LOCUS       NP_062670                722 aa            linear   ROD 30-APR-2024
DEFINITION  probable carboxypeptidase X1 precursor [Mus musculus].
ACCESSION   NP_062670
VERSION     NP_062670.2
DBSOURCE    REFSEQ: accession NM_019696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 722)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 722)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   3  (residues 1 to 722)
  AUTHORS   Kim,Y.H., Barclay,J.L., He,J., Luo,X., O'Neill,H.M., Keshvari,S.,
            Webster,J.A., Ng,C., Hutley,L.J., Prins,J.B. and Whitehead,J.P.
  TITLE     Identification of carboxypeptidase X (CPX)-1 as a positive
            regulator of adipogenesis
  JOURNAL   FASEB J 30 (7), 2528-2540 (2016)
   PUBMED   27006448
  REMARK    GeneRIF: These findings establish CPX-1 as a positive regulator of
            adipogenesis situated downstream of FGF-1/BAMBI that may contribute
            to hyperplastic adipose tissue expansion via affecting
            extracellular matrix remodeling.
REFERENCE   4  (residues 1 to 722)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (residues 1 to 722)
  AUTHORS   Chang,E.J., Kwak,H.B., Kim,H., Park,J.C., Lee,Z.H. and Kim,H.H.
  TITLE     Elucidation of CPX-1 involvement in RANKL-induced
            osteoclastogenesis by a proteomics approach
  JOURNAL   FEBS Lett 564 (1-2), 166-170 (2004)
   PUBMED   15094061
  REMARK    GeneRIF: transient up-regulation pattern of CPX-1 expression may be
            important for the successful progression from pre-osteoclasts to
            mature osteoclasts.
REFERENCE   6  (residues 1 to 722)
  AUTHORS   Lei,Y., Xin,X., Morgan,D., Pintar,J.E. and Fricker,L.D.
  TITLE     Identification of mouse CPX-1, a novel member of the
            metallocarboxypeptidase gene family with highest similarity to
            CPX-2
  JOURNAL   DNA Cell Biol 18 (2), 175-185 (1999)
   PUBMED   10073577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY282671.1, AF077738.1 and AK132611.1.
            
            On Apr 29, 2009 this sequence version replaced NP_062670.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003713.1, AF077738.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.22 cM"
     Protein         1..722
                     /product="probable carboxypeptidase X1 precursor"
                     /EC_number="3.4.17.10"
                     /note="carboxypeptidase X (M14 family); probable
                     carboxypeptidase X1; metallocarboxypeptidase CPX-1;
                     metallocarboxypeptidase 1; carboxypeptidase X 1 (M14
                     family)"
                     /calculated_mol_wt=78952
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1973
     mat_peptide     21..722
                     /product="Probable carboxypeptidase X1.
                     /id=PRO_0000004408"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z100.2)"
                     /calculated_mol_wt=78952
     Region          30..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z100.2)"
     Site            49
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z100.2)"
     Region          106..262
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(154,182,189)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z100.2)"
     Site            210
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z100.2)"
     Region          288..609
                     /region_name="M14_CPX_like"
                     /note="Peptidase M14 carboxypeptidase subfamily N/E-like;
                     Carboxypeptidase X subgroup; cd03869"
                     /db_xref="CDD:349441"
     Site            307
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z100.2)"
     Site            order(349,352,414,423..424,487..488,494,498,554,558,560,
                     580)
                     /site_type="active"
                     /db_xref="CDD:349441"
     Site            461
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z100.2)"
     Region          613..689
                     /region_name="Peptidase_M14NE-CP-C_like"
                     /note="Peptidase associated domain: C-terminal domain of
                     M14 N/E carboxypeptidase; putative folding, regulation, or
                     interaction domain; cd11308"
                     /db_xref="CDD:200604"
     CDS             1..722
                     /gene="Cpxm1"
                     /gene_synonym="Cpx-1; Cpx1; Cpxm"
                     /coded_by="NM_019696.2:124..2292"
                     /db_xref="CCDS:CCDS16740.1"
                     /db_xref="GeneID:56264"
                     /db_xref="MGI:MGI:1934569"
ORIGIN      
        1 mwglllavta fapsvglglg apsasvpgla pgstlaphss vaqpstkane tserhvrlrv
       61 ikkkkivvkk rkklrhpgpl gtarpvvpth paktltlpek qepgcpplgl eslrvsdsql
      121 easssqsfgl gahrgrlniq sgledgdlyd gawcaeqqdt epwlqvdakn pvrfagivtq
      181 grnsvwrydw vtsfkvqfsn dsqtwwksrn stgmdivfpa nsdaetpvln llpepqvarf
      241 irllpqtwfq ggapclraei lacpvsdpnd lfpeahtlgs snsldfrhhn ykamrklmkq
      301 vneqcpnitr iysigkshqg lklyvmemsd hpgehelgep evryvagmhg nealgrelll
      361 llmqflchef lrgdprvtrl ltetrihllp smnpdgyeta yhrgselvgw aegrwthqgi
      421 dlnhnfadln tqlwyaeddg lvpdtvpnhh lplptyytlp natvapetwa vikwmkripf
      481 vlsanlhgge lvvsypfdmt rtpwaarelt ptpddavfrw lstvyagtnr amqdtdrrpc
      541 hsqdfslhgn vingadwhtv pgsmndfsyl htncfevtve lscdkfphek elpqewennk
      601 dalltyleqv rmgitgvvrd kdtelgiada viaveginhd vttawggdyw rlltpgdyvv
      661 tasaegyhtv rqhcqvtfee gpvpcnfllt ktpkerlrel latrgklppd lrrklerlrg
      721 qk
//
