LOCUS       NM_018867               3506 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxypeptidase X, M14 family member 2 (Cpxm2), mRNA.
ACCESSION   NM_018867
VERSION     NM_018867.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3506)
  AUTHORS   Grabowski,K., Herlan,L., Witten,A., Qadri,F., Eisenreich,A.,
            Lindner,D., Schadlich,M., Schulz,A., Subrova,J., Mhatre,K.N.,
            Primessnig,U., Plehm,R., van Linthout,S., Escher,F., Bader,M.,
            Stoll,M., Westermann,D., Heinzel,F.R. and Kreutz,R.
  TITLE     Cpxm2 as a novel candidate for cardiac hypertrophy and failure in
            hypertension
  JOURNAL   Hypertens Res 45 (2), 292-307 (2022)
   PUBMED   34916661
  REMARK    GeneRIF: Cpxm2 as a novel candidate for cardiac hypertrophy and
            failure in hypertension.
REFERENCE   2  (bases 1 to 3506)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3506)
  AUTHORS   Drake,K.A., Chaney,C.P., Das,A., Roy,P., Kwartler,C.S., Rakheja,D.
            and Carroll,T.J.
  TITLE     Stromal beta-catenin activation impacts nephron progenitor
            differentiation in the developing kidney and may contribute to
            Wilms tumor
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32541007
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3506)
  AUTHORS   Holmes,G., Gonzalez-Reiche,A.S., Lu,N., Zhou,X., Rivera,J.,
            Kriti,D., Sebra,R., Williams,A.A., Donovan,M.J., Potter,S.S.,
            Pinto,D., Zhang,B., van Bakel,H. and Jabs,E.W.
  TITLE     Integrated Transcriptome and Network Analysis Reveals
            Spatiotemporal Dynamics of Calvarial Suturogenesis
  JOURNAL   Cell Rep 32 (1), 107871 (2020)
   PUBMED   32640236
REFERENCE   5  (bases 1 to 3506)
  AUTHORS   Buniello,A., Hardisty-Hughes,R.E., Pass,J.C., Bober,E., Smith,R.J.
            and Steel,K.P.
  TITLE     Headbobber: a combined morphogenetic and cochleosaccular mouse
            model to study 10qter deletions in human deafness
  JOURNAL   PLoS One 8 (2), e56274 (2013)
   PUBMED   23457544
REFERENCE   6  (bases 1 to 3506)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   7  (bases 1 to 3506)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 3506)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 3506)
  AUTHORS   Xin,X., Day,R., Dong,W., Lei,Y. and Fricker,L.D.
  TITLE     Identification of mouse CPX-2, a novel member of the
            metallocarboxypeptidase gene family: cDNA cloning, mRNA
            distribution, and protein expression and characterization
  JOURNAL   DNA Cell Biol 17 (10), 897-909 (1998)
   PUBMED   9809751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100735.15, AK019509.1 and BB027417.1.
            
            On May 1, 2009 this sequence version replaced NM_018867.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019509.1, AF017639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC100735.15        170207-170507       c
            302-3500            AK019509.1         301-3499
            3501-3506           BB027417.1         282-287
FEATURES             Location/Qualifiers
     source          1..3506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 75.6 cM"
     gene            1..3506
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /note="carboxypeptidase X, M14 family member 2"
                     /db_xref="GeneID:55987"
                     /db_xref="MGI:MGI:1926006"
     exon            1..456
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2423
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /note="metallocarboxypeptidase 2; carboxypeptidase X2;
                     inactive carboxypeptidase-like protein X2;
