LOCUS       NM_024472               2662 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ceramide-1-phosphate transfer protein (Cptp), mRNA.
ACCESSION   NM_024472
VERSION     NM_024472.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Mishra,S.K., Gao,Y.G., Deng,Y., Chalfant,C.E., Hinchcliffe,E.H. and
            Brown,R.E.
  TITLE     CPTP: A sphingolipid transfer protein that regulates autophagy and
            inflammasome activation
  JOURNAL   Autophagy 14 (5), 862-879 (2018)
   PUBMED   29164996
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Simanshu,D.K., Kamlekar,R.K., Wijesinghe,D.S., Zou,X., Zhai,X.,
            Mishra,S.K., Molotkovsky,J.G., Malinina,L., Hinchcliffe,E.H.,
            Chalfant,C.E., Brown,R.E. and Patel,D.J.
  TITLE     Non-vesicular trafficking by a ceramide-1-phosphate transfer
            protein regulates eicosanoids
  JOURNAL   Nature 500 (7463), 463-467 (2013)
   PUBMED   23863933
  REMARK    GeneRIF: crystal structure of CPTP
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL670236.9.
            
            On May 1, 2007 this sequence version replaced NM_024472.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040664.1, SRR7345562.5028109.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AL670236.9         175757-176030       c
            275-499             AL670236.9         173703-173927       c
            500-2662            AL670236.9         171313-173475       c
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.66 cM"
     gene            1..2662
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="ceramide-1-phosphate transfer protein"
                     /db_xref="GeneID:79554"
                     /db_xref="MGI:MGI:1933107"
     exon            1..274
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..499
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1028
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="glycolipid transfer protein domain-containing
                     protein 1; glycolipid transfer protein domain containing
                     1"
                     /codon_start=1
                     /product="ceramide-1-phosphate transfer protein"
                     /protein_id="NP_077792.2"
                     /db_xref="CCDS:CCDS19047.1"
                     /db_xref="GeneID:79554"
                     /db_xref="MGI:MGI:1933107"
                     /translation="MDDSEKDFNLKVVLVSFKQCLTDKGEVLLDHYIAGWKGLVRFLN
                     SLGAVFSFISKDVVAKLQIMERLRSSPQSEHYASLQSMVAYEVSNKLVDMDHRSHPRH
                     PHSGCRTVLRLHRALHWLQLFLDGLRTSSEDARTSTLCSEAYNATLANYHSWIVRQAV
                     TVAFCALPSRKVFLEAMNMESTEQAVEMLGEALPFIEHVYDISQKLYAEHSLLDLP"
     exon            500..2662
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="Cptp"
                     /gene_synonym="Gltpd1"
                     /note="major polyA site"
ORIGIN      
        1 agaggctgga ctttgggttg cagctccagg tttctgctca accgcaggct ccgagcttga
       61 ggggaaagca tggggacggg gacccttacc tgacgtgaac caggcggcag agccacgtct
      121 ctgtacacca ccggggcgga ctggcaaaga atcgtctccc acagcagcct aattgtagct
