LOCUS       NP_573502               1405 aa            linear   ROD 10-FEB-2025
DEFINITION  protein crumbs homolog 1 precursor [Mus musculus].
ACCESSION   NP_573502
VERSION     NP_573502.2
DBSOURCE    REFSEQ: accession NM_133239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1405)
  AUTHORS   Cho,S.H., Kim,J.H. and Kim,S.
  TITLE     Perturbed cell cycle phase-dependent positioning and nuclear
            migration of retinal progenitors along the apico-basal axis
            underlie global retinal disorganization in the LCA8-like mouse
            model
  JOURNAL   Dev Biol 517, 39-54 (2025)
   PUBMED   39284539
REFERENCE   2  (residues 1 to 1405)
  AUTHORS   Schwammle,M.E., Bucher,F., Schlunck,G. and Martin,G.
  TITLE     Genotyping single point mutations in rd1 and rd8 mice using melting
            curve analysis of qPCR fragments
  JOURNAL   Sci Rep 14 (1), 19909 (2024)
   PUBMED   39198547
  REMARK    GeneRIF: a simple and effective PCR based method for genotyping rd1
            (Pde6b) and rd8 (Crb1) in mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1405)
  AUTHORS   Seyed-Razavi,Y., Lee,S.R., Fan,J., Shen,W., Cornish,E.E. and
            Gillies,M.C.
  TITLE     JR5558 mice are a reliable model to investigate subretinal fibrosis
  JOURNAL   Sci Rep 14 (1), 18752 (2024)
   PUBMED   39138242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1405)
  AUTHORS   Peng,S., Li,J.J., Song,W., Li,Y., Zeng,L., Liang,Q., Wen,X.,
            Shang,H., Liu,K., Peng,P., Xue,W., Zou,B., Yang,L., Liang,J.,
            Zhang,Z., Guo,S., Chen,T., Li,W., Jin,M., Xing,X.B., Wan,P.,
            Liu,C., Lin,H., Wei,H., Lee,R.W.J., Zhang,F. and Wei,L.
  TITLE     CRB1-associated retinal degeneration is dependent on bacterial
            translocation from the gut
  JOURNAL   Cell 187 (6), 1387-1401 (2024)
   PUBMED   38412859
  REMARK    GeneRIF: CRB1-associated retinal degeneration is dependent on
            bacterial translocation from the gut.
REFERENCE   5  (residues 1 to 1405)
  AUTHORS   Rivera-Garcia,L.G., Francis-Malave,A.M., Castillo,Z.W., Uong,C.D.,
            Wilson,T.D., Ferchmin,P.A., Eterovic,V., Burton,M.D. and
            Carrasquillo,Y.
  TITLE     Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco
            cembranoid in a mouse model of inflammatory pain
  JOURNAL   J Inflamm (Lond) 21 (1), 2 (2024)
   PUBMED   38267952
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1405)
  AUTHORS   Pellikka,M., Tanentzapf,G., Pinto,M., Smith,C., McGlade,C.J.,
            Ready,D.F. and Tepass,U.
  TITLE     Crumbs, the Drosophila homologue of human CRB1/RP12, is essential
            for photoreceptor morphogenesis
  JOURNAL   Nature 416 (6877), 143-149 (2002)
   PUBMED   11850625
REFERENCE   7  (residues 1 to 1405)
  AUTHORS   Chang,B., Hawes,N.L., Hurd,R.E., Davisson,M.T., Nusinowitz,S. and
            Heckenlively,J.R.
  TITLE     Retinal degeneration mutants in the mouse
  JOURNAL   Vision Res 42 (4), 517-525 (2002)
   PUBMED   11853768
  REMARK    Review article
REFERENCE   8  (residues 1 to 1405)
  AUTHORS   den Hollander,A.I., Ghiani,M., de Kok,Y.J., Wijnholds,J.,
            Ballabio,A., Cremers,F.P. and Broccoli,V.
  TITLE     Isolation of Crb1, a mouse homologue of Drosophila crumbs, and
            analysis of its expression pattern in eye and brain
  JOURNAL   Mech Dev 110 (1-2), 203-207 (2002)
   PUBMED   11744384
  REMARK    GeneRIF: Isolation of Crb1, a mouse homologue of Drosophila crumbs,
            and analysis of its expression pattern in eye and brain.
REFERENCE   9  (residues 1 to 1405)
  AUTHORS   den Hollander,A.I., ten Brink,J.B., de Kok,Y.J., van Soest,S., van
            den Born,L.I., van Driel,M.A., van de Pol,D.J., Payne,A.M.,
            Bhattacharya,S.S., Kellner,U., Hoyng,C.B., Westerveld,A.,
            Brunner,H.G., Bleeker-Wagemakers,E.M., Deutman,A.F.,
            Heckenlively,J.R., Cremers,F.P. and Bergen,A.A.
