LOCUS       NM_001013391            6534 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus cleavage and polyadenylation specific factor 6
            (Cpsf6), transcript variant 2, mRNA.
ACCESSION   NM_001013391 XM_483955
VERSION     NM_001013391.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6534)
  AUTHORS   Liu,X., Xie,H., Liu,W., Zuo,J., Li,S., Tian,Y., Zhao,J., Bai,M.,
            Li,J., Bao,L., Han,J. and Zhang,Z.C.
  TITLE     Dynamic regulation of alternative polyadenylation by PQBP1 during
            neurogenesis
  JOURNAL   Cell Rep 43 (8), 114525 (2024)
   PUBMED   39037895
REFERENCE   2  (bases 1 to 6534)
  AUTHORS   Ge,Y., Huang,J., Chen,R., Fu,Y., Ling,T., Ou,X., Rong,X., Cheng,Y.,
            Lin,Y., Zhou,F., Lu,C., Yuan,S. and Xu,A.
  TITLE     Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and
            enhanced antiviral immune responses
  JOURNAL   PLoS Pathog 20 (2), e1012061 (2024)
   PUBMED   38416782
  REMARK    GeneRIF: Downregulation of CPSF6 leads to global mRNA 3' UTR
            shortening and enhanced antiviral immune responses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6534)
  AUTHORS   Li,N., Cai,Y., Zou,M., Zhou,J., Zhang,L., Zhou,L., Xiang,W., Cui,Y.
            and Li,H.
  TITLE     CFIm-mediated alternative polyadenylation safeguards the
            development of mammalian pre-implantation embryos
  JOURNAL   Stem Cell Reports 18 (1), 81-96 (2023)
   PUBMED   36563685
REFERENCE   4  (bases 1 to 6534)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6534)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6534)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 6534)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 6534)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   9  (bases 1 to 6534)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6534)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077684.1, BC068133.1, AK033801.1, AK164584.1 and CD547792.1.
            
            On Apr 10, 2009 this sequence version replaced NM_001013391.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.5194.1, AK049749.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK077684.1         2-25
            25-2995             BC068133.1         1-2971
            2996-5192           AK033801.1         81-2277
            5193-6380           AK164584.1         1496-2683
            6381-6534           CD547792.1         1-154               c
FEATURES             Location/Qualifiers
     source          1..6534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.41 cM"
     gene            1..6534
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="cleavage and polyadenylation specific factor 6"
                     /db_xref="GeneID:432508"
                     /db_xref="MGI:MGI:1913948"
     exon            1..135
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1731
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cleavage and polyadenylation specificity factor subunit 6"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 6 isoform 2"
                     /protein_id="NP_001013409.1"
                     /db_xref="CCDS:CCDS24193.1"
                     /db_xref="GeneID:432508"
                     /db_xref="MGI:MGI:1913948"
                     /translation="MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNG
                     DAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVH
