LOCUS       NM_009948               2894 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus carnitine palmitoyltransferase 1b, muscle (Cpt1b),
            mRNA.
ACCESSION   NM_009948
VERSION     NM_009948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2894)
  AUTHORS   Choi,J., Smith,D.M., Scafidi,S., Riddle,R.C. and Wolfgang,M.J.
  TITLE     Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation
            in a non-cell-autonomous manner
  JOURNAL   Cell Rep 43 (12), 115006 (2024)
   PUBMED   39671290
REFERENCE   2  (bases 1 to 2894)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   3  (bases 1 to 2894)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   4  (bases 1 to 2894)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   5  (bases 1 to 2894)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2894)
  AUTHORS   Cox,K.B., Johnson,K.R. and Wood,P.A.
  TITLE     Chromosomal locations of the mouse fatty acid oxidation genes
            Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene
  JOURNAL   Mamm Genome 9 (8), 608-610 (1998)
   PUBMED   9680378
REFERENCE   7  (bases 1 to 2894)
  AUTHORS   Britton,C.H., Mackey,D.W., Esser,V., Foster,D.W., Burns,D.K.,
            Yarnall,D.P., Froguel,P. and McGarry,J.D.
  TITLE     Fine chromosome mapping of the genes for human liver and muscle
            carnitine palmitoyltransferase I (CPT1A and CPT1B)
  JOURNAL   Genomics 40 (1), 209-211 (1997)
   PUBMED   9070950
REFERENCE   8  (bases 1 to 2894)
  AUTHORS   Paumen,M.B., Ishida,Y., Muramatsu,M., Yamamoto,M. and Honjo,T.
  TITLE     Inhibition of carnitine palmitoyltransferase I augments
            sphingolipid synthesis and palmitate-induced apoptosis
  JOURNAL   J Biol Chem 272 (6), 3324-3329 (1997)
   PUBMED   9013572
REFERENCE   9  (bases 1 to 2894)
  AUTHORS   Uenaka,R., Kuwajima,M., Ono,A., Matsuzawa,Y., Hayakawa,J.,
            Inohara,N., Kagawa,Y. and Ohta,S.
  TITLE     Increased expression of carnitine palmitoyltransferase I gene is
            repressed by administering L-carnitine in the hearts of
            carnitine-deficient juvenile visceral steatosis mice
  JOURNAL   J Biochem 119 (3), 533-540 (1996)
   PUBMED   8830050
REFERENCE   10 (bases 1 to 2894)
  AUTHORS   Gelb,B.D.
  TITLE     Genomic structure of and a cardiac promoter for the mouse carnitine
            palmitoyltransferase II gene
  JOURNAL   Genomics 18 (3), 651-655 (1993)
   PUBMED   8307575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ092541.1, AK029141.1 and CJ238532.1.
            
            On Dec 11, 2007 this sequence version replaced NM_009948.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017174.2, BC018270.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               CJ092541.1         1-483
            484-2341            AK029141.1         460-2317
            2342-2894           CJ238532.1         128-680
FEATURES             Location/Qualifiers
     source          1..2894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.89 cM"
     gene            1..2894
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /note="carnitine palmitoyltransferase 1b, muscle"
                     /db_xref="GeneID:12895"
                     /db_xref="MGI:MGI:1098297"
     exon            1..65
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            66..225
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2403
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /EC_number="2.3.1.21"
                     /note="muscle-type carnitine palmitoyltransferase I"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform"
                     /protein_id="NP_034078.2"
                     /db_xref="CCDS:CCDS27749.1"
                     /db_xref="GeneID:12895"
                     /db_xref="MGI:MGI:1098297"
                     /translation="MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLI
                     RIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVDCIQRCLPERYGHFGTPQ
                     TEALLSMVIFSTGVWATGIFFFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLS
                     SRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYYRMETLAKEFQDKTAPR
                     LQKYLVLKSWWATNYVSDWWEEYVYLRSRSPLMVNSNYYAMDFVLIKNTNVQAARLGN
                     AVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRH
                     VAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEW
                     AEARQTFFSSGKNKMSLDAIERAAFFVTLDEDSHCYNPDDETSLSLYGKALLHGNCYN
                     RWFDKSFTLISCKNGLLGLNTEHSWADAPIIGHLWEFVLGTDTFHLGYTETGHCVGEP
                     NTTLPPPQRLPWDIPEQCREAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSP
                     DAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTNESAAFVQAMMKGSH
                     KKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVSSPFLAEVLSEPW
                     SLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADDGYGVSYMIAGENTMFFHISSKY
                     SSSETNAQRFGNHIRQALLDIAELFKISKTDS"
     exon            226..365
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            366..543
