LOCUS       NM_013499               1674 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus complement C3b/C4b receptor 1 like (Cr1l), transcript
            variant 1, mRNA.
ACCESSION   NM_013499
VERSION     NM_013499.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Kuniyoshi,N., Hanada,S., Ando,R., Yustinasari,L.R., Kuratomi,M.,
            Kagawa,S., Imai,H. and Kusakabe,K.T.
  TITLE     Expression dynamics of Crry at the implantation sites in normal
            pregnancy and response against miscarriage induction
  JOURNAL   J Vet Med Sci 85 (1), 92-98 (2023)
   PUBMED   36450590
  REMARK    GeneRIF: Expression dynamics of Crry at the implantation sites in
            normal pregnancy and response against miscarriage induction.
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Nagano,F., Mizuno,T., Imai,M., Takahashi,K., Tsuboi,N., Maruyama,S.
            and Mizuno,M.
  TITLE     Expression of a Crry/p65 is reduced in acute lung injury induced by
            extracellular histones
  JOURNAL   FEBS Open Bio 12 (1), 192-202 (2022)
   PUBMED   34709768
  REMARK    GeneRIF: Expression of a Crry/p65 is reduced in acute lung injury
            induced by extracellular histones.
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   Bosco,A., Anderson,S.R., Breen,K.T., Romero,C.O., Steele,M.R.,
            Chiodo,V.A., Boye,S.L., Hauswirth,W.W., Tomlinson,S. and
            Vetter,M.L.
  TITLE     Complement C3-Targeted Gene Therapy Restricts Onset and Progression
            of Neurodegeneration in Chronic Mouse Glaucoma
  JOURNAL   Mol Ther 26 (10), 2379-2396 (2018)
   PUBMED   30217731
  REMARK    GeneRIF: Our study uncovers a damaging effect of complement C3 or
            downstream complement activation in glaucoma, and it establishes
            AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic
            C3-mediated complement activation in the glaucomatous retina
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Lenis,T.L., Sarfare,S., Jiang,Z., Lloyd,M.B., Bok,D. and Radu,R.A.
  TITLE     Complement modulation in the retinal pigment epithelium rescues
            photoreceptor degeneration in a mouse model of Stargardt disease
  JOURNAL   Proc Natl Acad Sci U S A 114 (15), 3987-3992 (2017)
   PUBMED   28348233
  REMARK    GeneRIF: CRRY role in the retinal epithelium and photoreceptor
            degeneration
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Molina,H., Wong,W., Kinoshita,T., Brenner,C., Foley,S. and
            Holers,V.M.
  TITLE     Distinct receptor and regulatory properties of recombinant mouse
            complement receptor 1 (CR1) and Crry, the two genetic homologues of
            human CR1
  JOURNAL   J Exp Med 175 (1), 121-129 (1992)
   PUBMED   1730912
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Taketo,M., Howard,T.A. and Seldin,M.F.
  TITLE     Mapping of recombinant retrovirus integration sites that cause
            expression of the viral genome in murine embryonal carcinoma cells
  JOURNAL   Mamm Genome 2 (4), 240-245 (1992)
   PUBMED   1543915
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Kurtz,C.B., O'Toole,E., Christensen,S.M. and Weis,J.H.
  TITLE     The murine complement receptor gene family. IV. Alternative
            splicing of Cr2 gene transcripts predicts two distinct gene
            products that share homologous domains with both human CR2 and CR1
  JOURNAL   J Immunol 144 (9), 3581-3591 (1990)
   PUBMED   2139460
REFERENCE   9  (bases 1 to 1674)
  AUTHORS   Paul,M.S., Aegerter,M., Cepek,K., Miller,M.D. and Weis,J.H.
  TITLE     The murine complement receptor gene family. III. The genomic and
            transcriptional complexity of the Crry and Crry-ps genes
  JOURNAL   J Immunol 144 (5), 1988-1996 (1990)
   PUBMED   2307848
REFERENCE   10 (bases 1 to 1674)
  AUTHORS   Kurtz,C.B., Paul,M.S., Aegerter,M., Weis,J.J. and Weis,J.H.
  TITLE     Murine complement receptor gene family. II. Identification and
            characterization of the murine homolog (Cr2) to human CR2 and its
            molecular linkage to Crry
  JOURNAL   J Immunol 143 (6), 2058-2067 (1989)
   PUBMED   2528587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA491482.1, AK004825.1 and AI098173.1.
