LOCUS       NM_053193               4538 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cleavage and polyadenylation specific factor 1
            (Cpsf1), transcript variant 2, mRNA.
ACCESSION   NM_053193 XM_910829
VERSION     NM_053193.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4538)
  AUTHORS   Quille,M.L., Carat,S., Quemener-Redon,S., Hirchaud,E., Baron,D.,
            Benech,C., Guihot,J., Placet,M., Mignen,O., Ferec,C., Houlgatte,R.
            and Friocourt,G.
  TITLE     High-throughput analysis of promoter occupancy reveals new targets
            for Arx, a gene mutated in mental retardation and
            interneuronopathies
  JOURNAL   PLoS One 6 (9), e25181 (2011)
   PUBMED   21966449
REFERENCE   2  (bases 1 to 4538)
  AUTHORS   Nakanishi,T., Kumagai,S., Kimura,M., Watanabe,H., Sakurai,T.,
            Kimura,M., Kashiwabara,S. and Baba,T.
  TITLE     Disruption of mouse poly(A) polymerase mGLD-2 does not alter
            polyadenylation status in oocytes and somatic cells
  JOURNAL   Biochem Biophys Res Commun 364 (1), 14-19 (2007)
   PUBMED   17927953
REFERENCE   3  (bases 1 to 4538)
  AUTHORS   Dass,B., Attaya,E.N., Michelle Wallace,A. and MacDonald,C.C.
  TITLE     Overexpression of the CstF-64 and CPSF-160 polyadenylation protein
            messenger RNAs in mouse male germ cells
  JOURNAL   Biol Reprod 64 (6), 1722-1729 (2001)
   PUBMED   11369601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056388.1.
            
            On Aug 13, 2009 this sequence version replaced NM_053193.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056388.1, AF322193.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.13 cM"
     gene            1..4538
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /note="cleavage and polyadenylation specific factor 1"
                     /db_xref="GeneID:94230"
                     /db_xref="MGI:MGI:2679722"
     exon            1..257
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..4439
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /EC_number="2.4.2.30"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cleavage and polyadenylation specificity factor subunit 1;
                     CPSF 160 kDa subunit; cleavage and polyadenylation
                     specificity factor 160 kDa subunit"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 1 isoform 2"
                     /protein_id="NP_444423.1"
                     /db_xref="CCDS:CCDS27577.1"
                     /db_xref="GeneID:94230"
                     /db_xref="MGI:MGI:2679722"
                     /translation="MYAVYKQAHPPTGLEFTMYCNFFNNSERNLVVAGTSQLYVYRLN
                     RDAEALTKNDGSTEGKAHREKLELVASFSFFGNVMSMASVQLAGAKRDALLLSFKDAK
                     LSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLIYGTRLV
                     VLPFRRESLAEEHEGLMGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLL
                     ILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIG
                     GVVIFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQAAFISYDK
                     MVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSL
                     LLKYTEKLQEPPASSVREAADKEEPPSKKKRVEPAVGWTGGKTVPQDEVDEIEVYGSE
                     AQSGTQLATYSFEVCDSMLNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGYGKN
                     GALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEETPKAESTEQEPSAPKAEED
                     GRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGI
                     RLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLAL
                     HKPPLHHQSKVIALCLYRDVSGMFTTESRLGGARDELGGRSGSEAEGLGSETSPTVDD
                     EEEMLYGDSSALFSPSKEEARRSSQPPADRDPAPFKADPTHWCLLVRENGTMEIYQLP
                     DWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEVRKEEATRQGELPLVKEVLLVALGSRQ
                     SRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGC
                     STEEGSGGRGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMGIDGPIDS
                     FAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESK
                     VYAVATSTNTPCTRIPRMTGEEKEFEAIERDDRYIHPQQEAFSIQLISPVSWEAIPNA
                     RIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVV
                     PEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFI
