LOCUS       NM_009949               2366 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus carnitine palmitoyltransferase 2 (Cpt2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_009949
VERSION     NM_009949.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. PMID: 37322272]
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Chae,S.A., Son,J.S., de Avila,J.M., Du,M. and Zhu,M.J.
  TITLE     Maternal exercise improves epithelial development of fetal
            intestine by enhancing apelin signaling and oxidative metabolism
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (5), R728-R738 (2022)
   PUBMED   36189989
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Pereyra,A.S., Lin,C.T., Sanchez,D.M., Laskin,J., Spangenburg,E.E.,
            Neufer,P.D., Fisher-Wellman,K. and Ellis,J.M.
  TITLE     Skeletal muscle undergoes fiber type metabolic switch without
            myosin heavy chain switch in response to defective fatty acid
            oxidation
  JOURNAL   Mol Metab 59, 101456 (2022)
   PUBMED   35150906
  REMARK    GeneRIF: Skeletal muscle undergoes fiber type metabolic switch
            without myosin heavy chain switch in response to defective fatty
            acid oxidation.
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   Morillas,M., Clotet,J., Rubi,B., Serra,D., Arino,J., Hegardt,F.G.
            and Asins,G.
  TITLE     Inhibition by etomoxir of rat liver carnitine octanoyltransferase
            is produced through the co-ordinate interaction with two histidine
            residues
  JOURNAL   Biochem J 351 Pt 2 (Pt 2), 495-502 (2000)
   PUBMED   11023836
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Cox,K.B., Johnson,K.R. and Wood,P.A.
  TITLE     Chromosomal locations of the mouse fatty acid oxidation genes
            Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene
  JOURNAL   Mamm Genome 9 (8), 608-610 (1998)
   PUBMED   9680378
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Uenaka,R., Kuwajima,M., Ono,A., Matsuzawa,Y., Hayakawa,J.,
            Inohara,N., Kagawa,Y. and Ohta,S.
  TITLE     Increased expression of carnitine palmitoyltransferase I gene is
            repressed by administering L-carnitine in the hearts of
            carnitine-deficient juvenile visceral steatosis mice
  JOURNAL   J Biochem 119 (3), 533-540 (1996)
   PUBMED   8830050
REFERENCE   9  (bases 1 to 2366)
  AUTHORS   Hotta,K., Kuwajima,M., Ono,A., Uenaka,R., Nakajima,H., Miyagawa,J.,
            Namba,M., Hanafusa,T., Horiuchi,M., Nikaido,H., Hayakawa,J.,
            Kono,N., Saheki,T. and Matsuzawa,Y.
  TITLE     Altered expression of carnitine palmitoyltransferase II in liver,
            muscle, and heart of mouse strain with juvenile visceral steatosis
  JOURNAL   Biochim Biophys Acta 1289 (1), 131-135 (1996)
   PUBMED   8605222
REFERENCE   10 (bases 1 to 2366)
  AUTHORS   Gelb,B.D.
  TITLE     Genomic structure of and a cardiac promoter for the mouse carnitine
            palmitoyltransferase II gene
  JOURNAL   Genomics 18 (3), 651-655 (1993)
   PUBMED   8307575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY325625.1, CD545813.1, AK144441.1 and AI853250.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_009949.3.
            
            On Dec 8, 2007 this sequence version replaced NM_009949.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U01163.1, AK144441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY325625.1         1-27
            28-591              CD545813.1         3-566
            592-2349            AK144441.1         592-2349
            2350-2366           AI853250.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..2366
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /note="carnitine palmitoyltransferase 2"
                     /db_xref="GeneID:12896"
                     /db_xref="MGI:MGI:109176"
     exon            1..275
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2100
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /EC_number="2.3.1.21"
                     /note="carnitine O-palmitoyltransferase 2, mitochondrial;
                     carnitine palmitoyltransferase II; CPT II"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 2,
                     mitochondrial precursor"
                     /protein_id="NP_034079.2"
                     /db_xref="CCDS:CCDS18443.1"
                     /db_xref="GeneID:12896"
                     /db_xref="MGI:MGI:109176"
