LOCUS       NM_016856               5315 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cleavage and polyadenylation specific factor 2
            (Cpsf2), mRNA.
ACCESSION   NM_016856
VERSION     NM_016856.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5315)
  AUTHORS   Wang,Y., Yasmin,L., Li,L., Gao,P., Xu,X., Sun,X. and Godbout,R.
  TITLE     DDX1 vesicles control calcium-dependent mitochondrial activity in
            mouse embryos
  JOURNAL   Nat Commun 13 (1), 3794 (2022)
   PUBMED   35778392
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5315)
  AUTHORS   Engdahl,C., Naslund,J., Lindgren,L., Ahlm,C. and Bucht,G.
  TITLE     The Rift Valley Fever virus protein NSm and putative cellular
            protein interactions
  JOURNAL   Virol J 9, 139 (2012)
   PUBMED   22838834
  REMARK    GeneRIF: Cpsf2,Ppil2, and SNAP-25 are the most promising targets
            for the NSm protein of the virus during an infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5315)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (bases 1 to 5315)
  AUTHORS   Collart,C., Remacle,J.E., Barabino,S., van Grunsven,L.A.,
            Nelles,L., Schellens,A., Van de Putte,T., Pype,S., Huylebroeck,D.
            and Verschueren,K.
  TITLE     Smicl is a novel Smad interacting protein and cleavage and
            polyadenylation specificity factor associated protein
  JOURNAL   Genes Cells 10 (9), 897-906 (2005)
   PUBMED   16115198
REFERENCE   5  (bases 1 to 5315)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 5315)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 5315)
  AUTHORS   Huang,Y.S., Jung,M.Y., Sarkissian,M. and Richter,J.D.
  TITLE     N-methyl-D-aspartate receptor signaling results in Aurora
            kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA
            polyadenylation at synapses
  JOURNAL   EMBO J 21 (9), 2139-2148 (2002)
   PUBMED   11980711
REFERENCE   8  (bases 1 to 5315)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 5315)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147746.1, AF012822.1, AK084961.1, AK078904.1 and BE951303.1.
            
            On May 14, 2009 this sequence version replaced NM_016856.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013628.1, SRR1660813.207788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1430              AK147746.1         2-1431
            1431-2920           AF012822.1         1417-2906
            2921-4524           AK084961.1         376-1979
            4525-4896           AK078904.1         85-456
            4897-5315           BE951303.1         6-424               c
FEATURES             Location/Qualifiers
     source          1..5315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.34 cM"
     gene            1..5315
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="cleavage and polyadenylation specific factor 2"
                     /db_xref="GeneID:51786"
                     /db_xref="MGI:MGI:1861601"
     exon            1..161
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            162..343
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2543
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="CPSF 100 kDa subunit; cleavage and polyadenylation
                     specificity factor 100 kDa subunit; cleavage and
                     polyadenylation specific factor 2, 100kD subunit"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 2"
                     /protein_id="NP_058552.1"
                     /db_xref="CCDS:CCDS26116.1"
                     /db_xref="GeneID:51786"
                     /db_xref="MGI:MGI:1861601"
                     /translation="MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSVDI
                     IDSLRKHVHQIDAVLLSHPDPLHLGALPFAVGKLGLNCAIYATIPVYKMGQMFMYDLY
                     QSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIW
                     KIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQ
                     LLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNV
                     VEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLE
                     CGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPTEKVTEIELRKRVKLEGKEL
                     EEYVEKEKLKKEAAKKLEQSKEADIDSSDESDVEEDVDQPSAHKTKHDLMMKGEGSRK
                     GSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGE
                     EPMDQDLSDVPTKCVSATESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHG
                     PPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK
                     DAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSAMAQQKAMKSL
                     FGEDEKELGEETEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGG
                     VLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV"
     exon            344..503
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            504..609
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            610..739
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            740..855
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1043
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1334
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1435
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1636
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1789
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2015
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2315
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2450
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..5315
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="hexamer: AATAAA"
     polyA_site      3308
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="major polyA site"
     regulatory      4829..4834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="hexamer: AATAAA"
     polyA_site      4851
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
     polyA_site      5026
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="major polyA site"
     regulatory      5125..5130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
                     /note="hexamer: TATAAA"
     polyA_site      5147
                     /gene="Cpsf2"
                     /gene_synonym="100kDa; 2610024B04Rik; Cpsf; MCPSF;
                     mKIAA1367"
ORIGIN      
        1 agccgctctg ctcaggccca agatggcggc caccacacag gggctcctgc cggctgctct
       61 ccgccgctga gcgcgcgcta gctctgctcg ctctccgacc tgcgttccac taggggttgg
      121 gaagggcggc ggacggtgcc ggggggagat tggcctggca ggccctttta gctacccatt
      181 actggaccag aaagatgaca tctatcatca agttaaccac cctctctggg gttcaagaag
      241 agtccgctct ttgctatctt ctccaggttg atgagtttag gtttttgttg gactgtggct
      301 gggatgaaca cttctctgtg gacattattg attccctgag gaagcatgtt caccagatcg
      361 atgcagtgct cctgtctcat cctgatccac tccacctcgg tgccctccca ttcgccgtgg
      421 ggaagctggg tctaaactgt gccatctatg caacaattcc tgtgtataaa atgggccaga
      481 tgttcatgta cgacctctat cagtctcgac acaatacaga agattttacc ctctttacat
      541 tggatgatgt ggatgcagcc tttgacaaaa tacagcagct gaagttctct cagattgtga
      601 acctgaaagg caaaggacat ggtttgtcta tcacacccct gccagctggt catatgatag
      661 gagggacaat atggaaaata gtcaaagatg gagaagaaga aattgtgtat gccgtggact
      721 tcaaccacaa gagggagatc cacttaaatg gatgttccct ggaaatgcta agcagaccct
      781 ctctacttat cacagactca tttaatgcta cttacgtgca gcctagaagg aagcagagag
      841 atgagcagct cctgacaaac gtcctggaaa cgcttcgggg cgacgggaac gtgctgatag
      901 ctgtggacac agcaggcaga gttctggagc ttgctcaact cctggatcag atttggagaa
      961 ctaaagatgc cgggttgggc gtttactcgc tggctctcct gaacaacgtc agttacaacg
     1021 tggtggagtt ttctaagtcg caggtagaat ggatgagtga taaattgatg agatgttttg
     1081 aagacaaaag aaataaccca tttcagtttc gccatctctc tctgtgccac ggtctttctg
     1141 acttggctcg agttccaagc cccaaagttg tacttgccag ccagcctgac ctggagtgtg
     1201 gattctcaag ggacctcttt attcagtggt gtcaggaccc taaaaactca atcattctaa
     1261 cttataggac aactccgggg actttagcac gtttcttaat cgataatcct actgagaaag
     1321 ttacagaaat cgagctgagg aaacgtgtga agcttgaagg gaaagaactt gaggaatatg
     1381 tggaaaaaga aaaactcaag aaagaagctg ctaagaaact ggagcagtcg aaagaggcag
     1441 acatcgactc cagtgacgag agtgacgtgg aggaagacgt ggaccagcca tcggctcaca
     1501 agacaaagca cgacctgatg atgaaggggg aaggcagccg caaagggagc ttcttcaaac
     1561 aggccaagaa gtcctacccc atgtttcctg ccccagagga aagaattaaa tgggacgagt
     1621 atggcgagat catcaaacca gaagatttct tagtgccaga acttcaggct actgaagaag
     1681 aaaaaagcaa attagaatct ggcttgacaa atggagagga acccatggac caggacctgt
     1741 ctgatgttcc caccaagtgt gtttctgcaa cagagtctat tgagataaaa gccagagtta
     1801 cttacataga ctatgaagga cgctccgatg gagactccat taaaaagatc atcaatcaga