            
            On Sep 22, 2004 this sequence version replaced NM_013499.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004825.1, BC028945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CA491482.1         38-47
            11-591              AK004825.1         2-582
            592-1654            AK004825.1         584-1646
            1655-1674           AI098173.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 98.43 cM"
     gene            1..1674
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /note="complement C3b/C4b receptor 1 like"
                     /db_xref="GeneID:12946"
                     /db_xref="MGI:MGI:88513"
     exon            1..383
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1588
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement regulatory protein Crry; protein
                     p65; complement receptor related protein; complement
                     component receptor 1-like protein; complement component
                     (3b/4b) receptor 1-like"
                     /codon_start=1
                     /product="complement component receptor 1-like protein
                     isoform 1 precursor"
                     /protein_id="NP_038527.2"
                     /db_xref="CCDS:CCDS15641.1"
                     /db_xref="GeneID:12946"
                     /db_xref="MGI:MGI:88513"
                     /translation="MEVSSRSSEPLDPVWLLVAFGRGGVKLEVLLLFLLPFTLGHCPA
                     PSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQ
                     CKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPIC
                     EWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSND
                     GEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGAS
                     SVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTL
                     EGSSQSQCQSDGSWNPLLAKCVSRSISGLIVGIFIGIIVFILVIIVFIWMILKYKKRN
                     TTDEKYKEVGIHLNYKEDSCVRLQSLLTSQENSSTTSPARNSLTQEVS"
     exon            384..563
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            564..663
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            664..749
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1151
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1337
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1361
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1437
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1542
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1662
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1637..1642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /note="hexamer: AATAAA"
     polyA_site      1656
                     /gene="Cr1l"
                     /gene_synonym="Crry; Mcp; mCRY"
                     /note="major polyA site"
ORIGIN      
        1 ataatgcctt gttttctttg gagtcgaagg ttcctgcaag tggaaaactt cctggagctg
       61 acctactagg tattgaacca gtttctgcat tgctgaatca atctcccaag ggtaattcca
      121 cagaaatccc aggggcttgg agtaaacaag accgcgccta gcccagctag aggaagtttt
      181 attccggaac ccagcgccat ttctgggtgg gactgctttc tacaccattt gccgtaaaac
      241 gttgtttgag aacggtgtga ggggaatgga ggtctcttct cggagttcag agcctctgga
      301 tccggtgtgg ctccttgtag ccttcggccg gggaggagtc aagctagaag ttttgctgct
      361 gttcttgctg ccatttactt tgggtcactg cccagcccca tcacagcttc cttctgccaa
      421 acctataaat ctaactgatg aatccatgtt tcccattgga acatatttgt tgtatgaatg
      481 tctcccagga tatatcaaga ggcagttctc tatcacctgc aaacaagact caacctggac
      541 gagtgctgaa gataagtgta tacgaaaaca atgtaaaact ccttcagatc ctgagaatgg
      601 cttggtacat gtacacacag gcattcagtt tggatcccgt attaattata cttgtaatca
      661 aggataccgc ctcattggtt cctcctctgc tgtatgtgtc atcactgatc aaagtgttga
      721 ttgggatact gaggcaccta tttgtgagtg gattccttgt gagatacccc caggcattcc
      781 caatggagat ttcttcagtt caaccagaga agactttcat tatggaatgg tggttaccta
      841 ccgctgcaac actgatgcga gagggaaggc gctctttaac ctggtgggtg agccctcctt
      901 atactgtacc agcaacgatg gtgaaattgg agtctggagc ggccctcctc ctcagtgcat
      961 tgaactcaac aaatgtactc ctcctcccta tgttgaaaat gcagtcatgc tgtctgagaa
     1021 cagaagcttg ttttccttaa gggatattgt ggagtttaga tgtcaccctg gctttatcat
     1081 gaaaggagcc agcagtgtgc attgtcagtc cctaaacaaa tgggagccag agttaccaag
     1141 ctgcttcaag ggagtgatat gtcgtctccc tcaggagatg agtggattcc agaaggggtt
     1201 gggaatgaaa aaagaatatt attatggaga gaatgtaacc ttggaatgtg aggatgggta
     1261 tactctagaa ggcagttctc aaagccagtg ccagtctgat ggcagctgga atcctcttct
     1321 ggccaaatgt gtatctcgct caatcagtgg tctaattgtt ggaattttca ttgggataat
     1381 cgtctttatt ttagtcatca ttgttttcat ttggatgatt ctgaagtata aaaaacgcaa
     1441 taccacagat gaaaagtata aagaagtggg tattcattta aattataaag aagacagctg
     1501 tgtccgcctt cagtctctgc tcacaagtca ggagaacagc agtaccacta gcccagcacg
     1561 gaattcactc actcaagaag tctcctaaat agcagcaacg tgaaatgaga acatgctctg
     1621 tctgtatcac ttttaaaata aactgtttcc ttttaagatc taaaaaaaaa aaaa
//