                     /translation="MMPRLLLRDWPRCPSLVLGAPSRPLSAVSGPAEYLQHSIVPTMH
                     YQDSLPRLPIPKLEDTMKRYLSAQKPLLNDSQFRKTEVLCKDFENGIGKELHAHLLAQ
                     DKQNKHTSYISGPWFDMYLTARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAV
                     RFLKTLRAGLLEPEVFHLNPARSDTDAFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYF
                     RLFNSTRIPKPSRDELFTDTKARHLLVLRKGHFYVFDVLDQDGNIVNPSEIQAHLKYI
                     LSDSSPVPEFPLAYLTSENRDVWAELRQKLIHGGNEETLRKVDSAVFCLCLDDFPMKD
                     LVHLSHTMLHGDGTNRWFDKSFNLIVAKDGTAAVHFEHAWGDGVAVLRFFNEVFRDST
                     QTPAIAPQSQPAATDSSVSVQKLSFKLSSALKAGVTAAKEKFDATMKTLTIDAIQFQR
                     GGKEFLKKKKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIF
                     TKRCSEAFVREPSKHSVGELQHMMAECSKYHGQLTKEAAMGQGFDRHLFALRYLAAAR
                     GVTLPELYQDPAYQRINHNILSTSTLSSPAVSLGGFAPVVPDGFGIAYAVHDDWIGCN
                     VSSYSGRNAREFLHCVQKCLEDMFDALEGKAIKT"
     exon            276..356
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     exon            357..463
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1768
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2350
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2329..2334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /note="putative"
     polyA_site      2349
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /note="putative"
ORIGIN      
        1 tgtgggcgga gttgaactgg acgttaagtc tctacgggtg tcccgggcct gagggcagcg
       61 gcctgcttgc tcgggaactc cctcagccac cgcgtcctca agccgccatt gccgcccggg
      121 acgatgatgc cgcgcctgct gttgcgtgac tggccccggt gcccctcgct tgtcctggga
      181 gcccctagtc ggcccttaag tgctgtctcg gggcccgccg agtatctgca gcacagcatc
      241 gtacccacca tgcactacca ggacagcctg cccaggctgc ctatccctaa acttgaagac
      301 accatgaaga gatacctcag tgcacagaag cctctcttga atgacagcca gttcaggaag
      361 acagaagtgt tgtgtaagga ttttgagaac ggcattggga aggagctgca tgcgcacctg
      421 ctcgctcagg ataaacagaa taagcacacc agctacatct caggcccctg gtttgatatg
      481 tatttaactg ctcgagactc tgtcgtttta aactttaatc cattcatggc attcaatccg
      541 gacccgaagt ctgagtataa tgaccagctc accagggcca ccaacttgac tgtttctgca
      601 gtgcggtttc tgaagacact tcgggctggc cttctagagc cagaagtgtt ccacttgaac
      661 cctgccagaa gtgacacaga tgccttcaaa agactcatcc gctttgttcc ttcctctctc
      721 tcctggtatg gagcctacct ggtcaatgca tatcccctgg atatgtccca atattttcgg
      781 cttttcaatt caactcgtat acccaaaccc agtcgtgatg aactctttac tgataccaag
      841 gctagacacc tcctggtcct aagaaaagga catttctatg tctttgatgt cctcgatcaa
      901 gatgggaaca ttgtgaatcc ctcagaaatc caggcacatc taaagtacat tctctcagac
      961 agcagccctg tgcccgagtt tcccctggct tatttgacca gtgagaaccg agatgtctgg
     1021 gcagagctca gacagaagtt gattcatggt ggcaatgagg aaaccctgag gaaagtggac
     1081 tctgctgtct tctgcctctg cttagatgac ttcccgatga aggatcttgt tcacttgtca
     1141 cacaccatgc tgcacggtga cggcacgaac cgctggtttg ataagtcctt taacctcatt
     1201 gtagccaaag atggcactgc tgcagtccac ttcgagcatg cgtgggggga tggtgtagca
     1261 gtccttaggt ttttcaatga agtgttcaga gacagcactc agacccctgc cattgctccc
     1321 cagagccagc cggccgccac cgactcctcc gtgtctgtgc agaagctcag ttttaagctc
     1381 agcagtgctc taaaggctgg cgtcaccgct gctaaggaga agtttgatgc caccatgaaa
     1441 accctcacca ttgacgccat tcagtttcag agaggtggca aggaattctt gaagaagaag
     1501 aagctgagcc ctgatgcagt ggcccagctg gccttccaga tggctttcct gcgacagtat
     1561 ggccagacag tggctaccta tgaatcctgc agcactgcag ccttcaaaca cggccgcaca
     1621 gagactattc gcccagcttc catctttact aagagatgct ccgaggcatt tgtcagggag
     1681 ccctccaagc acagtgtggg cgagcttcag catatgatgg ctgagtgctc caaataccat
     1741 ggccagctga ccaaagaagc agcgatgggc cagggctttg accgacactt gtttgctcta
     1801 cggtatctgg cagcagccag aggggtcacc ctgcctgagc tctatcagga ccctgcatac
     1861 cagcggataa accacaacat cctgtccacc agcactctga gcagcccagc agtgagcctc
     1921 ggtggctttg cccctgtggt ccctgatggc tttggcattg cgtatgctgt tcacgatgac
     1981 tggataggct gcaatgtctc ctcctactca ggacgcaatg cccgagagtt tctccactgt
     2041 gtccagaagt gcttggaaga catgttcgat gccctcgaag gcaaagccat caaaacttag
     2101 cttcttggtc gatgaaaagc ctccattctt cctcatgaac attggtgttc atgtagctgg
     2161 aaggtaccat cttgtcaaca aaactagttc ctggtgcttg agcagccagt gctgcaggtg
     2221 tgagcggaag atcccaactg aaggtaatga gagactgcag ctctaaagcc ctttcttaag
     2281 gagatcgggt tggaaagcta actcagctgt atttattgtt taaatagaaa taaacccagt
     2341 gttgcttgca aaaaaaaaaa aaaaaa
//
