccg ctgcgtgtgc gcgccgggat acgccggtgc gaactgtcag ctggacgtgg
      661 acgagtgcca gagccagccg tgcgcgcacg gtggcgtgtg tcacgacctg gtcaacggtt
      721 tccggtgcga ctgcgcggac acgggttacg aaggcgcgcg ctgcgagcag gaggtgctgg
      781 agtgcgcctc tgcgccctgc gcgcacaacg cgtcctgcct cgacggcttc cggagcttcc
      841 gctgcctctg ctggccaggc ttcagtggag agcggtgcga agtggatgag gacgaatgtg
      901 catcgggccc ctgtcaaaat gggggccagt gcttgcagcg ctctgacccg accttgtacg
      961 ggggtgttca ggccatcttc ccgggagcct tcagcttcag ccacgccgct ggcttccttt
     1021 gcagctgtcc tctgggcttt gctgggaatg actgcagcat ggatgtggat gagtgtgcct
     1081 cagggccgtg cctcaatgga ggtagctgcc aggacctgcc caatggtttc cagtgctact
     1141 gccaggatgg atacacaggc ctgacatgtc aggaagatat ggatgaatgc cagtcggaac
     1201 catgcctgca tggtggaacc tgcagcgaca ctgtagcagg ctacatctgc cagtgccctg
     1261 aggcctgggg tggacatgac tgttctgtgc agctcacagg ctgccagggc catacctgcc
     1321 cactggctgc cacctgcatc cccaccttca agtctggcct ccacggttac ttctgccgct
     1381 gcccaccggg gacctatggg cctttctgtg gccagaatac gaccttctcg gttgtgtctg
     1441 ggagttctgt gtggggattg gtgccagctg ctgcctccct gggtctggca ctgagatttc
     1501 gtaccaccct gcttgccgga accctggcta ctctcaaaga cactcgggac agcttggagc
     1561 tggttctggt gggggccgtg ctccaagcca cactctcgag acatggcact gcggtgctca
     1621 tccttacact gcctgaccta gccttaaatg atgggcattg gcaccaggtg gaagtgacgc
     1681 tccacctggg aaccctggag ctgcggctct ggcacgaggg ctgccctggc cagctctgtg
     1741 tggcctctgg tccggtggct acaggcccta cagcctcggt ggcctctggg cctccgggat
     1801 cctactccat ctatctgggc ggcggggtct ttgccggctg cttccaggat gtgcgtgtgg
     1861 aagggcacct tctgctgcct gaggagctca agggaactgt gcttctgggt tgtgagcgca
     1921 gggaaccttg ccagcctctg ccttgtgccc atggaggggc ctgcgtggac ctgtggactc
     1981 acttccgctg cgactgcccg agaccttacc gtggagccac atgcactgat gaggttcctg
     2041 ctgccacttt tggcttgggt ggagccacga gctcagcctc ttttctgctc caccaactag
     2101 gcccaaacct caccgtgtca tttttcctcc gcacccgcga acctgccggc ctgttgctcc
     2161 agtttgccaa tgattcagtt gcgagcctga ctgtgttcct gagtgagggc cagatccggg
     2221 ctgaggggct gggtcaccct gctgtggtcc tccctgggcg ctgggatgat ggactccccc
     2281 acttggtgat gctcagcttt gggcctgacc agctgcagga cctgggccag cggctgtatg
     2341 tgggtgggag gttctaccct gatgacaccc agctctgggg tgggcccttc cgaggctgtc
     2401 tccaggacct acaactcaac agcatccacc tccccttctt ctcttccccg atggagaact
     2461 caagttggcc cagtgaactg gaagctggcc agtcctccaa cctcacccag ggttgtgtct
     2521 ctgaggacac gtgcaatccc aatccctgtt tcaatggtgg cacgtgccac gtcacctgga
     2581 atgacttcta ctgcacctgc tccgagaact tcacggggcc cacctgtgcc cagcagcgat
     2641 ggtgccccag gcagccatgc ctgcctcctg ccacctgtga ggaggttcca gatggctttg
     2701 tgtgtgtggc cgaggccacg ttccgcgagg gccctcctgc tgtgttcaca ggccacaacg
     2761 tgtcctcatc gctcagcggg ctcaccctgg ccttccgcac gcgcgactcc gaggctgggc
     2821 tactgcgcgc cgtctccgcc gcaggtgccc actccaatat ctggttggcg gtgcgcaacg
     2881 gctcgctggc aggagatgtg gcgggttcgg tgctgcccgc gcccgggccg cgcgtggccg
     2941 acggcgcctg gcatcgcgtg cgcctagccc gggagttccc acaggccgct gcctcgcgct
     3001 ggctgctgtg gctggacggc gcggcgacac ccgtggcctt gcacggcttg ggcggcgacc
     3061 tgggctttct gcagggtccg ggtgcagtgc ctctgctact ggctgagaac ttcacgggct
     3121 gcctgggccg cgtggcactt ggcgacttcc cgttaccctt ggcgccaccg cggtctggca
     3181 cggtgtctgg ggcgcgcgag cacttcgtgg cctggcccgg gtctccggcc gtgagtctcg
     3241 gctgccgtgg cggacccgta tgttcaccct cgccctgcct gcacggtggc gcctgccgcg
     3301 acctcttcga cgcctttgct tgctcctgcg gccccgcctg ggaaggaccc cgctgcgaga
     3361 tccgcgctga cccatgtcgc tccactccct gtgtccgggg ccaatgccat gcgcgccccg
     3421 acggccgctt cgagtgtcgc tgccctccgg gcttctccgg cccgcgctgc aggttgcctg
