LOCUS       NM_019696               2434 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxypeptidase X, M14 family member 1 (Cpxm1), mRNA.
ACCESSION   NM_019696
VERSION     NM_019696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Kim,Y.H., Barclay,J.L., He,J., Luo,X., O'Neill,H.M., Keshvari,S.,
            Webster,J.A., Ng,C., Hutley,L.J., Prins,J.B. and Whitehead,J.P.
  TITLE     Identification of carboxypeptidase X (CPX)-1 as a positive
            regulator of adipogenesis
  JOURNAL   FASEB J 30 (7), 2528-2540 (2016)
   PUBMED   27006448
  REMARK    GeneRIF: These findings establish CPX-1 as a positive regulator of
            adipogenesis situated downstream of FGF-1/BAMBI that may contribute
            to hyperplastic adipose tissue expansion via affecting
            extracellular matrix remodeling.
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Chang,E.J., Kwak,H.B., Kim,H., Park,J.C., Lee,Z.H. and Kim,H.H.
  TITLE     Elucidation of CPX-1 involvement in RANKL-induced
            osteoclastogenesis by a proteomics approach
  JOURNAL   FEBS Lett 564 (1-2), 166-170 (2004)
   PUBMED   15094061
  REMARK    GeneRIF: transient up-regulation pattern of CPX-1 expression may be
            important for the successful progression from pre-osteoclasts to
            mature osteoclasts.
REFERENCE   6  (bases 1 to 2434)
  AUTHORS   Lei,Y., Xin,X., Morgan,D., Pintar,J.E. and Fricker,L.D.
  TITLE     Identification of mouse CPX-1, a novel member of the
            metallocarboxypeptidase gene family with highest similarity to
            CPX-2
  JOURNAL   DNA Cell Biol 18 (2), 175-185 (1999)
   PUBMED   10073577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY282671.1, AF077738.1 and AK132611.1.
            
            On Apr 29, 2009 this sequence version replaced NM_019696.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003713.1, AF077738.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               BY282671.1         1-429
            430-880             AF077738.1         375-825
            881-2418            AK132611.1         127-1664
            2419-2434           AF077738.1         2364-2379
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.22 cM"
     gene            1..2434
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /note="carboxypeptidase X, M14 family member 1"
                     /db_xref="GeneID:56264"
                     /db_xref="MGI:MGI:1934569"
     exon            1..271
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2292
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /EC_number="3.4.17.10"
                     /note="carboxypeptidase X (M14 family); probable
                     carboxypeptidase X1; metallocarboxypeptidase CPX-1;
                     metallocarboxypeptidase 1; carboxypeptidase X 1 (M14
                     family)"
                     /codon_start=1
                     /product="probable carboxypeptidase X1 precursor"
                     /protein_id="NP_062670.2"
                     /db_xref="CCDS:CCDS16740.1"
                     /db_xref="GeneID:56264"
                     /db_xref="MGI:MGI:1934569"
                     /translation="MWGLLLAVTAFAPSVGLGLGAPSASVPGLAPGSTLAPHSSVAQP
                     STKANETSERHVRLRVIKKKKIVVKKRKKLRHPGPLGTARPVVPTHPAKTLTLPEKQE
                     PGCPPLGLESLRVSDSQLEASSSQSFGLGAHRGRLNIQSGLEDGDLYDGAWCAEQQDT
                     EPWLQVDAKNPVRFAGIVTQGRNSVWRYDWVTSFKVQFSNDSQTWWKSRNSTGMDIVF
                     PANSDAETPVLNLLPEPQVARFIRLLPQTWFQGGAPCLRAEILACPVSDPNDLFPEAH
                     TLGSSNSLDFRHHNYKAMRKLMKQVNEQCPNITRIYSIGKSHQGLKLYVMEMSDHPGE
                     HELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGDPRVTRLLTETRIHLLPSM
                     NPDGYETAYHRGSELVGWAEGRWTHQGIDLNHNFADLNTQLWYAEDDGLVPDTVPNHH
                     LPLPTYYTLPNATVAPETWAVIKWMKRIPFVLSANLHGGELVVSYPFDMTRTPWAARE
                     LTPTPDDAVFRWLSTVYAGTNRAMQDTDRRPCHSQDFSLHGNVINGADWHTVPGSMND
                     FSYLHTNCFEVTVELSCDKFPHEKELPQEWENNKDALLTYLEQVRMGITGVVRDKDTE
                     LGIADAVIAVEGINHDVTTAWGGDYWRLLTPGDYVVTASAEGYHTVRQHCQVTFEEGP
