LOCUS       NM_133239               4702 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus crumbs family member 1, photoreceptor morphogenesis
            associated (Crb1), mRNA.
ACCESSION   NM_133239
VERSION     NM_133239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4702)
  AUTHORS   Cho,S.H., Kim,J.H. and Kim,S.
  TITLE     Perturbed cell cycle phase-dependent positioning and nuclear
            migration of retinal progenitors along the apico-basal axis
            underlie global retinal disorganization in the LCA8-like mouse
            model
  JOURNAL   Dev Biol 517, 39-54 (2025)
   PUBMED   39284539
REFERENCE   2  (bases 1 to 4702)
  AUTHORS   Schwammle,M.E., Bucher,F., Schlunck,G. and Martin,G.
  TITLE     Genotyping single point mutations in rd1 and rd8 mice using melting
            curve analysis of qPCR fragments
  JOURNAL   Sci Rep 14 (1), 19909 (2024)
   PUBMED   39198547
  REMARK    GeneRIF: a simple and effective PCR based method for genotyping rd1
            (Pde6b) and rd8 (Crb1) in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4702)
  AUTHORS   Seyed-Razavi,Y., Lee,S.R., Fan,J., Shen,W., Cornish,E.E. and
            Gillies,M.C.
  TITLE     JR5558 mice are a reliable model to investigate subretinal fibrosis
  JOURNAL   Sci Rep 14 (1), 18752 (2024)
   PUBMED   39138242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4702)
  AUTHORS   Peng,S., Li,J.J., Song,W., Li,Y., Zeng,L., Liang,Q., Wen,X.,
            Shang,H., Liu,K., Peng,P., Xue,W., Zou,B., Yang,L., Liang,J.,
            Zhang,Z., Guo,S., Chen,T., Li,W., Jin,M., Xing,X.B., Wan,P.,
            Liu,C., Lin,H., Wei,H., Lee,R.W.J., Zhang,F. and Wei,L.
  TITLE     CRB1-associated retinal degeneration is dependent on bacterial
            translocation from the gut
  JOURNAL   Cell 187 (6), 1387-1401 (2024)
   PUBMED   38412859
  REMARK    GeneRIF: CRB1-associated retinal degeneration is dependent on
            bacterial translocation from the gut.
REFERENCE   5  (bases 1 to 4702)
  AUTHORS   Rivera-Garcia,L.G., Francis-Malave,A.M., Castillo,Z.W., Uong,C.D.,
            Wilson,T.D., Ferchmin,P.A., Eterovic,V., Burton,M.D. and
            Carrasquillo,Y.
  TITLE     Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco
            cembranoid in a mouse model of inflammatory pain
  JOURNAL   J Inflamm (Lond) 21 (1), 2 (2024)
   PUBMED   38267952
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4702)
  AUTHORS   Pellikka,M., Tanentzapf,G., Pinto,M., Smith,C., McGlade,C.J.,
            Ready,D.F. and Tepass,U.
  TITLE     Crumbs, the Drosophila homologue of human CRB1/RP12, is essential
            for photoreceptor morphogenesis
  JOURNAL   Nature 416 (6877), 143-149 (2002)
   PUBMED   11850625
REFERENCE   7  (bases 1 to 4702)
  AUTHORS   Chang,B., Hawes,N.L., Hurd,R.E., Davisson,M.T., Nusinowitz,S. and
            Heckenlively,J.R.
  TITLE     Retinal degeneration mutants in the mouse
  JOURNAL   Vision Res 42 (4), 517-525 (2002)
   PUBMED   11853768
  REMARK    Review article
REFERENCE   8  (bases 1 to 4702)
  AUTHORS   den Hollander,A.I., Ghiani,M., de Kok,Y.J., Wijnholds,J.,
            Ballabio,A., Cremers,F.P. and Broccoli,V.
  TITLE     Isolation of Crb1, a mouse homologue of Drosophila crumbs, and
            analysis of its expression pattern in eye and brain
  JOURNAL   Mech Dev 110 (1-2), 203-207 (2002)
   PUBMED   11744384
  REMARK    GeneRIF: Isolation of Crb1, a mouse homologue of Drosophila crumbs,
            and analysis of its expression pattern in eye and brain.
REFERENCE   9  (bases 1 to 4702)
  AUTHORS   den Hollander,A.I., ten Brink,J.B., de Kok,Y.J., van Soest,S., van
            den Born,L.I., van Driel,M.A., van de Pol,D.J., Payne,A.M.,
            Bhattacharya,S.S., Kellner,U., Hoyng,C.B., Westerveld,A.,
            Brunner,H.G., Bleeker-Wagemakers,E.M., Deutman,A.F.,
            Heckenlively,J.R., Cremers,F.P. and Bergen,A.A.
