LOCUS       NM_013495               4331 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus carnitine palmitoyltransferase 1a, liver (Cpt1a),
            mRNA.
ACCESSION   NM_013495
VERSION     NM_013495.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4331)
  AUTHORS   Chen,H., Liu,C., Cui,S., Xia,Y., Zhang,K., Cheng,H., Peng,J.,
            Yu,X., Li,L., Yu,H., Zhang,J., Zheng,J.S. and Zhang,B.
  TITLE     Intermittent fasting triggers interorgan communication to suppress
            hair follicle regeneration
  JOURNAL   Cell 188 (1), 157-174 (2025)
   PUBMED   39674178
REFERENCE   2  (bases 1 to 4331)
  AUTHORS   Choi,J., Smith,D.M., Scafidi,S., Riddle,R.C. and Wolfgang,M.J.
  TITLE     Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation
            in a non-cell-autonomous manner
  JOURNAL   Cell Rep 43 (12), 115006 (2024)
   PUBMED   39671290
REFERENCE   3  (bases 1 to 4331)
  AUTHORS   Ming,S., Li,X., Xiao,Q., Qu,S., Wang,Q., Fang,Q., Liang,P., Xu,Y.,
            Yang,J., Yang,Y., Huang,X. and Wu,Y.
  TITLE     TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the
            SHP1/BTK axis
  JOURNAL   J Clin Invest 135 (1), e159400 (2024)
   PUBMED   39405126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4331)
  AUTHORS   Qiu,J., Yue,F., Kim,K.H., Chen,X., Khedr,M.A., Chen,J., Gu,L.,
            Ren,J., Ferreira,C.R., Ellis,J. and Kuang,S.
  TITLE     Overexpression of CPT1A disrupts the maintenance and regenerative
            function of muscle stem cells
  JOURNAL   FASEB J 38 (19), e70071 (2024)
   PUBMED   39382025
  REMARK    GeneRIF: Overexpression of CPT1A disrupts the maintenance and
            regenerative function of muscle stem cells.
REFERENCE   5  (bases 1 to 4331)
  AUTHORS   Choi,J., Smith,D.M., Lee,Y.J., Cai,D., Hossain,M.J., O'Connor,T.J.,
            Deme,P., Haughey,N.J., Scafidi,S., Riddle,R.C. and Wolfgang,M.J.
  TITLE     Etomoxir repurposed as a promiscuous fatty acid mimetic
            chemoproteomic probe
  JOURNAL   iScience 27 (9), 110642 (2024)
   PUBMED   39252970
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4331)
  AUTHORS   Britton,C.H., Mackey,D.W., Esser,V., Foster,D.W., Burns,D.K.,
            Yarnall,D.P., Froguel,P. and McGarry,J.D.
  TITLE     Fine chromosome mapping of the genes for human liver and muscle
            carnitine palmitoyltransferase I (CPT1A and CPT1B)
  JOURNAL   Genomics 40 (1), 209-211 (1997)
   PUBMED   9070950
REFERENCE   7  (bases 1 to 4331)
  AUTHORS   Paumen,M.B., Ishida,Y., Muramatsu,M., Yamamoto,M. and Honjo,T.
  TITLE     Inhibition of carnitine palmitoyltransferase I augments
            sphingolipid synthesis and palmitate-induced apoptosis
  JOURNAL   J Biol Chem 272 (6), 3324-3329 (1997)
   PUBMED   9013572
REFERENCE   8  (bases 1 to 4331)
  AUTHORS   Uenaka,R., Kuwajima,M., Ono,A., Matsuzawa,Y., Hayakawa,J.,
            Inohara,N., Kagawa,Y. and Ohta,S.
  TITLE     Increased expression of carnitine palmitoyltransferase I gene is
            repressed by administering L-carnitine in the hearts of
            carnitine-deficient juvenile visceral steatosis mice
  JOURNAL   J Biochem 119 (3), 533-540 (1996)
   PUBMED   8830050
REFERENCE   9  (bases 1 to 4331)
  AUTHORS   Britton,C.H., Schultz,R.A., Zhang,B., Esser,V., Foster,D.W. and
            McGarry,J.D.