                     VPCNFLLTKTPKERLRELLATRGKLPPDLRRKLERLRGQK"
     exon            272..433
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            434..543
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            544..683
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            684..771
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            772..922
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1011
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1135
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1332
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1512
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1810
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1950
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2053
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2421
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /note="hexamer: ATTAAA"
     polyA_site      2421
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /note="major polyA site"
ORIGIN      
        1 agaggggcgt ggggcggtgg agggcgggcg agcaggaagg ggcggggggc tccgcagacg
       61 cccgcaggaa gaagagaacc caccaagaac ctcggcacag cgcgctcgtc gacccttccc
      121 gctatgtggg gtctcttgct cgcagtgacc gcctttgcgc cttccgtcgg tctggggctg
      181 ggggctccca gcgcctcagt gccgggcctg gcgccgggct caaccctggc tccacacagc
      241 agcgttgcac agccgtccac aaaggcaaat gagacctcag aacggcatgt ccggcttcga
      301 gtcatcaaga aaaaaaagat cgttgtcaag aagcgaaaga agctaaggca ccctggtccc
      361 ttggggactg ctaggcctgt ggtgcccact cacccagcaa agaccctcac tctccctgag
      421 aaacaagaac caggatgtcc ccctctaggc ttggagtcct tgagggtttc agatagccag
      481 ctggaggcct ccagcagcca gtcctttggt cttggagcac accgaggacg gctcaatatc
      541 cagtcaggtc tggaggacgg tgacctgtat gatggcgctt ggtgcgctga gcaacaagac
      601 actgaacctt ggcttcaggt ggatgcaaag aatcccgtcc gcttcgcagg aattgttaca
      661 cagggcagaa actctgtgtg gaggtatgac tgggtcacat cattcaaggt ccagttcagc
      721 aatgacagcc agacctggtg gaagagtagg aacagtactg gaatggacat agtatttcct
      781 gccaattcag acgcagagac cccagtgttg aaccttctgc cagagcctca ggtggctcga
      841 ttcattcgcc tgctgcctca gacctggttt cagggaggtg caccttgcct ccgggcagag
      901 atcctggcct gcccagtctc agatcctaat gacctgttcc ctgaggccca cacactggga
      961 tcttcgaact ctttggactt ccggcatcac aattataaag ctatgagaaa gctgatgaaa
     1021 caggtgaatg agcagtgccc caacatcacg cgcatctaca gcatcgggaa gagccaccag
     1081 ggtttgaagc tgtatgtgat ggaaatgtca gaccatcctg gggagcatga gctgggcgag
     1141 cccgaggtcc gctacgtggc tggaatgcat gggaatgagg ccctggggcg ggagttgctt
     1201 ctgcttttga tgcagttctt atgccatgag ttcctgcgag gggacccgag agtgactcgg
     1261 ctgctcactg agacacgaat ccatctattg ccctccatga atcctgatgg ctatgagact
     1321 gcctaccaca ggggctcaga gctggtgggc tgggcagagg gccgctggac ccaccagggc
     1381 attgacctta accacaattt tgctgacctc aacacacaac tgtggtatgc agaggatgat
     1441 ggactggtac ccgacactgt ccccaaccat cacctgccac tgcctaccta ctatacattg
     1501 cccaatgcca ccgtggctcc tgaaacgtgg gcagtgatca aatggatgaa gcgcatcccg
     1561 tttgtgctga gtgccaacct ccatgggggc gagcttgtgg tgtcctatcc tttcgacatg
     1621 actcggactc cgtgggctgc tcgtgaactc actcccacac cagatgatgc tgtcttccgc
     1681 tggctcagca ctgtctatgc tggcacgaat agggccatgc aggataccga ccgccgacct
     1741 tgtcatagcc aggacttctc cttgcatggc aacgtcatca atggagccga ctggcacaca
     1801 gttcctggga gcatgaacga cttcagctac ctacacacca attgctttga ggtcacagtg
     1861 gagctgtcct gtgacaagtt ccctcatgag aaggagctgc ctcaggagtg ggaaaacaac
     1921 aaagatgctc ttctcaccta cctggagcag gtgcgcatgg gcattactgg agttgtccgg
     1981 gataaagaca cagagctcgg cattgcggat gctgtcattg ccgtggaggg cattaaccac
     2041 gatgttacaa cagcttgggg cggagattac tggcggctgc tgacacctgg ggactatgtg
     2101 gtgacagcca gtgctgaggg ttaccataca gtcagacaac actgtcaggt cacctttgaa
     2161 gagggccctg ttccctgcaa tttcctactc accaagactc ccaaagagag gcttcgagaa
     2221 ctgttggcaa cacgagggaa gttgccccca gaccttcgga ggaagctgga gcggctgagg
     2281 ggacagaagt aacgtcttca gctgaagaga gccacatcct tggacaggct ggacctgtcc
     2341 agaactgaag gaggaggggg aagagagagg gacggggtag aagaggtgct ctggctcatt
     2401 aaagcttcgt ggtgcctgat aaaaaaaaaa aaaa
//