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            544..645
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            646..783
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            784..861
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            862..969
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1054
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1250
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1436
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1542
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1659
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1824
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1959
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2112
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2226
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2319
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2894
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /note="hexamer: AATAAA"
     polyA_site      2678
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /note="major polyA site"
     regulatory      2871..2876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /note="hexamer: AATAAA"
     polyA_site      2894
                     /gene="Cpt1b"
                     /gene_synonym="Cpt1; Cpt1-m; Cpti; Cpti-m; M-cpti"
                     /note="major polyA site"
ORIGIN      
        1 tgaaggacgt ggggacatgg gccagagagg ccagacccat acaccgacag aagcaaacct
       61 gagctgtgct gaataaaccc caggatggcg gaagcacacc aggcagtagc tttccagttc
      121 actgtgaccc cagacggggt cgacttccgg cttagtcggg aggctctgag acacatctac
      181 ctgtctggaa tcaactcctg gaagaaacgc cttattcgaa tcaagaatgg catccttagg
      241 ggtgtgtacc ctggcagccc caccagctgg ctggttgttg tcatggcaac agttggttcc
      301 aactactgca aggtggacat ctccatggga ctggtcgatt gcatccagag atgcctcccg
      361 gaaaggtatg gccactttgg gaccccacag acagaggcac ttctcagcat ggtcatcttc
      421 tccaccggag tctgggcgac aggcattttc ttcttccgac aaaccctgaa gctgctgctc
      481 tcctaccacg ggtggatgtt cgagatgcac agcaagacca gccatgccac caagatctgg
      541 gctatctgtg tccgtctcct gtccagccgg cggcccatgc tctacagctt ccaaacgtca
      601 ctgcctaagc ttcctgtccc cagcgtgcca gccacaattc accggtactt ggattctgtg
      661 cggcccttat tggatgatga agcatattac cgcatggaga cattggccaa ggaattccag
      721 gacaagactg cccccaggct gcagaaatac ctggtgctca agtcatggtg ggcaactaac
      781 tatgtgagtg actggtggga agaatatgtc tacctccgaa gcaggagccc cctcatggtg
      841 aacagcaact attatgccat ggattttgtg cttattaaga acacaaatgt gcaagcagcc
      901 cgtctaggca atgccgttca cgccatgatc atgtatcgcc gcaaactgga ccgtgaagag
      961 atcaagccgg tcatggcact gggtatggtg cccatgtgct cctaccagat ggagaggatg
     1021 ttcaacacta cacgcatccc aggcaaagag acagacttgc tacagcacct ctcagagagc
     1081 aggcacgtgg ctgtctacca caaaggtcgc ttcttcaagg tctggctcta tgagggctcg
     1141 cgcctgctca agccccgaga cctggagatg cagttccaga gaatcctcga cgacccttcc
     1201 ccacctcagc ctggggagga gaagctggca gccctcaccg caggaggaag ggtagagtgg
     1261 gcagaggcac gtcagacctt cttcagctct ggcaagaaca agatgtctct ggacgccatc
     1321 gaacgtgctg ctttctttgt gaccctggat gaagattctc attgctacaa ccctgacgat
     1381 gagaccagtc ttagcctcta cggcaaagcc ttgctccatg gcaactgcta taacaggtgg
     1441 tttgacaaat ctttcaccct tatctcctgc aagaatggcc tgttaggcct caacaccgaa
     1501 cactcgtggg cagacgcgcc catcattggg cacctctggg agtttgtcct gggcactgat
     1561 acctttcacc tgggctacac ggagacagga cactgtgtgg gtgagccaaa caccacgttg
     1621 ccaccccctc agcggctgcc gtgggacatt cccgagcagt gccgggaagc catcgagaac
     1681 tcgtaccaag tagccaaggc actggccgat gacgtggagc tctactgctt ccagttctta
     1741 ccctttggca aaggtcttat caagaagtgt aggaccagcc ccgacgcttt tgtgcagatt
     1801 gccctacagc tggctcattt ccgggacaaa ggcaagttct gcctgactta cgaggcctcg
     1861 atgacaagaa tgttccgaga ggggcggact gagactgtgc gttcctgtac caacgagtcc
     1921 gcagcctttg tgcaggccat gatgaagggg tcccataaga aacaagacct ccaagatctc
     1981 ttccggaaag cctccgaaaa gcaccaaaac atgtaccgcc tagccatgac aggggctggg
     2041 atcgaccggc acctcttctg cctttacatc gtctccaagt acttaggagt tagctctcct
     2101 ttcctggctg aggtactttc tgaaccctgg agcctctcca ccagccagat cccccagttc
     2161 cagatctgca tgtttgaccc aaaacagtat cccaatcatc tgggtgctgg aggtggcttt
     2221 ggtcccgtgg cggatgatgg ctacggggtc tcttacatga tcgcaggaga aaacaccatg
     2281 ttcttccaca tctccagcaa atactcaagt tcagagacga acgcccagcg ctttgggaac
     2341 cacatccgcc aagcactgtt ggacatcgcc gaacttttca aaatttccaa gacagacagc
     2401 tgaggaaaag agatacccca gctgccctct ggtccccacc tggtggaaga agaggcctgt
     2461 ggccagctca caggcataag gggtggcgtg cacacacgcc cagttcggag aacagctctt
     2521 gaggcagtgc tccccggagg aggcagtgct ccctgggcag atactgctcc tctagggccc
     2581 ccgctggagg tgggattgga gcagcagggg aattttgatt tttttttttt ttttttggct
     2641 tggtagatgt taataaaaat aaggctgtat aattcttact tggctgttag gtgcctatgt
     2701 ttttgttaga gaacgataag gccctttcct gccccagctc agcctaggat ggaggcgatg
     2761 gaaggggtcg gagaatgttc ataatgggct tcttacctgc tttgaaatgg gtgctcttct
     2821 tgaataatgc ggacttggag agcgctgtcc aacctctcat gtgcacttgg aataaattct
     2881 tactttagaa cctt
//