     3481 tcctgcctca gggatgcaac ctcaactcca catgcaagga tggcgcccct tgtgaaggcg
     3541 gccccttagg caccaactgc agttgccagg aaggtcttgc tggcctcaga tgtcagagtc
     3601 tcgacaaacc ctgtgaagcc agcccttgct tgaatggggg cacttgccgg gtggccagtg
     3661 gcatatttga atgtacttgc agtgcaggat tctctggcca gttctgtgaa gtggtgaaaa
     3721 ccctacctct gcctctgccg ttcccactgc tggaggtagc agtgcctgca gcctgtgcct
     3781 gcctcctcct tctcctcctg ggcctcctct caggaatcct ggctgccaga aagcgccgcc
     3841 agtctgaggg cacttacagc ccaagtcagc aggaggtggc tggggctcgt ctggagatgg
     3901 acagtgtcct caaggtgcca ccagaggaga gacttattta ggtttgcctg gctgctggtg
     3961 ccatgtcctg aaggtcctaa agggtcacca caggacttct acctggagac ccaaggagac
     4021 tgtttccaga gctgggacat ccacaggatg tgcccccatg gttggcagcc cttgctctgt
     4081 ccatcatgga ctcaggaaat ggggaacaac tcagggaagc agaggaggct gtgagagtgt
     4141 gtacttctct gacctgctgg gctggataca gggcacatgt tggtgcccat gatatgacag
     4201 ggtgtgtgca tgtgcttctg tgcatatgtg tttgtgtatg tgtgtgcatc tttctgtttg
     4261 gggaagagga ggaaagagag aggagaagga gaaggagact atacataggg atgtgttggt
     4321 ctgcagattg taatgtgtta tgactgtggt aagggcttca tgtctgggaa ccacccagat
     4381 ggttacctct gggacagggg cagcccaagg ctgcacgttc tctagcactg gacaggccag
     4441 agcttaccca agcacctaga ctttggtctt gacatcttgt tcaacctcca agaacagcca
     4501 gaagctggga tagggaggag tctccttggt ttccagaaca aaagcccttt gggcaggtct
     4561 gtaggaacca aggagcggct gccctgggtt gccctgcctg ctgtgggcat ttgccagagt
     4621 ggagcaacca acctgtctgc ctacctcaca tcacacggct attctgagga tccgagagac
     4681 aaacaggcag aaaactccag tctggtggga agaactggct gcccttgggt gttggaaagt
     4741 gtcttgccca cctagagttg aaaaggcttc ttgggaccct agcaagaagg ccagagaggt
     4801 ggaagaacgg agatgctatt atcttctgtc cctgacccct gcaaactcac ccctttgcct
     4861 gcagttctgt tgccaaggaa ggctctgttg tgtgccaaac aacagtgtcc agcagatgga
     4921 catcaggcag cttctgcatt ggcgctcagg ctgcagaagc cgattacatc ctgtggacac
     4981 tcagtgcaag tgacttctga caactcctct cccagggcat tggcctgaag gtttagcctc
     5041 ccttgaactt tccagaggcc tctgacttgg agatgtgtcc tttgtcatct ttgtttatca
     5101 ggcagtgcct tctcacagga gttcccatgt gcaaacgcca ggtgactttt acacaaggaa
     5161 gctcggtgtc tccaggtttc agctgcctcc caaggcacag acttggggga accaggagat
     5221 cagtagaagc tttgttaaga gaccctggat gctaagcgag aaggcctact tggttcttac
     5281 tctgtagtgg tgaggccact ttgccccgag ctatctccat gccccttggg agaggggaga
     5341 ggaaacaggc tcttgggtga actgtttcag ttgccagctc ctaagatgat tcttgtggaa
     5401 tgccaacgga acgaaacatc ccagttccac gtcagtgtca ccaatgtggc ctacacaagt
     5461 actctcactt gggggagatg gtgttcttgc tgagacaagg gggaggagtg gagcttgttc
     5521 ctttgtgtag tcctgcccat gatgtagtgt ccactatgat tccctcatgg ggagggatgg
     5581 tgtaagtggc tcagagcctc aagcatgcat aggctggagg acagtggcct ctgcttctgc
     5641 aggatggctg gtggaggtgg ccaagtgcct gctcaggcag ccatccccca gagctccttg
     5701 taggactcag gactacagcc ctctccccag ttttattgac cacatataga attcatcgtt
     5761 ggattgcaaa gtctacccag tgaaatggac agatgacaac aaacatgtga actacaggtg
     5821 tgtgccttct taggctgccc gacaccctgt caccctattg gcccactagg ctgtggcact
     5881 gcctcatctt gggtggaacc cggaatttgt taggatggag gaagtggggc tgaggcctgt
     5941 cctgggacac cagaatgcca gaaggcttcc cacgacccag tgagactccg ctccctggta
     6001 gctgagcaca ccaccaagac agagccctgg ggaaggaggg ctacctctct ggcctagacc
     6061 tcagggaccc ataaacaacc tctcagacag agagggtccc taaagtaaca ggtacctctg
     6121 atgaccccac ccccttgttc ccaaccccca gaaaccctgg ggtaggctgt ctgaccattt
     6181 acacatagga aatgagaaat caggtcaaat gtgcacaatt tcctgcatgt ctctgatgga
     6241 tgttttctta aacggtcagt ctgtgtttta ccttggttta ttgaaaggaa tcaattttca
     6301 agattcatca aatcaataag gtaaaaagga aaagcaagat caaagaaaaa ataacaaaac
     6361 atttcattat aa
//
