LOCUS       NM_007757               3186 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coproporphyrinogen oxidase (Cpox), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_007757 XM_358852
VERSION     NM_007757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Kang,X., Shimada,S., Miyahara,H., Higuchi,K. and Mori,M.
  TITLE     BALB.NCT-Cpoxnct is a unique mouse model of hereditary
            coproporphyria
  JOURNAL   Mol Genet Metab Rep 35, 100964 (2023)
   PUBMED   36967721
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3186)
  AUTHORS   Miyasaka,Y., Okuda,K., Miura,I., Motegi,H., Wakana,S. and Ohno,T.
  TITLE     A novel ENU-induced Cpox mutation causes microcytic hypochromic
            anemia in mice
  JOURNAL   Exp Anim 71 (4), 433-441 (2022)
   PUBMED   35527013
  REMARK    GeneRIF: A novel ENU-induced Cpox mutation causes microcytic
            hypochromic anemia in mice.
REFERENCE   4  (bases 1 to 3186)
  AUTHORS   Mori,M., Liu,C., Yoshizawa,T., Miyahara,H., Dai,J., Igarashi,Y.,
            Cui,X., Li,Y., Kang,X. and Higuchi,K.
  TITLE     Polygenic control of the wavy coat of the NCT mouse: involvement of
            an intracisternal A particle insertional mutation of the protease,
            serine 53 (Prss53) gene, and a modifier gene
  JOURNAL   Mamm Genome 33 (3), 451-464 (2022)
   PUBMED   35067752
REFERENCE   5  (bases 1 to 3186)
  AUTHORS   Liu,C., Miyahara,H., Dai,J., Cui,X., Li,Y., Kang,X., Higuchi,K. and
            Mori,M.
  TITLE     Involvement of increased endoplasmic reticulum stress in the
            development of cataracts in BALB.NCT-Cpoxnct mice
  JOURNAL   Exp Eye Res 215, 108905 (2022)
   PUBMED   34968474
REFERENCE   6  (bases 1 to 3186)
  AUTHORS   Shiels,A., Griffin,C.S. and Muggleton-Harris,A.L.
  TITLE     Immunochemical comparison of the major intrinsic protein of
            eye-lens fibre cell membranes in mice with hereditary cataracts
  JOURNAL   Biochim Biophys Acta 1097 (4), 318-324 (1991)
   PUBMED   1742336
REFERENCE   7  (bases 1 to 3186)
  AUTHORS   Matsuzawa,A. and Wada,E.
  TITLE     Retarded and distinct progress of lens opacification in congenic
            hereditary cataract mice, Balb/c-nct/nct
  JOURNAL   Exp Eye Res 47 (5), 705-711 (1988)
   PUBMED   3197771
REFERENCE   8  (bases 1 to 3186)
  AUTHORS   Piatigorsky,J., Fukui,H.N. and Kinoshita,J.H.
  TITLE     Differential metabolism and leakage of protein in an inherited
            cataract and a normal lens cultured with ouabain
  JOURNAL   Nature 274 (5671), 558-562 (1978)
   PUBMED   672986
REFERENCE   9  (bases 1 to 3186)
  AUTHORS   Hamai,Y., Fukui,H.N. and Kuwabara,T.
  TITLE     Morphology of hereditary mouse cataract
  JOURNAL   Exp Eye Res 18 (6), 537-546 (1974)
   PUBMED   4853271
REFERENCE   10 (bases 1 to 3186)
  AUTHORS   Iwata,S. and Kinoshita,J.H.
  TITLE     Mechanism of development of hereditary cataract in mice
  JOURNAL   Invest Ophthalmol 10 (7), 504-512 (1971)
   PUBMED   4253692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ142773.1, BY728426.1, CA535096.1, D16333.1 and AC159200.2.