  TITLE     Mutations in a human homologue of Drosophila crumbs cause retinitis
            pigmentosa (RP12)
  JOURNAL   Nat Genet 23 (2), 217-221 (1999)
   PUBMED   10508521
REFERENCE   10 (bases 1 to 4702)
  AUTHORS   Parr,G.R. and Hammes,G.G.
  TITLE     A kinetic study of the subunit dissociation and reassembly of
            rabbit muscle phosphofructokinase
  JOURNAL   Biochemistry 15 (4), 857-862 (1976)
   PUBMED   129154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606536.13, AC116810.14 and AC138741.7.
            
            On Aug 1, 2007 this sequence version replaced NM_133239.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MT470368.1, AF406641.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AL606536.13        95624-95859
            237-815             AC116810.14        131151-131729       c
            816-1011            AC116810.14        122272-122467       c
            1012-1151           AC116810.14        117348-117487       c
            1152-1334           AC116810.14        108692-108874       c
            1335-2291           AC116810.14        42240-43196         c
            2292-2839           AC116810.14        37099-37646         c
            2840-3005           AC116810.14        35244-35409         c
            3006-3912           AC116810.14        30943-31849         c
            3913-4041           AC116810.14        28848-28976         c
            4042-4168           AC116810.14        25785-25911         c
            4169-4702           AC138741.7         145012-145545       c
FEATURES             Location/Qualifiers
     source          1..4702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 60.87 cM"
     gene            1..4702
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /note="crumbs family member 1, photoreceptor morphogenesis
                     associated"
                     /db_xref="GeneID:170788"
                     /db_xref="MGI:MGI:2136343"
     exon            1..236
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..4384
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /note="protein crumbs homolog 1"
                     /codon_start=1
                     /product="protein crumbs homolog 1 precursor"
                     /protein_id="NP_573502.2"
                     /db_xref="CCDS:CCDS15336.1"
                     /db_xref="GeneID:170788"
                     /db_xref="MGI:MGI:2136343"
                     /translation="MKLKRTAYLLFLYLSSSLLICIKNSFCNKNNTRCLSGPCQNNST
                     CKHFPQDNNCCLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGNFLCQCPPGYS
                     GLNCETATNSCGGNLCQHGGTCRKDPEHPVCICPPGYAGRFCETDHNECASSPCHNGA
                     MCQDGINGYSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCLNEIGRYTCVCPQEFSGV
                     NCELEIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQPCLHGGLC
                     VDGRNSYHCDCTGSGFTGMHCESLIPLCWSKPCHNDATCEDTVDSYICHCRPGYTGAL
                     CETDINECSSNPCQFWGECVELSSEGLYGNTAGLPSSFSYVGASGYVCICQPGFTGIH
                     CEEDVDECLLHPCLNGGTCENLPGNYACHCPFDDTSRTFYGGENCSEILLGCTHHQCL
                     NNGKCIPHFQNGQHGFTCQCLSGYAGPLCETVTTLSFGSNGFLWVTSGSHTGIGPECN
                     ISLRFHTVQPNALLLIRGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEW
                     HFVEVTIAETLTLALVGGSCKEKCTTKSSVPVENHQSICALQDSFLGGLPMGTANNSV
                     SVLNIYNVPSTPSFVGCLQDIRFDLNHITLENVSSGLSSNVKAGCLGKDWCESQPCQN
                     RGRCINLWQGYQCECDRPYTGSNCLKEYVAGRFGQDDSTGYAAFSVNDNYGQNFSLSM
                     FVRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFFLSDGNVHLISLR
                     IKPNEIELYQSSQNLGFISVPTWTIRRGDVIFIGGLPDREKTEVYGGFFKGCVQDVRL
