LOCUS       NM_153679               2811 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carnitine palmitoyltransferase 1c (Cpt1c), transcript
            variant 1, mRNA.
ACCESSION   NM_153679
VERSION     NM_153679.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Iborra-Lazaro,G., Djebari,S., Sanchez-Rodriguez,I.,
            Gratacos-Batlle,E., Sanchez-Fernandez,N., Radosevic,M., Casals,N.,
            Navarro-Lopez,J.D., Soto Del Cerro,D. and Jimenez-Diaz,L.
  TITLE     CPT1C is required for synaptic plasticity and oscillatory activity
            that supports motor, associative and non-associative learning
  JOURNAL   J Physiol 601 (16), 3533-3556 (2023)
   PUBMED   37309891
  REMARK    GeneRIF: CPT1C is required for synaptic plasticity and oscillatory
            activity that supports motor, associative and non-associative
            learning.
REFERENCE   3  (bases 1 to 2811)
  AUTHORS   Fosch,A., Rodriguez-Garcia,M., Miralpeix,C., Zagmutt,S.,
            Larranaga,M., Reguera,A.C., Garcia-Chica,J., Herrero,L., Serra,D.,
            Casals,N. and Rodriguez-Rodriguez,R.
  TITLE     Central Regulation of Brown Fat Thermogenesis in Response to
            Saturated or Unsaturated Long-Chain Fatty Acids
  JOURNAL   Int J Mol Sci 24 (2), 1697 (2023)
   PUBMED   36675212
  REMARK    GeneRIF: Central Regulation of Brown Fat Thermogenesis in Response
            to Saturated or Unsaturated Long-Chain Fatty Acids.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2811)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2811)
  AUTHORS   Ding,Y., Zhang,H., Liu,Z., Li,Q., Guo,Y., Chen,Y., Chang,Y. and
            Cui,H.
  TITLE     Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress
            and apoptosis of hippocampal neuron in response to beta-Amyloid
            peptide fragment Abeta25-35
  JOURNAL   Bioengineered 12 (1), 5440-5449 (2021)
   PUBMED   34424821
  REMARK    GeneRIF: Carnitine palmitoyltransferase 1 (CPT1) alleviates
            oxidative stress and apoptosis of hippocampal neuron in response to
            beta-Amyloid peptide fragment Abeta25-35.
REFERENCE   6  (bases 1 to 2811)
  AUTHORS   Lohse,I., Reilly,P. and Zaugg,K.
  TITLE     The CPT1C 5'UTR contains a repressing upstream open reading frame
            that is regulated by cellular energy availability and AMPK
  JOURNAL   PLoS One 6 (9), e21486 (2011)
   PUBMED   21961029
REFERENCE   7  (bases 1 to 2811)
  AUTHORS   Dai,Y., Wolfgang,M.J., Cha,S.H. and Lane,M.D.
  TITLE     Localization and effect of ectopic expression of CPT1c in CNS
            feeding centers
  JOURNAL   Biochem Biophys Res Commun 359 (3), 469-474 (2007)
   PUBMED   17559810
  REMARK    GeneRIF: CPT1c is appropriately localized in regions and cell types
            to regulate energy homeostasis
REFERENCE   8  (bases 1 to 2811)
  AUTHORS   Wolfgang,M.J., Kurama,T., Dai,Y., Suwa,A., Asaumi,M., Matsumoto,S.,
            Cha,S.H., Shimokawa,T. and Lane,M.D.
  TITLE     The brain-specific carnitine palmitoyltransferase-1c regulates
            energy homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7282-7287 (2006)
   PUBMED   16651524
  REMARK    GeneRIF: CPT1c is necessary for the regulation of energy
            homeostasis
REFERENCE   9  (bases 1 to 2811)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2811)
  AUTHORS   Price,N., van der Leij,F., Jackson,V., Corstorphine,C., Thomson,R.,
            Sorensen,A. and Zammit,V.
  TITLE     A novel brain-expressed protein related to carnitine
            palmitoyltransferase I
  JOURNAL   Genomics 80 (4), 433-442 (2002)
   PUBMED   12376098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN842042.1, AK035790.1 and BU758114.1.