     1861 tgaagccacg gcagctcatc attgtccacg gcccaccaga ggccagccag gatctggccg
     1921 agtgctgccg tgcgtttggt gggaaagata ttaaagtgta catgccaaag ctgcacgaga
     1981 ccgtcgatgc caccagtgaa acgcatatct accaggtaag attaaaagac tcacttgtca
     2041 gctcccttca gttctgtaaa gctaaagatg ccgagttagc ttggatagat ggcgtcttag
     2101 acatgagagt ttccaaagtg gacacgggag ttattttaga agaaggagag ctcaaggacg
     2161 atggagaaga ctctgaaatg caagtggatg ctccatccga ttctagtgcc atggcccagc
     2221 agaaggccat gaagagtctg tttggagagg acgagaaaga gttgggtgag gagactgaga
     2281 tcatccccac gctggagcct ttgccacctc acgaggttcc tggacatcag tcagttttta
     2341 tgaatgaacc aagactgtct gacttcaagc aagttctttt gcgggagggg attcaagcgg
     2401 aatttgtagg gggcgtactt gtctgcaaca atcaagtagc agttcgcaga acagaaactg
     2461 gacgcatcgg attagaaggc tgcctttgtc aagactttta taggatacga gaccttttat
     2521 atgaacagta tgccattgtg taaaggacat gatgtcaaga tgtgtctgct tgacctttct
     2581 caggaagaaa ggattctcat ctgaggctaa acttttgctg tcttgttttg taacatacaa
     2641 aaagaatctg ccagaaaacg tgagcatgta ctagattttg aaaaatatga atcaagggcc
     2701 tggggtgtag ctcagtggta gagctcttgc ctagcatgtg caaggcccta ggtttgattc
     2761 tctgtcctga ataaagaaag aaagaaaatg taaatagaac ctattttgta aatgctcttg
     2821 cctagctctg aatgctagag gcccaacgaa gagacaggcc cagagccaag gggattggtg
     2881 tcctctgcag gtcccttgtt ccaagagctc attacttgaa gaagaaaaag gagaaaacaa
     2941 acaaacaaac aaaagaacag tgcaacttag caaacctgtt gatggcctta cagaaactgg
     3001 tgtgtgcaca tttgtgtgga cagtttcttg tgttttctgg aataagaagg gagaattgta
     3061 tagaaagagt atgctatgta cgataaaaga agcctcgtgg aacatttttc ttgagaaggg
     3121 gtgacgtgcg gctgctcctg tgagctctgc tcctcgtgga gccctctcta cctgtgcagt
     3181 gggaggcagt acacagttag tttagaaaca catttttatt tctcccattt cttgtttatt
     3241 aagatttttg ttgttgttca ctttgaattt ataacctcat catttgaata aatgttatct
     3301 aaaagaaagc ctctaagctg agtgtggtac gtgcgcttct aatcccagca ctcaggaggc
     3361 tggtgtagga ggactgtgaa ttagaggcca gcctgagctg catggttaga gcctgtctca
     3421 gccagcaaga ggagagcctg ctgtgttacc aggtctgtac atattttatt tagactcatc
     3481 ttaactattg gtccggtaac tgtctctgaa accatccaat gctcggtctt tttaaaaagc
     3541 aaatgtggaa gctcgcattt ttataaggta acagtgtgat ttaattaaag gttgtaaatg
     3601 gtttcctttc tgaacttgtt ttttaagttt atgtaaacag tggttggatt ttatgcttat
     3661 ttttacaaaa atagtactga acctggggaa ttgccaccct cgatacagta caaatgaatt
     3721 ctgttggaga gtaaaaactg aaaatatgta attctgttga cttgaacaat gaaccatgct
     3781 gtcctgttgt agtttcccag actaattttt agaaagtagc atgaacaagg caatccttga
     3841 tgccttacgt ggaagccgtc ttctctacac ttagcactca gagaggcctc actcttgttt
     3901 aactttggaa ctatgtctat ttcaacccag tgatctgcta tcggtctaga attagtcttt
     3961 tattcagctt catgtgctaa cagaaccttc tcttgtggat tatagccctg aagcaaagtt
     4021 tgtagccttt tgatactgaa aaccagatgc acaaaatagt gttgcagaga tgagtgtaaa
     4081 gagcgtattg tccttttatc agccatgaaa cattcctctt tcactcctgt tactagatag
     4141 aggaggccta taattatatt tccattccag gggaagaaat cctgcggttg ttacatgcta
     4201 taaagctctg catataccta ttacatggta attatatcta aaactatttc ttgcctaacc
     4261 tttctgctga cctacgaaca ggaatcagac tttaaaatat tccttgaaga tgattgttgt
     4321 acaataatgt cattggagag caatccaact gcctgtgtct agatgacatc atccaaaaat
     4381 tcctgaaatg gagaccttca ctctagcctc agctacttaa gaaaagcatg acttctaaag
     4441 acaacagtga gataagtcat gagagcagag agagtctcag atgcaagaat aaacacaggg
     4501 tgtgagacac cagtcgataa ctgcacatag ttttcttata aagaaattgt atctgggcac
     4561 ggcacggtgg cacatacctg taatttcatc aacttcattc aaacttggct gaaggccagt
     4621 ctggaccaca tacgaccctg cttcaaaaga aggagaaagg ggatggggac ataggtcggt
     4681 ggaagagtgc ttacctagca tgtgtgaggc cctgggtttg acccccaggt ctagaggttg
     4741 gggggttact tagtgtatct gttgctgtat ggttatacat ttttgcaatt attcctatat
     4801 ttttgtgact ccgtaggtga cctgagacaa taaagaagaa attagtttgt acggtgggtt
     4861 gtttaccttt ttttttcctt tccttttttt tttttttctt ggtgtctgta tgcagtttac
     4921 ataccgtaaa atatttactc tttttaaata tacaattcgc tggttttggt gacatcttca
     4981 accacttcta tgtaattcca gaattttttt taatcattcc aaaaaagaaa cccagtaacc
     5041 atttgtaccc cattttaacc atttgtaccc cattttctct tctccctggg tactcatcaa
     5101 tcttcctgtc tcttccagac attttataaa gaatcatgta acacgtagcc ttttgtgtcc
     5161 tctttcactt caactaacgg ttgttttcaa gattcgttaa cgtagtaaag cgttagcata
     5221 attcttgttt gcttcgggat gtagtcttgc attgtgtagc taaagctggt tcaaactcat
     5281 aatcctcctg cctctggtgt actgggattg taggc
//