            
            On Dec 1, 2007 this sequence version replaced NM_007757.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16333.1, BC017680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               CJ142773.1         2-141
            141-672             BY728426.1         1-532
            673-1171            CA535096.1         1-499
            1172-1624           D16333.1           1086-1538
            1625-3186           AC159200.2         103197-104758       c
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16"
     gene            1..3186
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /note="coproporphyrinogen oxidase"
                     /db_xref="GeneID:12892"
                     /db_xref="MGI:MGI:104841"
     exon            1..743
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1552
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /EC_number="1.3.3.3"
                     /note="coproporphyrinogen-III oxidase, mitochondrial;
                     clone 560; COX; coprogen oxidase; coproporphyrinogenase;
                     Coproporphyrinogen III oxidase, mitochondrial precursor
                     (Coproporphyrinogenase) (Coprogen oxidase) (COX);
                     oxygen-dependent coproporphyrinogen-III oxidase,
                     mitochondrial"
                     /codon_start=1
                     /product="oxygen-dependent coproporphyrinogen-III oxidase,
                     mitochondrial precursor"
                     /protein_id="NP_031783.2"
                     /db_xref="CCDS:CCDS49878.1"
                     /db_xref="GeneID:12892"
                     /db_xref="MGI:MGI:104841"
                     /translation="MALRLGRLGSDPWWRAVLGDYAQLRAASPRCASARVCQLPGTAG
                     PQPRRGLGYGPWARGGSGLGTRLAATLAGLAGLAAAAFGHVQRAEMVPKSSGARSPSP
                     GRREEDGDELARRCSTFMSSPVTELRELRRRPEDMKTKMELMIMETQAQVCRALAQVD
                     GVADFTVDRWERKEGGGGITCVLQDGRVFEKAGVSISVVHGNLSEEAANQMRGRGKTL
                     KTKDSKLPFTAMGVSSVIHPKNPYAPTMHFNYRYFEVEEADGNTHWWFGGGCDLTPTY
                     LNQEDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIVHRGERRGIGGIFFDDLDSP
                     SKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPRDKLWQQLRRGRYVEFNLLYDRGT
                     KFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWVH"
     exon            744..887
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     exon            888..998
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1140
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1359
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1464
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..3186
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3160..3165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /note="hexamer: AATAAA"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /note="hexamer: ATTATA"
     polyA_site      3181
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
                     /note="major polyA site"
     polyA_site      3186
                     /gene="Cpox"
                     /gene_synonym="cac; Cpo; CPX; HCP; M100835; nct; Rgsc835"
ORIGIN      
        1 agtcttatct gctctttccg ggagcggtca ggcgagtgca ggaggcgata ggacgggact
       61 acagttccca gcagcctcct cggctcccgc cagcagcctg cgacctacac tcgcagcagc
      121 tcttccgaac tccacgtagc agtgctgggg agtctgggtc tcaggaccct gggagctccg
      181 gtgggtctgc aggatcggat ttgcccagtc ccggcgggag atggccttgc ggctgggccg
      241 cctgggttcg gacccctggt ggcgagcggt gctgggcgac tatgctcagc tgcgcgccgc
      301 gtccccgcgc tgcgcgtccg cccgcgtctg ccagctgcct ggcacggctg gtccccagcc
