LOCUS       NM_018813               2560 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cleavage and polyadenylation specificity factor 3
            (Cpsf3), transcript variant 1, mRNA.
ACCESSION   NM_018813
VERSION     NM_018813.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Heller-Trulli,D., Liu,H., Mukherjee,S. and Moore,C.L.
  TITLE     UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic
            Potential in 3T3-L1 Cells
  JOURNAL   Mol Cell Biol 42 (12), e0017422 (2022)
   PUBMED   36519931
  REMARK    GeneRIF: UBE3D Regulates mRNA 3'-End Processing and Maintains
            Adipogenic Potential in 3T3-L1 Cells.
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Vivori,C., Papasaikas,P., Stadhouders,R., Di Stefano,B.,
            Rubio,A.R., Balaguer,C.B., Generoso,S., Mallol,A., Sardina,J.L.,
            Payer,B., Graf,T. and Valcarcel,J.
  TITLE     Dynamics of alternative splicing during somatic cell reprogramming
            reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and
            TIA1
  JOURNAL   Genome Biol 22 (1), 171 (2021)
   PUBMED   34082786
  REMARK    GeneRIF: Dynamics of alternative splicing during somatic cell
            reprogramming reveals functions for RNA-binding proteins CPSF3,
            hnRNP UL1, and TIA1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Yang,X.C., Sullivan,K.D., Marzluff,W.F. and Dominski,Z.
  TITLE     Studies of the 5' exonuclease and endonuclease activities of
            CPSF-73 in histone pre-mRNA processing
  JOURNAL   Mol Cell Biol 29 (1), 31-42 (2009)
   PUBMED   18955505
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Collart,C., Remacle,J.E., Barabino,S., van Grunsven,L.A.,
            Nelles,L., Schellens,A., Van de Putte,T., Pype,S., Huylebroeck,D.
            and Verschueren,K.
  TITLE     Smicl is a novel Smad interacting protein and cleavage and
            polyadenylation specificity factor associated protein
  JOURNAL   Genes Cells 10 (9), 897-906 (2005)
   PUBMED   16115198
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY094575.1, AK149953.1, CF725936.1 and AK158036.1.
            
            On Aug 14, 2009 this sequence version replaced NM_018813.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158036.1, AK157205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY094575.1         5-78
            75-819              AK149953.1         2-746
            820-820             CF725936.1         429-429
            821-2315            AK149953.1         748-2242
            2316-2560           AK158036.1         2229-2473
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.3 cM"
     gene            1..2560
                     /gene="Cpsf3"
                     /note="cleavage and polyadenylation specificity factor 3"
                     /db_xref="GeneID:54451"
                     /db_xref="MGI:MGI:1859328"
     exon            1..248
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2253
                     /gene="Cpsf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cleavage and polyadenylation specificity factor subunit 3;
                     CPSF 73 kDa subunit; mRNA 3'-end-processing endonuclease
                     CPSF-73; cleavage and polyadenylation specificity factor
                     73 kDa subunit"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 3 isoform 1"
                     /protein_id="NP_061283.2"
                     /db_xref="CCDS:CCDS25834.1"
                     /db_xref="GeneID:54451"
                     /db_xref="MGI:MGI:1859328"
                     /translation="MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIH
                     PGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAI
                     YRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVL
                     GAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREER
                     EARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAK
                     KCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMIQN
                     GLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYIS
                     FSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRN
                     TEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAM
                     STVKQTQAIPYTGPFYLLYYQLQKLTGDVEELEIQEKPALKVFKSITVVQEPGMVVLE
                     WLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEVMLQDIFGE
                     DCVSVKDDSVLSVTVDGKTANINLETRAVECEEGSEDDESLREMVELAAQRLYEALTP