                     SLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQSPVVTPCN
                     KQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGGSRAAFPQGGRGRGRFPGAVPGGDRFP
                     GPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPP
                     VLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPP
                     LTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDR
                     GDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVT
                     AISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRR
                     HKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR"
     exon            136..345
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            346..449
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            450..595
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..769
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1274
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1390
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1544
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1734
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..6534
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="hexamer: AATAAA"
     polyA_site      1895
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="major polyA site"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="hexamer: AATAAA"
     polyA_site      2172
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="major polyA site"
     regulatory      3892..3897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="hexamer: AATAAA"
     polyA_site      3916
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
     regulatory      6512..6517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="hexamer: AATAAA"
     polyA_site      6533
                     /gene="Cpsf6"
                     /gene_synonym="4733401N12Rik; CFIM; CFIM68; HPBRII-4;
                     HPBRII-7"
                     /note="major polyA site"
ORIGIN      
        1 gccagatccg ctgctgctgc ctcggcgggc cgacctgcag gaggcggcgg cggcggcggc
       61 cgaggccgag ggaagatggc ggacggtgtg gaccacatag acatttacgc ggatgtgggt
      121 gaagagttca accaggaagc agaatatggt ggacatgatc agatagattt gtatgatgat
      181 gtcatctctc catctgcaaa taatggcgat gccccagaag atcgcgacta catggatact
      241 cttccaccaa ctgttggtga tgatgtgggt aaaggagccg caccaaacgt tgtgtacact
      301 tacactggga agagaatcgc attgtatatt ggaaatctaa catggtggac aacagatgag
      361 gacctaactg aggccgttca ttctttggga gtaaatgata ttttggagat aaaattcttt
      421 gaaaatcggg caaatggaca atcaaaggga tttgcccttg ttggtgttgg atctgaagca
      481 tcttccaaaa agttaatgga tcttttgcct aaaagagaac ttcatggtca gagtcctgtt
      541 gtaactccat gcaataagca gttcctgagt caatttgaaa tgcaatccag gaaaactaca
      601 cagtcaggac agatgtctgg ggaagggaaa gccggtcctc caggaggcgg ttcacgcgca
      661 gcgtttcctc aaggtggtag aggacggggc cggtttccag gggctgttcc tggtggggac
      721 agatttcctg ggccagcagg accaggaggg ccacctccac cttttccagc tggacaaact
      781 ccaccacgtc cacctttagg cccacctggc ccacctggtc caccaggtcc tccacctcct
      841 ggtcaggttc tgccacctcc tctagcagga cctcctaacc gaggagaccg ccctccacca
      901 ccagttcttt ttcctggaca accttttggg cagcctccgc tgggtccact tcctcctggg
      961 cctccacctc cagttccagg ctacggcccc cctccaggtc caccgcctcc acagcaggga
     1021 ccacctccac ctccaggccc ctttccacct cgcccaccag gtccactagg gcctcccctc