                     carboxypeptidase X 2 (M14 family)"
                     /codon_start=1
                     /product="inactive carboxypeptidase-like protein X2
                     precursor"
                     /protein_id="NP_061355.3"
                     /db_xref="CCDS:CCDS21921.1"
                     /db_xref="GeneID:55987"
                     /db_xref="MGI:MGI:1926006"
                     /translation="MARLGTACPALALALALVAVALAGVRAQGAAFEEPDYYSQELWR
                     RGRYYGHPEPEPEPELFSPSMHEDLRVEEQEQQEPHQQGHRTPKKAIKPKKAPKREKL
                     VAETPPPGKNSNRKGRRSKNLEKAASDDHGVPVAHEDVRESCPPLGLETLKITDFQLH
                     ASTSKRYGLGAHRGRLNIQAGINENDFYDGAWCAGRNDLHQWIEVDARRLTKFTGVIT
                     QGRNSLWLSDWVTSYKVMVSNDSHTWVTVKNGSGDMIFEGNSEKEIPVLNELPVPMVA
                     RYIRINPQSWFDNGSICMRMEILGCPLPDPNNYYHRRNEMTTTDDLDFKHHNYKEMRQ
                     LMKVVNEMCPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYIAGAHGNEVL
                     GRELLLLLLHFLCQEYSAQNARIVRLVEETRIHILPSLNPDGYEKAYEGGSELGGWSL
                     GRWTHDGIDINNNFPDLNSLLWEAEDQQNAPRKVPNHYIAIPEWFLSENATVATETRA
                     VIAWMEKIPFVLGGNLQGGELVVAYPYDMVRSLWKTQEHTPTPDDHVFRWLAYSYAST
                     HRLMTDARRRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYLHTNCFELSIYVGCDKY
                     PHESELPEEWENNRESLIVFMEQVHRGIKGIVRDLQGKGISNAVISVEGVNHDIRTAS
                     DGDYWRLLNPGEYVVTAKAEGFITSTKNCMVGYDMGATRCDFTLTKTNLARIREIMET
                     FGKQPVSLPSRRLKLRGRKRRQRG"
     exon            457..555
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..665
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..805
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..890
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1041
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1130
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1254
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1451
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1631
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1929
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2069
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2169
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..3506
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /note="hexamer: AATAAA"
     polyA_site      2491
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /note="major polyA site"
     regulatory      3472..3477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /note="hexamer: CATAAA"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
                     /note="hexamer: AATAAA"
     polyA_site      3490
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
     polyA_site      3501
                     /gene="Cpxm2"
                     /gene_synonym="4632435C11Rik; CPX-2; Cpx2"
ORIGIN      
        1 gcctgtccca cccaccatct gcacccgctg cagcgcccgc gcccctgtcc cgcgccgtag
       61 tcgtcatttg tagcccgcct gccgctcccg gggacccgat cctaccctgg gtgcggggca
      121 gagcgggcat ggcccgtctg gggaccgcct gccctgcgct ggcgctggcc ctggcacttg
      181 tggcggtggc cctggctgga gtcagagccc agggcgcagc cttcgaggag cctgactatt
      241 acagccagga gctctggcgg cgcgggcgct attatgggca tccggagcct gagccggagc
      301 cggagctctt ctcgccttca atgcatgaag accttagggt ggaggagcag gaacagcagg
      361 agccgcacca gcagggccac agaactccca agaaggccat caagcccaag aaggctccca
      421 agagggagaa gttagttgca gagacgcctc caccaggtaa aaatagcaac agaaaaggca
      481 gaagaagcaa gaatcttgag aaagctgcca gtgatgacca tggtgtccct gtggctcatg
      541 aggatgtcag agagagttgc ccacctcttg gtctggaaac attaaaaatc acagacttcc