                     DTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDN
                     AQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGAAEG
                     PSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRA
                     FRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDR
                     VTAHF"
     exon            258..285
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            286..419
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            420..500
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            501..652
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            653..799
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            800..939
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1050
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1144
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1232
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1355
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1407
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1502
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1577
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1658
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1748
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1859
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2001
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2180
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2317
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2492
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2699
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2789
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2933
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3086
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3203
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3294
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3379
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3521
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3674
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3851
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3918
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..3966
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4122
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            4123..4252
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4391
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     exon            4392..4516
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4487..4492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /note="hexamer: TATAAA"
     polyA_site      4516
                     /gene="Cpsf1"
                     /gene_synonym="CPSF160"
                     /note="major polyA site"
ORIGIN      
        1 cgcaggcgca gtacttcgga acccggtggc tgggttggcg cgcgcggccg gaccgagtcc
       61 gctgccgtcc ctgtcccccg agtcggcggc tccggcgtga cagtggcggc gacatgtacg
      121 cggtgtacaa gcaggcgcac ccgcccaccg ggctggagtt taccatgtac tgcaacttct
      181 tcaacaacag tgagcgcaac ctcgtggtgg ccggcacctc gcagctctat gtgtaccgcc
      241 tgaaccgcga cgccgaggct ctgaccaaga atgatgggag cacagagggg aaggcccacc
      301 gagagaaact agagctggta gcctccttct ctttttttgg caatgtcatg tccatggcca
      361 gtgtgcagct tgcaggcgcc aaacgtgatg ccttgcttct cagtttcaaa gacgctaagc
      421 tgtctgtggt ggagtatgac ccaggcactc atgacctgaa gaccctgtct ctacactact
      481 ttgaggagcc tgaacttcgg gatgggtttg tgcagaacgt gcatacgcct cgtgtgcggg
      541 tggaccctga cgggcgctgt gcagcaatgc tcatctatgg cacgaggctg gtagttctgc
      601 ctttccgcag agagagcctg gctgaggaac atgaggggct catgggcgaa gggcagaggt
      661 ctagcttctt gcccagctac atcattgatg tacgggctct ggatgagaaa ctactcaaca
      721 tcattgacct gcagttcctg catggctact atgagcccac cctgcttatc ctgtttgagc
      781 ccaaccagac ttggccaggg cgggtggctg tgaggcagga cacgtgctcc attgtggcta
      841 tctcgctgaa catcacacag aaagtccatc cagtcatctg gtccctcacc agcttgcctt
      901 ttgactgtac ccaggccctg gctgtgccca agcccatagg tggggtagtg atcttcgctg
      961 tcaactcact gttgtacctg aaccagagtg ttcccccata tggtgtggct ctcaatagtc
     1021 tcaccacagg caccaccgct ttcccattgc gtacccaaga gggtgtacgg atcaccctag
     1081 actgcgcaca ggcggccttc atctcttatg acaagatggt catctccctc aagggtggtg