  TITLE     Mutations in a human homologue of Drosophila crumbs cause retinitis
            pigmentosa (RP12)
  JOURNAL   Nat Genet 23 (2), 217-221 (1999)
   PUBMED   10508521
REFERENCE   10 (residues 1 to 1405)
  AUTHORS   Parr,G.R. and Hammes,G.G.
  TITLE     A kinetic study of the subunit dissociation and reassembly of
            rabbit muscle phosphofructokinase
  JOURNAL   Biochemistry 15 (4), 857-862 (1976)
   PUBMED   129154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606536.13, AC116810.14 and AC138741.7.
            
            On Aug 1, 2007 this sequence version replaced NP_573502.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MT470368.1, AF406641.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1405
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 60.87 cM"
     Protein         1..1405
                     /product="protein crumbs homolog 1 precursor"
                     /note="protein crumbs homolog 1"
                     /calculated_mol_wt=150200
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3170
     mat_peptide     28..1405
                     /product="Protein crumbs homolog 1. /id=PRO_0000007501"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHS2.3)"
                     /calculated_mol_wt=150200
     Site            41
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          113..143
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          147..182
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(147,150,164)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          186..221
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          224..259
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          262..298
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          <308..336
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          338..394
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(338,341,364)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          396..437
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(396,399,413)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          513..648
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Site            560
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Site            656
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          675..706
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          742..859
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Site            756
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Site            879
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          888..922
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            967
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Site            974
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          979..1104
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Site            999
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          1140..1174
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1176..1211
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1176,1179,1192)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          1213..1248
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1213,1216,1230)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1242
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Site            1264
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VHS2.3)"
     Region          1296..1332
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1296,1299,1313)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1340..1360
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHS2.3)"
     CDS             1..1405
                     /gene="Crb1"
                     /gene_synonym="7530426H14Rik; A930008G09Rik; CRB1-A;
                     CRB1-A2; CRB1-B; CRB1-C"
                     /coded_by="NM_133239.2:167..4384"
                     /db_xref="CCDS:CCDS15336.1"
                     /db_xref="GeneID:170788"
                     /db_xref="MGI:MGI:2136343"
ORIGIN      
        1 mklkrtayll flylssslli ciknsfcnkn ntrclsgpcq nnstckhfpq dnnccldtan
       61 nldkdcedlk dpcfsspcqg iatcvkipge gnflcqcppg ysglncetat nscggnlcqh
      121 ggtcrkdpeh pvcicppgya grfcetdhne casspchnga mcqdgingys cfcvpgyqgr
      181 hcdlevdecv sdpckneavc lneigrytcv cpqefsgvnc eleidecrsq pclhgatcqd
      241 apggyscdca pgflgehcel svnecesqpc lhgglcvdgr nsyhcdctgs gftgmhcesl
      301 iplcwskpch ndatcedtvd syichcrpgy tgalcetdin ecssnpcqfw gecvelsseg
      361 lygntaglps sfsyvgasgy vcicqpgftg ihceedvdec llhpclnggt cenlpgnyac
      421 hcpfddtsrt fyggencsei llgcthhqcl nngkciphfq ngqhgftcqc lsgyagplce
      481 tvttlsfgsn gflwvtsgsh tgigpecnis lrfhtvqpna lllirgnkdv smklellngc
      541 vhlsievwnq lkvllsishn tsdgewhfve vtiaetltla lvggsckekc ttkssvpven
      601 hqsicalqds flgglpmgta nnsvsvlniy nvpstpsfvg clqdirfdln hitlenvssg
      661 lssnvkagcl gkdwcesqpc qnrgrcinlw qgyqcecdrp ytgsnclkey vagrfgqdds
      721 tgyaafsvnd nygqnfslsm fvrtrqplgl llalenstyq yvsvwlehgs lalqtpgspk
      781 fmvnfflsdg nvhlislrik pneielyqss qnlgfisvpt wtirrgdvif igglpdrekt
      841 evyggffkgc vqdvrlnsqt leffpnstnn ayddpilvnv tqgcpgdntc ksnpchnggv
      901 chslwddfsc scptntagra ceqvqwcqls pcpptaecql lpqgfecian avfsglsrei
      961 lfrsngnitr eltnitfafr thdtnvmilh aekepeflni siqdarlffq lrsgnsfytl
     1021 hlmgsqlvnd gtwhqvtfsm idpvaqtsrw qmevndqtpf visevatgsl nflkdntdiy
     1081 vgdqsvdnpk glqgclstie iggiylsyfe nlhgfpgkpq eeqflkvstn mvltgclpsn
     1141 achsspclhg gncedsyssy rcaclsgwsg thceinidec fsspcihgnc sdgvaayhcr
     1201 cepgytgvnc evdvdncksh qcangatcvp eahgysclcf gnftgrfcrh srlpstvcgn
     1261 ekrnftcyng gscsmfqedw qcmcwpgftg ewceedinec asdpcinggl crdlvnrflc
     1321 icdvafager celdladdrl lgiftavgsg tlalffilll agvasliasn kratqgtysp
     1381 sgqekagprv emwirmpppa lerli
//