            
            On Nov 16, 2011 this sequence version replaced NM_153679.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083317.1, AK035790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 21961029
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CN842042.1         4-40
            38-2789             AK035790.1         2-2753
            2790-2811           BU758114.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     gene            1..2811
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /note="carnitine palmitoyltransferase 1c"
                     /db_xref="GeneID:78070"
                     /db_xref="MGI:MGI:2446526"
     exon            1..257
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      163..252
                     /regulatory_class="uORF"
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21961029]"
                     /note="this uORF is predicted to encode a 29 aa peptide
                     (PMID:21961029)"
     exon            258..411
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2667
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /EC_number="3.1.2.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carnitine palmitoyltransferase 1, brain; carnitine
                     palmitoyltransferase I; palmitoyl thioesterase CPT1C"
                     /codon_start=1
                     /product="palmitoyl thioesterase CPT1C isoform 1"
                     /protein_id="NP_710146.1"
                     /db_xref="CCDS:CCDS21221.1"
                     /db_xref="GeneID:78070"
                     /db_xref="MGI:MGI:2446526"
                     /translation="MAEAHQASSLLSSLSSDGAEVELSSPVWQEIYLCALRSWKRHLW
                     RVWNDFLAGVVPATPLSWLFLFSTIQLACLLQLDPSLGLMEKIKELLPDWGGQHHQLQ
                     GFLSAAVFASCLWGALIFTLHVALRLLLSHHGWLLEPHGAMSSPTKTWLALVRIFSGR
                     HPRLFSFQRALPRQPVPSAQETVRKYLESVRPVLGDDAFDRATALANDFLRLHAPRLQ
                     LYLQLKSWCTSNYVSDWWEEFVYLRSRGSLINSTYYMMDFLYVTPTPLQAARAGNAVH
                     TLLLYRHLLNRQEISPTLLMGMRPLCSAQYERMFNTTRIPGVEKDHLRHLQDSRHVAV
                     FHRGRFFRVGTHSPNGLLSPRALEQQFQDILDDPSPACPLEEHLAALTAAPRSMWAQV
                     RESVKTHAATALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGRGHDRWFD
                     KSFTLIVFSNGKLGLSVEHSWADCPVSGHLWEFTLATECFQLGYATDGHCKGHPDPTL
                     PQPQRLQWDLPEQIQPSISLALRGAKTLSGNIDCHVFPFSHFGKSFIKCCHVSSDSFI
                     QLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMDNKETDQHC
                     LALFRVAVDKHQALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLSTS
                     QVPVQQTHLIDVHNYPDYVSSGGGFGPAHDHGYGISYIFMGENAITFHISSKKSSTET
                     DSHRLGQHIENALLDVASLFRVGQHFKRQFRGENSDYRYNFLSCKTVDPNTPTSSTNL
                     "
     exon            412..551
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            552..723
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            724..825
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            826..963
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1038
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1146
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1231
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1427
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1610
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1716
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1833
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1998
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2130
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2283
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2397
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2490
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2794
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /note="hexamer: AATAAA"