  TITLE     Human liver mitochondrial carnitine palmitoyltransferase I:
            characterization of its cDNA and chromosomal localization and
            partial analysis of the gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 1984-1988 (1995)
   PUBMED   7892212
REFERENCE   10 (bases 1 to 4331)
  AUTHORS   Gelb,B.D.
  TITLE     Genomic structure of and a cardiac promoter for the mouse carnitine
            palmitoyltransferase II gene
  JOURNAL   Genomics 18 (3), 651-655 (1993)
   PUBMED   8307575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ081259.1, BC054791.1 and AK147770.1.
            
            On Dec 11, 2007 this sequence version replaced NM_013495.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054791.1, AK147770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               CJ081259.1         2-381
            381-2982            BC054791.1         362-2963
            2983-3563           AK147770.1         2938-3518
            3564-4331           BC054791.1         3545-4312
FEATURES             Location/Qualifiers
     source          1..4331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.08 cM"
     gene            1..4331
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /note="carnitine palmitoyltransferase 1a, liver"
                     /db_xref="GeneID:12894"
                     /db_xref="MGI:MGI:1098296"
     exon            1..74
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            75..228
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2409
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /EC_number="2.3.1.21"
                     /note="CPT I; CPT1-L; CPTI-L; carnitine
                     palmitoyltransferase 1, liver; L-CPT I;
                     succinyltransferase CPT1A"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, liver
                     isoform"
                     /protein_id="NP_038523.2"
                     /db_xref="CCDS:CCDS29395.1"
                     /db_xref="GeneID:12894"
                     /db_xref="MGI:MGI:1098296"
                     /translation="MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFI
                     RFKNGIITGVFPASPSSWLIVVVGVISSMHTKVDPSLGMIAKINRTLDTTGRMSSQTK
                     NIVSGVLFGTGLWVAIIMTMRYSLKVLLSYHGWMFAEHGKMSRSTRIWMAMVKVFSGR
                     KPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEGDFQRMTALAQDFAVNLGPKLQ
                     WYLKLKSWWATNYVSDWWEEYIYLRGRGPIMVNSNYYAMEMLYITPTHIQAARAGNTI
                     HAILLYRRTVDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHVKDSRHI
                     VVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDTSEPQPGEAKLAALTAADRVPWA
                     KCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFD
                     RWFDKSITFVVFKNSKIGINAEHSWADAPIVGHLWEYVMATDVFQLGYSEDGHCKGDK
                     NPNIPKPTRLQWDIPGECQEVIETSLSSASFLANDVDLHSFPFDTFGKGLIKKCRTSP
                     DAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCNFVLAMMDPTT
                     TAEQRFKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPW
                     RLSTSQTPQQQVELFDFEKYPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKF
                     SSPETDSHRFGKHLRQAMMDIITLFGLTANSKK"
     exon            229..368
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            369..540