     1081 acacttgctc ctcctccaca tcttccggga ccacctccag gtgccccgcc accagctcca
     1141 catgtgaatc ctgctttttt tcctccacca actaatagtg gcatgccaac atcagatagt
     1201 cgaggtccac caccaacaga cccatatggc cgacctcccc catatgatag gggtgactac
     1261 ggtccccctg ggagggaaat ggatactgca agaacacctc tgagtgaagc tgagtttgaa
     1321 gaaatcatga atagaaatcg ggcaatctca agcagtgcta tttcaagagc tgtgtctgac
     1381 gctagtgctg gtgattatgg gagtgctatt gaaacattgg taacagcaat ttctttaatt
     1441 aaacaatcca aagtctctgc agatgatcgt tgcaaagttc ttattagctc tctgcaggat
     1501 tgccttcatg gaatcgagtc caagtcctat gggtctggat ccagacgtga acgatcaaga
     1561 gaacgggacc atagtagatc acgggaaaag agtcgtcgcc ataaatctcg gagtagagat
     1621 cgccacgatg actattacag agagagaagc agagaacgag agagacaccg ggatcgggac
     1681 cgcgaccgtg accgagagcg tgaccgagag cgagaatacc gtcatcgtta gaagctgaag
     1741 gaagaggaac accttccaag acaaaagagt cttctcgggg gaaaagtgac gcttgtccag
     1801 cagtttgctt cttgtgattg aactgaacct gtaaggcttc atggataaac tgaacaggaa
     1861 tagatctgaa taaagcaaat ctgcataaat ggtaaccagt agctctactt ttatttttta
     1921 tgttgcttaa ctgttttatt tgaaggaaac ctgtgtgatt taaaaagtta atagcttttg
     1981 caactttatt actggttata tatatttggc cattataatg tgcaagcaat tggaaaaaag
     2041 tcaagtaaat gcttgttttt atagtagttt gttcttgtta aaatgttcct atgataatgt
     2101 ctgtaaacag caccgatttg attacactag atgtagtgtt gtaataaact gtttatgggg
     2161 ctgatgtgta aagctgttca cgttatttga tgtttacacc tcagggaaag gcttgtgttc
     2221 agcaatatct aaagataatg ttactatgac aacattttta ctgtccttta aaaagcattg
     2281 caatagcgtg tttggatatg catcaatcta atcttgcgtt cagtgaatta aacatgacta
     2341 attaagtgtc tattgccctt gattttgata ttagaatagg tgactacatg ggtatttaat
     2401 atttctatat tctgcttttc tagctgtttt tacctagtta gcttgtgatt ttgctgaatg
     2461 gtatgtaaac gtgtaaaaac tgaaatttga cagagcaatc cagtcaatgt gttaggggtc
     2521 aaaaaaattg aaggctgtaa catttttggt aaaaactcat gtatttgcta cagtagtgca
     2581 gcttaattac aacccagata tactgaaata ataaattgtg aactgctagc atttaagata
     2641 gattttgata attctggttt catgcagtaa tttactgttt gatgctgatg gtgccatagg
     2701 cagtgtaatt atggctatac agcaagatgc gtaaagaaag ctctagtatt gtacttgatt
     2761 cagatttctg aagggtgtga tgtttattaa cattgggctg tattgttcag tgtgaataat
     2821 gaaaatttat aattacactg tcttcatggc tcaaggaatt gtgtgtgtat tcctgtaacc
     2881 ttgttgatct atgcttgatt agagttaatc agctgatttt tttttctttt tttttccttt
     2941 ctttcatttt tttttttaaa agatccagcc ttaataaaag gttgtattaa aagcacctgg
     3001 ctagcatgtg ttatgcaaaa aatagcagag acagactgac tgtcaatttg attgcctatt
     3061 tttataggaa ggtaaaaatc tgaattacta aagaaattta gataaagtcc taaagctaat
     3121 ttgtgttaaa tgttttaaag atcttattac ctgtgagaga tctgtgcatt gactttttga
     3181 agtttacgta aatttaagag cagagcttaa ggtctgtgcc ataggttgag gtaatgagca
     3241 gcttgagagg tttgtacttt tcttcagtgt tgtcttctct gcttttaaaa cactcagaaa
     3301 tatccatacc actgccagtt cattttaaag catctgtgag cagggtattt tttgaaaggt
     3361 atcattggtg tttaccacaa ctgttgttag ctctcagaaa tgatttttct taagtgttta
     3421 atcttgttga aatgcaatta ccttttaatt tgggagttgt atcaaaatct attttcttgt
     3481 tttgtatata ggtcttgtaa gtttttgtca ttttttagct ttttttaata gttcaattac
     3541 aatgccctaa tgtgaagctg tgtggacata catgtgttta caagggggat tagttaatag
     3601 tgagattaac aggtaagtac aatgtccata gatagaattt ctctgaacat tttaaaaatg
     3661 gaatcaaaaa atacatatac ttgaaatgaa actggagatt ttgtactaat tttaatcctt
     3721 tattaccttt tattttttct ttttaaaaaa atcagttgga accctttgtt tgctctcctt
     3781 atgtcacact tcttgcttgg cctatttcac tcataagcga ctttggatgc agacagtgta