     polyA_site      2794
                     /gene="Cpt1c"
                     /gene_synonym="6530437J22Rik; 9630004I06Rik; CPT I-C; CPT
                     IC; CPT1-B; CPTI-B"
                     /note="major polyA site"
ORIGIN      
        1 agggacagaa cgcggaggga tcggaggagg cggggataaa acctagggcc agaacaccca
       61 gttcagggag ggaggaggcg cccgcgaggt gtctctgggt ttcaggataa cagccaaaga
      121 cggttgatca gtttgtggac tcattacacg gggactggat gtatgtacat gggaaactgg
      181 gtactggact caaactgggg gaaggaggtg tatatggaat tgacctcagg aaccgcagct
      241 gctgacctct gaccggtggg cccagggaac atggctgagg cacaccaggc ctcgagcttg
      301 ctgtcttcac tgagttccga tggggcagaa gtagagctca gctcgccagt gtggcaggaa
      361 atttacctct gtgccctgcg ctcctggaaa aggcatctct ggcgtgtctg gaatgacttt
      421 cttgctggtg tggtccctgc aacccccctc agctggctct tcctcttcag tacaatccag
      481 cttgcctgtc tcctccagct ggacccttcc ctaggactga tggagaagat taaagagtta
      541 ctgccagact ggggcggaca gcaccatcag ctccaggggt tcttgtcagc agcagttttt
      601 gcatcttgtt tgtggggagc cctcatcttc acccttcatg tggctctgag gctccttctg
      661 tcccaccatg gctggcttct ggaacctcat ggcgccatgt cctcacccac gaagacctgg
      721 ctggcattgg tcagaatctt ttccgggagg cacccgaggc tcttcagctt ccaacgcgcg
      781 ctcccgcgac agccagtgcc ctcggcgcag gagaccgtgc gcaagtacct agagtctgta
      841 cgccctgtgc tcggagacga cgctttcgac cgcgctacag cgctggcaaa tgacttcctg
      901 aggttgcacg caccacggct acagctctat ttgcaactca agtcctggtg tacttccaac
      961 tacgtcagcg actggtggga agagtttgtg tacctgcgct ctcgaggctc actgattaat
     1021 agcacctact acatgatgga ttttctgtac gtcaccccca caccgctgca ggcagcccgc
     1081 gcgggcaatg ctgtgcatac cctgctcctg tatcgccacc tgctgaaccg gcaggagatc
     1141 tcaccgacat tgctgatggg gatgcgaccc ttgtgttccg cccagtatga gaggatgttc
     1201 aacactacac ggattccagg ggtggaaaaa gaccaccttc gtcaccttca agacagccga
     1261 cacgtggctg tcttccaccg gggcagattc ttccgtgtag ggactcactc tcccaatggc
     1321 ctgctttccc cacgggccct ggaacagcag ttccaggaca tcctggatga cccctcccca
     1381 gcctgtcccc ttgaggaaca cctagctgct ctgactgctg ctcccaggag tatgtgggct
     1441 caggtgcggg agtcggtgaa gacccacgca gccaccgccc tggaggctgt ggaaggggct
     1501 gccttctttg tgtccctcga ttctgagccc gcgggactga ccagagagga ccccgcagct
     1561 tccctggacg cttatgccca cgctctgctg gctggccgag gccatgaccg ctggtttgac
     1621 aaatccttca ccctcatcgt cttctccaat gggaagctgg gcctcagcgt ggaacactca
     1681 tgggccgact gccctgtctc agggcatttg tgggagttca ccctggccac agagtgcttc
     1741 cagttgggtt atgccacaga tggccactgt aaggggcacc ctgaccctac cctgccacag
     1801 ccccagcgcc tgcagtggga ccttccagag cagatccagc cgtccatctc gctggccctg
     1861 aggggagcca agaccttgtc tggcaacatc gactgccacg tcttcccctt ctcccacttc
     1921 ggcaagagct tcatcaaatg ctgtcatgtc tcttcagaca gcttcatcca gttggtcctg
     1981 cagctggccc acttccggga caggggtcaa ttctgcctga cttatgagtc agccatgacc
     2041 cgactgttcc tggaaggcag gacagagaca gtgaggtctt gcaccagaga agcctgccag
     2101 tttgtgagag ccatggacaa caaggagaca gaccaacatt gcctcgccct gttccgagtg
     2161 gccgtggaca agcaccaggc tctactgaag gcggcgatga gtggccaggg gattgaccgt
     2221 cacctctttg cactgtacat catgtcccgg ctcctccata tgcagtcgcc cttcctgacc
     2281 caggtccagt cgcagcaatg gctgctgtcc accagccagg tccctgtgca gcagacacac
     2341 ctgattgatg tccacaatta tccggattac gtttcctctg gaggtggatt tgggcctgcc
     2401 catgaccatg ggtatggtat ctcctacatc ttcatggggg aaaacgcaat caccttccat
     2461 atctccagca agaaatcaag cacagaaaca gactctcacc ggctggggca gcacatcgaa
     2521 aatgccctgt tggatgtagc ctccctgttc cgggttggac agcatttcaa gcgccagttc
     2581 aggggggaga attcggatta tagatacaac tttctctcct gtaagactgt ggaccccaat
     2641 acccctacat cctccaccaa cttgtgagcc cctcagcagg gagctggtct ccctcaggat
     2701 ggaaggtgtt gctcccaggg cttggctggc gcagacaggg gtatcgggga ttcccacacc
     2761 cacctggtaa taaagatgtg agttgggtgc agtaaaaaaa aaaaaaaaaa a
//