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            541..642
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            643..780
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            781..858
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            859..966
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1054
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1250
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1439
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1545
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1662
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1827
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1962
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2115
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2229
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2322
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..4301
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4277..4282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /note="hexamer: AATAAA"
     polyA_site      4301
                     /gene="Cpt1a"
                     /gene_synonym="C730027G07; Cpt1; CPTI"
                     /note="major polyA site"
ORIGIN      
        1 gtcggtgagc ctggcctcgc ccgccccggc ccggactccg ctcgctcatt ccgccgccgc
       61 cgtctgcaga ctcggtcacc actcaagatg gcagaggctc accaagctgt ggccttccag
      121 ttcacagtca cccctgatgg catcgatctc cgcctgagcc atgaagccct caaacagatc
      181 tgcctgtcag ggctgcactc ctggaagaag aagttcatcc gattcaagaa tggcatcatc
      241 actggtgtgt tccccgcgag tccctccagc tggcttatcg tggtggtggg tgtgatatca
      301 tccatgcata ccaaagtgga cccctccctg ggcatgattg caaagatcaa tcggacccta
      361 gacaccactg gccgcatgtc aagccagacg aagaacatcg tgagtggcgt cctctttggc
      421 acagggctct gggtggcgat catcatgact atgcgctact cgctgaaggt gctgctctcc
      481 taccatggct ggatgtttgc agagcacggc aaaatgagcc gcagcaccag aatctggatg
      541 gctatggtca aggtcttctc gggtcgaaag cccatgttgt acagcttcca gacgtctctg
      601 ccgcgcctgc ctgtcccagc tgtcaaagat accgtgagca ggtacctgga gtctgtgagg
      661 ccactgatga aggagggaga cttccaacgc atgacagcac tggcccagga ttttgctgtc
      721 aaccttggac ccaaattgca gtggtatttg aagctaaaat cctggtgggc cacaaattat
      781 gtgagtgact ggtgggagga atacatctac ctgcggggcc gagggccgat catggttaac
      841 agcaactact acgccatgga gatgctctac atcaccccaa cccatattca ggcagcgaga
      901 gctggcaaca ccatccacgc catactgctg tatcgtcgca cggtagaccg tgaggaactc
      961 aaacctattc gtcttctggg atctacaatt cccctctgct ctgctcagtg ggagcgactc
     1021 ttcaatactt cccgcatccc tggggaggag acagacacca tccaacacgt caaggacagc
     1081 aggcacattg tcgtgtacca cagaggccgt tacttcaagg tctggctcta ccatgacggg
     1141 aggctgctga ggccccgtga gctggagcag cagatgcagc agatcctgga tgacacctca
     1201 gagccgcagc ccggggaagc caagcttgcc gccctcactg ccgcagacag agtgccctgg
     1261 gcgaagtgtc ggcagaccta ttttgcacga ggaaaaaata agcaatctct ggatgcggta
     1321 gaaaaggcag cattcttcgt gacgttggac gaatcggaac agggatatag agaggaggac
     1381 cctgaggcat ctattgacag ctatgccaaa tctctgctgc atggtagatg tttcgacagg
     1441 tggtttgaca agtccatcac ctttgttgtc ttcaaaaaca gcaagatagg cataaacgca
     1501 gagcattcct gggcggacgc gcccatcgtg ggccatctgt gggagtatgt catggccacc
     1561 gacgtcttcc agctgggcta ctcagaggat ggacactgta aaggagacaa gaaccccaac
     1621 atccccaaac ccaccaggct acagtgggac attccaggag aatgccagga ggtcatagag