                     NSQTLEFFPNSTNNAYDDPILVNVTQGCPGDNTCKSNPCHNGGVCHSLWDDFSCSCPT
                     NTAGRACEQVQWCQLSPCPPTAECQLLPQGFECIANAVFSGLSREILFRSNGNITREL
                     TNITFAFRTHDTNVMILHAEKEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLVND
                     GTWHQVTFSMIDPVAQTSRWQMEVNDQTPFVISEVATGSLNFLKDNTDIYVGDQSVDN
                     PKGLQGCLSTIEIGGIYLSYFENLHGFPGKPQEEQFLKVSTNMVLTGCLPSNACHSSP
                     CLHGGNCEDSYSSYRCACLSGWSGTHCEINIDECFSSPCIHGNCSDGVAAYHCRCEPG
                     YTGVNCEVDVDNCKSHQCANGATCVPEAHGYSCLCFGNFTGRFCRHSRLPSTVCGNEK
                     RNFTCYNGGSCSMFQEDWQCMCWPGFTGEWCEEDINECASDPCINGGLCRDLVNRFLC
                     ICDVAFAGERCELDLADDRLLGIFTAVGSGTLALFFILLLAGVASLIASNKRATQGTY
                     SPSGQEKAGPRVEMWIRMPPPALERLI"
     exon            237..815
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1011
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1151
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1334
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..2291
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2839
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3005
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3912
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4041
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4168
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4702
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtgcttt ctgattctct gtctgtggag gagccctggg aggggtggga cagagatggc
       61 atcctggctc tctgaggcac ctgctcttct ctgaaccaca caggagtcaa gagccaaaca
      121 gggatagctt cagcagcact tcagagggtg ttctctaagt aagaacatga agctcaagag
      181 aactgcctac cttctcttcc tgtacctcag ctcctcactg ctcatctgca taaagaattc
      241 attttgcaat aaaaacaata ccaggtgcct ttcaggtcct tgccaaaaca attctacgtg
      301 caagcatttt ccacaagaca acaattgttg cttagacaca gccaataatt tggacaaaga
      361 ctgtgaagat ctgaaagacc cttgcttctc gagtccctgc caaggaattg ccacttgtgt
      421 gaaaatccca ggggaaggga acttcctgtg tcagtgtcct cctgggtaca gcgggctgaa
      481 ctgtgaaact gccaccaatt cctgtggagg gaacctctgc caacatggag gcacctgccg
      541 taaagaccct gagcaccctg tctgtatctg ccctcctgga tatgctggaa ggttctgtga
      601 gactgatcac aatgagtgtg cttctagccc ttgccacaat ggggctatgt gccaggatgg
      661 aatcaatggc tactcctgct tctgtgtgcc tggataccaa ggcaggcatt gtgacttgga
      721 agtggatgaa tgtgtttctg atccctgcaa gaatgaggct gtgtgcctca atgagatagg
      781 aagatacact tgtgtctgcc ctcaagagtt ttctggcgtg aactgtgagt tggaaattga
      841 tgaatgcaga tcccagcctt gtctccacgg tgccacatgt caggacgctc cagggggcta
      901 ctcctgtgac tgtgcacctg gattccttgg agagcactgt gaactcagcg ttaatgaatg
      961 tgaaagtcag ccgtgtctcc atggaggtct atgtgtggat ggaagaaaca gttaccactg
     1021 tgactgcaca ggtagtggat tcacagggat gcactgtgag tccttgattc ctctttgttg
     1081 gtcaaagcct tgtcacaacg acgcgacatg tgaagatact gttgacagct atatttgtca
     1141 ctgccggcct ggatacacag gtgccctgtg tgagacagac ataaatgaat gcagtagcaa
     1201 cccctgccaa ttttgggggg aatgtgtcga gctgtcctca gagggtctat atggaaacac
     1261 tgctggcctg ccttcctcct tcagctatgt tggagcctcg ggctatgtgt gtatctgtca
     1321 gcctggattc acaggaattc actgtgaaga agacgttgat gaatgtttac tgcacccttg
     1381 cctaaatggt ggtacttgtg agaacctgcc tgggaattat gcctgtcact gtccctttga
     1441 tgacacttct aggacatttt atggaggaga aaactgctca gaaattctcc tgggctgcac
     1501 tcatcaccag tgtctgaaca atggaaaatg tatccctcat ttccaaaatg gccagcatgg
     1561 attcacttgc cagtgtcttt ctggctatgc ggggcccctg tgtgaaactg tcaccacact
     1621 ttcatttggg agcaatggct tcctatgggt cacaagtggc tcccatacag gcatagggcc
     1681 agaatgtaac atatccttga ggtttcacac tgttcaacca aacgcacttc tcctcatccg
     1741 aggcaacaag gacgtgtcta tgaagctgga gttgctgaat ggttgtgttc acttatcaat