      601 agctgcatgc ctccacatcg aagcgttatg gcctgggagc ccaccggggg agactcaaca
      661 tccaggcagg cattaatgaa aatgactttt acgatggggc ttggtgtgct ggtaggaacg
      721 acttgcatca gtggatcgaa gtggatgccc ggcgcctgac caagttcaca ggggtcatta
      781 cccaaggaag gaactctctc tggctgagtg actgggtgac atcctataaa gtcatggtga
      841 gcaatgacag ccacacatgg gttactgtga agaatggatc tggcgacatg atatttgaag
      901 gaaacagtga gaaggagatt cctgtgctca atgagctgcc agtccccatg gtggcccgct
      961 acattcgcat aaaccctcag tcctggtttg ataacgggag catctgcatg aggatggaga
     1021 tcttgggctg cccactgccg gatcctaata actattatca ccgacgtaat gagatgacca
     1081 ccacggatga cctggatttt aagcaccaca actataagga aatgcgccag ttgatgaagg
     1141 ttgtcaatga aatgtgcccc aatattacca ggatttacaa cattggcaaa agccaccagg
     1201 gcctgaaatt gtatgcggta gagatctctg accatcctgg ggaacatgaa gttggtgagc
     1261 ccgagttcca ctacatcgca ggggcccacg gcaatgaggt tctgggacga gaactgctgc
     1321 tgctgctgct gcacttcctc tgccaggaat actcggcgca gaacgcacgc atcgtccgct
     1381 tggtggagga gactcgaatc cacattctac cctccctcaa tcctgatggc tatgagaagg
     1441 cctatgaagg aggttccgag ttgggaggct ggtccctggg acgttggacc catgatggca
     1501 tcgatatcaa caacaacttt ccggatttaa actcgctgct ctgggaggca gaggaccagc
     1561 agaatgcccc aaggaaggtc cccaaccact acattgccat ccctgagtgg tttctgtctg
     1621 agaatgccac agtggccaca gagaccagag ccgtcatcgc ctggatggag aagatcccgt
     1681 ttgtgctggg aggcaaccta caggggggtg agctggtcgt ggcatacccc tatgacatgg
     1741 tgcggtccct gtggaagacc caggagcaca ccccaacacc tgatgatcat gtgttccgct
     1801 ggctggcgta ttcctacgcc tccactcacc gcctcatgac agatgccagg aggcgagtgt
     1861 gccacacgga agattttcag aaggaggagg gcaccgtcaa tggggcttcc tggcacacag
     1921 tggctggaag tctaaacgat ttcagctacc tccatacaaa ctgctttgag ctgtccatct
     1981 acgtgggctg tgataaatac ccacacgaga gcgagctgcc ggaggaatgg gagaataacc
     2041 gggagtctct gattgtgttc atggagcagg ttcatcgagg catcaaaggc atagtgagag
     2101 atttacaagg gaaagggatt tcaaatgctg tcatctctgt ggaaggtgtt aaccatgaca
     2161 tccggacagc cagcgatggg gattactggc gtctactgaa ccctggcgaa tatgtggtca
     2221 cagccaaggc ggaaggcttt atcacttcca ccaagaactg catggttggc tatgatatgg
     2281 gagctactcg gtgtgacttc accctcacaa agaccaacct ggctaggata agagaaatta
     2341 tggagacatt tgggaagcag cctgtcagcc taccctccag gcgcctgaag ctgcggggac
     2401 ggaaaaggcg gcagcgtggg tgaccctgtc ggacacttga gacatacccc agaccgtgca
     2461 aataaaaatc cactccagta gtaactctgt agcaggcttt ccctgttgtt ttgactgtaa
     2521 ttcaagagac actcaggagc atacctgcat ggcttggctg accccaaagg ggagggctgg
     2581 tggctcaggg tgttttgttt tttgtttttt gttttttcct ttgttctcat ttatccaaat
     2641 accttgaaca gagcagcaga gaaaggccgg tggcagtgag ggaattaatt cagtgagtca
     2701 gtctgagatt ctaaaaaggg tgcttgacca ctggccagga agggaaatca ggccttcccc
     2761 catttgcgtg acattcaagc ttcccagtgc atttgcaagt ggcacagttg acattgcagc
     2821 acccagggaa tcctttgccc cagatgttat catttgagat gctcttatgc agcctaagaa
     2881 aatccatcct ctctggcccc aggggacaag ccaagctgct atgtacacac tcggtgttct
     2941 attgacaata gaggcattta ttaccaagtg tgcatcgctg agtcctaaat cagctctgct
     3001 cctttttcca acaaagcttg tcttcctaag agcagacaga agtggagagc acccaagaat
     3061 gagtgctggg cagcagaccc tgggggaggg ggcttgctat cccagaaagc ccctaaaccc
     3121 tttgctgctc cattagccct ggggtgagga gagccagaca tgttaggagg ccagagcagt
     3181 cagtcagggc atcttggaaa agaccttgaa ggaagcaaac cctgggttcc ttttgctcca
     3241 gaatgtgaga gctccaagtt ggccccaatc aggaggggag taatgatgaa catacagacg
     3301 gccacatctt gccaatcaag catcatctga tgaaaaagaa agcaatctta ggattacctg
     3361 ggacacgtca gtctgggaga ggtggttgaa tcattgtgta agggaatagt gtatcttatc
     3421 tgtgttcatc ctgctgcctt gttgacctgg agagaatgaa acaaacaaac acataaacaa
     3481 ataaagcaaa tggtaagatt ctctca
//
