LOCUS       NM_001330138            1799 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus CASP2 and RIPK1 domain containing adaptor with death
            domain (Cradd), transcript variant 1, mRNA.
ACCESSION   NM_001330138 XM_006513178
VERSION     NM_001330138.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Braun,V.Z., Karbon,G., Schuler,F., Schapfl,M.A., Weiss,J.G.,
            Petermann,P.Y., Spierings,D.C.J., Tijhuis,A.E., Foijer,F., Labi,V.
            and Villunger,A.
  TITLE     Extra centrosomes delay DNA damage-driven tumorigenesis
  JOURNAL   Sci Adv 10 (13), eadk0564 (2024)
   PUBMED   38552015
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Kim,J.Y., Wang,L.Q., Sladky,V.C., Oh,T.G., Liu,J., Trinh,K.,
            Eichin,F., Downes,M., Hosseini,M., Jacotot,E.D., Evans,R.M.,
            Villunger,A. and Karin,M.
  TITLE     PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent
            transition from simple steatosis to steatohepatitis
  JOURNAL   Cell Metab 34 (10), 1548-1560 (2022)
   PUBMED   36041455
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Ando,K., Parsons,M.J., Shah,R.B., Charendoff,C.I., Paris,S.L.,
            Liu,P.H., Fassio,S.R., Rohrman,B.A., Thompson,R., Oberst,A.,
            Sidi,S. and Bouchier-Hayes,L.
  TITLE     NPM1 directs PIDDosome-dependent caspase-2 activation in the
            nucleolus
  JOURNAL   J Cell Biol 216 (6), 1795-1810 (2017)
   PUBMED   28432080
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Di Donato,N., Jean,Y.Y., Maga,A.M., Krewson,B.D., Shupp,A.B.,
            Avrutsky,M.I., Roy,A., Collins,S., Olds,C., Willert,R.A.,
            Czaja,A.M., Johnson,R., Stover,J.A., Gottlieb,S., Bartholdi,D.,
            Rauch,A., Goldstein,A., Boyd-Kyle,V., Aldinger,K.A., Mirzaa,G.M.,
            Nissen,A., Brigatti,K.W., Puffenberger,E.G., Millen,K.J.,
            Strauss,K.A., Dobyns,W.B., Troy,C.M. and Jinks,R.N.
  TITLE     Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal
            Apoptosis and Cause Megalencephaly with a Rare Lissencephaly
            Variant
  JOURNAL   Am J Hum Genet 99 (5), 1117-1129 (2016)
   PUBMED   27773430
REFERENCE   5  (bases 1 to 1799)
  AUTHORS   Peintner,L., Dorstyn,L., Kumar,S., Aneichyk,T., Villunger,A. and
            Manzl,C.
  TITLE     The tumor-modulatory effects of Caspase-2 and Pidd1 do not require
            the scaffold protein Raidd
  JOURNAL   Cell Death Differ 22 (11), 1803-1811 (2015)
   PUBMED   25857265
  REMARK    GeneRIF: The tumor-modulatory effects of Caspase-2 and Pidd1 do not
            require the scaffold protein Raidd
REFERENCE   6  (bases 1 to 1799)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   7  (bases 1 to 1799)
  AUTHORS   Felmer,R., Horvat,S., Clinton,M. and Clark,A.J.
  TITLE     Overexpression of Raidd cDNA inhibits differentiation of mouse
            preadipocytes
  JOURNAL   Cell Prolif 36 (1), 45-54 (2003)
   PUBMED   12558660
  REMARK    GeneRIF: Overexpression of Raidd cDNA in 3T3L1 cells inhibited
            differentiation of the preadipocytes.
REFERENCE   8  (bases 1 to 1799)
  AUTHORS   Wong,M.L., Islas-Trejo,A. and Medrano,J.F.
  TITLE     Structural characterization of the mouse high growth deletion and
            discovery of a novel fusion transcript between suppressor of
            cytokine signaling-2 (Socs-2) and viral encoded semaphorin receptor
            (Plexin C1)
  JOURNAL   Gene 299 (1-2), 153-163 (2002)
   PUBMED   12459263
REFERENCE   9  (bases 1 to 1799)
  AUTHORS   Hofmann,K.
  TITLE     The modular nature of apoptotic signaling proteins
  JOURNAL   Cell Mol Life Sci 55 (8-9), 1113-1128 (1999)
   PUBMED   10442092
  REMARK    Review article
REFERENCE   10 (bases 1 to 1799)
  AUTHORS   Horvat,S. and Medrano,J.F.
  TITLE     A 500-kb YAC and BAC contig encompassing the high-growth deletion
            in mouse chromosome 10 and identification of the murine Raidd/Cradd
            gene in the candidate region
  JOURNAL   Genomics 54 (1), 159-164 (1998)
   PUBMED   9806843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ571215.1, AI430259.1, AC153940.3, AA109538.1 and BE991734.1.
