LOCUS       NM_001289713            1622 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxypeptidase, vitellogenic-like (Cpvl), transcript
            variant 2, mRNA.
ACCESSION   NM_001289713 XM_006506614
VERSION     NM_001289713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1622)
  AUTHORS   Wang,L., Piao,L., Yuan,X., Tong,L., Han,X., Wang,J., Shi,D.,
            Shao,S., Xu,X., Zhuang,M., Cheng,D. and Liu,Z.
  TITLE     Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and
            Metastasis of Osteosarcoma through the TGF-beta/Smad Signaling
            Pathway
  JOURNAL   Ann Clin Lab Sci 53 (6), 890-904 (2023)
   PUBMED   38182149
  REMARK    GeneRIF: Carboxypeptidase Vitellogenic-Like Promotes the
            Proliferation and Metastasis of Osteosarcoma through the
            TGF-beta/Smad Signaling Pathway.
REFERENCE   3  (bases 1 to 1622)
  AUTHORS   Srivastava,U., Paigen,B.J. and Korstanje,R.
  TITLE     Differences in health status affect susceptibility and mapping of
            genetic loci for atherosclerosis (fatty streak) in inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2380-2386 (2012)
   PUBMED   22837474
REFERENCE   4  (bases 1 to 1622)
  AUTHORS   de Wit,T., Dekker,S., Maas,A., Breedveld,G., Knoch,T.A.,
            Langeveld,A., Szumska,D., Craig,R., Bhattacharya,S., Grosveld,F.
            and Drabek,D.
  TITLE     Tagged mutagenesis by efficient Minos-based germ line transposition
  JOURNAL   Mol Cell Biol 30 (1), 68-77 (2010)
   PUBMED   19884347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK017087.1 and BC137839.1.
            
            On Jan 25, 2014 this sequence version replaced XM_006506614.1.
            
            Summary: This gene encodes a member of the serine carboxypeptidase
            family of proteases that cleave amino acids from the C-terminus of
            a protein substrate. The human ortholog of this gene, where it was
            first characterized, was found to be upregulated during the
            maturation of monocytes to macrophages. The encoded protein may be
            involved in antigen processing, digestion of phagocytosed proteins
            in the lysosome and lamellipodium formation. Disruption of this
            gene in mice was found to cause embryonic lethality. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the
            same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               AK017087.1         2-789
            789-1522            BC137839.1         864-1597
            1523-1622           AK017087.1         1392-1491
FEATURES             Location/Qualifiers
     source          1..1622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 26.19 cM"
     gene            1..1622
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /note="carboxypeptidase, vitellogenic-like"
                     /db_xref="GeneID:71287"
                     /db_xref="MGI:MGI:1918537"
     exon            1..39
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            40..225
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1487
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /EC_number="3.4.16.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; probable serine carboxypeptidase CPVL"
                     /codon_start=1
                     /product="probable serine carboxypeptidase CPVL isoform 1
                     precursor"
                     /protein_id="NP_001276642.1"
                     /db_xref="CCDS:CCDS51777.1"
                     /db_xref="GeneID:71287"
                     /db_xref="MGI:MGI:1918537"
                     /translation="MVRAKWKMVVSLILFMVSPGDGLFHAVYRSILVSQSFKGDAGQP
                     LFLSPYIKNGKIKEGQRKSMVSPFPGMNDKSYAGYITVNQTYNSNLFFWFFPARMQPE
                     DAPVVLWLQGGPGGSSMFGLFVEHGPYIITSNMTVVARDFPWTFTLSMLYIDNPVGTG
                     FSFTDHFQGYATSEDDVAQDLYSALIQFFTLFPEYAKNDFYVTGESYAGKYVPALAHY
                     IHSLNPVRKFKIRLKGIAIGDAYTDPESIIGGYAAFLYEIGLLDEQQQKYFQKQCSKC
                     VKYIKEQEWMKAFEILDKLLDGDVTTGSSFFQNVTGCTNYYNILQCTEPKEQSYFAKF
                     LTLPQVRQAIHVGNQNFSDGAEVEKHLREDTVKSVKPWLSEIMNYYKVLIYNGQLDII
                     VAAALTERSLMAMDWKGSRAYRRARRKVWKIFKSDNEVAGYVRRVGKFHQVIVRGGGH
                     ILPYDQPMRSFDMINRFIYDRGWEPYNS"
     exon            226..344
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            345..459
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            460..518
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            519..598
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            599..665
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            666..788
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            789..920
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1019
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1193
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1376
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1622
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="Cpvl"
                     /gene_synonym="4933436L16Rik; HVLP"
                     /note="major polyA site"
ORIGIN      
        1 agaaccttat tcctaggaaa cgccagaggt cataaccagg ccaacaagaa atggttcgtg
       61 ccaagtggaa gatggttgtt tcactgatct tgtttatggt cagccctggt gatggactgt
      121 ttcatgcagt ataccgaagt atccttgttt cccagtcctt caagggggat gcaggacagc
      181 ctctttttct tagcccatac atcaaaaacg ggaagatcaa ggaggggcaa aggaagagca
      241 tggtcagtcc gttccctgga atgaacgaca agagttatgc cggctacatc acggtgaacc
      301 agacttacaa cagcaacctc ttcttctggt tctttccggc tcggatgcag cctgaggatg
      361 ccccagtagt cctctggctt cagggtggac ctggaggttc atccatgttt ggactctttg
      421 tagaacacgg gccttatatt atcacaagta acatgaccgt tgtggccaga gacttccctt
      481 ggacctttac cctttccatg ctctacattg ataatccggt gggtacaggc ttcagcttca
      541 ccgatcattt ccagggatac gccaccagcg aggatgatgt agcccaagac ttgtacagtg
      601 ccctgattca gttcttcacg ttgtttcccg agtatgcaaa gaatgatttt tacgtcactg
      661 gcgagtctta tgcagggaaa tatgttccgg ccctagcaca ctatatccac tccctcaacc
      721 ccgtgcggaa gttcaagatt cgcctaaaag gaattgccat tggagatgca tacactgatc
      781 ctgaatcgat tataggaggg tatgcggcat tcctatatga aattggcttg ttggatgaac
      841 agcagcagaa gtacttccag aagcagtgta gcaagtgcgt aaaatacatc aaagagcagg
      901 agtggatgaa ggcctttgaa atcctggata agctgctaga tggagatgta acaactggtt
      961 catctttctt ccagaatgtg acaggatgta ccaattacta caacatttta cagtgcacgg
     1021 aacccaagga gcaaagttac tttgcaaaat tcttgacgct cccccaagtg agacaagcca
     1081 tccacgtggg aaaccagaac ttcagtgacg gtgctgaggt tgagaagcac ctgcgagagg
     1141 acacagtgaa gtcggtgaag ccctggctgt ctgagatcat gaattactac aaggttctca
     1201 tctacaatgg ccaactggac atcatcgtgg cggctgccct gacagagcgc tccttgatgg
     1261 ccatggactg gaagggatcc cgagcataca gaagggcacg tcgaaaggtc tggaagatct
     1321 tcaaatcgga taatgaagtg gctggttatg tgaggcgtgt gggcaaattc catcaggtaa
     1381 tcgtccgagg tggaggacac attttgccct atgaccagcc aatgagatct tttgatatga
     1441 tcaatcgctt catctatgac agaggatggg aaccttataa ttcataagat actttcctga
     1501 aacaggagtc tcaatcacaa aataatattg tttaaaaaaa actaaatata tcatgtaaat
     1561 ttaaaattta tcatttttat attttcaagg tactttttag tcaataaaag tttccctgaa
     1621 ac
//