      181 ttgatcaacc ctccccatcg ctggcctctg ctgcaccctt tgccctccgc gggagtagag
      241 accaccactc ccccaccatc ggaacccatc tcagatcttc tgcccaatct cttcctgaga
      301 aaatgaacca cagaatgaga taatccacca tgacgactac acgttctgtg tgaaactgtt
      361 tcagcttgtg ttggaagatg gatgactcag agaaagattt caaccttaaa gtcgtcctgg
      421 tcagcttcaa gcagtgtctc actgacaagg gagaggtgct gctggaccac tatattgccg
      481 gctggaaggg acttgtcagg tttctaaaca gcctgggggc cgtcttctca ttcatttcca
      541 aggatgtggt cgcaaagctg cagatcatgg agcgtctgag aagcagccca cagtctgaac
      601 actacgctag cttgcagtcc atggtagcct acgaggtgag caacaagctg gtggacatgg
      661 atcaccgttc ccatccccga caccctcact caggctgccg gactgtgctg cgcctacatc
      721 gtgctctgca ctggctacag ctgttcctgg acggcctgcg caccagctct gaggatgctc
      781 gtacctccac actctgcagt gaggcctaca atgccacgct ggctaactat cactcctgga
      841 tagtacgtca agctgtcact gtggccttct gtgccttacc ctcacgcaag gtcttcctcg
      901 aggccatgaa tatggagtcc actgagcaag cagtggagat gctgggggag gccctgccct
      961 tcattgagca tgtgtatgac atctcccaga agctctatgc tgagcattcc ctgctagacc
     1021 tgccctaggc gtggacttac cctgctcaga actgggttta ggcaacctgg gactactccc
     1081 acagcagtgc tttctggata ctactatcac ccctgaaagc tgagcttgtt gagagccaca
     1141 gtctgtgata ggaaaggtgt taggcagctg aaccaagaaa ggtgggtgct ggccgtcctc
     1201 tcagtccggg atgagacaat ggaactccag ttttgccctc cacttcagct tatgtgtgtg
     1261 ttcaggcagt cttgatggaa gtgcagatgg caaatggaga agatgggggc tgggggtgtc
     1321 atggacctgc aacaacccaa ggttgctcta cctcctgtgt acaatctgaa atggtgtaag
     1381 gacgcgggac cctggagctg tcttcctcgc agccagcatg cccagccact gtgtgtcctc
     1441 ctgagttcat cttgagcctt agacacagca ctggtgccag gcaaacagtc ctgggcctac
     1501 atgcttgggg cctcttcata ttccaaaagc tgtctttggg taagatgaag ttcctctggc
     1561 agtggcatga gtgctgaagg ctctttccct gcccttcacc tgctttcttg atagtctctc
     1621 tgcataccaa acaggccctt gtctcctggg aaatggaaac tatgaaatca atagctgagg
     1681 cttctctagg aaagcctgcc ctggtcagta caacctgttt cacagcttct atagaatagt
     1741 tacatcagcc ttctgaagat ggcctcttag agcacatgca cccccaagat tctaagatgt
     1801 caatactaac tgaccaaacc atacctctct agccagccct gctgctcctg ttgtctggta
     1861 cccaggtgac tgaggacatg actggtggaa ggaaactagg cccctttgtc tgtcagatgg
     1921 ccatacccag catggctgat gcccagtgta taagacccta cgcttttcca ctggtcttaa
     1981 tgttaaaccc taggacagtg tcctcagcat agctggtgtg tgtgaatgca aactttgggg
     2041 catatctctt ccattaagca ctgtgatata tgtagtattt ccaacaaata aattatacct
     2101 acatgattgg gtatagcatt ctgggatggg tcacaggtgt gtcaggtgcc taattatgtg
     2161 ggggaagaac atagaaatat ataggtgggg agggagctaa ccctaggaat aaggctaaag
     2221 catgtgtctc cagtcctgaa gactcaaagg gcaacgtgaa tcatgagaca tgttcaggac
     2281 tgaaggagtt gccatgtatc tgtccttgat gtatcttaat catacataca ctatgagatc
     2341 tgtgttacct ccattttgca ggtgagaaaa gaaacacctg aatggcctac cttaaagggc
     2401 taagtgggaa aataggtctg aagataaccc aggcactgtg tgacaaagcg ggaagaaaac
     2461 tagagatgct ttcttcatgg caacaaccta gagggtacaa cctagtggtt tcttcttggt
     2521 actccactgt atacacccca tctgcttggg ctgtacattg tctgaccatg cttataacaa
     2581 aagtcacata ctactagcca agactgagaa cttagagcga ctggccagaa agtaaagata
     2641 caacagttga tatgtgtgcc ac
//