                     VH"
     exon            249..312
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..410
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..539
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            540..717
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..807
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..958
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1134
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1293
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1440
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1593
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1702
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1801
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1896
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1984
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2054
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2151
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2560
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf3"
                     /note="hexamer: AATAAA"
     polyA_site      2339
                     /gene="Cpsf3"
                     /note="major polyA site"
ORIGIN      
        1 cgcacctccg ggaacctaaa gaacctcgtt ctcgaaccgg aagttggagg gccgaatcta
       61 gctccgggaa cgctagagcg ccggaagttg tgtgttggtg gtgggggttt tttcttcttt
      121 ggtttgcagt agctgtgctt tgaatttaga gactgcggcg acgagttcgt ggtccacgct
      181 gctcctgaga ctgccaggat gtctgcgatt cctgcagagg agagcgacca gctgctgatc
      241 cgaccccttg gtgctgggca agaagtggga agatcatgta ttattctgga gttcaaagga
      301 aggaaaatca tgctggactg tgggatccac cctggcctgg aaggaatgga tgcccttcct
      361 tacattgacc ttatcgaccc agctgagatc gaccttctgt tgatcagtca tttccatttg
      421 gatcactgtg gagccctgcc ctggttcctt cagaagacaa gtttcaaagg acggacattt
      481 atgacccacg ccacaaaagc tatttataga tggcttctct cagactatgt caaagtcagc
      541 aacatatcgg cagatgacat gctgtacact gagacagact tggaagaaag catggacaaa
      601 atcgaaacca tcaattttca tgaagttaag gaagttgcag gaatcaagtt ctggtgttac
      661 catgccggcc acgtcctggg agcagccatg tttatgatag agatcgctgg tgtgaagctt
      721 ttgtatacag gtgatttctc aagacaagaa gacagacacc taatggctgc tgagattcct
      781 aatattaagc cagacatcct gatcattgag tctacgtatg ggacccatat ccatgagaag
      841 cgtgaagagc gagaagcaag attctgcaac actgtgcacg acattgtcaa cagagggggc
      901 agagggctca ttcctgtctt tgctctcgga agagctcagg agctgctcct gattctagat
      961 gagtactggc agaaccaccc ggagctgcat gacataccca tttactacgc atcgtctctg
     1021 gccaagaagt gcatggccgt gtaccagacc tacgtgaatg ccatgaacga caagatccgg
     1081 aagcagatca acatcaacaa cccctttgtt ttcaagcaca tcagcaacct caagagcatg
     1141 gatcactttg atgacattgg ccccagtgtt gtgatggcct caccaggcat gattcaaaac
     1201 ggcttatcca gagagctgtt tgaaagctgg tgtacagata agaggaatgg cgtcatcatc
     1261 gcggggtact gtgtcgaagg gacacttgcc aagcacatca tgtctgaacc tgaagaaatc
     1321 acgaccatgt ctggacagaa gttgccactg aaaatgtcgg ttgattacat ttctttctct
     1381 gctcacacag attaccagca aaccagtgaa tttattcgtg ctctgaagcc acctcacgtg
     1441 attttagtcc atggggaaca gaatgaaatg gccaggctga aagcagcgct gatccgagaa
     1501 tatgaagata atgatgaagt tcacatcgag gttcacaatc ctcggaacac agaggccgtg
     1561 accttaaact tcaggggaga gaagctcgcc aaggtcatgg gctttttggc agacaagaaa
     1621 ccagaacagg gccagcgggt ctctggaatt cttgttaaaa gaaactttaa ttaccacata
     1681 ctctctccct gtgacctctc caattacact gacctggcca tgagcactgt gaaacagacc
     1741 caggccatcc cgtacaccgg gcccttttac ctgctctact accagctcca gaaattgacg
     1801 ggtgatgtag aagaattaga aattcaagaa aagcctgctc tgaaggtgtt caaaagcatc
     1861 actgtggtgc aggagccggg catggtggtt ctggagtggc tggcgaaccc ctctaacgac
     1921 atgtatgcag acacagtgac caccgtgata ttggaagttc agtcaaatcc aaagataagg
     1981 aaaggtgcag tacagaaggt ctctaagaag ctagagatgc acgtttacag caagaggctg
     2041 gaggtcatgc tccaggacat atttggagaa gactgtgtca gtgtgaaaga tgactccgtc
     2101 ctcagtgtca cagtggacgg gaaaacagca aatattaatc tggagactcg ggctgtagaa
     2161 tgtgaagaag gaagtgaaga tgatgaatcc ctccgagaaa tggtggaact ggccgcccag
     2221 agactgtacg aggctctgac gccggtgcac tgacagcctt gcctcccaga ctcccagact
     2281 tttttacact cagccaagag ttaacttctg ttcttcaaat aaaataacct tagtttctcc
     2341 gggggtgcct gtttactttt gcatcagatg gcttgactac tgcaggacca ccaactgatg
     2401 tgtcctttat tctccaacta atcctcaagg gagccacttc tgcctgagca ccacactgag
     2461 tctgcctcca ggcactttcc gcagtgtatg ctgaaatctt cagctctccg tctgtcttcc
     2521 tctggtctgt actggcaaat ctgagttttg agttgaatgc
//
