LOCUS       NM_176073               1923 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxypeptidase Q (Cpq), transcript variant 2, mRNA.
ACCESSION   NM_176073
VERSION     NM_176073.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Della Fazia,M.A., Castelli,M., Bartoli,D., Pieroni,S.,
            Pettirossi,V., Piobbico,D., Viola-Magni,M. and Servillo,G.
  TITLE     HOPS: a novel cAMP-dependent shuttling protein involved in protein
            synthesis regulation
  JOURNAL   J Cell Sci 118 (Pt 14), 3185-3194 (2005)
   PUBMED   16014383
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK624628.1, AK135096.1 and BB472698.2.
            
            On May 22, 2007 this sequence version replaced NM_176073.3.
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037067.1, AK135096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CK624628.1         1-15
            16-1920             AK135096.1         3-1907
            1921-1923           BB472698.2         291-293
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.74 cM"
     gene            1..1923
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /note="carboxypeptidase Q"
                     /db_xref="GeneID:54381"
                     /db_xref="MGI:MGI:1889205"
     exon            1..194
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            195..642
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1628
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /EC_number="3.4.17.-"
                     /note="hematopoietic lineage switch 2; plasma glutamate
                     carboxypeptidase"
                     /codon_start=1
                     /product="carboxypeptidase Q precursor"
                     /protein_id="NP_788262.1"
                     /db_xref="CCDS:CCDS27414.1"
                     /db_xref="GeneID:54381"
                     /db_xref="MGI:MGI:1889205"
                     /translation="MRSLFFLFIVHLLALGSGKAVFKNGVSQRTFREIKEEIANYEDV
                     AKAIINLAVYGKYQNRSYERLGLLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLENVH
                     LEQVRIPHWERGEESAVMLEPRIHKMAILGLGSSIGTPPGGITAEVLVVASFDELQRR
                     ASEARGKIIVYNQPYTGYEKTVQYRVQGAVEAAKVGAVASLIQSVASFSIYSPHTGIQ
                     KYQDGVPKIPTACITVEDAEMMSRMASRGNKIVIHLEMGAKTYPDTDSFNTVAEITGS
                     MYPEEVVLVSGHLDSWDVGQGALDDGGGAFISWEALSLVKDLGLRPKRTLRLVLWTAE
                     EQGGIGASQYYELHKANISKYSLVMEADSGTFLPTGLQFTGSDKARAIMKEVMNLLQP
                     LNVTKVFSNGEGTDINFWIQAGVPGASLRDDLYKYFFFHHSHGDTMTVMDPKQMNVAA
                     AVWAVVAYVVADMDEMLPRS"
     exon            643..850
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1058
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1170
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1262
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1464
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1923
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /note="hexamer: AATAAA"
     polyA_site      1875
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /note="major polyA site"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
                     /note="hexamer: ATTAAA"
     polyA_site      1923
                     /gene="Cpq"
                     /gene_synonym="1190003P12Rik; 2610034C17Rik; Hls2; Lal-1;
                     Pgcp"
ORIGIN      
        1 gctgtcctgg cacacaaaga agccaggcct gcagactact ggggctccgg gctgttcctg
       61 aggcctctgg aggcccgccc tgtggctcca gtgcgctctg aggaccttcc tggtcccgcc
      121 cccgaacgtg cctgtggtct gcaggcctca ccgggtgttg tggccgctgc tgctccgcag
      181 agcctcgtga tcaggaagaa aagcaactag gaacaatgag gtcccttttc ttcctgttca
      241 ttgttcacct tttagccttg ggctctggta aagctgtatt caagaatggt gtttctcagc
      301 gaacatttcg agaaataaaa gaagaaatag ccaactatga agatgttgct aaagcaatta
      361 tcaaccttgc tgtttatggt aaataccaga accggtccta tgagcgtttg ggacttctag
      421 ttgatactgt tggacccaga ctgagtggct ctaagaacct agagaaagct attcaaatca
      481 tgtaccaaaa cctgcagcaa gatgggctag aaaatgttca cctggagcag gtcagaatac
      541 cccactggga gaggggagaa gaatctgcag tgatgcttga gcctcgaatt cacaagatgg
      601 ctattctagg tcttggcagc agcattggga ctcccccagg aggcatcaca gcagaagtgc
      661 tggtggtagc ctcttttgat gaacttcaaa gaagagcatc agaagcaaga gggaagatca
      721 ttgtttataa ccagccttac actggctatg agaagactgt gcagtaccgg gtgcagggag
      781 ctgtggaagc tgccaaggtg ggagctgtgg catccctcat ccaatcagta gcttcctttt
      841 ccatctacag tcctcacaca ggtattcaga aatatcaaga tggtgtgccc aagattccaa
      901 cagcctgtat cacagtagaa gatgcagaaa tgatgtctcg aatggcttct cgtgggaaca
      961 aaattgtcat tcatctggaa atgggagcaa agacctatcc agatactgat tccttcaata
     1021 ctgttgcaga gatcactggg agcatgtatc cagaggaagt tgtcctggtc agtggacatt
     1081 tggacagctg ggatgttggg cagggtgcac tggatgatgg tggtggagcc ttcatatcat
     1141 gggaagcact ctcacttgtt aaagatcttg ggctgcgtcc aaagaggact ctgcgcctgg
     1201 tgctctggac tgcagaagaa caaggaggaa ttggtgcctc ccagtattat gagctacata
     1261 aggcaaatat ttccaagtac agcttggtga tggaagctga ctcaggaacc ttcttaccca
     1321 ctggactgca gttcactggc agtgacaagg ccagggctat catgaaggaa gtcatgaatc
     1381 ttctgcaacc cctcaatgtc accaaggtct ttagtaatgg agaaggaact gatattaact
     1441 tctggatcca agctggagta cctggagcca gtctgcgtga tgacttgtac aagtatttct
     1501 ttttccatca ttcccacgga gacaccatga ctgtcatgga tccaaagcag atgaatgttg
     1561 ctgctgctgt atgggctgtt gtcgcttatg ttgttgcaga catggatgaa atgctgccca
     1621 ggtcctaagg agaacaagaa gagaggacct tgttctctgt agttgggaat cccaactctg
     1681 aatctttaca acatccatcg tcacaaaaga gtgttataca tttaatccac agggcatagt
     1741 tttctttata ccttctgtta atcatctttc cttaatactt tcttatctgt ttctagaata
     1801 aatcatgatc cctactgcac caccttgaaa atgttgtttc cagttttaaa ataagcaata
     1861 aatatttgaa atgcttctga tttttcattt tcatttaaaa acattaaatt aaatgtaatg
     1921 aga
//