      361 tcgccgcggg ctgggctacg gcccctgggc tagaggcggg tccgggctgg ggacccggct
      421 ggccgcgacg ctggcggggt tggcagggct ggcagccgcc gcctttgggc acgtgcagcg
      481 ggcggagatg gtgcccaaga gctcgggggc gcggagcccc tcacctggac ggcgggagga
      541 ggacggggac gagctggccc gccgctgcag caccttcatg tcctcgccgg tgaccgagct
      601 gcgggagctg cggaggaggc cggaggacat gaagaccaag atggagctga tgattatgga
      661 gacccaggct caggtgtgtc gggcactggc gcaggtagat ggcgttgccg acttcactgt
      721 ggaccggtgg gagaggaaag aaggaggagg tggcatcacc tgtgtgcttc aggacgggcg
      781 tgtgtttgaa aaggccgggg tgagcatttc cgtcgttcat gggaatcttt ctgaggaagc
      841 agcgaaccaa atgagaggca gaggcaaaac tctgaagacg aaagatagta aattgccatt
      901 tactgctatg ggtgtaagtt ctgtgattca ccccaagaat ccttatgcgc ccaccatgca
      961 tttcaactac agatactttg aagtagagga agctgacggt aacacacact ggtggtttgg
     1021 gggtggctgt gacctcacac cgacatactt gaaccaagag gatgctgtcc atttccaccg
     1081 tactctaaag gaagcttgcg atcagcatgg gccagacatc tacccaaagt ttaaaaaatg
     1141 gtgtgacgac tacttcttta tagttcaccg cggggagcgg aggggcatcg gcggcatctt
     1201 ttttgacgat cttgactccc cctccaagga ggaggctttc cgcttcgtga agacgtgtgc
     1261 tgaggctgtg gtcccttcct atgttcccat tgtgaagaag cactgcgatg actcctacac
     1321 ccccagggac aagctgtggc agcagctgag gagagggcgg tatgtggagt ttaatctgtt
     1381 gtatgatcgg ggcaccaagt ttggcctctt tactccagga tccaggatcg aaagtatctt
     1441 gatgtcttta cctctaacag caagatggga gtacatgcat tctcccccag agaattccaa
     1501 agaagctgaa attctggaag tgttgcgcca tccaaaggac tgggtgcact gatgcatcag
     1561 acagagcctt gctccagggc ctggtggaca caggtggtgt cttcgtgcac tgtggccact
     1621 gtgtggcagg cagtgtcttc cgtgccttac tgtccccgcc ttcttcaccc tgggcacccc
     1681 gtctgtggca ggcggttttg atcttttcca gtgctgtggg aggaggtggc tcagaggtgg
     1741 gtggggatgt caaactgtca gattccttgt ctgtgacatc catttgtact tttagaataa
     1801 ttttctgtga ccagtcagtt tgacattgtg tttccaggtc tttgagataa gggaatgtaa
     1861 atactatgat aggtaccagg aaactcttca ttttatatgt tgcttgaagt tttagttttt
     1921 gctacagaag tttatcaggg aatacatttt atcttcatta gttcagtcag gatgcccttc
     1981 ttgggaactt tggaatgcaa tttgaagcca gtccgtggtg atgtttgcct ttaatctcag
     2041 tattcaggaa gcagaggctg gtggatctct gtgattttga ggccaggcta ttctacaaag
     2101 ggagttctag tccagccagg gctacacaga gaaaccctgt cttgaaaaag aaccaacccc
     2161 cccccccaaa aaaaaaaacg aaaaaaagaa agaaaggaag aaagaaagaa agcaatttga
     2221 agaaacatgt ttttctttgt tgcttttgaa gtttctttga cgtaattttc atgtatcttt
     2281 ctctatattc cagaatatta taaaaaaata ctcatttttt ttttaaagat agctatttaa
     2341 gagctctgga aattttcttt agtcagtttt tgtattatat aatgatgacc tagtttacaa
     2401 ctgcagatgg cattattatt atttaaataa gtgatatctt cagtggtaag gtttttgtga
     2461 gatcataatt agctaacatt aggattctat gtaattttga aagtgaaagc ttatatccct
     2521 ggattctgat acttaaaagt tttatatttt agagacttag atatgggaga ttagcctaag
     2581 gacaaatgaa acacattttt tttctcttta attaaagaga atggagtcta acctgggcat
     2641 tttatatttt ttatttaaaa aatgggccaa tagaaattgt gttacttttt aaattagaga
     2701 ttcttcaact tttatctttt cttttaaaag tcacagcaga tttctttttc tttctttttt
     2761 tttaaaaatt aggtattttc tttatttaca tttcaaatgc tttcccaaaa gtcccccata
     2821 cccccccccc actcccctac ccacccactc ccacttcttg gccctggcgt tcccccgtac
     2881 tggggcatat aaagtttgca agaccaaggg gcctctcttc ccaatgatgg ccgactaggt
     2941 catcttctgc tacatatgca gccgatttct taatgtgtgg tttacttgtc taaataatag
     3001 tctgactgcg ctatgttact tgatttataa tatattgaat ttgtaaagaa caatatttaa
     3061 atattatcct ggaatatgtt ggatgtatgt gattgtgttt gccactttta gggtaagaaa
     3121 atctacagat tcttcaacat gtcttacata gattcagcta ataaatttta ttataacata
     3181 agaaaa
//