     1681 acatccctaa gcagtgccag ttttttggca aatgatgtgg acctgcattc cttcccattt
     1741 gacacctttg gcaaaggctt gatcaagaag tgccggacga gtcccgatgc cttcatccag
     1801 ctggcactgc agctcgcaca ttacaaggac atgggcaagt tctgcctcac gtatgaggct
     1861 tccatgactc ggctcttccg agaggggagg acagagactg tacgctcctg cactacggag
     1921 tcctgcaact ttgtgctggc catgatggac cccacaacaa cggcagagca gaggttcaag
     1981 ctgttcaaga tagcttgtga aaagcaccag cacctgtacc gcctcgccat gacgggcgct
     2041 ggcatcgacc gccacctctt ctgcctctat gtggtgtcca agtatctggc agtcgactca
     2101 cctttcctga aggaggtact gtctgagcca tggaggttgt ccacgagcca gactcctcag
     2161 cagcaggtgg aactgtttga ctttgagaaa taccctgact atgtgtcctg tggcgggggc
     2221 tttgggccgg ttgctgatga cggctatggt gtttcctaca ttattgtggg agagaatttc
     2281 atccacttcc atatttcttc caagttctct agccctgaga cagactcaca ccgctttggg
     2341 aagcacttga gacaagccat gatggacatt atcaccttgt ttggcctcac cgccaattcc
     2401 aaaaagtaac tgtcggagcc gcacggaagg aaaatggact ctagtgatac aaaccaaatg
     2461 aataggtgtt gctcctgacc ataggacagg cagaaaattg ttcttataaa actcagtttt
     2521 ccttccagaa ggtttaccgt cggtctccct agaacaaccg taggctccac cgtttgactt
     2581 gtgaccctac tacatccaga gatgccttgg ctccaggaat attgggcaca gtcccccgaa
     2641 gtcttttgaa tcggctccta atggataaag ggatttaaat gctggtgaat ccctggattt
     2701 tgggggttgt atcaatatgt gttggaggtg acagacttcc tcagtggtga ccctgtggat
     2761 acttgggact tgacttcacc caggcagtga gagcatcacc ttgtggaaag agaaagtggc
     2821 ttcagagcca gtggaggtaa cagctctagc taacacacct gtaacacact aatggaatgg
     2881 ttaggcctgg ggattaaggt tctgctatga atgacagcca ccatcgcttt gggagtccac
     2941 atttgactcc acatttcctg gaagcaggat accacctcct cagtgccacc ttcgaaaccc
     3001 agtgccttaa cgatgggagc ccattggcaa gtggggccat agagaaggct tagcatgtga
     3061 agcctttggg tggatatgtg agggtgctgc ttcccctcac aagttcctgc atagagatgt
     3121 ccctaagtaa gcacttcccc caccctagaa gatgaggtcc ctggtggagg gagcgatgca
     3181 gaatctcatt ggccaccagt tccattaagc aacaaaataa cagatgtgtc cacagaggga
     3241 agtgaggggc ttggtagtca aaggctacca agttggacac cagctggaga gtgtggcagc
     3301 cattggcaag gagagtgaga ccctggtcac tgagtcaggc atactgacac aggcagccaa
     3361 agccttgtca tggcagccag gagatagaga tcctggcaga tacaccaacg ggctcatctt
     3421 ctaatcccac ccagtcagat tccaaccaga gcaaattcga tagaaggcta ggtcattttg
     3481 gtgacagact cgggggtctc aagtaatggg tgctttgtac ccaaatacca tccctctgtg
     3541 agagtgcctt tcttgacaac atccaataga ctgtaaagca actccgtttg gtattccatg
     3601 taaacatagc ataatggagt ggcctcccct acctgttacc atcctgtcct gacaagttta
     3661 gctcttcgtg ttttaaatca tgtatttatt ttccagtgcc cctttggcct tgcttgattc
     3721 ctactcgtgt gctagctgta acagaagtga gggtggggtg gccagaagta cagagaggtg
     3781 ctggctgaac agctcatgcg tgttttataa gtatccatga atacaaaaaa aagaatcaca
     3841 cctacaaggg ccaaagtttt tttcctacta aaaacaagaa aacaaaaggc aacataaata
     3901 tatagcagag acaactgtaa gtcaaagccg cctgaccgcg ctcttaggac tacttgctaa
     3961 cctctgttac tcggagtatt cctgctagta cccaagtgtg acattcctct ctcaggtctc
     4021 cagtgtcctt ccttgctgct cctgagcagt taccaatgca attttttact ccttccaagg
     4081 cagaagagtg ggctttcact gtaagtgttc aaaggaggag gtaagactac tatgtattta
     4141 atgtggaaca aaacatagtc ttaccgcagc caaggttcga atttggtttt ctaatctgtc
     4201 cattgcatgt aaataccata tgctgtttgg atataaatct tagaaatgca tgtgtgaacg
     4261 aatatagctg accattaata aaacattaat cccgcctact aaaaaaaaaa aaaaaaaaaa
     4321 aaaaaaaaaa a
//