     3841 ttagccttgc ttgctgctgc tggtccatta ctttaagtgt tgttaggaaa aaataaaata
     3901 gctttggttt gtctaatttt gcagtgtctc ctacctgata acacatgaat gtatagcagt
     3961 aaaagtaaaa attacaaacc ttgttatttg tcaaagccct tctgttgtct aggagccagt
     4021 ttcatttgaa aactggtttt taatgtgtaa aagcaatcca aagagatgaa attttacaga
     4081 caccaaaaaa gagagagaga gacaaacaag tcagagagaa gaaaaaagga gttaaacacg
     4141 tgtagttcat atagagaggc agtgacagct tgagcttgtc ttgagtccca gcgtcgctca
     4201 gtgctgtgta gtcacattcc ttgcagctag tagtgagatt ccacaaggta tttctcctga
     4261 cgtggcactt tgaattcaat atactgcttt gagggaaagg aaatagattt gtagaaagga
     4321 ttccttcagt gtaaatttac atgtgtttat gttttgtcag ttttcatcag caagatgagc
     4381 aagattctaa gtgacttgcc atagttgttg atcatgtcag gccatttcat gtctccttaa
     4441 cctataatct taagcagtta actacaattt ggaatttaca aatagcatgt agcttaaggt
     4501 attattttaa tttgattctc ctatggagac tgttgcttta gtttttacta gtttaaagtc
     4561 agttctaaaa ataaacatgg acgctttcat gaacattgta taatatttta tagtaaaggg
     4621 ggggaagttg tttaaagggt aagactttat ctttccctgt gttgacacgt gccaatagcc
     4681 tgagtacatt ctgtttcata caacaagatg ccactgcaag actcttccac tggagtgctc
     4741 atgtcacttc agttttgcta cccaagtggt tgttgcagtg tctatatctt gcaaggtggc
     4801 cccaatattg tgttttaagc ttcagcttca gttattttaa gaggaagttt atgctctgat
     4861 tcttcactga gaattcagta ttgagattct tgctattaca cagatagact gatttctaaa
     4921 ttttattcat gaacttcatt tgcatcccat agccctctgt aaatgtttcc cccagttgta
     4981 tgtacttact aaatgcatgc tttttcattg tacatactag acattttttg tgctaaaatt
     5041 tattaagtag ggtttttgta gcaaagcatt ctatttttat gttcttatag tgtatgtgtt
     5101 aacattaata ttcagtttaa acactggtgt atttattttt agcaacttga ctcctagaag
     5161 ccttagacta atttttaaat aaacattcaa ccaaaaatta tgaatttctt gagatgtggc
     5221 cttatacgtg gtgttttctg tgttcataac gtgaaatatt ttaaatttag attttattta
     5281 aatcaagatt tagaattagt ttcattttaa gtcaaaatag aaaatgtatt aagcgtctag
     5341 gcttctggga ggaagttctt aacactcttc tttcttggca ttagaaagaa gcaatatgaa
     5401 tttatgaata ttctaaatat tcaggccatt gtattgtgtt cagattgctt taggcttgtt
     5461 ttagcccagt gtttctttaa agttccaggt ggttggcatt catgaatata cagctactgt
     5521 ggtttttata tgggtgtatg aaatcttggt tacatatagg cagatttctg tttttaaaga
     5581 attcctgcta cattaattat actgtatcag gaggcattta aaatattagg taacatttaa
     5641 ttgaagtcac acaggtcttg gatggtattc gtggatagta aatactacga gcagtttttc
     5701 atatcagaga gtgagtaccc taaaactcca ccatgggagt aaattaaaat aatttcataa
     5761 ttggctatac ccttcatttt agtaaaaata cttcattttg aaagttattt ttttgccaca
     5821 ctgtttactg cgtaacactt ctcagcattt ctgtatgcaa actattttaa aatacagtga
     5881 tcaattcgtg tttatttttt acttcggaaa ttgtagtact caggtggtat tcaatgggca
     5941 atgattcttt gatgtgaatc ataatgtatt ttgaggactg caactataac acacgacttt
     6001 agccttaaga aaaggtctat tactccttcc tttgcatccc atggtatatt agcaaagtag
     6061 tttacagccc tgcacagcct tacaaagttg ttttacaatt tttttatgga aaacccttaa
     6121 caagagaaaa ttgtatcata ttacagtgct gatgagttat tgaatgatca ccctttgtaa
     6181 ataagttgtc tgataccaga aggccaaaga aagtcttgag attttagcta ttgaatgtgg
     6241 tgacttcata agatttctgt gcaaaaggta aggtgagatt ccattcagta ggcattctgt
     6301 tgatgtccat gaaaactaga cttccatatt agcttccttc aaaaggctca ttcccatttt
     6361 attaaaatgt ttgtacttgc aattttgtgt ttaatgttta ctttgtcttt tctttcttta
     6421 gcatttaggt gactgttcag cagttttcta tatggccatt gttggcctaa aactgcgcta
     6481 gtaacaagca tggtatttat cttgtattga aaataaaaac aaagttttgg taat
//