     1141 agatttatgt gctgaccctc atcactgacg gcatgcgaag tgtccgagcg tttcactttg
     1201 acaaggcagc tgctagtgtc cttaccacca gtatggtcac aatggagccc ggatacctgt
     1261 tcctaggctc tcgcctgggc aattccctcc tcctcaagta cacggagaag ctgcaggagc
     1321 ccccagccag ctccgtccgt gaggctgctg acaaggaaga gccaccctca aagaagaagc
     1381 gagtggagcc tgcagtgggc tggacaggag gcaagacggt gccacaggac gaggtggatg
     1441 aaattgaagt ttatggcagt gaggcccagt caggcacaca gctggctact tactcttttg
     1501 aggtatgtga cagcatgctc aacattggac cctgtgccaa cgctgctgtg ggcgagcctg
     1561 ccttcctctc tgaagagttc cagaatagcc ctgagccaga cctggagatt gtggtttgtt
     1621 ccggctacgg gaagaatggg gccctgtcag tgttgcagaa gagtatccgg ccccaggtgg
     1681 tgacaacctt tgaacttcct ggctgctatg atatgtggac agtcattgct cctgtgcgga
     1741 aagaggagga agaaaccccc aaagcagaga gcacagagca ggagcccagt gccccgaaag
     1801 cagaggagga tgggcgaaga catggcttcc ttattcttag ccgggaagac tcaaccatga
     1861 tcctacagac tggccaggag atcatggagc tggacaccag tggttttgcc actcagggtc
     1921 ctactgtctt tgctggaaac attggggaca atcgttacat tgttcaagtc tcgccactgg
     1981 gcattcgcct gttggaaggc gtgaatcaat tgcacttcat ccctgtggac ctgggcgccc
     2041 ccatcgtgca gtgtgccgtg gctgatccct atgtggttat catgagtgct gagggacacg
     2101 ttaccatgtt cctactcaag agcgattcct atggtggccg tcatcaccgc ctggcactac
     2161 acaagcctcc actgcatcat cagtccaagg tgattgctct ctgcctgtac cgcgatgtca
     2221 gtggcatgtt caccactgag agccgcctgg gtggggcccg tgatgaactg ggtggccgaa
     2281 gtggctccga ggcagaaggc ctgggctcag aaacgagccc cacagtggat gatgaggaag
     2341 agatgctcta tggggactcc agtgccctct tcagtcccag caaagaggag gcccgtagga
     2401 gcagccagcc accggctgat cgtgaccctg cacccttcaa ggcagacccc actcactggt
     2461 gcctgctggt gcgggagaat ggcaccatgg agatctacca gctcccagac tggcggctgg
     2521 tattcctagt taagaacttc cccgtggggc agcgggttct ggtggacagt tcatttggac
     2581 agcccactac acaaggtgaa gtccgaaagg aagaagccac acgccagggg gagctgcctt
     2641 tggttaagga ggtgttgttg gttgctctgg gaagccggca gagcaggccc tacctgctgg
     2701 tacacgtgga ccaggagttg cttatctatg aagcctttcc ccatgactct cagcttggcc
     2761 agggaaatct taaagtccgt ttcaaaaagg tccctcacaa tatcaacttc cgtgaaaaga
     2821 agccaaagcc gtccaagaag aaggccgaag gttgcagcac tgaggaggga tctggaggcc
     2881 ggggccgtgt ggcacgtttc cgctactttg aggatattta tggctattcg ggggttttca
     2941 tctgtggacc ctcacctcac tggctcctgg tgactggccg cggagctctg cgtctgcacc
     3001 ccatgggcat tgatggcccc attgactcct ttgctccttt ccacaatgtg aactgccccc
     3061 gtggtttcct gtacttcaac agacaggggg agctgaggat cagcgtcctg cctgcctacc
     3121 tgtcctacga tgccccatgg cctgtcagga agatcccact ccgatgcaca gcccactatg
     3181 tggcctacca tgtggaatcc aaggtctatg ctgtggccac tagtaccaac acaccttgca
     3241 ctaggatccc acgcatgact ggcgaggaaa aagaattcga ggccattgag agagacgaca
     3301 gatacatcca cccccagcaa gaagccttct ccatccagct catctccccg gtcagctggg
     3361 aggccattcc caatgccagg atcgagctag aggaatggga gcatgtcacg tgcatgaaga
     3421 cagtgtcact gcgcagtgag gagaccgtgt caggcctaaa gggctatgtg gctgctggga
     3481 cctgcctcat gcagggggag gaggtcacgt gccgtgggcg gatcctgatc atggatgtga
     3541 ttgaagtggt gcctgagcct gggcagcccc tgaccaagaa caaattcaag gtcctgtatg
     3601 agaaggagca gaaagggccc gtgactgcgc tgtgccactg caatggccac ctggtgtcgg
     3661 ccattggcca aaaaatcttc ctgtggagcc tgcgggctag cgagctgacc ggcatggcct
     3721 tcatcgacac ccagctgtac atccaccaga tgatcagtgt caagaacttc atcctggcag
     3781 cagacgtcat gaagagcatc tcactgctgc gttaccaaga ggagagcaag acgctgagcc
     3841 tggtgtcccg ggatgccaag cctttggagg tatacagcgt ggacttcatg gtggacaatg
     3901 cccaactggg cttcttggtg tctgaccgag accgcaatct tatggtgtat atgtatctgc
     3961 cagaagccaa agagagtttt gggggcatgc gcctgctacg cagagcggat ttccatgtgg
     4021 gtgcccacgt gaatacgttc tggaggaccc cgtgccgagg tgctgccgag ggccccagca
     4081 agaagtcagt cgtgtgggaa aacaagcata tcacatggtt tgcaaccctt gacggtggca
     4141 ttgggctcct gctgcccatg caagaaaaga cataccgacg cttgctgatg ctgcagaatg
     4201 cactgacgac catgctaccc caccacgctg gcctcaaccc ccgcgccttc cgaatgttgc
     4261 acgtagaccg gcgcatcttg cagaatgctg tgcgcaacgt ccttgatggg gaactgctaa
     4321 accgctacct atacctcagc accatggagc gcagtgagct ggccaagaag ataggtacca
     4381 cgcctgacat tatcctggat gacttgctgg agacagaccg ggtcacggct cacttctaac
     4441 tctaggatgc tgctctggtg ttgtacactt ccctctaccc attttgtata aaacacaaag
     4501 aaaacgattt ctttcaaaaa aaaaaaaaaa aaaaaaaa
//