     1801 tgaagtctgg aatcagttaa aggtgctcct gtctatttct cacaacacca gtgatggaga
     1861 atggcatttc gtggaggtaa caatcgcaga aactctaacc cttgccctag ttggcggctc
     1921 ctgcaaggag aagtgcacca ccaagtcttc tgttccagtt gagaatcatc aatcaatatg
     1981 tgctttgcag gactcttttt tgggtggctt accaatgggg acagccaaca acagtgtgtc
     2041 tgtgcttaac atctataatg tgccgtccac accttccttt gtaggctgtc tccaagacat
     2101 tagatttgat ttgaatcaca ttactctgga gaacgtttca tctggcctgt catcaaatgt
     2161 taaagcaggc tgcctgggaa aggactggtg tgaaagtcaa ccctgtcaaa acagaggacg
     2221 ctgcatcaac ttgtggcagg gttatcagtg tgaatgtgac aggccctata caggctccaa
     2281 ctgcctgaaa gagtatgtag cgggaagatt tggccaagat gactccacag gatatgcggc
     2341 ctttagtgtt aatgataatt atggacagaa cttcagtctt tcaatgtttg tccgaacacg
     2401 tcaacccctg ggcttacttc tggctttgga aaatagtact taccagtatg tcagtgtctg
     2461 gctagagcac ggcagcctag cactgcagac tccaggctct cccaagttca tggtaaactt
     2521 ttttctcagt gatggaaatg ttcacttaat atctttgaga atcaaaccaa atgaaattga
     2581 actgtatcag tcttcacaaa acctaggatt catttctgtt cctacatgga caattcgaag
     2641 aggagacgtc atcttcattg gtggcttacc tgacagagag aagactgaag tttatggtgg
     2701 cttcttcaaa ggctgtgttc aagatgtcag attaaacagc cagactctgg aattctttcc
     2761 caattcaaca aacaatgcat acgatgaccc aattcttgtc aatgtgactc aaggctgtcc
     2821 cggagacaac acatgtaagt ccaacccctg tcataatgga ggtgtctgcc actccctgtg
     2881 ggatgacttc tcctgctcct gccctacaaa cacagcgggg agagcctgcg agcaagttca
     2941 gtggtgtcaa ctcagcccat gtcctcccac tgcagagtgc cagctgctcc ctcaagggtt
     3001 tgaatgtatc gcaaacgctg ttttcagcgg attaagcaga gaaatactct tcagaagcaa
     3061 tgggaacatt accagagaac tcaccaatat cacatttgct ttcagaacac atgatacaaa
     3121 tgtgatgata ttgcatgcag aaaaagaacc agagtttctt aatattagca ttcaagatgc
     3181 cagattattc tttcaattgc gaagtggcaa cagcttttat acgctgcacc tgatgggttc
     3241 ccaattggtg aatgatggca catggcacca agtgactttc tccatgatag acccagtggc
     3301 ccagacctcc cggtggcaaa tggaggtgaa cgaccagaca ccctttgtga taagtgaagt
     3361 tgctactgga agcctgaact ttttgaagga caatacagac atctatgtgg gtgaccaatc
     3421 tgttgacaat ccgaaaggcc tgcagggctg tctgagcaca atagagattg gaggcatata
     3481 tctttcttac tttgaaaatc tacatggttt ccctggtaag cctcaggaag agcaatttct
     3541 caaagtttct acaaatatgg tacttactgg ctgtttgcca tcaaatgcct gccactccag
     3601 cccctgtttg catggaggaa actgtgaaga cagctacagt tcttatcggt gtgcctgtct
     3661 ctcgggatgg tcagggacac actgtgaaat caacattgat gagtgctttt ctagcccctg
     3721 tatccatggc aactgctctg atggagttgc agcctaccac tgcaggtgtg agcctggata
     3781 caccggtgtg aactgtgagg tggatgtaga caattgcaag agtcatcagt gtgcaaatgg
     3841 ggccacctgt gttcctgaag ctcatggcta ctcttgtctc tgctttggaa attttaccgg
     3901 gagattttgc agacacagca gattaccctc aacagtctgt gggaatgaga agagaaactt
     3961 cacttgctac aatggaggca gctgctccat gttccaggag gactggcaat gtatgtgctg
     4021 gccaggtttc actggagagt ggtgtgaaga ggacatcaac gagtgtgcct ccgatccctg
     4081 catcaatgga ggactgtgca gggacttggt caacaggttc ctatgcatct gtgatgtggc
     4141 cttcgctggc gagcgctgtg agctggacct ggctgatgac aggctcctgg gcattttcac
     4201 cgctgttggc tccggaactt tggccctgtt cttcatcctc ttgcttgctg gggttgcttc
     4261 tcttattgcc tccaacaaaa gggcgactca aggaacctac agccccagcg gtcaggagaa
     4321 ggctggccct cgagtggaaa tgtggatcag gatgccgccc ccggcactgg aaaggctcat
     4381 ctaggagact gctgctcttc tcaggacaga gaagaacatg atgagtaccg ggtcgtgcct
     4441 gagtgaagat ggctttacat cactagagat acatacagct gggactgtgg gaaggacctt
     4501 cctgtggagt cactgagtag ttatgtcatc cattcacaga agagtgtccc tgtgtttgcc
     4561 tgtcagcctc agaattagca aaacatctag cagacagaga acacagtatt tcagaagaac
     4621 tccagaggct gccccttaaa ctctttactg gttgatccac ataaaatgct tagtagccaa
     4681 gtgccattaa ttatacagag cc
//