            
            On Aug 19, 2016 this sequence version replaced XM_006513178.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ571215.1, AJ224740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BQ571215.1         1-144
            145-624             AI430259.1         1-480
            625-1287            AC153940.3         123869-124531       c
            1288-1766           AA109538.1         1-479               c
            1767-1799           BE991734.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 49.26 cM"
     gene            1..1799
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /note="CASP2 and RIPK1 domain containing adaptor with
                     death domain"
                     /db_xref="GeneID:12905"
                     /db_xref="MGI:MGI:1336168"
     exon            1..241
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            242..545
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..847
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /note="caspase and RIP adapter with death domain;
                     RIP-associated protein with a death domain"
                     /codon_start=1
                     /product="death domain-containing protein CRADD"
                     /protein_id="NP_001317067.1"
                     /db_xref="CCDS:CCDS24135.1"
                     /db_xref="GeneID:12905"
                     /db_xref="MGI:MGI:1336168"
                     /translation="MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEI
                     KAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEVTAELPTGDW
                     MAGIPSHILSSSPSDQQINQLAQRLGPEWEPVVLSLGLSQTDIYRCKANHPHNVHSQV
                     VEAFVRWRQRFGKQATFLSLHKGLQAVEADPSLLQHMLE"
     exon            546..1785
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /note="hexamer: AATAAA"
     polyA_site      1256
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
     regulatory      1761..1766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /note="hexamer: ATTAAA"
     polyA_site      1785
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /note="major polyA site"
ORIGIN      
        1 ccctcctcac ctgccacctc ccgatttggc ggaagatcgc gagcaaggct gggatccgac
       61 gtcccgcttg tgtgggctga gggtggcaga agccccgccc gccacccttg ctccccttgc
      121 cttcattgcc accgcaagcc accccgcagc acactagcga cctgagctca ttcagtgtcc
      181 catgcatgcg tgctcacggc cctactgcga cccacattcc gaattcttgt gaggcttatc
      241 ggaagaaatg gaagccagag acaagcaggt actccgctcc ctgcgtctgg agctgggtgc
      301 cgaggtactg gtggaaggac tggttcttca gtacctttac caggaaggaa ttttgacaga
      361 aaaccacatt caagaaatca aagctcaaac cacaggcctc cggaagacaa tgctgttgct
      421 ggacatcctg ccttccaggg gccccaaagc ttttgacacc ttcctcgatt ccctccagga
      481 atttccctgg gtaagagaga agctggagaa ggcgagagag gaagtcacag ccgagctgcc
      541 tacaggtgac tggatggccg gaatcccctc acacatcctc agcagctcgc catcagacca
      601 gcagattaac cagctggctc agaggctagg cccggagtgg gagcccgtgg tcctgtctct
      661 gggactgtcc cagaccgaca tctaccgctg caaggccaac catccccaca acgtgcattc
      721 gcaggtggtg gaggcctttg tccgctggcg ccagcgtttt gggaagcagg ccaccttcct
      781 aagcttacac aagggcctcc aggcagtgga ggctgatccc tccctgctcc agcacatgct
      841 ggagtgacct gacccccccc cgcgcccccc ccccacttgc tgtgggggtg gtggggcgtg
      901 ggttcccaag tcacactggc tgaaccggac ttttctcagc aggtggcttt gttctgggct
      961 tttcagtgat ctgtttacgg aaagagatcg tccaccactc actcaaccat cgattggctt
     1021 taattgcttg aagactgcgc tgttgtaact atggtttgga actttgtggc tggcctttaa
     1081 caggaggcca gaaaaaacac aacacccacc ctacccaacc ccccaaaaaa tcatgctaca
     1141 gcatcgaatg caggtgtcct gcatacaagg cagctacact tgtgttgcct ggagactgga
     1201 ttgtgcattt agctcttcat aatggtgatg ataataaaaa agcaaattgt gatatagaat
     1261 gtgcctcttt caatgagaga gtattatatc acacacacac acacacacac acacacacat
     1321 acacacacac acaccactct tctgttgcat agacggaggg tgtaaaaata tgggagtgga
     1381 gcaagattga tagcagtcat gtgacgacgg agataaataa ctcaggcagg atgtatagat
     1441 taagcatgag acaccgaagc tccctgcaga ggccagggag agaacggaag accttcatct
     1501 taacaaattg tatgaggagt ctctgtccat ttgttaaagg cattggatca gagacaagag
     1561 ggctcagtgt ttctcttgag gcctgaatgg ctgaaggcgg tgagttcccg aggggcgtca
     1621 tgggttgtcc agcctttcat taactgcaca tagtgttagc cagacaggtg tacgtgtttg
     1681 tcatcccatc taagagactg aagcaggagg atcacctgta catgactgct tctttcaaca
     1741 ttttaaaatg tgtaacttct attaaattct ctcagtgcaa ataaaaaaaa aaaaaaaaa
//
