LOCUS       NM_153107               2189 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxypeptidase Z (Cpz), mRNA.
ACCESSION   NM_153107 XM_994610 XM_994626
VERSION     NM_153107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Moeller,C., Swindell,E.C., Kispert,A. and Eichele,G.
  TITLE     Carboxypeptidase Z (CPZ) modulates Wnt signaling and regulates the
            development of skeletal elements in the chicken
  JOURNAL   Development 130 (21), 5103-5111 (2003)
   PUBMED   12944424
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Novikova,E., Fricker,L.D. and Reznik,S.E.
  TITLE     Metallocarboxypeptidase Z is dynamically expressed in mouse
            development
  JOURNAL   Mech Dev 102 (1-2), 259-262 (2001)
   PUBMED   11287206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ067998.1, AC116705.11, BX518878.1 and CD742096.1.
            
            On Dec 29, 2006 this sequence version replaced NM_153107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF356844.1, SRR14995047.571506.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               CJ067998.1         73-478
            407-602             AC116705.11        156064-156259       c
            603-815             AC116705.11        154022-154234       c
            816-1012            AC116705.11        151082-151278       c
            1013-1174           AC116705.11        150374-150535       c
            1175-1693           BX518878.1         2-520
            1694-2189           CD742096.1         1-496               c
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.16 cM"
     gene            1..2189
                     /gene="Cpz"
                     /note="carboxypeptidase Z"
                     /db_xref="GeneID:242939"
                     /db_xref="MGI:MGI:88487"
     exon            1..194
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2056
                     /gene="Cpz"
                     /codon_start=1
                     /product="carboxypeptidase Z precursor"
                     /protein_id="NP_694747.2"
                     /db_xref="CCDS:CCDS19229.1"
                     /db_xref="GeneID:242939"
                     /db_xref="MGI:MGI:88487"
                     /translation="MPTMPLLLAALAALAVLALAARPSPSCSPGPDPSGKCQRLVYTH
                     SATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVESSPEYMLLGVIHFLLEGQCNPDL
                     RLLGCSVLAPRCEGGHTQRPCRHVCEGLREACQPAFDAIDMAWPYFLDCAQYFAPEEE
                     GCYDPLEELRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSI
                     GRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREVLIYLAQYLCSEYLL
                     GNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLT
                     SEYYRLASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVS
                     YPFDFSKNPHEKKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIIN
                     GADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQQNKEPLLNFLEMVH
                     RGIKGMVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKV
                     MKRVTIPLRMKKAGRVDFILHPLATGPKNFLPGPSRALPRFQDPQREPTQMDFEPPRA
                     RRQPASGSKPWWWAYFTSLSPYKPRWLLKY"
     exon            195..227
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            228..602
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            603..815
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1012
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1174
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1333
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1469
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1609
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1709
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..2173
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpz"
                     /note="hexamer: ATTAAA"
     polyA_site      2173
                     /gene="Cpz"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcagcc gaagggccca gcagcgcctc tcgcgctccc cgagtgccac atcactgcgc
       61 cctcccgcgc atccgtgcat ctgtgcccac catgccgaca atgccgctgc tgctggccgc
      121 gctggctgcg ctggccgtgc tggcccttgc cgcgcgcccc agccccagct gctcgcctgg
      181 acccgacccc tccggtaaat gtcagaggct ggtctacaca cacagtgcca cctgtgtgga
      241 cctgcatctc aggacctgtg cggatgccgc ctataaccat acatcgttcc ccacaccgct
      301 ggagcaccgg tcgtgggagg cagtggagtc tagccctgag tacatgctgt tgggtgtgat
      361 acactttctc ctggagggtc agtgcaaccc tgacctgcgg ctgctagggt gctctgtgtt
      421 ggccccccga tgtgagggag gccacacaca aaggccctgc cggcatgtct gtgagggcct
      481 tcgggaggcc tgccagccgg cctttgacgc catcgacatg gcctggccct acttccttga
      541 ttgtgcccaa tacttcgcac cagaggagga aggctgctat gaccctctgg aagagctccg
      601 tggagagctg gatgttgagg aggccctgcc ctctggcctg ccacctacct tcattcgctt
      661 cgcccaccac tcctatgctc agatggtccg agtgctgaag aggacagcgg cccgctgttc
      721 ccaggtggcc aagacctaca gcattgggcg cagctttgaa ggcaaggacc tggtggtcat
      781 cgagttctcg agccgcccag gccagcatga actgatggag cctgaggtga agctcattgg
      841 aaacattcat ggcaatgagg tggccggacg ggaagtgctc atctacctgg cccagtacct
      901 gtgctcggag tacctgctgg gcaaccctcg catccagcgc ctgctgaaca ccacccgcat
      961 ccacctgctg ccatccatga accctgatgg ctacgaagtg gcagctgcag agggtgctgg
     1021 atacaatggc tggaccagtg gaaggcagaa tgcacagaac ctggatctga accgcaactt
     1081 ccctgacctc acgtcagagt actaccggct ggcctcgact cgtggtgtgc gcacagacca
     1141 tatccccatc tcacagtact actggtgggg taaggtggcc cccgagacca aagccatcat
     1201 gaagtggata cagaccattc ccttcgtcct ctcagccagc ctgcatggcg gcgacctggt
     1261 ggtatcctac cccttcgact tctccaagaa cccccatgag aaaaagatgt tttctcccac
     1321 accagatgag aagatgttca agcttctggc cagagcctat gctgatgtcc accccatgat
     1381 gatggacagg tcggagaaca ggtgtggggg caacttcctg aagcggggga gcatcatcaa
     1441 cggggcggac tggtacagct tcactggagg tatgtctgac ttcaactact tacataccaa
     1501 ctgctttgag atcactgtgg aactgggctg tgtgaagttc cccccagagg aggcgctgta
     1561 tggcctgtgg caacagaaca aggagcccct actcaacttc ctggagatgg tacaccgagg
     1621 catcaagggt atggtgacag ataaatacgg aaagccagtc aagaacgcac ggattctggt
     1681 gaaaggcatc cgccacgatg tcaccacagc ccctgatggt gactactgga gacttcttcc
     1741 cccgggttcc catatcgtca ttgctcaggc ccctggctat tccaaggtca tgaagagagt
     1801 caccattccc ttgcgcatga agaaggccgg ccgtgtggac ttcatcctcc atcctctggc
     1861 gacaggaccc aagaacttcc ttcctggacc ttcgagagct ttacctcggt tccaggatcc
     1921 tcagagagag cccacacaga tggattttga gccccccagg gctcgtaggc agccagctag
     1981 tgggagcaag ccatggtggt gggcttactt cacatcactg agcccgtaca agccacgctg
     2041 gctgctcaag tactagcacc cctctcaggc ccgaccttga tgtccacctc cacagcctgg
     2101 gcttctgcct ggagcctggc agccacagac atcatacaca gcctctgaag cttattaaag
     2161 tatgttcacc cacaaaaaaa aaaaaaaaa
//
